product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal LOX Antibody
catalog :
NB100-2528R
quantity :
0.1 ml
price :
319.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
DyLight 550
reactivity :
human, mouse, rat, zebrafish
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-2528R
Product Name :
Rabbit Polyclonal LOX Antibody
List Price :
319.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
lysyl oxidaseEC 1.4.3.13, MGC105112, protein-lysine 6-oxidase
Background :
Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
DyLight 550
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to an internal region of the human LOX protein (within residues 300-350). [Swiss-Prot P28300]
Localization :
Nucleus, cytoplasm, secreted.
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human and mouse. Predicted to react with rat and bovine based on 100% sequence homology. Immunogen sequence has 92% homology to porcine, Xenopus and Zebrafish.
Storage :
Store at 4C in the dark.
Swissprot Human :
P28300
Uses :
This LOX antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot analysis. In Western blot a band is observed ~50 kDa representing the Lox propeptide. In ICC/IF, cytoplasmic staining was observed in HeLa cells.
Research Area :
Cancer, Cytoskeleton Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.