product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
LOX Antibody - BSA Free
catalog :
NB100-2527
quantity :
0.1 ml (also 0.025 ml)
price :
449 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 213
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 5b
Mart xed nez Nieto G, Teppo H, Petrelius N, Izzi V, Devarajan R, Pet xe4 ist xf6 T, et al. Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis. Front Oncol. 2022;12:981009 pubmed publisher
Cetin M, Saatci Ö, Rezaeian A, Rao C, Beneker C, Sreenivas K, et al. A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer. Cell Chem Biol. 2024;31:1926-1941.e11 pubmed publisher
Sasaki M, Hara T, Wang J, Zhou Y, Kennedy K, Umeweni C, et al. Lysyl Oxidase Regulates Epithelial Differentiation and Barrier Integrity in Eosinophilic Esophagitis. Cell Mol Gastroenterol Hepatol. 2024;17:923-937 pubmed publisher
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Wang Q, Sundar I, Lucas J, Park J, Nogales A, Martinez Sobrido L, et al. Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization. Nat Commun. 2023;14:1295 pubmed publisher
Ning Y, Zhou I, Roberts J, Rotile N, Akam E, Barrett S, et al. Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment. Sci Transl Med. 2022;14:eabq6297 pubmed publisher
Jiang C, Wang M, Yao W, Lv G, Liu X, Wang G. Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification. Front Mol Biosci. 2022;9:778857 pubmed publisher
Novotny T, Eckhardt A, Doubková M, Knitlova J, Vondrášek D, Vanaskova E, et al. The possible role of hypoxia in the affected tissue of relapsed clubfoot. Sci Rep. 2022;12:4462 pubmed publisher
Yang Y, Tsai M, Chang Y, Wang C, Chu P, Lin H, et al. MIR29A Impedes Metastatic Behaviors in Hepatocellular Carcinoma via Targeting LOX, LOXL2, and VEGFA. Int J Mol Sci. 2021;22: pubmed publisher
Samanta D, Huang T, Shah R, Yang Y, Pan F, Semenza G. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep. 2020;32:108073 pubmed publisher
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan N, et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest. 2020;: pubmed publisher
Casciello F, Al Ejeh F, Miranda M, Kelly G, Baxter E, Windloch K, et al. G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome. Theranostics. 2020;10:4515-4529 pubmed publisher
Park K, Han J, Kim S, Lim Y. Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. Biomolecules. 2020;10: pubmed publisher
Sharma M, Boytard L, Hadi T, Koelwyn G, Simon R, Ouimet M, et al. Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity. Sci Rep. 2020;10:5555 pubmed publisher
Grassi E, Pantazopoulou V, Pietras A. Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Oncogene. 2020;39:4028-4044 pubmed publisher
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Persson C, von Stedingk K, Fredlund E, Bexell D, Påhlman S, Wigerup C, et al. ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. Exp Cell Res. 2020;388:111845 pubmed publisher
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Kim Y, Hwang S, Khalmuratova R, Kang S, Lee M, Song Y, et al. α-Helical cell-penetrating peptide-mediated nasal delivery of resveratrol for inhibition of epithelial-to-mesenchymal transition. J Control Release. 2020;317:181-194 pubmed publisher
Liou A, Liao C, Chou S, Chang Y, Chang C, Shih C. Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model. J Biomed Sci. 2019;26:93 pubmed publisher
Lin Y, Huang S, Wu J, Chu T, Huang S, Lee C, et al. Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis. BMC Cancer. 2019;19:1083 pubmed publisher
Valle Tenney R, Rebolledo D, Lipson K, Brandan E. Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers. Matrix Biol. 2020;87:48-65 pubmed publisher
Komabayashi Suzuki M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, et al. Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development. Cell Rep. 2019;29:1113-1129.e5 pubmed publisher
Sampurno S, Chittleborough T, Carpinteri S, Hiller J, Heriot A, Lynch A, et al. Modes of carbon dioxide delivery during laparoscopy generate distinct differences in peritoneal damage and hypoxia in a porcine model. Surg Endosc. 2019;: pubmed publisher
Mahiddine K, Blaisdell A, Ma S, Créquer Grandhomme A, Lowell C, Erlebacher A. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020;130:389-403 pubmed publisher
Bobek J, Oralová V, Kratochvilova A, Zvackova I, Lesot H, Matalova E. Tuftelin and HIFs expression in osteogenesis. Histochem Cell Biol. 2019;152:355-363 pubmed publisher
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Yekelchyk M, Guenther S, Preussner J, Braun T. Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population. Basic Res Cardiol. 2019;114:36 pubmed publisher
Preston K, Rom I, Vrakas C, Landesberg G, Etwebi Z, Muraoka S, et al. Postprandial activation of leukocyte-endothelium interaction by fatty acids in the visceral adipose tissue microcirculation. FASEB J. 2019;33:11993-12007 pubmed publisher
Magae J, Furukawa C, Kuwahara S, Jeong Y, Nakajima H, Chang Y. 4-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition. Biosci Biotechnol Biochem. 2019;83:2244-2248 pubmed publisher
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Choi S, Kim M, Yoon Y, Koh D, Kim M, Cho S, et al. Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A. Biochim Biophys Acta Gene Regul Mech. 2019;1862:771-785 pubmed publisher
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Cui D, Arima M, Hirayama T, Ikeda E. Hypoxia-induced disruption of neural vascular barrier is mediated by the intracellular induction of Fe(II) ion. Exp Cell Res. 2019;: pubmed publisher
Delbrel E, Uzunhan Y, Soumare A, Gille T, Marchant D, Planes C, et al. ER Stress is Involved in Epithelial-To-Mesenchymal Transition of Alveolar Epithelial Cells Exposed to a Hypoxic Microenvironment. Int J Mol Sci. 2019;20: pubmed publisher
Xu X, Jia Y, Zhou X, Xie D, Huang X, Jia L, et al. Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-β/collagen pathway in preeclampsia. Exp Mol Med. 2019;51:20 pubmed publisher
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Chen C, Sun J, Chen S, Liu Y, Zhu S, Wang Z, et al. A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells. Int J Nanomedicine. 2019;14:753-769 pubmed publisher
Ma W, Li T, Wu S, Li J, Wang X, Li H. LOX and ACSL5 as potential relapse markers for pancreatic cancer patients. Cancer Biol Ther. 2019;20:787-798 pubmed publisher
Adam R, Xia Z, Pravoverov K, Hong J, Case A, Schultz H, et al. Sympathoexcitation in response to cardiac and pulmonary afferent stimulation of TRPA1 channels is attenuated in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 2019;316:H862-H872 pubmed publisher
Simmen S, Cosin Roger J, Melhem H, Maliachovas N, Maane M, Baebler K, et al. Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium. Cell Mol Gastroenterol Hepatol. 2019;7:339-355 pubmed publisher
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Martinez C, Kerr B, Jin C, Cistulli P, Cook K. Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher
Vogel J, Thiel C, Tauber S, Stockmann C, Gassmann M, Ullrich O. Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity. Int J Mol Sci. 2019;20: pubmed publisher
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Lam G, Sefton M. Hypoxia-inducible factor drives vascularization of modularly assembled engineered tissue. Tissue Eng Part A. 2018;: pubmed publisher
Kasagi Y, Dods K, Wang J, Chandramouleeswaran P, Benitez A, Gambanga F, et al. Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α. J Allergy Clin Immunol. 2018;: pubmed publisher
Williams A, Walton C, MacCannell K, Avelar A, Shohet R. HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility. Am J Physiol Heart Circ Physiol. 2019;316:H554-H565 pubmed publisher
Delbrel E, Soumare A, Naguez A, Label R, Bernard O, Bruhat A, et al. HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Sci Rep. 2018;8:17939 pubmed publisher
Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, et al. Evidence for Fucoidan-P-selectin Axis as a Therapeutic Target on Hypoxia-induced Pulmonary Hypertension. Am J Respir Crit Care Med. 2018;: pubmed publisher
Lee S, Abel E, Long F. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018;9:4831 pubmed publisher
Bíliková P, Svandova E, Veselá B, Doubek J, Poliard A, Matalova E. Coupling activation of pro-apoptotic caspases with autophagy in the Meckel´s cartilage. Physiol Res. 2019;68:135-140 pubmed
Han J, Lee J, Kong J, Ji Y, Kim J, Choe S, et al. Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor. Mol Cell Biol. 2019;39: pubmed publisher
Wang Z, Yang K, Zheng Q, Zhang C, Tang H, Babicheva A, et al. Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2019;316:L216-L228 pubmed publisher
Wang Y, Zhong S, Schofield C, Ratcliffe P, Lu X. Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively. J Cell Sci. 2018;131: pubmed publisher
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, et al. Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 2018;25:561-570.e6 pubmed publisher
Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, et al. Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension. Am J Pathol. 2018;188:2474-2486 pubmed publisher
Reddy S, Agarwal H, Barthwal M. Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive mice. J Mol Cell Cardiol. 2018;123:46-57 pubmed publisher
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Heikal L, Ghezzi P, Mengozzi M, Ferns G. Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo. Mol Med. 2018;24:22 pubmed publisher
Joung J, Oh H, Lee S, Kim Y, Jung H. Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma. J Pathol Transl Med. 2018;52:323-330 pubmed publisher
Logue S, McGrath E, Cleary P, Greene S, Mnich K, Almanza A, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018;9:3267 pubmed publisher
Ow C, Ngo J, Ullah M, Barsha G, Meex R, Watt M, et al. Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2018;315:F1358-F1369 pubmed publisher
Tong B, Pantazopoulou V, Johansson E, Pietras A. The p75 neurotrophin receptor enhances HIF-dependent signaling in glioma. Exp Cell Res. 2018;371:122-129 pubmed publisher
Wu J, Tsai H, Liu G, Wu C, Tai M. Autophagic cell death participates in POMC-induced melanoma suppression. Cell Death Discov. 2018;4:11 pubmed publisher
Pezzoli D, Di Paolo J, Kumra H, Fois G, Candiani G, Reinhardt D, et al. Fibronectin promotes elastin deposition, elasticity and mechanical strength in cellularised collagen-based scaffolds. Biomaterials. 2018;180:130-142 pubmed publisher
Regan Anderson T, Ma S, Perez Kerkvliet C, Peng Y, Helle T, Krutilina R, et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol Cancer Res. 2018;16:1761-1772 pubmed publisher
Dai Z, Zhu M, Peng Y, Machireddy N, Evans C, Machado R, et al. Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor. Am J Respir Crit Care Med. 2018;198:1423-1434 pubmed publisher
Nascimento B, Bocco B, Fernandes G, Fonseca T, McAninch E, Cardoso C, et al. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. 2018;159:3090-3104 pubmed publisher
Nakazeki F, Nishiga M, Horie T, Nishi H, Nakashima Y, Baba O, et al. Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo. Sci Rep. 2018;8:8553 pubmed publisher
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Raykhel I, Moafi F, Myllym ki S, Greciano P, Matlin K, Moyano J, et al. BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia. J Cell Sci. 2018;131: pubmed publisher
Barben M, Ail D, Storti F, Klee K, Schori C, Samardzija M, et al. Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress. Cell Death Differ. 2018;25:2071-2085 pubmed publisher
Williams A, Khadka V, Tang M, Avelar A, Schunke K, Menor M, et al. HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. Physiol Genomics. 2018;50:479-494 pubmed publisher
Wang T, Wei W, Mansai H, Huang C, Li L, Ye Q, et al. Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells. Mol Med Rep. 2018;17:7149-7155 pubmed publisher
Yamashita M, Ogasawara M, Kawasaki Y, Niisato M, Saito H, Kasai S, et al. Deficiency of protein-L-isoaspartate (D-aspartate) O-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma. Oncotarget. 2018;9:13287-13300 pubmed publisher
Cui H, Banerjee S, Guo S, Xie N, Liu G. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages. J Immunol. 2018;200:3218-3230 pubmed publisher
Zhu N, Yi B, Guo Z, Zhang G, Huang S, Qin Y, et al. Pim-1 Kinase Phosphorylates Cardiac Troponin I and Regulates Cardiac Myofilament Function. Cell Physiol Biochem. 2018;45:2174-2186 pubmed publisher
Conotte S, Tassin A, Conotte R, Colet J, Zouaoui Boudjeltia K, Legrand A. Metabonomic profiling of chronic intermittent hypoxia in a mouse model. Respir Physiol Neurobiol. 2018;256:157-173 pubmed publisher
Barben M, Schori C, Samardzija M, Grimm C. Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia. Mol Neurodegener. 2018;13:12 pubmed publisher
Wong K, Beirowski B. Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development. Commun Integr Biol. 2018;11:e1433441 pubmed publisher
Takai K, Drain A, Lawson D, Littlepage L, Karpuj M, Kessenbrock K, et al. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018;32:244-257 pubmed publisher
Lin C, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, et al. A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. Sci Rep. 2018;8:2743 pubmed publisher
Wei M, Wang S, Zheng J, Chen J, Yan X, An H, et al. Herbal compound Teng-Long-Bu-Zhong-Tang inhibits metastasis in human RKO colon carcinoma. Oncol Lett. 2017;14:7767-7772 pubmed publisher
Lennikov A, Mirabelli P, Mukwaya A, Schaupper M, Thangavelu M, Lachota M, et al. Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis. Angiogenesis. 2018;21:267-285 pubmed publisher
Buart S, Terry S, Noman M, Lanoy E, Boutros C, Fogel P, et al. Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3. Oncotarget. 2017;8:108786-108801 pubmed publisher
Liu L, Liu W, Wang L, Zhu T, Zhong J, Xie N. Hypoxia-inducible factor 1 mediates intermittent hypoxia-induced migration of human breast cancer MDA-MB-231 cells. Oncol Lett. 2017;14:7715-7722 pubmed publisher
Tojo K, Tamada N, Nagamine Y, Yazawa T, Ota S, Goto T. Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury. FASEB J. 2017;: pubmed publisher
Heid J, Cencioni C, Ripa R, Baumgart M, Atlante S, Milano G, et al. Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Sci Rep. 2017;7:16839 pubmed publisher
Carpinteri S, Sampurno S, Malaterre J, Millen R, Dean M, Kong J, et al. Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery. Br J Surg. 2017;: pubmed publisher
Bernard O, Jeny F, Uzunhan Y, Dondi E, Terfous R, Label R, et al. Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signalings. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00153.2017 pubmed publisher
Sethumadhavan S, Silva M, Philbrook P, Nguyen T, Hatfield S, Ohta A, et al. Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells. PLoS ONE. 2017;12:e0187314 pubmed publisher
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product information
master code :
NB100-2527
SKU :
NB100-2527
product name :
LOX Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The LOX Antibody - BSA Free from Novus is a rabbit polyclonal antibody to LOX. This antibody reacts with feline,human,mouse,porcine,rat. The LOX Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Western Blot,IF/IHC,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Simple Western,Knockdown Validated.
target :
LOX
category :
Primary Antibodies
buffer :
PBS pH 7.2
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to an internal region of the human LOX protein (within residues 200-300). [Swiss-Prot P28300].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Feline,Human,Mouse,Porcine,Rat
gene symbol :
LOX
Antibody validation :
Biological Validation
applications :
Immunohistochemistry,Western Blot,IF/IHC,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Simple Western,Knockdown Validated
USD :
449 USD
alt names :
lysyl oxidaseEC 1.4.3.13, MGC105112, protein-lysine 6-oxidase
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.