product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal ERO1L Antibody
catalog :
NB100-2525R
quantity :
0.1 ml
price :
319.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
DyLight 550
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-2525R
Product Name :
Rabbit Polyclonal ERO1L Antibody
List Price :
319.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EC 1.8.4, EC 1.8.4.-, Endoplasmic oxidoreductin-1-like protein, ERO1 (S. cerevisiae)-like, ERO1A, ERO1-alpha, ERO1-L, ERO1-L-alpha, ERO1-like (S. cerevisiae), ERO1-like protein alpha, oxidoreductin-1-L-alpha, Oxidoreductin-1-L-alpha
Background :
Perhaps the most distinctive feature of protein folding in the ER is the abundance of disulfide bonds that must form during maturation of proteins traveling along the secretory pathway. Formation of disulfide bonds is a redox reaction. Thus, to match the flux of disulfide bonds that exit from the ER by virtue of protein secretion, a flux of oxidizing equivalents into the ER is required. In eukaryotic cells, the essential protein relay supporting this flux, and hence disulfide bond formation, involves endoplasmic reticulum oxidoreductin 1 (Ero1) and protein disulfide isomerase (PDI). The temporal pattern of hypoxic ERO1-L alpha induction is very similar to that of genes triggered by the hypoxia inducible transcription factor (HIF-1) and is characteristically mimicked by cobalt and by deferoxamine, but is absent in cells with a defective aryl hydrocarbon receptor translocator (ARNT, HIF-1 alpha). We speculate from these findings that the expression of ERO1-L alpha is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes.
Buffer :
50mM sodium borate containing 1% BSA.
Clonality :
Polyclonal
Conjugate :
DyLight 550
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to the N-terminal region of human ERO1L [UniProt Q96HE7]
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human, mouse, and rat.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q96HE7
TMW :
57 kDa
Uses :
This ERO1L antibody is useful for Western Blot, where a band ~57 kDa is observed. Depending on the samples used ERO1L can also appear as a doublet which is believed to represent the oxidized and reduced forms of the protein.
Research Area :
Cancer, ER Markers, Hypoxia, Membrane Trafficking and Chaperones, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.