product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal SIRT6 Antibody
catalog :
NB100-2522H
quantity :
0.1 ml
price :
309.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
HRP
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-2522H
Product Name :
Rabbit Polyclonal SIRT6 Antibody
List Price :
309.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EC 3.5.1.-, NAD-dependent deacetylase sirtuin-6, SIR2L6sir2-related protein type 6, SIR2-like protein 6, sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6, sirtuin 6, sirtuin type 6
Background :
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in the ageing process.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
HRP
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to a C-terminal region of the mouse SIRT6 protein (within residues 250-334). [Swiss-Prot P59941]
Localization :
Nuclear
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Mouse. Rat reactivity reported in scientific literature (PMID: 25288139) Immunogen sequence has 78% homology to human. Human reactivity reported in scientific literature (PMID: 25660418)
Storage :
Store at 4C in the dark.
TMW :
37 kDa
Uses :
This SIRT6 antibody is useful for Western blot and Immunohistochemistry paraffin embedded sections. In Western blot a band is seen at ~37 kDa representing SIRT6, and a non-specific higher MW band can be seen at ~61 kDa. This antibody does not appear to detect the human protein in Western blot. In IHC-P, staining was observed in the nucleus of mouse testis. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 23899523)
Research Area :
Cancer, Chromatin Modifiers, Chromatin Research, DNA Repair, Epigenetics, Histone Deacetylases, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.