product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal AGPAT6 Antibody
catalog :
NB100-2389F
quantity :
0.1 ml
price :
299.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human, mouse, cow
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-2389F
Product Name :
Rabbit Polyclonal AGPAT6 Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
DKFZp586M1819,1-acyl-sn-glycerol-3-phosphate acyltransferase zeta, EC 2.3.1.15, glycerol-3-phosphate acyltransferase 4,1-AGP acyltransferase 6, glycerol-3-phosphate acyltransferase 6,1-AGPAT 6, GPAT4,1-acylglycerol-3-phosphate O-acyltransferase 6, LPAAT-zetaLPAATZ, Lysophosphatidic acid acyltransferase zeta, testis spermatogenesis apoptosis-related protein 7, TSARG7, 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acidacyltransferase, zeta), Acyl-CoA:glycerol-3-phosphate acyltransferase 4
Background :
Member of 1-acylglycerol-3-phosphate-O-acyltransferase (AGPATs) family, AGPAT6 (glycerol-3-phosphate acyltransferase 4) is an enzyme essential for biosynthesis of glycerolipids and triacylglycerol in eukaryotes, as well as for catalyzing the conversion of lysophosphatidic acid to phosphatidic acid. It esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, which is a required step in glycerolipid biosynthesis. AGPAT6 is active against both saturated as well as unsaturated long-chain fatty acyl-CoAs and is inhibited by N-ethylmaleimide (NEM). Its HXXXXD motif is critical for its acyltransferase activity and constitutes the site for binding of glycerol-3-phosphate's phosphate moiety. Localized in ER membrane as multi-pass membrane protein, AGPAT6 is ubiquitously expressed with relatively high expression levels in skeletal muscle, heart, mammary epithelium and testis. AGPAT6 contributes to the production of milk fat and has been considered a candidate gene for regulating milk composition. Mouse model deficient in AGPAT6 exhibit weight loss and resistance to both diet-induced as well as genetically induced obesity.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
FITC
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to an N-terminal portion of human AGPAT6 (between residues 1-100). [Swiss-Prot Q86UL3]
Localization :
Membrane
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human, monkey and mouse. Predicted to react with bovine, porcine, and rat based on 100% sequence homology.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q86UL3
TMW :
58 kDa
Uses :
This AGPAT6 antibody is useful for Western blot, where a band is seen at ~58 kDa representing AGPAT6 protein.
Research Area :
Diabetes Research, Lipid and Metabolism, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.