product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
LC3A Antibody - BSA Free
catalog :
NB100-2331
quantity :
0.1 ml (also 0.025 ml)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
OTI2B3
reactivity :
human, mouse, rat, dogs, zebrafish
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 158
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 10a
  • western blot; mouse; 1:500; loading ...; fig 10b
Venugopalan V, Al Hashimi A, Rehders M, Golchert J, Reinecke V, Homuth G, et al. The Thyroid Hormone Transporter Mct8 Restricts Cathepsin-Mediated Thyroglobulin Processing in Male Mice through Thyroid Auto-Regulatory Mechanisms That Encompass Autophagy. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3a
Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K. Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice. J Neurochem. 2018;145:80-89 pubmed publisher
  • western blot; human; loading ...; fig 1a
Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed publisher
  • western blot; human; 1:50; loading ...; fig 10a
Hossini A, Quast A, Plötz M, Grauel K, Exner T, Küchler J, et al. PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells. PLoS ONE. 2016;11:e0154770 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; tbl 2
Piras A, Collin L, Grüninger F, Graff C, Rönnbäck A. Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol Commun. 2016;4:22 pubmed publisher
  • western blot; rat; 1:500; fig 3
Jacob F, Yonis A, Cuello F, Luther P, Schulze T, Eder A, et al. Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. PLoS ONE. 2016;11:e0145937 pubmed publisher
  • western blot; zebrafish ; 1:2000; fig 5
Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; mouse; fig 2
Li W, Zou J, Yue F, Song K, Chen Q, McKeehan W, et al. Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed. Aging Cell. 2016;15:370-9 pubmed publisher
  • western blot; mouse
García Prat L, Martínez Vicente M, Perdiguero E, Ortet L, Rodríguez Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed publisher
Manganelli V, Misasi R, Riitano G, Capozzi A, Mattei V, Caglar T, et al. Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells. Cells. 2023;12: pubmed publisher
Kania E, Long J, McEwan D, Welkenhuyzen K, La Rovere R, Luyten T, et al. LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner. Cell Death Dis. 2023;14:436 pubmed publisher
Lisi L, Pizzoferrato M, Ciotti G, Martire M, Navarra P. mTOR Inhibition Is Effective against Growth, Survival and Migration, but Not against Microglia Activation in Preclinical Glioma Models. Int J Mol Sci. 2023;24: pubmed publisher
Heo M, Suh J, Lee S, Poulsen K, An Y, Moorthy B, et al. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab. 2023;72:101717 pubmed publisher
Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher
Jussila M, Boswell C, Griffiths N, Pumputis P, Ciruna B. Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2. Nat Commun. 2022;13:5598 pubmed publisher
Cui Y, Guo H, Zhang Q, Fang J, Xie Y, Chen S, et al. The combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway. BMC Vet Res. 2022;18:307 pubmed publisher
Jiang R, Smailovic U, Haytural H, Tijms B, Li H, Haret R, et al. Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis. Acta Neuropathol Commun. 2022;10:96 pubmed publisher
Akkoç Y, Dalci K, Karakas H, Erbil Bilir S, Yalav O, Sakman G, et al. Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis. Autophagy. 2022;:1-18 pubmed publisher
Jiang R, Shimozawa M, Mayer J, Tambaro S, Kumar R, Abelein A, et al. Autophagy Impairment in App Knock-in Alzheimer's Model Mice. Front Aging Neurosci. 2022;14:878303 pubmed publisher
Record M, Attia M, Carayon K, Pucheu L, Buñay J, Soul xe8 s R, et al. Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles. J Extracell Vesicles. 2022;11:e12211 pubmed publisher
Gawande D, S Narasimhan K, Bhatt J, Pavuluri R, Kesherwani V, Suryavanshi P, et al. Glutamate delta 1 receptor regulates autophagy mechanisms and affects excitatory synapse maturation in the somatosensory cortex. Pharmacol Res. 2022;178:106144 pubmed publisher
Abdelrahman R, El Tanbouly G. Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/ IL-17/ IL-23 immunoinflammatory pathway. Toxicol Appl Pharmacol. 2022;440:115931 pubmed publisher
Yin R, Wang H, Li C, Wang L, Lai S, Yang X, et al. Induction of apoptosis and autosis in cardiomyocytes by the combination of homocysteine and copper via NOX-mediated p62 expression. Cell Death Discov. 2022;8:75 pubmed publisher
Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, et al. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nat Commun. 2022;13:894 pubmed publisher
Lee H, Kwon Y, Jin H, Liu H, Kang W, Chun Y, et al. Anticancer activity and metabolic profile alterations by ortho-topolin riboside in in vitro and in vivo models of non-small cell lung cancer. FASEB J. 2022;36:e22127 pubmed publisher
Zhang H, Li X, Li Y, Yang X, Liao R, Wang H, et al. CREB Ameliorates Osteoarthritis Progression Through Regulating Chondrocytes Autophagy via the miR-373/METTL3/TFEB Axis. Front Cell Dev Biol. 2021;9:778941 pubmed publisher
Asare P, Tran H, Hurtado P, Perkins G, Nguyen P, Jersmann H, et al. Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke. Ther Adv Respir Dis. 2021;15:17534666211039769 pubmed publisher
Lu J, Zhong C, Luo J, Shu F, Lv D, Liu Z, et al. HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer. Mol Ther Nucleic Acids. 2021;26:927-944 pubmed publisher
Nurmi K, Niemi K, Kareinen I, Silventoinen K, Lorey M, Chen Y, et al. Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages. Clin Transl Immunology. 2021;10:e1323 pubmed publisher
Li L, Zhong J, Li M, Sun Y, Niu Y, Wu C, et al. Disruption of MAP7D1 Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure. Biomed Res Int. 2021;2021:8569921 pubmed publisher
Bowles K, Silva M, Whitney K, Bertucci T, Berlind J, Lai J, et al. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. 2021;184:4547-4563.e17 pubmed publisher
Amaya C, Cameron C, Devarkar S, Seager S, Gerstein M, Xiong Y, et al. Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology. J Biol Chem. 2021;297:100937 pubmed publisher
Cachón González M, Wang S, Cox T. Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease. Hum Mol Genet. 2021;30:2082-2099 pubmed publisher
Khan A, Johnson R, Wittmer C, Maile M, Tatsukawa K, Wong J, et al. NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease. Brain. 2021;: pubmed publisher
Kang H, Sarsenova M, Kim D, Kim M, Lee J, Sung E, et al. Establishing a 3D In Vitro Hepatic Model Mimicking Physiologically Relevant to In Vivo State. Cells. 2021;10: pubmed publisher
Sayed W, Elzainy A. Impact of platelet-rich plasma versus selenium in ameliorating induced toxicity in rat testis: histological, immunohistochemical, and molecular study. Cell Tissue Res. 2021;385:223-238 pubmed publisher
Kim J, Kim S, Kang H, Lee S, Park S, Cho Y, et al. TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Nat Metab. 2021;3:410-427 pubmed publisher
Huang Y, Liu H, Yuan Y, Guo Y, Wan D, Pan S. Exercise Preconditioning Increases Beclin1 and Induces Autophagy to Promote Early Myocardial Protection via Intermittent Myocardial Ischemia-Hypoxia. Int Heart J. 2021;62:407-415 pubmed publisher
Manganelli V, Capozzi A, Recalchi S, Riitano G, Mattei V, Longo A, et al. The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence. Biomolecules. 2021;11: pubmed publisher
Ordög K, Horvath O, Eros K, Bruszt K, Tóth S, Kovacs D, et al. Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes. Life Sci. 2021;268:118936 pubmed publisher
Zhuang L, Ly R, Rösl F, Niebler M. p53 Is Regulated in a Biphasic Manner in Hypoxic Human Papillomavirus Type 16 (HPV16)-Positive Cervical Cancer Cells. Int J Mol Sci. 2020;21: pubmed publisher
Pargianas M, Kosmas I, Papageorgiou K, Kitsou C, Papoudou Bai A, Batistatou A, et al. Follicle inhibition at the primordial stage without increasing apoptosis, with a combination of everolimus, verapamil. Mol Biol Rep. 2020;47:8711-8726 pubmed publisher
Moon Y, Kim I, Chang S, Park B, Lee S, Yoo S, et al. Hypoxia regulates allele-specific histone modification of the imprinted H19 gene. Biochim Biophys Acta Gene Regul Mech. 2020;1863:194643 pubmed publisher
Manganelli V, Matarrese P, Antonioli M, Gambardella L, Vescovo T, Gretzmeier C, et al. Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs. Autophagy. 2020;:1-21 pubmed publisher
Leist S, Dinnon K, Schäfer A, Tse L, Okuda K, Hou Y, et al. A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice. Cell. 2020;183:1070-1085.e12 pubmed publisher
Fucci C, Resnati M, Riva E, Perini T, Ruggieri E, Orfanelli U, et al. The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis. Cell Rep. 2020;32:108162 pubmed publisher
Dong W, Luo Y, Zhang G, Zhang H, Liang Y, Zhuo Y, et al. Carbon Nanospheres Exert Antitumor Effects Associated with Downregulation of 4E-BP1 Expression on Prostate Cancer. Int J Nanomedicine. 2020;15:5545-5559 pubmed publisher
Nettesheim A, Dixon A, Shim M, Coyne A, Walsh M, Liton P. Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model. Invest Ophthalmol Vis Sci. 2020;61:31 pubmed publisher
Di Pardo A, Pepe G, Capocci L, Marracino F, Amico E, Del Vecchio L, et al. Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease. Neurobiol Dis. 2020;143:105009 pubmed publisher
Zhang R, Varela M, Forn Cuni G, Torraca V, van der Vaart M, Meijer A. Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell Death Dis. 2020;11:277 pubmed publisher
Fedele A, Proud C. Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling. Biosci Rep. 2020;40: pubmed publisher
Li W, Dai Y, Shi B, Yue F, Zou J, Xu G, et al. LRPPRC sustains Yap-P27-mediated cell ploidy and P62-HDAC6-mediated autophagy maturation and suppresses genome instability and hepatocellular carcinomas. Oncogene. 2020;39:3879-3892 pubmed publisher
Szekerczés T, Gógl A, Illyes I, Mandl J, Borka K, Kiss A, et al. Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis. Pathol Oncol Res. 2020;: pubmed publisher
Yuan J, Yuan Y, Pan S, Cai K. Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury. J Physiol Sci. 2020;70:10 pubmed publisher
Pomilio C, Gorojod R, Riudavets M, Vinuesa A, Presa J, Gregosa A, et al. Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer's disease patients. GeroScience. 2020;42:613-632 pubmed publisher
Lindahl M, CHALAZONITIS A, Palm E, Pakarinen E, Danilova T, Pham T, et al. Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiol Dis. 2020;134:104696 pubmed publisher
Sarnyai F, Szekerczés T, Csala M, Sumegi B, Szarka A, Schaff Z, et al. BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury. Pathol Oncol Res. 2020;26:1797-1803 pubmed publisher
Bryant J, Batis N, Franke A, Clancey G, Hartley M, Ryan G, et al. Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma. Oncotarget. 2019;10:5229-5244 pubmed publisher
Ding Y, Dvornikov A, Ma X, Zhang H, Wang Y, Lowerison M, et al. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Dis Model Mech. 2019;12: pubmed publisher
Yong T, Zhang X, Bie N, Zhang H, Zhang X, Li F, et al. Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nat Commun. 2019;10:3838 pubmed publisher
Gregosa A, Vinuesa A, Todero M, Pomilio C, Rossi S, Bentivegna M, et al. Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy. Neurobiol Dis. 2019;:104542 pubmed publisher
Liou Y, Chen P, Chu S, Kao S, Chang Y, Hsieh Y, et al. Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species-induced apoptosis and reduces cell stemness. Environ Toxicol. 2019;34:1208-1220 pubmed publisher
Di Pardo A, Pepe G, Castaldo S, Marracino F, Capocci L, Amico E, et al. Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model. Front Mol Neurosci. 2019;12:100 pubmed publisher
Morelli M, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G. Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival. Cancers (Basel). 2019;11: pubmed publisher
Zhang R, Varela M, Vallentgoed W, Forn Cuni G, van der Vaart M, Meijer A. The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection. PLoS Pathog. 2019;15:e1007329 pubmed publisher
Hoffmann A, Minakaki G, Menges S, Salvi R, Savitskiy S, Kazman A, et al. Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose. Sci Rep. 2019;9:544 pubmed publisher
Minakaki G, Canneva F, Chevessier F, Bode F, Menges S, Timotius I, et al. Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy. Behav Brain Res. 2019;363:199-215 pubmed publisher
Hollins S, Brock L, Barreto R, Harms L, Dunn A, Garcia Sobrinho P, et al. A Rodent Model of Anxiety: The Effect of Perinatal Immune Challenges on Gastrointestinal Inflammation and Integrity. Neuroimmunomodulation. 2018;25:163-175 pubmed publisher
Hanemaaijer E, Panahi M, Swaddiwudhipong N, Tikka S, Winblad B, Viitanen M, et al. Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells. Eur J Cell Biol. 2018;97:557-567 pubmed publisher
Ozturk D, Kocak M, Akcay A, Kınoglu K, Kara E, Buyuk Y, et al. MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress. Autophagy. 2018;:1-16 pubmed publisher
Hirt J, Porter K, Dixon A, McKinnon S, Liton P. Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model. Cell Death Discov. 2018;4:14 pubmed publisher
Schäffner I, Minakaki G, Khan M, Balta E, Schlötzer Schrehardt U, Schwarz T, et al. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2018;99:1188-1203.e6 pubmed publisher
Maier L, Kallenberger S, Jechow K, Waschow M, Eils R, Conrad C. Unraveling mitotic protein networks by 3D multiplexed epitope drug screening. Mol Syst Biol. 2018;14:e8238 pubmed publisher
Battista R, Resnati M, Facchi C, Ruggieri E, Cremasco F, Paradiso F, et al. Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation. PLoS ONE. 2018;13:e0201621 pubmed publisher
Kustermann M, Manta L, Paone C, Kustermann J, Lausser L, Wiesner C, et al. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. 2018;14:1911-1927 pubmed publisher
Lu J, Dong W, He H, Han Z, Zhuo Y, Mo R, et al. Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer. Int J Biol Macromol. 2018;118:599-609 pubmed publisher
Saera Vila A, Kish P, Kahana A. Autophagy in Zebrafish Extraocular Muscle Regeneration. Methods Mol Biol. 2019;1854:105-117 pubmed publisher
Chmielewska M, Dedukh D, Haczkiewicz K, Rozenblut Kościsty B, Kaźmierczak M, Kolenda K, et al. The programmed DNA elimination and formation of micronuclei in germ line cells of the natural hybridogenetic water frog Pelophylax esculentus. Sci Rep. 2018;8:7870 pubmed publisher
Lim H, Lim Y, Kim K, Jeon Y, Park K, Kim J, et al. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes. Nat Commun. 2018;9:1438 pubmed publisher
Pernas L, Bean C, Boothroyd J, Scorrano L. Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids. Cell Metab. 2018;27:886-897.e4 pubmed publisher
Anunobi R, Boone B, Cheh N, Tang D, Kang R, Loux T, et al. Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy. J Surg Res. 2018;226:181-191 pubmed publisher
Fusco C, Mandriani B, Di Rienzo M, Micale L, Malerba N, Cocciadiferro D, et al. TRIM50 regulates Beclin 1 proautophagic activity. Biochim Biophys Acta Mol Cell Res. 2018;1865:908-919 pubmed publisher
Jeong A, Ka H, Han S, Lee S, Lee E, Soh S, et al. Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism. EMBO Rep. 2018;19: pubmed publisher
Piacentini M, Baiocchini A, Del Nonno F, Melino G, Barlev N, Rossin F, et al. Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2. Cell Death Dis. 2018;9:257 pubmed publisher
Inomata Y, Nagasaka S, Miyate K, Goto Y, Hino C, Toukairin C, et al. Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart. Biochem Biophys Res Commun. 2018;496:1141-1147 pubmed publisher
Festa B, Chen Z, Berquez M, Debaix H, Tokonami N, Prange J, et al. Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney. Nat Commun. 2018;9:161 pubmed publisher
Nager M, Sallán M, Visa A, Pushparaj C, Santacana M, Macià A, et al. Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers. Autophagy. 2018;14:619-636 pubmed publisher
Palucci I, Matic I, Falasca L, Minerva M, Maulucci G, De Spirito M, et al. Transglutaminase type 2 plays a key role in the pathogenesis of Mycobacterium tuberculosis infection. J Intern Med. 2018;283:303-313 pubmed publisher
Minakaki G, Menges S, Kittel A, Emmanouilidou E, Schaeffner I, Barkovits K, et al. Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. Autophagy. 2017;:1-61 pubmed publisher
Jiang M, Han Z, Li W, Yue F, Ye J, Li B, et al. Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation. Oncotarget. 2017;8:80295-80302 pubmed publisher
Desseille C, Deforges S, Biondi O, Houdebine L, D Amico D, Lamaziere A, et al. Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice. Front Mol Neurosci. 2017;10:332 pubmed publisher
Theofilas P, Ehrenberg A, Nguy A, Thackrey J, Dunlop S, Mejia M, et al. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018;61:1-12 pubmed publisher
Kaverina N, Borovjagin A, Kadagidze Z, Baryshnikov A, Baryshnikova M, Malin D, et al. Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy. Autophagy. 2017;13:1905-1923 pubmed publisher
Agarwal A, Tunison K, Dalal J, Nagamma S, Hamra F, Sankella S, et al. Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice. Endocrinology. 2017;158:3954-3973 pubmed publisher
Solanas G, Peixoto F, Perdiguero E, Jardi M, Ruiz Bonilla V, Datta D, et al. Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress. Cell. 2017;170:678-692.e20 pubmed publisher
Benítez B, Sands M. Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis. Sci Rep. 2017;7:6332 pubmed publisher
McLendon P, Davis G, Gulick J, Singh S, Xu N, Salomonis N, et al. An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circ Res. 2017;121:604-616 pubmed publisher
Nazim U, Moon J, Lee Y, Seol J, Park S. PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. Oncotarget. 2017;8:26819-26831 pubmed publisher
Massimini M, Palmieri C, De Maria R, Romanucci M, Malatesta D, De Martinis M, et al. 17-AAG and Apoptosis, Autophagy, and Mitophagy in Canine Osteosarcoma Cell Lines. Vet Pathol. 2017;54:405-412 pubmed publisher
Fu Q, Chen K, Zhu Q, Wang W, Huang F, Miao L, et al. ?-catenin promotes intracellular bacterial killing via suppression of Pseudomonas aeruginosa-triggered macrophage autophagy. J Int Med Res. 2017;45:556-569 pubmed publisher
Bae S, Byun S, Bae S, Min D, Woo H, Lee K. TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway. Autophagy. 2017;13:820-833 pubmed publisher
Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, et al. Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. Cancer Res. 2017;77:2938-2951 pubmed publisher
Lopez A, Lee S, Wojta K, Ramos E, Klein E, Chen J, et al. A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain. 2017;140:1128-1146 pubmed publisher
Mattoscio D, Casadio C, Miccolo C, Maffini F, Raimondi A, Tacchetti C, et al. Autophagy regulates UBC9 levels during viral-mediated tumorigenesis. PLoS Pathog. 2017;13:e1006262 pubmed publisher
García Prat L, Muñoz Cánoves P, Martínez Vicente M. Monitoring Autophagy in Muscle Stem Cells. Methods Mol Biol. 2017;1556:255-280 pubmed publisher
Schulze U, Vollenbröker B, Kühnl A, Granado D, Bayraktar S, Rescher U, et al. Cellular vacuolization caused by overexpression of the PIKfyve-binding deficient Vac14L156R is rescued by starvation and inhibition of vacuolar-ATPase. Biochim Biophys Acta Mol Cell Res. 2017;1864:749-759 pubmed publisher
Nuschke A, Rodrigues M, Wells A, Sylakowski K, Wells A. Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. Stem Cell Res Ther. 2016;7:179 pubmed
Lu Y, Liu X, Liu T, Fan R, Xu Y, Zhang X, et al. Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function. Biomed Pharmacother. 2016;84:1551-1557 pubmed publisher
Lee S, Kang J, Kim S, Ahn J, Kim J, Lee S. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017;174:195-209 pubmed publisher
Shingu T, Ho A, Yuan L, Zhou X, Dai C, Zheng S, et al. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017;49:75-86 pubmed publisher
Jiang C, Jin S, Jiang Z, Wang J. Inhibitory effects of silibinin on proliferation and lung metastasis of human high metastasis cell line of salivary gland adenoid cystic carcinoma via autophagy induction. Onco Targets Ther. 2016;9:6609-6618 pubmed
Zhang D, Pan J, Xiang X, Liu Y, Dong G, Livingston M, et al. Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity. J Am Soc Nephrol. 2017;28:1131-1144 pubmed publisher
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product information
brand :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB100-2331
SKU :
NB100-2331
product name :
LC3A Antibody - BSA Free
Description :
The LC3A Antibody - BSA Free from Novus is a rabbit polyclonal antibody to LC3A. This antibody reacts with human, mouse, rat, amphibian, canine, fish, plant, zebrafish. The LC3A Antibody - BSA Free has been validated for the following applications: Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Southern Blot, Immunohistochemistry Whole-Mount, Chromatin Immunoprecipitation (ChIP).
target :
LC3A
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This LC3A Antibody was prepared from a synthetic peptide made to an internal portion of the human LC3 protein sequence (between residues 25-121). [Uniprot: Q9H492].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat, Amphibian, Canine, Fish, Plant, Zebrafish
specificity :
This LC3A Antibody detects both LC3A and LC3B
gene symbol :
MAP1LC3A
applications :
Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Southern Blot, Immunohistochemistry Whole-Mount, Chromatin Immunoprecipitation (ChIP)
USD :
459 USD
alt names :
ATG8E, Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, LC3, LC3A, MAP1 light chain 3-like protein 1, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A, Microtubule-associated protein 1 light chain 3 alpha, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3A
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.