product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
IRE1 alpha Antibody
catalog :
NB100-2324
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight488
clone name :
711-66
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
citations: 37
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6e
Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed publisher
  • western blot; mouse; loading ...; fig 7
Alnasser H, Guan Q, Zhang F, Gleave M, Nguan C, Du C. Requirement of clusterin expression for prosurvival autophagy in hypoxic kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2016;310:F160-73 pubmed publisher
Wu D, Zhang X, Zimmerly K, Wang R, Livingston A, Iwawaki T, et al. Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Neutrophilic Airway Inflammation. bioRxiv. 2023;: pubmed publisher
Espina M, Di Franco N, Bra xf1 as Navarro M, Navarro I, Brito V, López Molina L, et al. The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice. Neurobiol Dis. 2023;184:106225 pubmed publisher
Xiao J, Huang J, Jian X, Wang H, Lan H, Liao Z, et al. IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties. Cell Mol Biol Lett. 2023;28:15 pubmed publisher
Chakraborty S, Basu A. miR-451a Regulates Neuronal Apoptosis by Modulating 14-3-3ζ-JNK Axis upon Flaviviral Infection. mSphere. 2022;7:e0020822 pubmed publisher
Li Q, Fan X, Lu W, Sun C, Pei Z, Zhang M, et al. Novel NPR2 Gene Mutations Affect Chondrocytes Function via ER Stress in Short Stature. Cells. 2022;11: pubmed publisher
Srinivasan M, Bhopale K, Caracheo A, Kaphalia L, Gong B, Popov V, et al. Exposure to binge ethanol and fatty acid ethyl esters exacerbates chronic ethanol-induced pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice. Am J Physiol Gastrointest Liver Physiol. 2022;322:G327-G345 pubmed publisher
Huang L, Liu Q, Zhou T, Zhang J, Tian Q, Zhang Q, et al. Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome. Int Immunopharmacol. 2021;101:108281 pubmed publisher
EINSTEIN J, Perelis M, Chaim I, Meena J, Nussbacher J, Tankka A, et al. Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer. Mol Cell. 2021;81:3048-3064.e9 pubmed publisher
Qu Z, Lu X, Qu Y, Tao T, Liu X, Li X. Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression. Int J Mol Med. 2021;47: pubmed publisher
Pandey R, Bakay M, Strenkowski B, Hain H, Hakonarson H. JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice. Sci Rep. 2021;11:7372 pubmed publisher
Ding R, Ou W, Chen C, Liu Y, Li H, Zhang X, et al. Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. Neurochem Int. 2020;141:104856 pubmed publisher
Srinivasan M, Bhopale K, Caracheo A, Amer S, Khan S, Kaphalia L, et al. Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells. Biochem Pharmacol. 2020;180:114174 pubmed publisher
Cicalese S, Okuno K, Elliott K, Kawai T, Scalia R, Rizzo V, et al. 78 kDa Glucose-Regulated Protein Attenuates Protein Aggregation and Monocyte Adhesion Induced by Angiotensin II in Vascular Cells. Int J Mol Sci. 2020;21: pubmed publisher
Garufi A, Federici G, Gilardini Montani M, Crispini A, Cirone M, D Orazi G. Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation. Biomolecules. 2020;10: pubmed publisher
Han L, Bittner S, Dong D, Cortez Y, Bittner A, Chan J, et al. Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165688 pubmed publisher
Xie W, Xie J, Vince R, More S. Guanabenz Attenuates Acetaminophen-Induced Liver Toxicity and Synergizes Analgesia in Mice. Chem Res Toxicol. 2020;33:162-171 pubmed publisher
Schmit K, Chen J, Ayama Canden S, Fransolet M, Finet L, Demazy C, et al. Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin. Cell Death Dis. 2019;10:919 pubmed publisher
Gu R, Huang T, Xiao J, Liao Z, Li J, Lan H, et al. The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation. Front Physiol. 2019;10:1198 pubmed publisher
Srinivasan M, Bhopale K, Amer S, Wan J, Kaphalia L, Ansari G, et al. Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice. Biomolecules. 2019;9: pubmed publisher
Park S, Kim Y, Yang S, Henderson M, Yang W, Lindahl M, et al. Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Kaphalia L, Srinivasan M, Kakumanu R, Kaphalia B, Calhoun W. Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism. Alcohol Clin Exp Res. 2019;43:1682-1694 pubmed publisher
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh Asahara N. Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia. Cells. 2019;8: pubmed publisher
Serrano R, Yu W, Graham R, Bryan R, Terkeltaub R. A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia. PLoS ONE. 2019;14:e0212235 pubmed publisher
Hsu Y, Chuang H, Lee Y, Lin Y, Chen Y, Hsiao T, et al. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radic Biol Med. 2019;135:235-244 pubmed publisher
Lee M, Bae S, Kim J, Song B, Choi J, Park J, et al. Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris. Lab Anim Res. 2018;34:288-294 pubmed publisher
Bretón Romero R, Weisbrod R, Feng B, Holbrook M, Ko D, Stathos M, et al. Liraglutide Treatment Reduces Endothelial Endoplasmic Reticulum Stress and Insulin Resistance in Patients With Diabetes Mellitus. J Am Heart Assoc. 2018;7:e009379 pubmed publisher
Cho Y, Kim D, Lee K, Jeong S, Kwon O. The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity. Exp Mol Med. 2018;50:102 pubmed publisher
Yang F, Wang S, Liu Y, Zhou Y, Shang L, Feng M, et al. IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells. Free Radic Biol Med. 2018;124:395-407 pubmed publisher
Tripathi M, Zhang C, Singh B, Sinha R, Moe K, DeSilva D, et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016;7:e2513 pubmed publisher
Li Y, Zalzala M, Jadhav K, Xu Y, Kasumov T, Yin L, et al. Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice. Hepatology. 2016;63:1860-74 pubmed publisher
Kim O, Jun W, Lee J. Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells. Nutrients. 2016;8: pubmed publisher
Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, et al. Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population. J Cell Physiol. 2016;231:1913-31 pubmed publisher
Quan X, Wang J, Liang C, Zheng H, Zhang L. Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells. Biochem Biophys Res Commun. 2015;463:1102-7 pubmed publisher
Clarke J, Lyra e Silva N, Figueiredo C, Frozza R, Ledo J, Beckman D, et al. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015;7:190-210 pubmed publisher
Ghosh A, Garg S, Mau T, O Brien M, Liu J, Yung R. Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging. J Gerontol A Biol Sci Med Sci. 2015;70:1320-9 pubmed publisher
product information
brand :
Novus
MasterCode :
NB100-2324
SKU :
NB100-2324
product name :
IRE1 alpha Antibody
Description :
The IRE1 alpha Antibody from NB100-2324 is a nb100-2324 antibody to . This antibody reacts with angiogenesis, apoptosis, cancer, diabetes research, hypoxia, lipid and metabolism, neurodegeneration, neuroscience, signal transduction, unfolded protein response.
target :
IRE1 alpha
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
Tris-Glycine, 0.15M NaCl
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This IRE1 alpha antibody was raised against a synthetic peptide within the human IRE1 alpha protein (within residues 700-800). [Swiss-Prot #O75460]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat
theoretical molecular weight :
110 kDa
gene symbol :
ERN1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunohistochemistry-NB100-2324-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunohistochemistry-NB100-2324-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Western-Blot-NB100-2324-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Western-Blot-NB100-2324-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Western-Blot-NB100-2324-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Western-Blot-NB100-2324-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2324-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2324-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunohistochemistry-Paraffin-NB100-2324-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunohistochemistry-Paraffin-NB100-2324-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunohistochemistry-Paraffin-NB100-2324-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-Antibody-Immunohistochemistry-Paraffin-NB100-2324-img0008.jpg
applications :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Knockout Validated, Knockdown Validated
USD :
399 USD
alt names :
EC 2.7.11, endoplasmic reticulum to nucleus signaling 1, Endoplasmic reticulum-to-nucleus signaling 1, ER to nucleus signalling 1, FLJ30999, hIRE1p, inositol-requiring 1, Inositol-requiring protein 1, IRE 1a, IRE1a, Ire1-alpha, IRE1MGC163279, IRE1P, MGC163277, protein kinase/endoribonuclease, serine/threonine-protein kinase/endoribonuclease IRE1
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.