product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
IRE1 alpha [p Ser724] Antibody - BSA Free
catalog :
NB100-2323
quantity :
0.1 ml (also 0.025 ml)
price :
449 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 650
clone name :
OTI2B3
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 205
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5e
Lei X, Lin H, Wang J, Ou Z, Ruan Y, Sadagopan A, et al. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression. Nat Commun. 2022;13:3882 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6h
Zhou Y, Ye X, Zhang C, Wang J, Guan Z, Yan J, et al. Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis. J Genet Genomics. 2021;48:403-410 pubmed publisher
  • western blot; mouse; loading ...; fig 11e
Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, et al. Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cell Mol Gastroenterol Hepatol. 2021;12:633-651 pubmed publisher
  • western blot; mouse; fig 1a
Lim Y, Kim S, Kim E. Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Mol Brain. 2021;14:65 pubmed publisher
  • western blot; human; loading ...; fig 6b
Wanschel A, Guizoni D, Lorza Gil E, Salerno A, Paiva A, Dorighello G, et al. The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction. Biomolecules. 2021;11: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Lanzillotta C, Greco V, Valentini D, Villani A, Folgiero V, Caforio M, et al. Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 2h
  • western blot; mouse; loading ...; fig 2e
Schiattarella G, Altamirano F, Tong D, French K, Villalobos E, Kim S, et al. Nitrosative stress drives heart failure with preserved ejection fraction. Nature. 2019;568:351-356 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:50; loading ...; fig 6d
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s4c
  • western blot; mouse; 1:1000; loading ...; fig 2b
Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed publisher
  • western blot; human; loading ...; fig 1c
Marcassa E, Raimondi M, Anwar T, Eskelinen E, Myers M, Triolo G, et al. Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin. Biol Open. 2017;6:551-562 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability. Nat Commun. 2017;8:14186 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Mukhopadhyay C, Triplett A, Bargar T, HECKMAN C, Wagner K, Naramura M. Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation. Proc Natl Acad Sci U S A. 2016;113:E8228-E8237 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Tripathi M, Zhang C, Singh B, Sinha R, Moe K, DeSilva D, et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016;7:e2513 pubmed publisher
  • immunohistochemistry; human; fig 4e
  • western blot; human; loading ...; fig 4a
Sareddy G, Viswanadhapalli S, Surapaneni P, Suzuki T, Brenner A, Vadlamudi R. Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway. Oncogene. 2017;36:2423-2434 pubmed publisher
Wang W, Hawkridge A, Ma Y, Zhang B, Mangrum J, Hassan Z, et al. Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death. J Biol Chem. 2023;299:104915 pubmed publisher
Xiao J, Huang J, Jian X, Wang H, Lan H, Liao Z, et al. IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties. Cell Mol Biol Lett. 2023;28:15 pubmed publisher
Yu J, Shen S, Yan Y, Liu L, Luo R, Liu S, et al. Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation. Nutrients. 2023;15: pubmed publisher
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, et al. Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway. Drug Dev Res. 2023;84:211-225 pubmed publisher
Rahman M, Umashankar B, Choucair H, Pazderka C, Bourget K, Chen Y, et al. Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids. Eur J Pharmacol. 2023;939:175470 pubmed publisher
Dudkevich R, Koh J, Beaudoin Chabot C, Celik C, Lebenthal Loinger I, Karako Lampert S, et al. Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism. Cell Rep. 2022;41:111739 pubmed publisher
Madhamanchi K, Madhamanchi P, Jayalakshmi S, Panigrahi M, Patil A, Phanithi P. Endoplasmic reticulum stress and unfolded protein accumulation correlate to seizure recurrence in focal cortical dysplasia patients. Cell Stress Chaperones. 2022;27:633-643 pubmed publisher
Pritchard K, Jing X, Teng M, Wells C, Jia S, Afolayan A, et al. Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia. PLoS ONE. 2022;17:e0269564 pubmed publisher
Peng D, Wang Y, Huang T, Luo D, Qiao L, Wang Q, et al. Ligustilide Improves Cognitive Impairment via Regulating the SIRT1/IRE1α/XBP1s/CHOP Pathway in Vascular Dementia Rats. Oxid Med Cell Longev. 2022;2022:6664990 pubmed publisher
Jian Z, Han Y, Zhang W, Li C, Guo W, Feng X, et al. Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancer. Cell Biosci. 2022;12:135 pubmed publisher
SOTO I, Couvillion M, Hansen K, McShane E, Moran J, Barrientos A, et al. Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes. Genome Biol. 2022;23:170 pubmed publisher
Chen Y, Zhang T, Zeng S, Xu R, Jin K, Coorey N, et al. Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways. Redox Biol. 2022;54:102379 pubmed publisher
Chen J, Wu C, Jheng J, Chao C, Huang J, Hung K, et al. The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition. J Biomed Sci. 2022;29:46 pubmed publisher
Chakraborty S, Basu A. miR-451a Regulates Neuronal Apoptosis by Modulating 14-3-3ζ-JNK Axis upon Flaviviral Infection. mSphere. 2022;7:e0020822 pubmed publisher
Fanning S, Cirka H, Thies J, Jeong J, Niemi S, Yoon J, et al. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. NPJ Parkinsons Dis. 2022;8:74 pubmed publisher
Wang X, Xin H, Xing M, Gu X, Hao Y. Acute Endoplasmic Reticulum Stress Induces Inflammation Reaction, Complement System Activation, and Lipid Metabolism Disorder of Piglet Livers: A Proteomic Approach. Front Physiol. 2022;13:857853 pubmed publisher
Li Q, Fan X, Lu W, Sun C, Pei Z, Zhang M, et al. Novel NPR2 Gene Mutations Affect Chondrocytes Function via ER Stress in Short Stature. Cells. 2022;11: pubmed publisher
Visa A, Alza L, Cant xed C, Herreros J. Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling. Biomed Pharmacother. 2022;149:112881 pubmed publisher
Lu H, Gomaa A, Wang Bishop L, Ballout F, Hu T, McDonald O, et al. Unfolded Protein Response Is Activated by Aurora Kinase A in Esophageal Adenocarcinoma. Cancers (Basel). 2022;14: pubmed publisher
Srinivasan M, Bhopale K, Caracheo A, Kaphalia L, Gong B, Popov V, et al. Exposure to binge ethanol and fatty acid ethyl esters exacerbates chronic ethanol-induced pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice. Am J Physiol Gastrointest Liver Physiol. 2022;322:G327-G345 pubmed publisher
Abdullah C, Aishwarya R, Alam S, Remex N, Morshed M, Nitu S, et al. The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes. Mitochondrion. 2022;62:159-175 pubmed publisher
Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, et al. ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Oncol Rep. 2022;47: pubmed publisher
Xia H, Zhao H, Yang W, Luo X, Wei J, Xia H. MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6. Cell Biol Int. 2022;46:243-254 pubmed publisher
Li S, Zhao F, Tang Q, Xi C, He J, Wang Y, et al. Sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA2b) mediates oxidation-induced endoplasmic reticulum stress to regulate neuropathic pain. Br J Pharmacol. 2021;: pubmed publisher
Fan Y, Wolford B, Lu H, Liang W, Sun J, Zhou W, et al. Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2. iScience. 2021;24:103196 pubmed publisher
Chunhacha P, Pinkaew D, Sinthujaroen P, Bowles D, Fujise K. Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure. Cell Death Discov. 2021;7:310 pubmed publisher
Khoi C, Lin Y, Chen J, Liu B, Lin T, Hung K, et al. Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells. Int J Mol Sci. 2021;22: pubmed publisher
Mareninova O, Dillon D, Wightman C, Yakubov I, Takahashi T, Gaisano H, et al. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis. Cell Mol Gastroenterol Hepatol. 2021;13:599-622 pubmed publisher
Shaban M, Müller C, Mayr Buro C, Weiser H, Meier Soelch J, Albert B, et al. Multi-level inhibition of coronavirus replication by chemical ER stress. Nat Commun. 2021;12:5536 pubmed publisher
Zhao P, Huang P, Xu T, Xiang X, Sun Y, Liu J, et al. Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila. iScience. 2021;24:102819 pubmed publisher
EINSTEIN J, Perelis M, Chaim I, Meena J, Nussbacher J, Tankka A, et al. Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer. Mol Cell. 2021;81:3048-3064.e9 pubmed publisher
Witte F, Ruiz Orera J, Mattioli C, Blachut S, Adami E, Schulz J, et al. A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion. Genome Biol. 2021;22:191 pubmed publisher
Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, et al. An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation. J Biol Chem. 2021;296:100781 pubmed publisher
Zhemkov V, Ditlev J, Lee W, Wilson M, Liou J, Rosen M, et al. The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains. elife. 2021;10: pubmed publisher
Zhang Y, Wu N, Gan Schreier H, Xu F, Tuma Kellner S, Staffer S, et al. FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides. Biochem J. 2021;478:1861-1877 pubmed publisher
Rigby M, Lawton A, Kaur G, Banduseela V, Kamm W, Lakkaraju A, et al. Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism. Commun Biol. 2021;4:454 pubmed publisher
Pandey R, Bakay M, Strenkowski B, Hain H, Hakonarson H. JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice. Sci Rep. 2021;11:7372 pubmed publisher
Parthibane V, Lin J, Acharya D, Abimannan T, Srideshikan S, Klarmann K, et al. SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis. J Biol Chem. 2021;296:100491 pubmed publisher
Chen N, Zhang Y, Wang M, Lin X, Li J, Li J, et al. Maternal obesity interrupts the coordination of the unfolded protein response and heat shock response in the postnatal developing hypothalamus of male offspring in mice. Mol Cell Endocrinol. 2021;527:111218 pubmed publisher
Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, et al. EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021;62:31 pubmed publisher
De Nisco N, Casey A, Kanchwala M, Lafrance A, Coskun F, Kinch L, et al. Manipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector Pair. mSystems. 2021;6: pubmed publisher
Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, et al. ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. Theranostics. 2021;11:841-860 pubmed publisher
Kalish B, Kim E, Finander B, Duffy E, Kim H, Gilman C, et al. Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nat Neurosci. 2021;24:204-213 pubmed publisher
Bontemps Karcher A, Magneron V, Conquet L, Elie C, Gloaguen C, Kereselidze D, et al. Renal adaptive response to exposure to low doses of uranyl nitrate and sodium fluoride in mice. J Trace Elem Med Biol. 2021;64:126708 pubmed publisher
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, et al. Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons. EBioMedicine. 2021;63:103138 pubmed publisher
Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, et al. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2021;196:101892 pubmed publisher
O Brien C, Santos P, Kulikowicz E, Lee J, Koehler R, Martin L. Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine. BMC Neurosci. 2020;21:43 pubmed publisher
Mello A, Hsu M, Koike S, Chu B, Cheng J, Yang J, et al. Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol. 2020;: pubmed publisher
Xiong Z, Yuan C, Shi J, Xiong W, Huang Y, Xiao W, et al. Restoring the epigenetically silenced PCK2 suppresses renal cell carcinoma progression and increases sensitivity to sunitinib by promoting endoplasmic reticulum stress. Theranostics. 2020;10:11444-11461 pubmed publisher
Chen Y, Griffiths A, Wang J, Zhang T, Song Q, Song Z. Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes. Am J Physiol Cell Physiol. 2020;319:C1130-C1140 pubmed publisher
Kim H, Cho Y, Kim H, Kang D, Cheon D, Kim Y, et al. A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nat Commun. 2020;11:5023 pubmed publisher
Ding R, Ou W, Chen C, Liu Y, Li H, Zhang X, et al. Endoplasmic reticulum stress and oxidative stress contribute to neuronal pyroptosis caused by cerebral venous sinus thrombosis in rats: Involvement of TXNIP/peroxynitrite-NLRP3 inflammasome activation. Neurochem Int. 2020;141:104856 pubmed publisher
Zhao Q, Zhong J, Bi Y, Liu Y, Liu Y, Guo J, et al. Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK. Phytomedicine. 2020;78:153306 pubmed publisher
Aryal Y, Lee E, Kim T, Sung S, Kim J, An S, et al. Stage-specific expression patterns of ER stress-related molecules in mice molars: Implications for tooth development. Gene Expr Patterns. 2020;37:119130 pubmed publisher
Ganesan M, Mathews S, Makarov E, Petrosyan A, Kharbanda K, Kidambi S, et al. Acetaldehyde suppresses HBV-MHC class I complex presentation on hepatocytes via induction of ER stress and Golgi fragmentation. Am J Physiol Gastrointest Liver Physiol. 2020;319:G432-G442 pubmed publisher
Winnay J, Solheim M, Sakaguchi M, Njølstad P, Kahn C. Inhibition of the PI 3-kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress-dependent apoptosis. FASEB J. 2020;34:12521-12532 pubmed publisher
Galeone A, Adams J, Matsuda S, Presa M, Pandey A, Han S, et al. Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation. elife. 2020;9: pubmed publisher
Yue X, Sun X, Che K, Hu J, Lv W, Sun X, et al. Lpl-C310R mutation is associated with impaired glucose tolerance and endoplasmic reticulum stress in skeletal muscle. Biochem Biophys Res Commun. 2020;529:480-486 pubmed publisher
Cicalese S, Okuno K, Elliott K, Kawai T, Scalia R, Rizzo V, et al. 78 kDa Glucose-Regulated Protein Attenuates Protein Aggregation and Monocyte Adhesion Induced by Angiotensin II in Vascular Cells. Int J Mol Sci. 2020;21: pubmed publisher
Hotokezaka Y, Katayama I, Nakamura T. ATM-associated signalling triggers the unfolded protein response and cell death in response to stress. Commun Biol. 2020;3:378 pubmed publisher
Murray H, Dieriks B, Swanson M, Anekal P, Turner C, Faull R, et al. The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta Neuropathol Commun. 2020;8:109 pubmed publisher
Zhao Y, Ma S, Cao M, Sun C. G604S-HERG mutation in LQT2 leads to autophagy via the UPR-related pathway. J Biosci. 2020;45: pubmed
Protto V, Tramutola A, Fabiani M, Marcocci M, Napoletani G, Iavarone F, et al. Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer's Disease Progression. Microorganisms. 2020;8: pubmed publisher
Wu X, Deng M, Gao Z, Dang Y, Li Y, Li C. Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress. Int Immunopharmacol. 2020;84:106559 pubmed publisher
Li C, Deng M, Gao Z, Dang Y, Zheng G, Yang X, et al. Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway. Food Funct. 2020;11:4416-4427 pubmed publisher
Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, et al. Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice. Life Sci Alliance. 2020;3: pubmed publisher
Bellini L, Strub T, Habel N, Pandiani C, Marchetti S, Martel A, et al. Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells. Cell Death Discov. 2020;6:22 pubmed publisher
Liu D, Zhang P, Zhou J, Liao R, Che Y, Gao M, et al. TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation. Cell Metab. 2020;31:726-740.e8 pubmed publisher
Garufi A, Federici G, Gilardini Montani M, Crispini A, Cirone M, D Orazi G. Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation. Biomolecules. 2020;10: pubmed publisher
Hinte F, van Anken E, Tirosh B, Brune W. Repression of viral gene expression and replication by the unfolded protein response effector XBP1u. elife. 2020;9: pubmed publisher
Liu X, Deng Y, Dai Z, Hu T, Cai W, Liu H, et al. Sodium tanshinone IIA sulfonate protects against Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells. Int J Biol Macromol. 2020;151:47-55 pubmed publisher
Woo M, Choi H, Park S, Ahn J, Jang Y, Ha T, et al. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells. Biochem Biophys Res Commun. 2020;524:744-749 pubmed publisher
Maeyashiki C, Melhem H, Hering L, Baebler K, Cosin Roger J, Schefer F, et al. Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model. Sci Rep. 2020;10:1438 pubmed publisher
Han L, Bittner S, Dong D, Cortez Y, Bittner A, Chan J, et al. Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165688 pubmed publisher
Yoshikawa Y, Sugimoto K, Ochiai Y, Ohashi N. Intracellular proliferation of Anaplasma phagocytophilum is promoted via modulation of endoplasmic reticulum stress signaling in host cells. Microbiol Immunol. 2020;64:270-279 pubmed publisher
Wang M, LAW M, Davis B, Yaaghubi E, Ghilardi A, Ferreira R, et al. Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Cell Death Discov. 2019;5:153 pubmed publisher
Younan P, Santos R, Ramanathan P, Iampietro M, Nishida A, Dutta M, et al. Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. PLoS Pathog. 2019;15:e1008068 pubmed publisher
Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, et al. IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease. Cell Death Dis. 2019;10:800 pubmed publisher
Gu R, Huang T, Xiao J, Liao Z, Li J, Lan H, et al. The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation. Front Physiol. 2019;10:1198 pubmed publisher
Velazquez K, Enos R, Bader J, Sougiannis A, Carson M, Chatzistamou I, et al. Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice. World J Hepatol. 2019;11:619-637 pubmed publisher
Mu K, Sun Y, Zhao Y, Zhao T, Li Q, Zhang M, et al. Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain. EBioMedicine. 2019;47:352-364 pubmed publisher
Wiersma V, van Ziel A, Vazquez Sanchez S, Nölle A, Berenjeno Correa E, Bonaterra Pastra A, et al. Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology. Acta Neuropathol. 2019;138:943-970 pubmed publisher
Ming Y, Zhu X, Tuma Kellner S, Ganzha A, Liebisch G, Gan Schreier H, et al. iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation. Cells. 2019;8: pubmed publisher
Comitato A, Schiroli D, Montanari M, Marigo V. Calpain Activation Is the Major Cause of Cell Death in Photoreceptors Expressing a Rhodopsin Misfolding Mutation. Mol Neurobiol. 2019;: pubmed publisher
Xia Z, Wu S, Wei X, Liao Y, Yi P, Liu Y, et al. Hypoxic ER stress suppresses β-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival. J Biol Chem. 2019;294:13811-13821 pubmed publisher
Shin G, Moon S, Kang H, Choi H, Han H, Kim K. PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway. Nat Commun. 2019;10:3185 pubmed publisher
Han S, Mao L, Liao Y, Sun S, Zhang Z, Mo Y, et al. Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α-RIG-I Antiviral Signaling. J Immunol. 2019;: pubmed publisher
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh Asahara N. Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia. Cells. 2019;8: pubmed publisher
Naughton M, McMahon J, Healy S, FitzGerald U. Profile of the unfolded protein response in rat cerebellar cortical development. J Comp Neurol. 2019;527:2910-2924 pubmed publisher
O Brien C, Santos P, Kulikowicz E, Reyes M, Koehler R, Martin L, et al. Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery. Dev Neurosci. 2019;:1-17 pubmed publisher
Zheng W, Xie W, Yin D, Luo R, Liu M, Guo F. ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling. Cell Commun Signal. 2019;17:42 pubmed publisher
Li H, O Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, et al. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes. 2019;68:1287-1302 pubmed publisher
Otto A, Gan Schreier H, Zhu X, Tuma Kellner S, Staffer S, Ganzha A, et al. Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:662-676 pubmed publisher
Lee M, Bae S, Kim J, Song B, Choi J, Park J, et al. Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris. Lab Anim Res. 2018;34:288-294 pubmed publisher
Yang F, Liu Y, Ren H, Zhou G, Yuan X, Shi X. ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase. Cell Immunol. 2019;336:40-47 pubmed publisher
Wu C, Silvers C, Messing E, Lee Y. Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells. J Biol Chem. 2019;294:3207-3218 pubmed publisher
Sun M, Zhang J, Jiang L, Pan Y, Tan J, Yu F, et al. TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking. Cell Rep. 2018;25:3086-3098.e3 pubmed publisher
Aggarwal S, Ahmad I, Lam A, Carlisle M, Li C, Wells J, et al. Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema. JCI Insight. 2018;3: pubmed publisher
Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park J, et al. Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 2018;10:76 pubmed publisher
Chang T, Lawrence D, Lu M, Tan J, Harnoss J, Marsters S, et al. Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. Mol Cell. 2018;71:629-636.e5 pubmed publisher
Cho Y, Kim D, Lee K, Jeong S, Kwon O. The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity. Exp Mol Med. 2018;50:102 pubmed publisher
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product information
brand :
Novus
MasterCode :
NB100-2323
SKU :
NB100-2323
product name :
IRE1 alpha [p Ser724] Antibody - BSA Free
Description :
The IRE1 alpha [p Ser724] Antibody - BSA Free from NB100-2323 is a nb100-2323 antibody to . This antibody reacts with angiogenesis, apoptosis, cancer, diabetes research, hypoxia, lipid and metabolism, neurodegeneration, neuroscience, signal transduction, unfolded protein response.
target :
IRE1 alpha
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This IRE1 alpha [p Ser724] antibody was raised against a synthetic peptide surrounding the phosphorylated serine 724 of the human IRE1 alpha protein. [Swiss-Prot #O75460]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat, Porcine, Drosophila, Goat, Mammal, Monkey, Primate, Rabbit, Golden Syrian Hamster
specificity :
NB100-2323 IRE1 alpha [p Ser724] Antibody detects IRE-1 alpha when phosphorylated at Ser724 residue
theoretical molecular weight :
110 kDa
gene symbol :
ERN1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Immunohistochemistry-NB100-2323-img0031.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Immunohistochemistry-NB100-2323-img0031.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Immunohistochemistry-NB100-2323-img0031.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0029.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0029.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0029.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0024.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0024.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0024.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0030.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0030.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0030.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0032.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0032.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0032.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0022.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0022.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Western-Blot-NB100-2323-img0022.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Immunohistochemistry-Paraffin-NB100-2323-img0025.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Immunohistochemistry-Paraffin-NB100-2323-img0025.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IRE1-alpha-[p-Ser724]-Antibody-Immunohistochemistry-Paraffin-NB100-2323-img0025.jpg
applications :
Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, In vitro assay, Chromatin Immunoprecipitation (ChIP), Knockdown Validated
USD :
449 USD
alt names :
EC 2.7.11, endoplasmic reticulum to nucleus signaling 1, Endoplasmic reticulum-to-nucleus signaling 1, ER to nucleus signalling 1, FLJ30999, hIRE1p, inositol-requiring 1, Inositol-requiring protein 1, IRE 1a, ire1 alpha p Ser724, ire1 alpha phosphorylation, IRE1a, ire1-alpha, IRE1MGC163279, IRE1P, MGC163277, phospho ire1 alpha, phospho-ire1 alpha, phospho-ire1a, p-ire1 alpha, protein kinase/endoribonuclease, serine/threonine-protein kinase/endoribonuclease IRE1
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.