product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Histone H2AX [p Ser139] Antibody
catalog :
NB100-2280
quantity :
0.1 ml
price :
569 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Novus Biologicals product webpage
citations: 26
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 7f
Marquez Exposito L, Tejedor Santamaria L, Santos Sánchez L, Valentijn F, Cantero Navarro E, Rayego Mateos S, et al. Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes. Front Pharmacol. 2021;12:662020 pubmed publisher
  • western blot; human; 1:1000; fig s6
Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
Eleftheriadis T, Pissas G, Filippidis G, Efthymiadi M, Liakopoulos V, Stefanidis I. Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells. Int J Mol Sci. 2022;23: pubmed publisher
Valentijn F, Knoppert S, Marquez Exposito L, Rodrigues Diez R, Pissas G, Tang J, et al. Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury. Kidney Int. 2022;102:1305-1319 pubmed publisher
Marquez Exposito L, Tejedor Santamaria L, Valentijn F, Tejera Mu xf1 oz A, Rayego Mateos S, Marchant V, et al. Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney. Antioxidants (Basel). 2022;11: pubmed publisher
Zhou Z, Yin H, Suye S, Zhu F, Cai H, Fu C. The changes of DNA double-strand breaks and DNA repair during ovarian reserve formation in mice. Reprod Biol. 2022;22:100603 pubmed publisher
Valentijn F, Knoppert S, Pissas G, Rodrigues Díez R, Marquez Exposito L, Broekhuizen R, et al. CCN2 Aggravates the Immediate Oxidative Stress-DNA Damage Response following Renal Ischemia-Reperfusion Injury. Antioxidants (Basel). 2021;10: pubmed publisher
Ruggiano A, Vaz B, Kilgas S, Popovic M, Rodriguez Berriguete G, Singh A, et al. The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. Cell Rep. 2021;37:110080 pubmed publisher
Jardim Perassi B, Mu W, Huang S, Tomaszewski M, Poleszczuk J, Abdalah M, et al. Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma. Theranostics. 2021;11:5313-5329 pubmed publisher
Grgic I, Tschanz F, Borgeaud N, Gupta A, Clavien P, Guckenberger M, et al. Tumor Oxygenation by Myo-Inositol Trispyrophosphate Enhances Radiation Response. Int J Radiat Oncol Biol Phys. 2021;110:1222-1233 pubmed publisher
Low H, Lee Y, Lee Y, Wang H, Chen Y, Chien P, et al. Reciprocal Regulation Between Indoleamine 2,3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells. Cancers (Basel). 2020;12: pubmed publisher
Park S, Ponce Balbuena D, Kuick R, Guerrero Serna G, Yoon J, Mellacheruvu D, et al. Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents. Mol Cell Proteomics. 2020;: pubmed publisher
Han J, Wang H, Zhang T, Chen Z, Zhao T, Lin L, et al. Resveratrol attenuates doxorubicin-induced meiotic failure through inhibiting oxidative stress and apoptosis in mouse oocytes. Aging (Albany NY). 2020;12:7717-7728 pubmed publisher
Pokrovska T, Jacobus E, Puliyadi R, Prevo R, FROST S, Dyer A, et al. External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase. Cancers (Basel). 2020;12: pubmed publisher
Ma H, Yang F, Ding X. Inhibition of thyroid hormone signaling protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration. Cell Death Dis. 2020;11:24 pubmed publisher
Kuang L, Hashimoto K, Huang E, Gentry M, Zhu H. Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides. Hum Mol Genet. 2020;29:624-634 pubmed publisher
Singh A, Oehler J, Torrecilla I, Kilgas S, Li S, Vaz B, et al. The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8. EMBO J. 2019;38:e102361 pubmed publisher
Lu M, Hartmann D, Braren R, Gupta A, Wang B, Wang Y, et al. Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis. BMC Cancer. 2019;19:887 pubmed publisher
Burdova K, Yang H, Faedda R, Hume S, Chauhan J, Ebner D, et al. E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition. EMBO J. 2019;38:e101443 pubmed publisher
Beeler J, Marshall C, Gonzalez Ericsson P, Shaver T, Santos Guasch G, Lea S, et al. p73 regulates epidermal wound healing and induced keratinocyte programming. PLoS ONE. 2019;14:e0218458 pubmed publisher
Ghoshal A, Rodrigues L, Gowda C, Elcheva I, Liu Z, Abraham T, et al. Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis. Oncogene. 2019;38:4182-4196 pubmed publisher
Wen J, Yan H, He M, Zhang T, Mu X, Wang H, et al. GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice. BMC Biol. 2019;17:23 pubmed publisher
C spedes M, Guill n M, L pez Casas P, Sarno F, Gallardo A, lamo P, et al. Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models. Dis Model Mech. 2016;9:1461-1471 pubmed
Frazier J, Beirne E, Ditzler S, Tretyak I, Casalini J, Thirstrup D, et al. Establishment and characterization of a canine soft tissue sarcoma patient-derived xenograft model. Vet Comp Oncol. 2017;15:754-763 pubmed publisher
Wang M, Topalovski M, Toombs J, Wright C, Moore Z, Boothman D, et al. Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer. Cancer Res. 2015;75:5058-69 pubmed publisher
Pearson H, McGlinn E, Phesse T, Schlüter H, Srikumar A, Gödde N, et al. The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis. Mol Cancer. 2015;14:169 pubmed publisher
product information
brand :
Novus
MasterCode :
NB100-2280
SKU :
NB100-2280
product name :
Histone H2AX [p Ser139] Antibody
Description :
The Histone H2AX [p Ser139] Antibody from NB100-2280 is a nb100-2280 antibody to . This antibody reacts with checkpoint signaling, dna double strand break repair, dna repair, epigenetics, mitotic regulators, phospho specific. The Histone H2AX [p Ser139] Antibody has been validated for the following applications: P16104.
target :
Histone H2AX
category :
Primary Antibodies
unit size :
0.1 ml
buffer :
TBS and 0.1% BSA
clonality :
Polyclonal
concentration :
0.1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This Histone H2AX [p Ser139] Antibody was developed against a synthetic phospho-peptide, which represented a portion of the C-terminus of human histone H2AX surrounding phosphorylated serine 139 (GeneID 3014).
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Canine
theoretical molecular weight :
15 kDa
gene symbol :
H2AX
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/gamma-H2AX-[p-Ser139]-Antibody-Immunohistochemistry-NB100-2280-img0022.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/gamma-H2AX-[p-Ser139]-Antibody-Simple-Western-NB100-2280-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/gamma-H2AX-[p-Ser139]-Antibody-Immunohistochemistry-NB100-2280-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/gamma-H2AX-[p-Ser139]-Antibody-Immunohistochemistry-Paraffin-NB100-2280-img0023.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/gamma-H2AX-[p-Ser139]-Antibody-Immunohistochemistry-NB100-2280-img0018.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/gamma-H2AX-[p-Ser139]-Antibody-Simple-Western-NB100-2280-img0009.jpg
accessionNumbers :
P16104
applications :
Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
USD :
569 USD
alt names :
H2A.X, H2A/X, H2AFX
storage :
Store at 4C. Do not freeze.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.