product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
EGLN1/PHD2 Antibody - BSA Free
catalog :
NB100-2219
quantity :
0.1 ml (also 0.025 ml)
price :
449 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 550
clone name :
6H12
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
citations: 18
Reference
Sun L, Wu C, Ming J, Guo E, Zhang W, Li L, et al. EGLN1 induces tumorigenesis and radioresistance in nasopharyngeal carcinoma by promoting ubiquitination of p53 in a hydroxylase-dependent manner. J Cancer. 2022;13:2061-2073 pubmed publisher
Elamaa H, Kaakinen M, N xe4 tynki M, Szabo Z, Ronkainen V, xc4 ij xe4 l xe4 V, et al. PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis. Angiogenesis. 2022;25:259-274 pubmed publisher
Röning T, Magga J, Laitakari A, Halmetoja R, Tapio J, Dimova E, et al. Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy. J Mol Cell Cardiol. 2022;164:148-155 pubmed publisher
Ju S, Lim L, Wi K, Park C, Ki Y, Choi D, et al. LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium. Int J Mol Sci. 2021;22: pubmed publisher
van Kuijk K, Demandt J, Perales Paton J, Theelen T, Kuppe C, Marsch E, et al. DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic effects of myeloid PHD knockdown. Cardiovasc Res. 2021;: pubmed publisher
Laitakari A, Huttunen R, Kuvaja P, Hannuksela P, Szabo Z, Heikkilä M, et al. Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span. FASEB J. 2020;34:5590-5609 pubmed publisher
Kim S, Jo C, Kim G. Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats. Hypertens Res. 2019;42:1905-1915 pubmed publisher
Chowdhury D, Alrefai H, Landero Figueroa J, Candor K, Porollo A, Fecher R, et al. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Rep. 2019;27:3873-3886.e7 pubmed publisher
Yamamoto A, Hester J, Macklin P, Kawai K, Uchiyama M, Biggs D, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. 2019;130:3640-3656 pubmed publisher
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, Macías D, et al. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metab. 2018;27:898-913.e7 pubmed publisher
Akat F, Ficicilar H, Durak A, Tuncay E, Dursun A, Topal Celikkan F, et al. Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat. Anatol J Cardiol. 2018;19:259-266 pubmed publisher
Flisinski M, Wisniewska Chudy E, Brymora A, Stefanska A, Strozecki P, Manitius J. Chronic kidney disease leads to hypoxia inducible factor-1alpha to hypoxia inducible factor-2alpha switch in the gastrocnemius muscle. J Physiol Pharmacol. 2017;68:419-425 pubmed
Wang S, Zeng H, Chen S, Zhou L, Xie X, He X, et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J Cell Mol Med. 2017;21:1967-1978 pubmed publisher
Choi J, Kim J, Song N, Suh J, Kim D, Kim S, et al. 15-Deoxy-?12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1? through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. Free Radic Res. 2016;50:1140-1152 pubmed
Zeng H, He X, Tuo Q, Liao D, Zhang G, Chen J. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep. 2016;6:20931 pubmed publisher
Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko K, Myllyharju J, et al. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med (Berl). 2016;94:301-10 pubmed publisher
Xie L, Pi X, Townley Tilson W, Li N, Wehrens X, Entman M, et al. PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. J Clin Invest. 2015;125:2759-71 pubmed publisher
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther. 2015;15:313-25 pubmed
product information
brand :
Novus
MasterCode :
NB100-2219
SKU :
NB100-2219
product name :
EGLN1/PHD2 Antibody - BSA Free
Description :
The EGLN1/PHD2 Antibody - BSA Free from NB100-2219 is a nb100-2219 antibody to . This antibody reacts with angiogenesis, cancer, chromatin research, hypoxia, immunology, lipid and metabolism.
target :
EGLN1/PHD2
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This EGLN1/PHD2 antibody was developed against a synthetic peptide made to an internal portion of mouse PHD2/HIF Prolyl Hydroxylase 2 (between residues 300-400). [Uniprot: Q91YE3]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat
theoretical molecular weight :
43 kDa
gene symbol :
EGLN1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Knockdown-Validated-NB100-2219-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Knockdown-Validated-NB100-2219-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-Paraffin-NB100-2219-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-Paraffin-NB100-2219-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-2219-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-2219-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0010.jpg
applications :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockout Validated, Knockdown Validated
USD :
449 USD
alt names :
C1orf12, EC 1.14.11.29, EC:1.14.11.291, ECYT3, egl nine homolog 1, egl nine-like protein 1, EGLN1, HALAH, HIF prolyl hydroxylase 2, HIFPH2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH2, HPH-2, Hypoxia-inducible factor prolyl hydroxylase 2, PHD2, PNAS-118, PNAS-137, Prolyl hydroxylase domain-containing protein 2, SM20, SM-20, zinc finger MYND domain-containing protein 6, ZMYND6
storage :
Store at 4C. Do not freeze.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.