Nbs1 Antibody (1D7) | Novus Biologicals NB100-221 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Nbs1 Antibody (1D7)

catalog :

NB100-221

quantity :

0.1 ml

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D7

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Novus Biologicals product webpage

citations: 36

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 2a	Xie L, Pi X, Townley Tilson W, Li N, Wehrens X, Entman M, et al. PHD2/3-dependent hydroxylation tunes cardiac response to Î²-adrenergic stress via phospholamban. J Clin Invest. 2015;125:2759-71 pubmed publisher
	Volcic M, Sparrer K, Koepke L, Hotter D, Sauter D, Stürzel C, et al. Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1. Nat Microbiol. 2020;5:1247-1261 pubmed publisher
	Seo J, Kang M, Yang W, Hwang W, Kim S, Hong S, et al. Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. Nat Commun. 2020;11:2024 pubmed publisher
	Fagan Solis K, Simpson D, Kumar R, Martelotto L, Mose L, Rashid N, et al. A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. Cell Rep. 2020;30:1385-1399.e7 pubmed publisher
	Suzuki C, Tanida I, Oliva Trejo J, Kakuta S, Uchiyama Y. Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions. Int J Mol Sci. 2019;21: pubmed publisher
	Fels J, Scharner B, Zarbock R, Zavala Guevara I, Lee W, Barbier O, et al. Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule. Int J Mol Sci. 2019;20: pubmed publisher
	Kinguchi S, Wakui H, Azushima K, Haruhara K, Koguchi T, Ohki K, et al. Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension. J Am Heart Assoc. 2019;8:e012395 pubmed publisher
	Mohr J, Voggel J, Vohlen C, Dinger K, Dafinger C, Fink G, et al. IL-6/Smad2 signaling mediates acute kidney injury and regeneration in a murine model of neonatal hyperoxia. FASEB J. 2019;33:5887-5902 pubmed publisher
	Li C, Mahon C, Sweeney N, Verschueren E, Kantamani V, Li D, et al. PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Cell Rep. 2019;26:1333-1343.e7 pubmed publisher
	Schuh C, Polesel M, Platonova E, Haenni D, Gassama A, Tokonami N, et al. Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis. J Am Soc Nephrol. 2018;29:2696-2712 pubmed publisher
	Przepiorski A, Sander V, TRAN T, Hollywood J, Sorrenson B, Shih J, et al. A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. Stem Cell Reports. 2018;11:470-484 pubmed publisher
	Westerlund I, Shi Y, Toskas K, Fell S, Li S, Surova O, et al. Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression. Proc Natl Acad Sci U S A. 2017;114:E6137-E6146 pubmed publisher
	Viall C, Chen Q, Stone P, Chamley L. Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies. Placenta. 2016;42:9-16 pubmed publisher
	Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, et al. Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway. Oncol Rep. 2015;34:2251-8 pubmed publisher
	Choi S, Hong H, Cho Y, Lee W, Yoo H. Identification of Sestrin3 Involved in the In vitro Resistance of Colorectal Cancer Cells to Irinotecan. PLoS ONE. 2015;10:e0126830 pubmed publisher
	Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, et al. Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension. Kidney Int. 2014;86:570-81 pubmed publisher
	Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, et al. Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice. Clin Exp Nephrol. 2014;18:65-74 pubmed publisher
	Nashida T, Sato R, Haga Tsujimura M, Yoshie S, Yoshimura K, Imai A, et al. Antigen-presenting cells in parotid glands contain cystatin D originating from acinar cells. Arch Biochem Biophys. 2013;530:32-9 pubmed publisher
	Moudry P, Lukas C, Macurek L, Neumann B, Hériché J, Pepperkok R, et al. Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Cell Death Differ. 2012;19:798-807 pubmed publisher
	Chang A, Ohse T, Krofft R, Wu J, Eddy A, Pippin J, et al. Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2. Nephrol Dial Transplant. 2012;27:1330-43 pubmed publisher
	E X, Pickering M, Debatis M, Castillo J, Lagadinos A, Wang S, et al. An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog. 2011;7:e1001342 pubmed publisher
	Demogines A, East A, Lee J, Grossman S, Sabeti P, Paull T, et al. Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet. 2010;6:e1001169 pubmed publisher
	Inoue S, Yoshinari K, Sugawara M, Yamazoe Y. Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver. Mol Pharmacol. 2011;79:148-56 pubmed publisher
	Cha H, Lowe J, Li H, Lee J, Belova G, Bulavin D, et al. Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res. 2010;70:4112-22 pubmed publisher
	Mandriota S, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, et al. Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. J Biol Chem. 2010;285:13092-106 pubmed publisher
	Lee J, Goodarzi A, Jeggo P, Paull T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 2010;29:574-85 pubmed publisher
	Lins S, Kim R, Krüger L, Chrzanowska K, Seemanova E, Digweed M. Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome. Gene. 2009;447:12-7 pubmed publisher
	Collaco R, Bevington J, Bhrigu V, Kalman Maltese V, Trempe J. Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Virology. 2009;392:24-33 pubmed publisher
	Abuzeid W, Jiang X, Shi G, Wang H, Paulson D, Araki K, et al. Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy. J Clin Invest. 2009;119:1974-85 pubmed publisher
	Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, et al. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol. 2008;2:296-316 pubmed publisher
	Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori A, Gerrits B, et al. MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res. 2009;37:2645-57 pubmed publisher
	Spycher C, Miller E, Townsend K, Pavic L, Morrice N, Janscak P, et al. Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol. 2008;181:227-40 pubmed publisher
	den Dulk B, van Eijk P, de Ruijter M, Brandsma J, Brouwer J. The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4. DNA Repair (Amst). 2008;7:858-68 pubmed publisher
	Takemura H, Rao V, Sordet O, Furuta T, Miao Z, Meng L, et al. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem. 2006;281:30814-23 pubmed
	Krüger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska K, et al. Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein. Carcinogenesis. 2007;28:107-11 pubmed
	Cerosaletti K, Concannon P. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. J Biol Chem. 2004;279:38813-9 pubmed

product information

brand :

Novus

MasterCode :

NB100-221

SKU :

NB100-221

product name :

Nbs1 Antibody (1D7)

Description :

The Nbs1 Antibody (1D7) from NB100-221 is a nb100-221 antibody to . This antibody reacts with breast cancer, cancer, cell cycle and replication, checkpoint signaling, chromatin research, dna double strand break repair, dna repair, homologous recombination, non homologous end joining, tumor suppressors. The Nbs1 Antibody (1D7) has been validated for the following applications: O60934.

target :

Nbs1

category :

Primary Antibodies

unit size :

0.1 ml

buffer :

PBS

clonality :

Monoclonal

clone :

1D7

conjugate :

Unconjugated

host :

Mouse

immunogen :

Nbs1 Antibody (1D7) was made to the complete coding region of the human p95/NBS1 expressed in E. coli.

isotype :

IgG1

purity :

Protein G purified

species :

Human, Mouse, Rat

specificity :

Nijmegen breakage syndrome (NBS, nibrin) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition

theoretical molecular weight :

85 kDa

gene symbol :

NBN

images :

https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-(1D7)-Western-Blot-NB100-221-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-(1D7)-Western-Blot-NB100-221-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-(1D7)-Western-Blot-NB100-221-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-(1D7)-Immunocytochemistry-Immunofluorescence-NB100-221-img0012.jpg

accessionNumbers :

O60934

applications :

Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Knockdown Validated

USD :

449 USD

alt names :

ATV, AT-V1, AT-V2, Cell cycle regulatory protein p95, FLJ10155, MGC87362, NBS, NBS1P95, nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, p95, p95 protein of the MRE11/RAD50 complex

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage