ATM Antibody (5C2) | Novus Biologicals NB100-220 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

ATM Antibody (5C2)

catalog :

NB100-220

quantity :

0.1 ml

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 38

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2c	Barnard R, Regan D, Hansen R, Maycotte P, Thorburn A, Gustafson D. Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease. J Pharmacol Exp Ther. 2016;358:282-93 pubmed publisher
	Najnin R, Al Mahmud M, Rahman M, Takeda S, Sasanuma H, Tanaka H, et al. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen. Cell Rep. 2023;42:111909 pubmed publisher
	Han Y, Lee Y, Jang Y, Kim H, Seo H, Jung T, et al. Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. Biomed Res Int. 2020;2020:7806860 pubmed publisher
	Iizuka Y, Chiba K, Kim H, Hirako S, Wada M, Matsumoto A. Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice. J Nutr Biochem. 2020;76:108265 pubmed publisher
	Gang X, Xuan L, Zhao X, Lv Y, Li F, Wang Y, et al. Speckle-type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase. Prostate. 2019;79:864-871 pubmed publisher
	Meister Broekema M, Freilich R, Jagadeesan C, Rauch J, Bengoechea R, Motley W, et al. Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. Nat Commun. 2018;9:5342 pubmed publisher
	Li M, Vera N, Yang Y, Zhang B, Ni W, Ziso Qejvanaj E, et al. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nat Commun. 2018;9:5103 pubmed publisher
	Walz J, Saha J, Arora A, Khammanivong A, O Sullivan M, Dickerson E. Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. Vet Comp Oncol. 2018;16:E99-E108 pubmed publisher
	Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed publisher
	Chen C, Chuang W, Lin A, Tsai C, Huang C, Chen Y, et al. Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBP? expression and activation. Toxicol Appl Pharmacol. 2016;307:115-122 pubmed publisher
	Karlas A, Berrè S, Couderc T, Varjak M, Braun P, Meyer M, et al. A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nat Commun. 2016;7:11320 pubmed publisher
	Gang X, Yang Y, Zhong J, Jiang K, Pan Y, Karnes R, et al. P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth. Oncotarget. 2016;7:15135-49 pubmed publisher
	Aumailley L, Garand C, Dubois M, Johnson F, Marette A, Lebel M. Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice. PLoS ONE. 2015;10:e0140292 pubmed publisher
	Milan E, Perini T, Resnati M, Orfanelli U, Oliva L, Raimondi A, et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 2015;11:1161-78 pubmed publisher
	Kim K, Cho Y, Park B, Lee J, Ro J, Go H, et al. Histological and immunohistochemical markers for progression prediction in transurethrally resected high-grade non-muscle invasive bladder cancer. Int J Clin Exp Pathol. 2015;8:743-50 pubmed
	Mendez G, Cilli D, Berardinelli F, Viganotti M, Ascenzi P, Tanzarella C, et al. Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation. IUBMB Life. 2012;64:853-61 pubmed publisher
	Daniel J, Pellegrini M, Lee B, Guo Z, Filsuf D, Belkina N, et al. Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol. 2012;198:295-304 pubmed publisher
	Hou Y, Toh M, Wang X. NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity. Cell Biochem Funct. 2012;30:233-42 pubmed publisher
	Vogel R, Seyffert M, Strasser R, de Oliveira A, Dresch C, Glauser D, et al. Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol. 2012;86:143-55 pubmed publisher
	Rankin A, Sarkar S, Faller D. Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. J Cell Physiol. 2012;227:2586-94 pubmed publisher
	Gapud E, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald G, et al. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011;108:2022-7 pubmed publisher
	Cam H, Easton J, High A, Houghton P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell. 2010;40:509-20 pubmed publisher
	Craig A, Holcakova J, Finlan L, Nekulova M, Hrstka R, Gueven N, et al. DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Mol Cancer. 2010;9:195 pubmed publisher
	Alimonti A, Nardella C, Chen Z, Clohessy J, Carracedo A, Trotman L, et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010;120:681-93 pubmed publisher
	Gonzalez Suarez I, Redwood A, Perkins S, Vermolen B, Lichtensztejin D, Grotsky D, et al. Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J. 2009;28:2414-27 pubmed publisher
	Efeyan A, Murga M, Martinez Pastor B, Ortega Molina A, Soria R, Collado M, et al. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS ONE. 2009;4:e5475 pubmed publisher
	Siehler S, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesmuller L. Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair (Amst). 2009;8:242-52 pubmed publisher
	Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed publisher
	Sun Y, Xu Y, Roy K, Price B. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007;27:8502-9 pubmed
	Fernandes N, Sun Y, Price B. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007;282:16577-84 pubmed
	Chen J, Ozanne S. Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress. FEBS Lett. 2006;580:6669-73 pubmed
	Sun Y, Jiang X, Chen S, Price B. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006;580:4353-6 pubmed
	Roy K, Wang L, Makrigiorgos G, Price B. Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. Biochem Biophys Res Commun. 2006;344:821-6 pubmed
	Jiang X, Sun Y, Chen S, Roy K, Price B. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006;281:15741-6 pubmed
	Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
	Sun Y, Jiang X, Chen S, Fernandes N, Price B. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005;102:13182-7 pubmed
	Fernandes N, Sun Y, Chen S, Paul P, Shaw R, Cantley L, et al. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005;280:15158-64 pubmed
	Lai C, Chun H, Nahas S, Mitui M, Gamo K, Du L, et al. Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004;101:15676-81 pubmed

product information

brand :

Novus

MasterCode :

NB100-220

SKU :

NB100-220

product name :

ATM Antibody (5C2)

Description :

The ATM Antibody (5C2) from NB100-220 is a nb100-220 antibody to . This antibody reacts with apoptosis, breast cancer, cancer, cell cycle and replication, checkpoint signaling, chromatin research, dna double strand break repair, dna repair, genes sensitive to dna damaging agents, hypoxia, modulation of dna pools, p53 pathway, protein kinase, tumor suppressors.

target :

ATM

category :

Primary Antibodies

unit size :

0.1 ml

buffer :

PBS

clonality :

Monoclonal

clone :

5C2

conjugate :

Unconjugated

host :

Mouse

immunogen :

ATM Antibody (5C2) was made to a recombinant protein expressed in E. coli corresponding to amino acids 980-1512.

isotype :

IgG1

purity :

Protein G purified

species :

Human, Mouse, Rat, Monkey

theoretical molecular weight :

351 kDa

gene symbol :

ATM

images :

https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Western-Blot-NB100-220-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Immunocytochemistry-Immunofluorescence-NB100-220-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Western-Blot-NB100-220-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Western-Blot-NB100-220-img0002.jpg

applications :

Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation

USD :

459 USD

alt names :

AT mutated, A-T mutated, AT1, ATA, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATC, ATD, ATDC, ATE, ATM serine/threonine kinase, DKFZp781A0353, EC 2.7.11.1, MGC74674, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage