product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Thrombospondin-1 Antibody (A6.1)
catalog :
NB100-2059
quantity :
0.25 ml (also 0.05 ml)
price :
399 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A6.1
reactivity :
human
application :
western blot, immunohistochemistry, neutralization, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Novus Biologicals product webpage
citations: 16
Reference
Jin A, Zhou J, Yu P, Zhou S, Chang C. High Expression of THBS1 Leads to a Poor Prognosis in Papillary Thyroid Cancer and Suppresses the Anti-Tumor Immune Microenvironment. Technol Cancer Res Treat. 2022;21:15330338221085360 pubmed publisher
Zhang X, Yang L, Szeto P, Abali G, Zhang Y, Kulkarni A, et al. The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis. Oncogene. 2020;39:5267-5281 pubmed publisher
Brauze D, Kiwerska K, Bednarek K, Grenman R, Janiszewska J, Giefing M, et al. Expression of Serpin Peptidase Inhibitor B2 (SERPINB2) is regulated by Aryl hydrocarbon receptor (AhR). Chem Biol Interact. 2019;309:108700 pubmed publisher
Mouton A, Ma Y, Rivera Gonzalez O, Daseke M, Flynn E, Freeman T, et al. Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis. Basic Res Cardiol. 2019;114:6 pubmed publisher
Chen X, Yang B, Tian J, Hong H, Du Y, Li K, et al. Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-β3 and TSP-1 to Elicit Macrophage M2 Polarization. Cell Physiol Biochem. 2018;51:2290-2308 pubmed publisher
Ogura J, Miyauchi S, Shimono K, Yang S, Gonchigar S, Ganapathy V, et al. Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. Biochem J. 2017;474:3391-3402 pubmed publisher
Chen S, Ning L, Xu X, Jiang W, Xing C, Jia W, et al. The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling. Cell Death Differ. 2016;23:1778-1791 pubmed publisher
Li S, Heller J, Bostick J, Lee A, Schjerven H, Kastner P, et al. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016;45:185-97 pubmed publisher
Stawski L, Haines P, Fine A, Rudnicka L, Trojanowska M. MMP-12 deficiency attenuates angiotensin II-induced vascular injury, M2 macrophage accumulation, and skin and heart fibrosis. PLoS ONE. 2014;9:e109763 pubmed publisher
Jayachandran A, Anaka M, Prithviraj P, Hudson C, McKeown S, Lo P, et al. Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma. Oncotarget. 2014;5:5782-97 pubmed
Cupi M, Sarra M, De Nitto D, Franzè E, Marafini I, Monteleone I, et al. Defective expression of scavenger receptors in celiac disease mucosa. PLoS ONE. 2014;9:e100980 pubmed publisher
Jaffrain Rea M, Angelini M, Gargano D, Tichomirowa M, Daly A, Vanbellinghen J, et al. Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. Endocr Relat Cancer. 2009;16:1029-43 pubmed publisher
Michaud Levesque J, Richard S. Thrombospondin-1 is a transcriptional repression target of PRMT6. J Biol Chem. 2009;284:21338-46 pubmed publisher
Chen Y, Beischlag T, Kim J, Perdew G, Stallcup M. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. J Biol Chem. 2006;281:12242-7 pubmed
Savouret J, Antenos M, Quesne M, Xu J, Milgrom E, Casper R. 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. J Biol Chem. 2001;276:3054-9 pubmed
Meyer B, Perdew G. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. Biochemistry. 1999;38:8907-17 pubmed
product information
brand :
Novus
MasterCode :
NB100-2059
SKU :
NB100-2059
product name :
Thrombospondin-1 Antibody (A6.1)
Description :
The Thrombospondin-1 Antibody (A6.1) from NB100-2059 is a nb100-2059 antibody to . This antibody reacts with cancer. The Thrombospondin-1 Antibody (A6.1) has been validated for the following applications: P07996.
target :
Thrombospondin-1
category :
Primary Antibodies
unit size :
0.25 ml (also 0.05 ml)
buffer :
PBS (pH 7.4), 0.2% BSA, Tween-20
clonality :
Monoclonal
clone :
A6.1
concentration :
0.2 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
BALB/C mice were injected with reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets.
isotype :
IgG1
purity :
Protein A or G purified
species :
Human
specificity :
This is specific to 450 kD protein, a non-reduced form, and 170 to 180 kD protein, a reduced form, of Thrombospondin
gene symbol :
THBS1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-NB100-2059-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-NB100-2059-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-NB100-2059-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Thrombospondin-1-Antibody-(A6.1)-Immunohistochemistry-Paraffin-NB100-2059-img0014.jpg
accessionNumbers :
P07996
applications :
Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Block/Neutralize
USD :
399 USD
alt names :
THBS, THBS-1, thrombospondin 1, thrombospondin-1p180, TSP1thrombospondin-1, TSPTSP-1
storage :
Store at 4C. Do not freeze.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.