SMN Antibody (2B1) | Novus Biologicals NB100-1936 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

SMN Antibody (2B1)

catalog :

NB100-1936

quantity :

0.1 ml (also 0.025 ml)

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B1

reactivity :

anurans, human, mouse, rat, zebrafish

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 50

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; fig 3a	Kobayashi M, Chandrasekhar A, Cheng C, Martinez J, Ng H, de La Hoz C, et al. Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22. Dis Model Mech. 2017;10:215-224 pubmed publisher
immunocytochemistry; zebrafish ; 1:100; fig s1 western blot; zebrafish ; 1:250; fig s1	SpirÃ³ Z, Koh A, Tay S, See K, Winkler C. Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish. Sci Rep. 2016;6:27470 pubmed publisher
ELISA; human	Kassim S, Jordan J, Schreiter J, Adhikarakunnathu S, Baribaud F, San Mateo L. Systematic identification of novel SLE related autoantibodies responsible for type I IFN production in human plasmacytoid dendritic cells. Cell Immunol. 2013;284:119-28 pubmed publisher
immunoprecipitation; human western blot; human immunoprecipitation; anurans western blot; anurans	Yong J, Golembe T, Battle D, Pellizzoni L, Dreyfuss G. snRNAs contain specific SMN-binding domains that are essential for snRNP assembly. Mol Cell Biol. 2004;24:2747-56 pubmed
western blot; human	Nelson P, Hatzigeorgiou A, Mourelatos Z. miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA. 2004;10:387-94 pubmed
immunoprecipitation; human	Massenet S, Pellizzoni L, Paushkin S, Mattaj I, Dreyfuss G. The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Mol Cell Biol. 2002;22:6533-41 pubmed
immunoprecipitation; human	Paushkin S, Gubitz A, Massenet S, Dreyfuss G. The SMN complex, an assemblyosome of ribonucleoproteins. Curr Opin Cell Biol. 2002;14:305-12 pubmed
immunoprecipitation; human	Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem. 2002;277:7540-5 pubmed
immunoprecipitation; human western blot; human	Gubitz A, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G. Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem. 2002;277:5631-6 pubmed
immunoprecipitation; human western blot; human	Friesen W, Massenet S, Paushkin S, Wyce A, Dreyfuss G. SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Mol Cell. 2001;7:1111-7 pubmed
western blot; mouse	Kerr D, Nery J, Traystman R, Chau B, Hardwick J. Survival motor neuron protein modulates neuron-specific apoptosis. Proc Natl Acad Sci U S A. 2000;97:13312-7 pubmed
immunoprecipitation; human immunocytochemistry; human western blot; human	Charroux B, Pellizzoni L, Perkinson R, Yong J, Shevchenko A, Mann M, et al. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol. 2000;148:1177-86 pubmed
immunocytochemistry; human	Giesemann T, Rathke Hartlieb S, Rothkegel M, Bartsch J, Buchmeier S, Jockusch B, et al. A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems. J Biol Chem. 1999;274:37908-14 pubmed
immunocytochemistry; human	Pellizzoni L, Kataoka N, Charroux B, Dreyfuss G. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing. Cell. 1998;95:615-24 pubmed
western blot; rat western blot; human	La Bella V, Cisterni C, Salaun D, Pettmann B. Survival motor neuron (SMN) protein in rat is expressed as different molecular forms and is developmentally regulated. Eur J Neurosci. 1998;10:2913-23 pubmed
immunoprecipitation; anurans western blot; anurans	Fischer U, Liu Q, Dreyfuss G. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell. 1997;90:1023-9 pubmed
immunoprecipitation; human immunocytochemistry; human western blot; human	Liu Q, Fischer U, Wang F, Dreyfuss G. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell. 1997;90:1013-21 pubmed
immunoprecipitation; anurans immunocytochemistry; anurans western blot; anurans immunoprecipitation; mouse immunocytochemistry; mouse western blot; mouse immunoprecipitation; human immunocytochemistry; human western blot; human	Liu Q, Dreyfuss G. A novel nuclear structure containing the survival of motor neurons protein. EMBO J. 1996;15:3555-65 pubmed
	Wu S, Lu I, Yang S, Hsieh C, Chai C, Tai M, et al. Spinal Irisin Gene Delivery Attenuates Burn Injury-Induced Muscle Atrophy by Promoting Axonal Myelination and Innervation of Neuromuscular Junctions. Int J Mol Sci. 2022;23: pubmed publisher
	Stewart L, Gerner L, Rettel M, Stein F, Burrows J, Mills I, et al. CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation. Cell Death Dis. 2021;12:1040 pubmed publisher
	Nishibe M, Toyoda H, Hiraga S, Yamashita T, Katsuyama Y. Synaptic and Genetic Bases of Impaired Motor Learning Associated with Modified Experience-Dependent Cortical Plasticity in Heterozygous Reeler Mutants. Cereb Cortex. 2021;: pubmed publisher
	Peng W, de Bruijn H, ten Hagen T, van Dam G, Roodenburg J, Berg K, et al. Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model. Photochem Photobiol. 2020;96:708-717 pubmed publisher
	Wen S, Li S, Li L, Fan Q. circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis. Biol Pharm Bull. 2020;43:558-564 pubmed publisher
	Martins F, Aguila M, Mandarim de Lacerda C. Eicosapentaenoic and docosapentaenoic acids lessen the expression of PPARγ/Cidec affecting adipogenesis in cultured 3T3-L1 adipocytes. Acta Histochem. 2020;122:151504 pubmed publisher
	Shaalan A, Proctor G. Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury. Sci Rep. 2019;9:11339 pubmed publisher
	Solek P, Koszla O, Mytych J, Badura J, Chelminiak Z, Cuprys M, et al. Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies. Apoptosis. 2019;24:773-784 pubmed publisher
	Stojanovic B, Milovanovic J, Arsenijević A, Stojanović B, Strazic Geljic I, Arsenijevic N, et al. Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Front Microbiol. 2019;10:185 pubmed publisher
	Codenotti S, Faggi F, Ronca R, Chiodelli P, Grillo E, Guescini M, et al. Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation. Cancer Lett. 2019;449:135-144 pubmed publisher
	Corsetti G, Chen Scarabelli C, Romano C, Pasini E, Dioguardi F, Onorati F, et al. Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients. Med Sci Monit Basic Res. 2019;25:33-44 pubmed publisher
	Hu S, Cheng M, Guo X, Wang S, Liu B, Jiang H, et al. Down-regulation of miR-200c attenuates AngII-induced cardiac hypertrophy via targeting the MLCK-mediated pathway. J Cell Mol Med. 2019;23:2505-2516 pubmed publisher
	Otsuki N, Arakawa R, Kaneko K, Aoki R, Arakawa M, Saito K. A new biomarker candidate for spinal muscular atrophy: Identification of a peripheral blood cell population capable of monitoring the level of survival motor neuron protein. PLoS ONE. 2018;13:e0201764 pubmed publisher
	Dahiya N, Chandrasekaran B, Kolluru V, Ankem M, DAMODARAN C, Vadhanam M. A natural molecule, urolithin A, downregulates androgen receptor activation and suppresses growth of prostate cancer. Mol Carcinog. 2018;57:1332-1341 pubmed publisher
	Babic Z, Zunic F, Pantic J, Radosavljevic G, Jovanovic I, Arsenijevic N, et al. IL-33 receptor (ST2) deficiency downregulates myeloid precursors, inflammatory NK and dendritic cells in early phase of sepsis. J Biomed Sci. 2018;25:56 pubmed publisher
	Jurisevic M, Arsenijević A, Pantic J, Gajovic N, Milovanovic J, Milovanovic M, et al. The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis. Oncotarget. 2018;9:28195-28212 pubmed publisher
	Solek P, Majchrowicz L, Koziorowski M. Aloe arborescens juice prevents EMF-induced oxidative stress and thus protects from pathophysiology in the male reproductive system in vitro. Environ Res. 2018;166:141-149 pubmed publisher
	Talreja D, Cashman S, Dasari B, Kumar B, Kumar Singh R. G-quartet oligonucleotide mediated delivery of functional X-linked inhibitor of apoptosis protein into retinal cells following intravitreal injection. Exp Eye Res. 2018;175:20-31 pubmed publisher
	Guo Y, Wang F, Li H, Liang H, Li Y, Gao Z, et al. Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway. Neurochem Res. 2018;43:1111-1117 pubmed publisher
	Adamson S, Polanowska Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort S, et al. Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:1020-1029 pubmed publisher
	Shaalan A, Carpenter G, Proctor G. Caspases are key regulators of inflammatory and innate immune responses mediated by TLR3 in vivo. Mol Immunol. 2018;94:190-199 pubmed publisher
	Bozec A, Zangari J, Butori Pepino M, Ilie M, Lalvee S, Juhel T, et al. MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma. Oncotarget. 2017;8:57174-57186 pubmed publisher
	Chen H, Lin Y, Chen W, Wang S, Chen C, Chen Y. Urethral proteomic analysis in ovariectomized mice administered 17β-oestradiol replacement therapy. J Obstet Gynaecol. 2017;37:757-765 pubmed publisher
	Mytych J, Romerowicz Misielak M, Koziorowski M. Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes. Toxicol In Vitro. 2017;42:1-9 pubmed publisher
	Solek P, Majchrowicz L, Bloniarz D, Krotoszynska E, Koziorowski M. Pulsed or continuous electromagnetic field induce p53/p21-mediated apoptotic signaling pathway in mouse spermatogenic cells in vitro and thus may affect male fertility. Toxicology. 2017;382:84-92 pubmed publisher
	Phua T, Sng M, Tan E, Chee D, Li Y, Wee J, et al. Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin. Sci Rep. 2017;7:44351 pubmed publisher
	Sidhar H, Giri R. Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Sci Rep. 2017;7:41420 pubmed publisher
	Rasheed N, Ahmed L, Abdallah D, El Sayeh B. Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis. Sci Rep. 2017;7:40617 pubmed publisher
	Corsetti G, Romano C, Stacchiotti A, Pasini E, Dioguardi F. Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study. Biol Trace Elem Res. 2017;178:86-97 pubmed publisher
	Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed publisher
	Turtle J, Strain M, Aceves M, Huang Y, Reynolds J, Hook M, et al. Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine. J Neurotrauma. 2017;34:1200-1208 pubmed publisher
	Li T, Sun K, Wang H, Zhou M, Ding K, Lu X, et al. Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy. Neurochem Res. 2015;40:1829-38 pubmed publisher

product information

brand :

Novus

MasterCode :

NB100-1936

SKU :

NB100-1936

product name :

SMN Antibody (2B1)

Description :

The SMN Antibody (2B1) from NB100-1936 is a nb100-1936 antibody to . This antibody reacts with apoptosis, neurodegeneration, neuroscience, transcription factors and regulators. The SMN Antibody (2B1) has been validated for the following applications: Q16637, P97801, O35876.

target :

SMN

category :

Primary Antibodies

unit size :

0.1 ml (also 0.025 ml)

buffer :

Tris-Glycine and 0.15M NaCl

clonality :

Monoclonal

clone :

2B1

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Purified recombinant His6-tagged human SMN protein. [Swiss-Prot# Q16637]

isotype :

IgG1

purity :

Protein G purified

species :

Human, Mouse, Rat, Primate, Xenopus, Zebrafish

gene symbol :

SMN1

images :

https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Western-Blot-NB100-1936-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Western-Blot-NB100-1936-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Western-Blot-NB100-1936-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Western-Blot-NB100-1936-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunocytochemistry-Immunofluorescence-NB100-1936-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Immunohistochemistry-NB100-1936-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/SMN-Antibody-(2B1)-Flow-Cytometry-NB100-1936-img0008.jpg

accessionNumbers :

Q16637, P97801, O35876

applications :

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin

USD :

449 USD

alt names :

Gemin-1, Kugelberg-Welander disease), SMNC, survival motor neuron protein, survival of motor neuron 1, telomeric

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage