product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
FANCD2 Antibody - BSA Free
catalog :
NB100-182
quantity :
0.05 ml (also 0.025 ml)
price :
479 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 104
Reference
Blaize J, Garzon J, Howlett N. FANCD2 genome binding is nonrandom and is enriched at large transcriptionally active neural genes prone to copy number variation. Funct Integr Genomics. 2024;24:180 pubmed publisher
Matsuzaki K, Shinohara A, Shinohara M. Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation. Nucleic Acids Res. 2024;52:5774-5791 pubmed publisher
Isik E, Shukla K, Pospisilova M, K xf6 nig C, Andrs M, Rao S, et al. MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops. Sci Adv. 2024;10:eadk2685 pubmed publisher
Jayabal P, Ma X, Shiio Y. Roles of USP1 in Ewing sarcoma. Genes Cancer. 2024;15:15-27 pubmed publisher
Sogari A, Rovera E, Grasso G, Mariella E, Reilly N, Lamba S, et al. Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells. Cell Rep Med. 2024;5:101376 pubmed publisher
Peake J, Horne K, Noguchi C, Gilligan J, Noguchi E. The p53 DNA damage response and Fanconi anemia DNA repair pathway protect against acetaldehyde-induced replication stress in esophageal keratinocytes. Cell Cycle. 2023;22:2088-2096 pubmed publisher
Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, et al. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. Nat Commun. 2023;14:5607 pubmed publisher
Gelot C, Kovacs M, Miron S, Mylne E, Haan A, Boeffard Dosierre L, et al. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis. Nature. 2023;621:415-422 pubmed publisher
Tsui V, Lyu R, Novakovic S, Stringer J, Dunleavy J, Granger E, et al. Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals. Cell Genom. 2023;3:100349 pubmed publisher
Hoffman T, Nangia V, Ill C, Passanisi V, Armstrong C, Yang C, et al. Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles. Sci Signal. 2023;16:eade8744 pubmed publisher
Stok C, Tsaridou S, van den Tempel N, Everts M, Wierenga E, Bakker F, et al. FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics. Cell Rep. 2023;42:112668 pubmed publisher
Barreto Galvez A, Niljikar M, Gagliardi J, Zhang R, Kumar V, Juruwala A, et al. Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks. bioRxiv. 2023;: pubmed publisher
Blaize J, Noori B, Hunter K, Henrikson K, Atoyan J, Ardito A, et al. Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia. bioRxiv. 2023;: pubmed publisher
Moore C, Yalcindag S, Czeladko H, Ravindranathan R, Wijesekara Hanthi Y, Levy J, et al. RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks. J Cell Biol. 2023;222: pubmed publisher
Andrs M, Stoy H, Boleslavska B, Chappidi N, Kanagaraj R, Nascakova Z, et al. Excessive reactive oxygen species induce transcription-dependent replication stress. Nat Commun. 2023;14:1791 pubmed publisher
Garribba L, De Feudis G, Martis V, Galli M, Dumont M, Eliezer Y, et al. Short-term molecular consequences of chromosome mis-segregation for genome stability. Nat Commun. 2023;14:1353 pubmed publisher
Jiang H, Kong N, Liu Z, West S, Chan Y. Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS-STING Activation. Adv Sci (Weinh). 2023;10:e2204388 pubmed publisher
Wu W, Barwacz S, Bhowmick R, Lundgaard K, Gon xe7 alves Dinis M, Clausen M, et al. Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells. Nat Commun. 2023;14:706 pubmed publisher
Benitez A, Sebald M, Kanagaraj R, Rodrigo Brenni M, Chan Y, Liang C, et al. GEN1 promotes common fragile site expression. Cell Rep. 2023;42:112062 pubmed publisher
Chung H, Lee J, Kim T, Kim S, Park K, Kim M, et al. ZNF212 promotes genomic integrity through direct interaction with TRAIP. Nucleic Acids Res. 2023;51:631-649 pubmed publisher
B xf6 hly N, Schmidt A, Zhang X, Slusarenko B, Hennecke M, Kschischo M, et al. Increased replication origin firing links replication stress to whole chromosomal instability in human cancer. Cell Rep. 2022;41:111836 pubmed publisher
Li N, Xu Y, Chen H, Chen L, Zhang Y, Yu T, et al. NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step. Cell Rep. 2022;41:111600 pubmed publisher
Heijink A, Stok C, Porubský D, Manolika E, de Kanter J, Kok Y, et al. Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51. Nat Commun. 2022;13:6722 pubmed publisher
Zheng C, Ren Z, Chen H, Yuan X, Suye S, Yin H, et al. FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value. Exp Cell Res. 2022;421:113388 pubmed publisher
Gemble S, Wardenaar R, Keuper K, Srivastava N, Nano M, Macé A, et al. Genetic instability from a single S phase after whole-genome duplication. Nature. 2022;604:146-151 pubmed publisher
Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, et al. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Sci Transl Med. 2022;14:eabj4772 pubmed publisher
Kolinjivadi A, Sankar H, Choudhary R, Tay L, Tan T, Murata Kamiya N, et al. The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse. Int J Mol Sci. 2022;23: pubmed publisher
Ruggiano A, Vaz B, Kilgas S, Popovic M, Rodriguez Berriguete G, Singh A, et al. The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. Cell Rep. 2021;37:110080 pubmed publisher
Fierheller C, Guitton Sert L, Alenezi W, Revil T, Oros K, Gao Y, et al. A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene. Genome Med. 2021;13:186 pubmed publisher
Katsuki Y, Abe M, Park S, Wu W, Yabe H, Yabe M, et al. RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair. Cell Rep. 2021;37:109879 pubmed publisher
Adeyemi R, Willis N, Elia A, Clairmont C, Li S, Wu X, et al. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. Mol Cell. 2021;81:4440-4456.e7 pubmed publisher
Munkhjargal A, Kim M, Kim D, Jeon Y, Kee Y, Kim L, et al. Promyelocytic Leukemia Proteins Regulate Fanconi Anemia Gene Expression. Int J Mol Sci. 2021;22: pubmed publisher
Peake J, Noguchi C, Lin B, Theriault A, O Connor M, Sheth S, et al. FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes. Mol Oncol. 2021;: pubmed publisher
González Acosta D, Blanco Romero E, Ubieto Capella P, Mutreja K, Míguez S, Llanos S, et al. PrimPol-mediated repriming facilitates replication traverse of DNA interstrand crosslinks. EMBO J. 2021;40:e106355 pubmed publisher
Fang X, Dai E, Bai L, Liu J, Kang R, Zhao Y, et al. The HMGB1-AGER-STING1 pathway mediates the sterile inflammatory response to alkaliptosis. Biochem Biophys Res Commun. 2021;560:165-171 pubmed publisher
Caggiano C, Cavallo F, Giannattasio T, Cappelletti G, Rossi P, Grimaldi P, et al. Testicular Germ Cell Tumors Acquire Cisplatin Resistance by Rebalancing the Usage of DNA Repair Pathways. Cancers (Basel). 2021;13: pubmed publisher
Duan W, Tang S, Gao L, Dotts K, Fink A, Kalvala A, et al. MiRNA-200C expression in Fanconi anemia pathway functionally deficient lung cancers. Sci Rep. 2021;11:4420 pubmed publisher
Jones M, Gelot C, Munk S, Koren A, Kawasoe Y, George K, et al. Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Mol Cell. 2021;81:426-441.e8 pubmed publisher
Fernandes P, Miotto B, Saint Ruf C, Said M, Barra V, N xe4 hse V, et al. FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability. Commun Biol. 2021;4:127 pubmed publisher
Ishimoto R, Tsuzuki Y, Matsumura T, Kurashige S, Enokitani K, Narimatsu K, et al. SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions. J Cell Biol. 2021;220: pubmed publisher
Calzetta N, González Besteiro M, Gottifredi V. Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity. Sci Adv. 2020;6: pubmed publisher
Ruiz Torres S, Brusadelli M, Witte D, Wikenheiser Brokamp K, Sauter S, Nelson A, et al. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell Stem Cell. 2021;28:424-435.e6 pubmed publisher
Lach F, Singh S, Rickman K, Ruiz P, Noonan R, Hymes K, et al. Esophageal cancer as initial presentation of Fanconi anemia in patients with a hypomorphic FANCA variant. Cold Spring Harb Mol Case Stud. 2020;6: pubmed publisher
Watts L, Natsume T, Saito Y, Garzón J, Dong Q, Boteva L, et al. The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. elife. 2020;9: pubmed publisher
Ma C, Hokutan K, Shen Y, Nepal M, Kim J, Zhang J, et al. TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response. Aging (Albany NY). 2020;12:20268-20284 pubmed publisher
Young S, Sebald M, Shah Punatar R, Larin M, Masino L, Rodrigo Brenni M, et al. MutSβ Stimulates Holliday Junction Resolution by the SMX Complex. Cell Rep. 2020;33:108289 pubmed publisher
Gemble S, Amor Gueret M. Identification and Analysis of Different Types of UFBs. Methods Mol Biol. 2021;2153:187-192 pubmed publisher
Olivieri M, Cho T, lvarez Quil n A, Li K, Schellenberg M, Zimmermann M, et al. A Genetic Map of the Response to DNA Damage in Human Cells. Cell. 2020;182:481-496.e21 pubmed publisher
Brannvoll A, Xue X, Kwon Y, Kompocholi S, Simonsen A, Viswalingam K, et al. The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Rep. 2020;32:107849 pubmed publisher
Kono T, Hoover P, Poropatich K, Paunesku T, Mittal B, Samant S, et al. Activation of DNA damage repair factors in HPV positive oropharyngeal cancers. Virology. 2020;547:27-34 pubmed publisher
Roh Y, Mun J, Kim S, Park W, Jeong M, Kim T, et al. Fanconi Anemia Pathway Activation by FOXM1 Is Critical to Bladder Cancer Recurrence and Anticancer Drug Resistance. Cancers (Basel). 2020;12: pubmed publisher
Gemble S, Buhagiar Labarchède G, Onclercq Delic R, Fontaine G, Lambert S, Amor Gueret M. Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms. Open Biol. 2020;10:190259 pubmed publisher
Rickman K, Noonan R, Lach F, Sridhar S, Wang A, Abhyankar A, et al. Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links. Genes Dev. 2020;34:832-846 pubmed publisher
Xing M, Zhang F, Liao H, Chen S, Che L, Wang X, et al. Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. Mol Cell. 2020;78:714-724.e5 pubmed publisher
Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller Rudorf A, Zwick M, et al. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure. J Clin Invest. 2020;130:2827-2844 pubmed publisher
Shao X, Joergensen A, Howlett N, Lisby M, Oestergaard V. A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts. Nucleic Acids Res. 2020;48:5467-5484 pubmed publisher
Miller H, Gorthi A, Bassani N, Lawrence L, Iskra B, Bishop A. Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility. Cancers (Basel). 2020;12: pubmed publisher
Cai M, Dunn C, Chen W, Kochupurakkal B, Nguyen H, Moreau L, et al. Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection. Cell Rep. 2020;30:2402-2415.e5 pubmed publisher
Yang Y, Guo T, Liu R, Ke H, Xu W, Zhao S, et al. FANCL gene mutations in premature ovarian insufficiency. Hum Mutat. 2020;41:1033-1041 pubmed publisher
Ardeljan D, Steranka J, Liu C, Li Z, Taylor M, Payer L, et al. Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication. Nat Struct Mol Biol. 2020;27:168-178 pubmed publisher
Li N, Wang J, Wallace S, Chen J, Zhou J, D Andrea A. Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair. Nucleic Acids Res. 2020;48:3014-3028 pubmed publisher
Chappidi N, Nascakova Z, Boleslavska B, Zellweger R, Isik E, Andrs M, et al. Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Mol Cell. 2019;: pubmed publisher
Achuthankutty D, Thakur R, Haahr P, Hoffmann S, Drainas A, Bizard A, et al. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. J Cell Biol. 2019;218:3943-3953 pubmed publisher
Mason J, Chan Y, Weichselbaum R, Bishop D. Non-enzymatic roles of human RAD51 at stalled replication forks. Nat Commun. 2019;10:4410 pubmed publisher
Sonneville R, Bhowmick R, Hoffmann S, Mailand N, Hickson I, Labib K. TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication. elife. 2019;8: pubmed publisher
Chang E, Tsai S, Aristizabal M, Wells J, Coulombe Y, Busatto F, et al. MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts. Nat Commun. 2019;10:4265 pubmed publisher
Bi J, Areecheewakul S, Li Y, Yang S, Zhang Y, Ebeid K, et al. MTDH/AEG-1 downregulation using pristimerin-loaded nanoparticles inhibits Fanconi anemia proteins and increases sensitivity to platinum-based chemotherapy. Gynecol Oncol. 2019;155:349-358 pubmed publisher
Fragkos M, Barra V, Egger T, Bordignon B, Lemaçon D, Naim V, et al. Dicer prevents genome instability in response to replication stress. Oncotarget. 2019;10:4407-4423 pubmed publisher
Tacconi E, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, et al. Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med. 2019;11:e9982 pubmed publisher
Pladevall Morera D, Munk S, Ingham A, Garribba L, Albers E, Liu Y, et al. Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability. Nucleic Acids Res. 2019;47:8004-8018 pubmed publisher
Tacconi E, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, et al. Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance. EMBO Mol Med. 2019;: pubmed publisher
Paquin K, Mamrak N, Garzon J, Cantres Velez J, Azzinaro P, Vuono E, et al. FANCD2 binding to H4K20me2 via a methyl-binding domain is essential for efficient DNA crosslink repair. Mol Cell Biol. 2019;: pubmed publisher
Huang J, Zhang J, Bellani M, Pokharel D, Gichimu J, James R, et al. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2. Cell Rep. 2019;27:1794-1808.e5 pubmed publisher
Andreev V, Hristova R, Asparuhova M, Danovski G, Stoynov S, Gospodinov A. Mammalian INO80 chromatin remodeler cooperates with FANCM to mediate DNA interstrand crosslink-induced checkpoint activation and repair. DNA Repair (Amst). 2019;74:38-50 pubmed publisher
Ramanagoudr Bhojappa R, Carrington B, Ramaswami M, Bishop K, Robbins G, Jones M, et al. Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. PLoS Genet. 2018;14:e1007821 pubmed publisher
Fernandez Vidal A, Arnaud L, Maumus M, Chevalier M, Mirey G, Salles B, et al. Exposure to the Fungicide Captan Induces DNA Base Alterations and Replicative Stress in Mammalian Cells. Environ Mol Mutagen. 2019;60:286-297 pubmed publisher
Balcerek J, Jiang J, Li Y, Jiang Q, Holdreith N, Singh B, et al. Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia. Nat Commun. 2018;9:3915 pubmed publisher
Andrews A, McCartney H, Errington T, D Andrea A, Macara I. A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links. Nat Commun. 2018;9:2592 pubmed publisher
Higgs M, Sato K, Reynolds J, Begum S, Bayley R, Goula A, et al. Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2. Mol Cell. 2018;71:25-41.e6 pubmed publisher
Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, et al. A homozygous FANCM frameshift pathogenic variant causes male infertility. Genet Med. 2019;21:62-70 pubmed publisher
Tremblay C, Huang F, Levesque G, Carreau M. Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity. BMC Res Notes. 2018;11:138 pubmed publisher
Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed publisher
Asur R, Kimble D, Lach F, Jung M, Donovan F, Kamat A, et al. Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype. Mol Genet Genomic Med. 2017;: pubmed publisher
Hooks K, Audoux J, Fazli H, Lesjean S, Ernault T, Senant N, et al. New insights into diagnosis and therapeutic options for proliferative hepatoblastoma. Hepatology. 2017;: pubmed publisher
Vierra D, Garzon J, Rego M, Adroved M, Mauro M, Howlett N. Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure. Oncotarget. 2017;8:76443-76457 pubmed publisher
Sakasai R, Isono M, Wakasugi M, Hashimoto M, Sunatani Y, Matsui T, et al. Aquarius is required for proper CtIP expression and homologous recombination repair. Sci Rep. 2017;7:13808 pubmed publisher
Porro A, Berti M, Pizzolato J, Bologna S, Kaden S, Saxer A, et al. FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2. Nat Commun. 2017;8:1073 pubmed publisher
Chang E, Novoa C, Aristizabal M, Coulombe Y, Segovia R, Chaturvedi R, et al. RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability. J Cell Biol. 2017;216:3991-4005 pubmed publisher
Preiss M, Cournoyer E, Paquin K, Vuono E, Belanger K, Walsh E, et al. Tuning the Multifunctionality of Iron Oxide Nanoparticles Using Self-Assembled Mixed Lipid Layers. Bioconjug Chem. 2017;28:2729-2736 pubmed publisher
Moriel Carretero M, Ovejero S, Gérus Durand M, Vryzas D, Constantinou A. Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors. J Cell Biol. 2017;216:4007-4026 pubmed publisher
Bou Samra E, Buhagiar Labarchède G, Machon C, Guitton J, Onclercq Delic R, Green M, et al. A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. Nat Commun. 2017;8:693 pubmed publisher
Feng W, Jasin M. BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. Nat Commun. 2017;8:525 pubmed publisher
Wilkes D, Sailer V, Xue H, Cheng H, Collins C, Gleave M, et al. A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents. Cold Spring Harb Mol Case Stud. 2017;3: pubmed publisher
Tacconi E, Lai X, Folio C, Porru M, Zonderland G, Badie S, et al. BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. EMBO Mol Med. 2017;9:1398-1414 pubmed publisher
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
Niraj J, Caron M, Drapeau K, Bérubé S, Guitton Sert L, Coulombe Y, et al. The identification of FANCD2 DNA binding domains reveals nuclear localization sequences. Nucleic Acids Res. 2017;45:8341-8357 pubmed publisher
Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, et al. RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. Mol Cell. 2017;66:658-671.e8 pubmed publisher
Jiang J, Bellani M, Li L, Wang P, Seidman M, Wang Y. Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair. ACS Chem Biol. 2017;12:1858-1866 pubmed publisher
Ren L, Chen L, Wu W, Garribba L, Tian H, Liu Z, et al. Potential biomarkers of DNA replication stress in cancer. Oncotarget. 2017;8:36996-37008 pubmed publisher
Bharathan S, Nandy K, Palani D, Janet A N, Natarajan K, George B, et al. Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation. Stem Cell Res. 2017;20:54-57 pubmed publisher
Zhang T, Du W, Wilson A, Namekawa S, Andreassen P, Meetei A, et al. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Sci Rep. 2017;7:45626 pubmed publisher
Spriggs C, Laimins L. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. MBio. 2017;8: pubmed publisher
Chun M, Choi H, Jun D, Kim S, Kim Y, Kim S, et al. Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism. FEBS Open Bio. 2017;7:284-292 pubmed publisher
Lv Z, Rickman K, Yuan L, Williams K, Selvam S, Woosley A, et al. S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Mol Cell. 2017;65:699-714.e6 pubmed publisher
product information
master code :
NB100-182
SKU :
NB100-182
product name :
FANCD2 Antibody - BSA Free
unit size :
0.05 ml (also 0.025 ml)
description :
The FANCD2 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to FANCD2. This antibody reacts with avian,canine,human,kangaroo,mouse,primate,rat,zebrafish,fish - danio rerio (zebrafish). The FANCD2 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Simple Western,Chromatin Immunoprecipitation,Immunoprecipitation,Chemotaxis,IF/IHC,Immunohistochemistry-Paraffin,RNA Inhibition,Immunofluorescence,Knockout Validated,Knockdown Validated,Immunohistochemistry,Immunoblotting,Chromatin Immunoprecipitation (ChIP).
target :
FANCD2
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This FANCD2 Antibody was developed against human FANCD2 fusion protein (N-terminal fragment). [Swiss-Prot #Q9BXW9]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Avian,Canine,Human,Kangaroo,Mouse,Primate,Rat,Zebrafish,Fish - Danio rerio (Zebrafish)
theoretical molecular weight :
164.1 kDa
gene symbol :
FANCD2
Antibody validation :
Biological Validation
applications :
Flow Cytometry,Western Blot,Simple Western,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunoprecipitation,Chemotaxis,IF/IHC,Immunohistochemistry-Paraffin,RNA Inhibition,Immunofluorescence,Knockout Validated,Knockdown Validated,Immunohistochemistry,Immunoblotting,Chromatin Immunoprecipitation (ChIP)
USD :
479 USD
alt names :
DKFZp762A223, FA4, FACD, FAD, FAD2, FA-D2, FADFAD2, FANCD, Fanconi anemia complementation group D2, Fanconi anemia group D2 protein, Fanconi anemia, complementation group D2, FLJ23826, FPN1, HFE4, IREG1, Protein FACD2, SLC11A3
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.