product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
DEC1 Antibody - BSA Free
catalog :
NB100-1800
quantity :
0.1 ml (also 0.025 ml)
price :
479 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 36
Reference
Verstappe J, Skrypek N, De Coninck J, Soen B, Taminau J, Tatari M, et al. ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states. iScience. 2024;27:111169 pubmed publisher
Shearn C, Anderson A, Devereaux M, El Kasmi K, Orlicky D, Sokol R. Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition. PLoS ONE. 2023;18:e0290385 pubmed publisher
Montalvo A, Gruskin Z, Leduc A, Liu M, Gao Z, Ahn J, et al. An adult clock component links circadian rhythms to pancreatic β-cell maturation. bioRxiv. 2023;: pubmed publisher
Karakaya S, Gunnesson L, Elias E, Martos Salvo P, Robledo M, Nilsson O, et al. Cytoplasmic HIF-2α as tissue biomarker to identify metastatic sympathetic paraganglioma. Sci Rep. 2023;13:11588 pubmed publisher
van den Berg L, Kokki K, Wowro S, Petricek K, Deniz O, Stegmann C, et al. Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange. Cell Rep. 2023;42:112739 pubmed publisher
Chen Z, Javed N, Moore M, Wu J, Sun G, Vinyard M, et al. Integrative dissection of gene regulatory elements at base resolution. Cell Genom. 2023;3:100318 pubmed publisher
Lv J, Wei Y, Yin J, Chen Y, Zhou G, Wei C, et al. The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment. Nat Med. 2023;29:1424-1436 pubmed publisher
Pathmanapan S, Poon R, de Renshaw T, Nadesan P, Nakagawa M, Seesankar G, et al. Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation. Cell Rep. 2023;42:112578 pubmed publisher
Centeno P, Pavet V, Marais R. The journey from melanocytes to melanoma. Nat Rev Cancer. 2023;23:372-390 pubmed publisher
Sui Y, Jiang H, Kellogg C, Oh S, Janknecht R. Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7. Front Oncol. 2023;13:1122238 pubmed publisher
Nechanitzky R, Nechanitzky D, Ramachandran P, Duncan G, Zheng C, G xf6 bl C, et al. Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis. Cell Death Differ. 2023;30:407-416 pubmed publisher
Zhang H, Jadhav R, Cao W, Goronzy I, Zhao T, Jin J, et al. Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses. Nat Immunol. 2023;24:96-109 pubmed publisher
Nakamura S, Tanimoto K, Bhawal U. Ribosomal Stress Couples with the Hypoxia Response in Dec1-Dependent Orthodontic Tooth Movement. Int J Mol Sci. 2022;24: pubmed publisher
Hu X, Zou M, Ni L, Zhang M, Zheng W, Liu B, et al. Dec1 Deficiency Ameliorates Pulmonary Fibrosis Through the PI3K/AKT/GSK-3β/β-Catenin Integrated Signaling Pathway. Front Pharmacol. 2022;13:829673 pubmed publisher
Sato F, Bhawal U, Osaki S, Sugiyama N, Oikawa K, Muragaki Y. Differential immunohistochemical expression of DEC1, CK‑1ε, and CD44 in oral atypical squamous epithelium and carcinoma in situ. Mol Med Rep. 2022;25: pubmed publisher
Zhong Y, Walker S, Pritykin Y, Leslie C, Rudensky A, van der Veeken J. Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families. Nat Immunol. 2022;23:122-134 pubmed publisher
Rauschmeier R, Reinhardt A, Gustafsson C, Glaros V, Artemov A, Dunst J, et al. Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis. J Exp Med. 2022;219: pubmed publisher
Feng D, Zheng B, Yu J, Zhang M, Ma Y, Hao X, et al. 17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression. Front Cardiovasc Med. 2021;8:768662 pubmed publisher
Uyeda M, Freeborn R, Cieniewicz B, Romano R, Chen P, Liu J, et al. BHLHE40 Regulates IL-10 and IFN-γ Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation. Front Immunol. 2021;12:683680 pubmed publisher
Sato F, Bhawal U, Sugiyama N, Osaki S, Oikawa K, Muragaki Y. Potential Role of DEC1 in Cervical Cancer Cells Involving Overexpression and Apoptosis. Clocks Sleep. 2020;2:26-38 pubmed publisher
Hu G, Dong X, Gong S, Song Y, Hutchins A, Yao H. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Res. 2020;48:9606-9620 pubmed publisher
Partridge E, Chhetri S, Prokop J, Ramaker R, Jansen C, Goh S, et al. Occupancy maps of 208 chromatin-associated proteins in one human cell type. Nature. 2020;583:720-728 pubmed publisher
Sundararajan V, Tan M, Zea Tan T, Pang Q, Ye J, Chung V, et al. SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2. Cancers (Basel). 2020;12: pubmed publisher
Pasula S, Tessneer K, Fu Y, Gopalakrishnan J, Pelikan R, Kelly J, et al. Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three-Dimensional Chromatin Network. Arthritis Rheumatol. 2020;72:780-790 pubmed publisher
Le H, Sato F, Kohsaka A, Bhawal U, Nakao T, Muragaki Y, et al. Dec1 Deficiency Suppresses Cardiac Perivascular Fibrosis Induced by Transverse Aortic Constriction. Int J Mol Sci. 2019;20: pubmed publisher
Li C, Zhu B, Son Y, Wang Z, Jiang L, Xiang M, et al. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity. 2019;51:491-507.e7 pubmed publisher
Rauschmeier R, Gustafsson C, Reinhardt A, A Gonzalez N, Tortola L, Cansever D, et al. Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity. EMBO J. 2019;38:e101233 pubmed publisher
Jarjour N, Schwarzkopf E, Bradstreet T, Shchukina I, Lin C, Huang S, et al. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nat Immunol. 2019;20:687-700 pubmed publisher
Sato F, Otsuka T, Kohsaka A, Le H, Bhawal U, Muragaki Y. Smad3 Suppresses Epithelial Cell Migration and Proliferation Via the Clock Gene Dec1, Which Negatively Regulates the Expression of Clock Genes Dec2 and Per1. Am J Pathol. 2019;: pubmed publisher
Huynh J, Lin C, Kimmey J, Jarjour N, Schwarzkopf E, Bradstreet T, et al. Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection. J Exp Med. 2018;215:1823-1838 pubmed publisher
Hamilton K, Wang Y, Raefsky S, Berkowitz S, Spangler R, Suire C, et al. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PLoS ONE. 2018;13:e0196223 pubmed publisher
Nakamura H, Bono H, Hiyama K, Kawamoto T, Kato Y, Nakanishi T, et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions. PLoS ONE. 2018;13:e0192136 pubmed publisher
Liu Q, Imaizumi T, Murakami K, Tanaka H, Wu Y, Yoshizawa T, et al. DEC1 negatively regulates the expression of CXCL10 and CCL5 induced by poly IC in normal human mesangial cells. Biomed Res. 2017;38:249-255 pubmed publisher
Murakami K, Wu Y, Imaizumi T, Aoki Y, Liu Q, Yan X, et al. DEC1 promotes hypoxia-induced epithelial-mesenchymal transition (EMT) in human hepatocellular carcinoma cells. Biomed Res. 2017;38:221-227 pubmed publisher
Sato F, Kohsaka A, Takahashi K, Otao S, Kitada Y, Iwasaki Y, et al. Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-?. Histochem Cell Biol. 2017;148:617-624 pubmed publisher
Sato H, Wu Y, Kato Y, Liu Q, Hirai H, Yoshizawa T, et al. DEC2 expression antagonizes cisplatin‑induced apoptosis in human esophageal squamous cell carcinoma. Mol Med Rep. 2017;16:43-48 pubmed publisher
product information
master code :
NB100-1800
SKU :
NB100-1800
product name :
DEC1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The DEC1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to 45992. This antibody reacts with human,mouse,rat. The DEC1 Antibody - BSA Free has been validated for the following applications: Flow Cytometry,Western Blot,Knockdown Validated,Chemotaxis,Chip Cytometry,IF/IHC,Simple Western,Immunohistochemistry,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Chromatin Immunoprecipitation,ELISA,Immunoprecipitation,Immunoblotting,Chromatin Immunoprecipitation Sequencing,Immunocytochemistry/ Immunofluorescence.
target :
1-Dec
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Synthetic peptide made to a C-terminal region of human DEC1 (between amino acids 350-412) [UniProt O14503]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
theoretical molecular weight :
46 kDa
gene symbol :
BHLHE40
Antibody validation :
Biological Validation
accessionNumbers :
O14503
applications :
Flow Cytometry,Western Blot,Knockdown Validated,Chemotaxis,Chip Cytometry,IF/IHC,Simple Western,Immunohistochemistry,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Chromatin Immunoprecipitation,ELISA,Immunoprecipitation,Immunoblotting,Chromatin Immunoprecipitation Sequencing,Immunocytochemistry/ Immunofluorescence
USD :
479 USD
alt names :
basic helix-loop-helix domain containing, class B, 2, basic helix-loop-helix family, member e40, bHLHb2, bHLHe40, Class B basic helix-loop-helix protein 2, class E basic helix-loop-helix protein 40, DEC1HLHB2, differentially expressed in chondrocytes 1, Differentially expressed in chondrocytes protein 1, differentiated embryo chondrocyte expressed gene 1, Enhancer-of-split and hairy-related protein 2, SHARP2, SHARP-2, Stimulated by retinoic acid gene 13 protein, STRA13FLJ99214, Stra14
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.