Rad51C Antibody (2H11/6) - BSA Free | Novus Biologicals NB100-177 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Rad51C Antibody (2H11/6) - BSA Free

catalog :

NB100-177

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H11/6

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 37

Reference
Longo M, Roy S, Chen Y, Tomaszowski K, Arvai A, Pepper J, et al. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nat Commun. 2023;14:4445 pubmed publisher
Tomaszowski K, Roy S, Guerrero C, Shukla P, Keshvani C, Chen Y, et al. Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress. Nat Commun. 2023;14:1333 pubmed publisher
Jamal K, Galbiati A, Armenia J, Illuzzi G, Hall J, Bentouati S, et al. Drug-gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition. Cancer Res Commun. 2022;2:1244-1254 pubmed publisher
Matsuzaki K, Kumatoriya K, Tando M, Kometani T, Shinohara M. Polyphenols from persimmon fruit attenuate acetaldehyde-induced DNA double-strand breaks by scavenging acetaldehyde. Sci Rep. 2022;12:10300 pubmed publisher
Kusi M, Zand M, Lin L, Chen M, Lopez A, Lin C, et al. 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity. Cell Rep. 2022;38:110220 pubmed publisher
Kanakkanthara A, Hou X, Ekstrom T, Zanfagnin V, Huehls A, Kelly R, et al. Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma. Cancer Res. 2022;82:307-319 pubmed publisher
Hurley R, McGehee C, Nesic K, Correia C, Weiskittel T, Kelly R, et al. Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance. NAR Cancer. 2021;3:zcab028 pubmed publisher
Mohan M, Akula D, Dhillon A, Goyal A, Anindya R. Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase. Nucleic Acids Res. 2019;47:11729-11745 pubmed publisher
Wu N, Nguyen X, Wang L, Appourchaux R, Zhang C, Panthu B, et al. The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation. PLoS Pathog. 2019;15:e1008093 pubmed publisher
Parmar K, Kochupurakkal B, Lazaro J, Wang Z, Palakurthi S, Kirschmeier P, et al. The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition. Clin Cancer Res. 2019;25:6127-6140 pubmed publisher
Malik A, Miguez R, Li X, Ho Y, Feldman E, Barmada S. Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization. elife. 2018;7: pubmed publisher
Wu D, Huang C, Jiao X, Ding Z, Zhang J, Chen F, et al. Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells. Oncotarget. 2017;8:88630-88644 pubmed publisher
Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, et al. BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability. Nat Commun. 2017;8:1470 pubmed publisher
Gayarre J, Martín Gimeno P, Osorio A, Paumard B, Barroso A, Fernandez V, et al. Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. Br J Cancer. 2017;117:1048-1062 pubmed publisher
Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, et al. MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells. Nat Commun. 2017;8:15983 pubmed publisher
Grindheim A, Hollås H, Raddum A, Saraste J, Vedeler A. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. J Cell Sci. 2016;129:314-28 pubmed publisher
Min A, Im S, Kim D, Song S, Kim H, Lee K, et al. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells. Breast Cancer Res. 2015;17:33 pubmed publisher
Park J, Singh T, Nassar N, Zhang F, Freund M, Hanenberg H, et al. Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. Oncogene. 2014;33:4803-12 pubmed publisher
Huang J, Wang Y, Dhillon K, Calses P, Villegas E, Mitchell P, et al. Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity. Mol Cancer Res. 2013;11:1564-73 pubmed publisher
Min A, Im S, Yoon Y, Song S, Nam H, Hur H, et al. RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib. Mol Cancer Ther. 2013;12:865-77 pubmed publisher
Jensen R, Ozes A, Kim T, Estep A, Kowalczykowski S. BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage. DNA Repair (Amst). 2013;12:306-11 pubmed publisher
Chun J, Buechelmaier E, Powell S. Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Mol Cell Biol. 2013;33:387-95 pubmed publisher
Wang Y, Huang J, Calses P, Kemp C, Taniguchi T. MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition. Cancer Res. 2012;72:4037-46 pubmed publisher
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A. 2012;109:11800-5 pubmed publisher
Sage J, Gildemeister O, Knight K. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J Biol Chem. 2010;285:18984-90 pubmed publisher
Gildemeister O, Sage J, Knight K. Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. J Biol Chem. 2009;284:31945-52 pubmed publisher
Shammas M, Shmookler Reis R, Koley H, Batchu R, Li C, Munshi N. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 2009;113:2290-7 pubmed publisher
Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer P, Powell S, et al. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res. 2008;68:605-14 pubmed publisher
Kuznetsov S, Pellegrini M, Shuda K, Fernandez Capetillo O, Liu Y, Martin B, et al. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007;176:581-92 pubmed
Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol. 2006;26:8075-86 pubmed
Bennett B, Knight K. Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. J Cell Biochem. 2005;96:1095-109 pubmed
Fan R, Kumaravel T, Jalali F, Marrano P, Squire J, Bristow R. Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Cancer Res. 2004;64:8526-33 pubmed
Liu Y, Masson J, Shah R, O Regan P, West S. RAD51C is required for Holliday junction processing in mammalian cells. Science. 2004;303:243-6 pubmed
Lambert S, Lopez B. Inactivation of the RAD51 recombination pathway stimulates UV-induced mutagenesis in mammalian cells. Oncogene. 2002;21:4065-9 pubmed
Maacke H, Hundertmark C, Miska S, Voss M, Kalthoff H, Sturzbecher H. Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen. J Cancer Res Clin Oncol. 2002;128:219-22 pubmed
French C, Masson J, Griffin C, O Regan P, West S, Thacker J. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem. 2002;277:19322-30 pubmed publisher
Masson J, Stasiak A, Stasiak A, Benson F, West S. Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Proc Natl Acad Sci U S A. 2001;98:8440-6 pubmed

product information

master code :

NB100-177

SKU :

NB100-177

product name :

Rad51C Antibody (2H11/6) - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The Rad51C Antibody (2H11/6) - BSA Free from Novus is a mouse monoclonal antibody to Rad51C. This antibody reacts with human,mouse,primate,yeast. The Rad51C Antibody (2H11/6) - BSA Free has been validated for the following applications: Western Blot,IF/IHC,Simple Western,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,CyTOF-ready.

target :

Rad51C

category :

Primary Antibodies

buffer :

PBS (pH 7.4)

clonality :

Monoclonal

clone :

2H11/6

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

His-tagged human Rad51C, over-expressed in E. coli. [UniProt# O43502]

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human,Mouse,Primate,Yeast

specificity :

Does not cross-react with Rad51B, Rad51D, Rad51, XRCC2, or XRCC3 in Western analysis

theoretical molecular weight :

40 kDa

gene symbol :

RAD51C

Antibody validation :

Biological Validation

applications :

Western Blot,IF/IHC,Simple Western,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,CyTOF-ready

USD :

409 USD

alt names :

BROVCA3, DNA repair protein RAD51 homolog 3, FANCO, MGC104277, R51H3, RAD51 homolog C, RAD51 homolog C (S. cerevisiae), RAD51L2RAD51 (S. cerevisiae) homolog C, RAD51-like protein 2, yeast RAD51 homolog 3

storage :

Store at 4C. Do not freeze.

more info or order :

Novus Biologicals product webpage