LSD1 Antibody (1B2E5) | Novus Biologicals NB100-1762 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

LSD1 Antibody (1B2E5)

catalog :

NB100-1762

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B2E5

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 12

Reference
Antona A, Leo G, Favero F, Varalda M, Venetucci J, Faletti S, et al. Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation. Cell Death Discov. 2023;9:201 pubmed publisher
Haydn T, Kehr S, Willmann D, Metzger E, Schüle R, Fulda S. Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells. Int J Cancer. 2020;146:3435-3449 pubmed publisher
Kim D, Nam H, Lee W, Yim H, Ahn J, Park S, et al. PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. Mol Cell. 2018;69:398-411.e6 pubmed publisher
Lobo J, Rodrigues A, Antunes L, Graça I, Ramalho Carvalho J, Vieira F, et al. High immunoexpression of Ki67, EZH2, and SMYD3 in diagnostic prostate biopsies independently predicts outcome in patients with prostate cancer. Urol Oncol. 2018;36:161.e7-161.e17 pubmed publisher
Pajtler K, Weingarten C, Thor T, Künkele A, Heukamp L, Buttner R, et al. The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma. Acta Neuropathol Commun. 2013;1:19 pubmed publisher
Kashyap V, Ahmad S, Nilsson E, Helczynski L, Kenna S, Persson J, et al. The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer. Mol Oncol. 2013;7:555-66 pubmed publisher
Serce N, Gnatzy A, Steiner S, Lorenzen H, Kirfel J, Buettner R. Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast. BMC Clin Pathol. 2012;12:13 pubmed publisher
Janzer A, Lim S, Fronhoffs F, Niazy N, Buettner R, Kirfel J. Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components. Biochem Biophys Res Commun. 2012;421:665-70 pubmed publisher
Bennani Baiti I, Machado I, Llombart Bosch A, Kovar H. Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol. 2012;43:1300-7 pubmed publisher
Schildhaus H, Riegel R, Hartmann W, Steiner S, Wardelmann E, Merkelbach Bruse S, et al. Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors. Hum Pathol. 2011;42:1667-75 pubmed publisher
Kauffman E, Robinson B, Downes M, Powell L, Lee M, Scherr D, et al. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol Carcinog. 2011;50:931-44 pubmed publisher
Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis. 2010;31:512-20 pubmed publisher

product information

master code :

NB100-1762

SKU :

NB100-1762

product name :

LSD1 Antibody (1B2E5)

unit size :

0.1 ml (also 0.025 ml)

description :

The LSD1 Antibody (1B2E5) - BSA Free from Novus is a mouse monoclonal antibody to LSD1. This antibody reacts with human,mouse,primate. The LSD1 Antibody (1B2E5) - BSA Free has been validated for the following applications: Chemotaxis,IF/IHC,ELISA,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry,Simple Western,Chromatin Immunoprecipitation (ChIP),Knockdown Validated.

target :

LSD1

category :

Primary Antibodies

buffer :

Ascites

clonality :

Monoclonal

clone :

1B2E5

conjugate :

Unconjugated

host :

Mouse

immunogen :

Purified recombinant fragment of human LSD1 (between amino acids 400-600) expressed in E. coli. [UniProt# O60341]

isotype :

IgG1

purity :

Unpurified

species :

Human,Mouse,Primate

theoretical molecular weight :

93 kDa

gene symbol :

KDM1A

Antibody validation :

Knockout/Knockdown

accessionNumbers :

O60341

applications :

Chemotaxis,IF/IHC,ELISA,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry,Simple Western,Chromatin Immunoprecipitation (ChIP),Knockdown Validated

USD :

409 USD

alt names :

amine oxidase (flavin containing) domain 2, AOF2lysine-specific histone demethylase 1, BHC110FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, Flavin-containing amine oxidase domain-containing protein 2, KIAA0601KDM1, LSD1BRAF35-HDAC complex protein BHC110, lysine (K)-specific demethylase 1, lysine (K)-specific demethylase 1A, lysine-specific histone demethylase 1A

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage