product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
MGMT Antibody (MT 23.2) - BSA Free
catalog :
NB100-168
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MT 23.2
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 19
Reference
Powell G, Pavlovic Djuranovic S, Djuranovic S. Gene dosage effects of poly(A) track-engineered hypomorphs. Mol Ther Nucleic Acids. 2021;26:865-878 pubmed publisher
Sari R, Altinoz M, Ozlu E, Sav A, Danyeli A, Baskan O, et al. Treatment Strategies for Dopamine Agonist-Resistant and Aggressive Prolactinomas: A Comprehensive Analysis of the Literature. Horm Metab Res. 2021;53:413-424 pubmed publisher
Kotsarenko K, Lylo V, Ruban T, Macewicz L, Lukash L. Effects of Some Growth Factors and Cytokines on the Expression of the Repair Enzyme MGMT and Protein MARP in Human Cells In Vitro : Effect of Some Growth Factors and Cytokines. Biochem Genet. 2018;56:459-477 pubmed publisher
Altinoz M, Elmaci I, Bölükbaşı F, Ekmekci C, Yenmiş G, Sari R, et al. MGMT gene variants, temozolomide myelotoxicity and glioma risk. A concise literature survey including an illustrative case. J Chemother. 2017;29:238-244 pubmed publisher
Oktay Y, Ülgen E, Can Ã, Akyerli C, Yüksel Å, Erdemgil Y, et al. IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation. Sci Rep. 2016;6:27569 pubmed publisher
Stepanenko A, Andreieva S, Korets K, Mykytenko D, Baklaushev V, Huleyuk N, et al. Temozolomide promotes genomic and phenotypic changes in glioblastoma cells. Cancer Cell Int. 2016;16:36 pubmed publisher
Lun X, Wells J, Grinshtein N, King J, Hao X, Dang N, et al. Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. Clin Cancer Res. 2016;22:3860-75 pubmed publisher
Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun. 2014;5:5513 pubmed publisher
Kewitz S, Stiefel M, Kramm C, Staege M. Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells. Leuk Res. 2014;38:138-43 pubmed publisher
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1? stability and MGMT expression. Cell Death Dis. 2012;3:e412 pubmed publisher
Lylo V, Matsevich L, Kotsarenko E, Babenko L, Korneliuk A, Sukhorada E, et al. [Induction of repair enzyme O6-methylguanine-DNA methyltransferase gene expression under the influence of cytokine EMAP II in human cells in vitro]. Tsitol Genet. 2011;45:53-60 pubmed
Herzig M, Hildreth K, Huamani J, Perez M, Goins B, McMahan C, et al. Human O6 -methylguanine-DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice. Mol Carcinog. 2013;52:275-85 pubmed publisher
Della Puppa A, Persano L, Masi G, Rampazzo E, Sinigaglia A, Pistollato F, et al. MGMT expression and promoter methylation status may depend on the site of surgical sample collection within glioblastoma: a possible pitfall in stratification of patients?. J Neurooncol. 2012;106:33-41 pubmed publisher
Tang J, Svilar D, Trivedi R, Wang X, Goellner E, Moore B, et al. N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide. Neuro Oncol. 2011;13:471-86 pubmed publisher
Pistollato F, Abbadi S, Rampazzo E, Persano L, Della Puppa A, Frasson C, et al. Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells. 2010;28:851-62 pubmed publisher
Cai S, Xu Y, Cooper R, Ferkowicz M, Hartwell J, Pollok K, et al. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. Cancer Res. 2005;65:3319-27 pubmed
Zuo C, Ai L, Ratliff P, Suen J, Hanna E, Brent T, et al. O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2004;13:967-75 pubmed
Roth T, Xu Y, Luo M, Kelley M. Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection. Cancer Gene Ther. 2003;10:603-10 pubmed
Liu L, Spiro T, Qin X, Majka S, Haaga J, Schupp J, et al. Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine. Clin Cancer Res. 2001;7:2318-24 pubmed
product information
master code :
NB100-168
SKU :
NB100-168
product name :
MGMT Antibody (MT 23.2) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The MGMT Antibody (MT 23.2) - BSA Free from Novus is a mouse monoclonal antibody to MGMT. This antibody reacts with human,mouse,mouse (negative). The MGMT Antibody (MT 23.2) - BSA Free has been validated for the following applications: IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Flow Cytometry,Immunohistochemistry,Flow (Intracellular),Simple Western,CyTOF-ready,Immunocytochemistry/ Immunofluorescence.
target :
MGMT
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
MT 23.2
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Recombinant human MGMT (O6-methylguanine-DNA methyltransferase) purified from E. coli [UniProt# P16455]
isotype :
IgG2b
purity :
Protein G purified
species :
Human,Mouse,Mouse (Negative)
theoretical molecular weight :
24 kDa
gene symbol :
MGMT
accessionNumbers :
P16455
applications :
IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Flow Cytometry,Immunohistochemistry,Flow (Intracellular),Simple Western,CyTOF-ready,Immunocytochemistry/ Immunofluorescence
USD :
409 USD
alt names :
6-O-methylguanine-DNA methyltransferase, EC 2.1.1.63, methylated-DNA--protein-cysteine methyltransferase, methylguanine-DNA methyltransferase, O-6-methylguanine-DNA methyltransferase, O6-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.