FEN-1 Antibody (4E7) - Azide and BSA Free | Novus Biologicals NB100-150 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

FEN-1 Antibody (4E7) - Azide and BSA Free

catalog :

NB100-150

quantity :

100 ul

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4.00E+07

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

more info or order :

Novus Biologicals product webpage

citations: 21

Reference
Ayyangar U, Karkhanis A, Tay H, Afandi A, Bhattacharjee O, Ks L, et al. Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024;43:1113-1134 pubmed publisher
Yuan B, Kikuchi H, Li J, Kawabata A, Yao K, Takagi N, et al. Cytotoxic Effects of Darinaparsin, a Novel Organic Arsenical, against Human Leukemia Cells. Int J Mol Sci. 2023;24: pubmed publisher
Zhang J, Chen M, Pang Y, Cheng M, Huang B, Xu S, et al. Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells. J Exp Clin Cancer Res. 2022;41:140 pubmed publisher
Zhang J, Jing L, Tan S, Zeng E, Lin Y, He L, et al. Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs. Cell Death Dis. 2020;11:602 pubmed publisher
Jaiswal A, Armas M, Izumi T, Strauss P, Narayan S. Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function. Neoplasia. 2012;14:495-508 pubmed
Ma Y, Liang D, Liu J, Axcrona K, Kvalheim G, Stokke T, et al. Prostate cancer cell lines under hypoxia exhibit greater stem-like properties. PLoS ONE. 2011;6:e29170 pubmed publisher
Tann A, Boldogh I, Meiss G, Qian W, Van Houten B, Mitra S, et al. Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair. J Biol Chem. 2011;286:31975-83 pubmed publisher
Jaiswal A, Narayan S. Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity. Biochemistry. 2011;50:1901-9 pubmed publisher
Guo Z, Zheng L, Xu H, Dai H, Zhou M, Pascua M, et al. Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. Nat Chem Biol. 2010;6:766-73 pubmed publisher
Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton J, et al. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA Repair (Amst). 2010;9:109-19 pubmed publisher
Kong X, Mohanty S, Stephens J, Heale J, Gomez Godinez V, Shi L, et al. Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells. Nucleic Acids Res. 2009;37:e68 pubmed publisher
Guo Z, Zheng L, Dai H, Zhou M, Xu H, Shen B. Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Nucleic Acids Res. 2009;37:3431-41 pubmed publisher
Szczesny B, Tann A, Longley M, Copeland W, Mitra S. Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem. 2008;283:26349-56 pubmed publisher
Liu P, Qian L, Sung J, de Souza Pinto N, Zheng L, Bogenhagen D, et al. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol. 2008;28:4975-87 pubmed publisher
Guo Z, Qian L, Liu R, Dai H, Zhou M, Zheng L, et al. Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair. Mol Cell Biol. 2008;28:4310-9 pubmed publisher
Guo Z, Chavez V, Singh P, Finger L, Hang H, Hegde M, et al. Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. J Mol Biol. 2008;377:679-90 pubmed publisher
Prasad R, Liu Y, Deterding L, Poltoratsky V, Kedar P, Horton J, et al. HMGB1 is a cofactor in mammalian base excision repair. Mol Cell. 2007;27:829-41 pubmed
Kundu C, Balusu R, Jaiswal A, Narayan S. Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways. Carcinogenesis. 2007;28:2089-95 pubmed
Kedar P, Kim S, Robertson A, Hou E, Prasad R, Horton J, et al. Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. J Biol Chem. 2002;277:31115-23 pubmed
Shibata Y, Nakamura T. Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay. J Biol Chem. 2002;277:746-54 pubmed
Qiu J, Li X, Frank G, Shen B. Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. J Biol Chem. 2001;276:4901-8 pubmed

product information

master code :

NB100-150

SKU :

NB100-150

product name :

FEN-1 Antibody (4E7) - Azide and BSA Free

unit size :

100 ul

description :

The FEN-1 Antibody (4E7) - Azide and BSA Free from Novus is a mouse monoclonal antibody to FEN-1. This antibody reacts with human,mouse. The FEN-1 Antibody (4E7) - Azide and BSA Free has been validated for the following applications: Western Blot,Simple Western,Immunoprecipitation,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry/ Immunofluorescence.

target :

FEN-1

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

4.00E+07

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant human FEN-1 protein encoding amino acids 1-380 purified E. coli.

isotype :

IgG1

purity :

Protein G purified

species :

Human,Mouse

specificity :

This is specific for FEN-1

theoretical molecular weight :

42 kDa

gene symbol :

FEN1

accessionNumbers :

P39748

applications :

Western Blot,Simple Western,Immunoprecipitation,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry/ Immunofluorescence

USD :

449 USD

alt names :

EC 3.1, FEN-1hFEN-1, flap structure-specific endonuclease 1DNase IV, Maturation factor 1, maturation factor-1, MF1flap endonuclease 1, RAD2

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage