EGLN3/PHD3 Antibody - BSA Free | Novus Biologicals NB100-139 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

EGLN3/PHD3 Antibody - BSA Free

catalog :

NB100-139

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 21

Reference
Duan M, Ru X, Zhou J, Li Y, Guo P, Kang W, et al. Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage. Fluids Barriers CNS. 2024;21:42 pubmed publisher
Luomala L, Mattila K, Vainio P, Nis xe9 n H, Pellinen T, Lohi J, et al. Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma. Cancer Med. 2024;13:e6998 pubmed publisher
Abudu Y, Kournoutis A, Brenne H, Lamark T, Johansen T. MORG1 limits mTORC1 signaling by inhibiting Rag GTPases. Mol Cell. 2024;84:552-569.e11 pubmed publisher
Chen Y, Liu Y, Xiong J, Ouyang L, Tang M, Mao C, et al. LINC02774 inhibits glycolysis in glioma to destabilize HIF-1α dependent on transcription factor RP58. MedComm (2020). 2023;4:e364 pubmed publisher
Zhang T, Xu D, Liu J, Wang M, Duan L, Liu M, et al. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nat Cell Biol. 2023;25:950-962 pubmed publisher
Saggese P, Pandey A, Fung E, Hall A, Yanagawa J, Rodriguez E, et al. Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma. bioRxiv. 2023;: pubmed publisher
Seike K, Kiledal A, Fujiwara H, Henig I, Burgos da Silva M, van den Brink M, et al. Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation. Immunity. 2023;56:353-368.e6 pubmed publisher
Ciminera A, Shuck S, Termini J. Elevated glucose increases genomic instability by inhibiting nucleotide excision repair. Life Sci Alliance. 2021;4: pubmed publisher
Nasteska D, Cuozzo F, Viloria K, Johnson E, Thakker A, Bany Bakar R, et al. Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice. JCI Insight. 2021;6: pubmed publisher
Ju S, Lim L, Wi K, Park C, Ki Y, Choi D, et al. LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium. Int J Mol Sci. 2021;22: pubmed publisher
Shi M, Dai W, Jia R, Zhang Q, Wei J, Wang Y, et al. APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma. Cancer Lett. 2021;496:144-155 pubmed publisher
Yoon H, Spinelli J, Zaganjor E, Wong S, German N, Randall E, et al. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 2020;32:215-228.e7 pubmed publisher
Kozlova N, Mennerich D, Samoylenko A, Dimova E, Koivunen P, Biterova E, et al. The pro-oncogenic adaptor CIN85 acts as an inhibitory binding partner of hypoxia-inducible factor prolyl hydroxylase 2. Cancer Res. 2019;: pubmed publisher
Miikkulainen P, Högel H, Seyednasrollah F, Rantanen K, Elo L, Jaakkola P. Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma. J Biol Chem. 2019;294:3760-3771 pubmed publisher
Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, et al. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Sci Rep. 2018;8:14290 pubmed publisher
Pan H, Strickland A, Madhu V, Johnson Z, Chand S, Brody J, et al. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biol. 2019;77:23-40 pubmed publisher
Akat F, Ficicilar H, Durak A, Tuncay E, Dursun A, Topal Celikkan F, et al. Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat. Anatol J Cardiol. 2018;19:259-266 pubmed publisher
Bryant J, Brown M, Dobrikov M, Dobrikova E, Gemberling S, Zhang Q, et al. Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2. Mol Cell Biol. 2018;38: pubmed publisher
Miikkulainen P, Högel H, Rantanen K, Suomi T, Kouvonen P, Elo L, et al. HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma. Cancer Metab. 2017;5:5 pubmed publisher
Bruno T, Valerio M, Casadei L, De Nicola F, Goeman F, Pallocca M, et al. Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1Î± stabilization. J Exp Clin Cancer Res. 2017;36:32 pubmed publisher
Barnes E, Chen C, Sedan O, Cornfield D. Loss of smooth muscle cell hypoxia inducible factor-1? underlies increased vascular contractility in pulmonary hypertension. FASEB J. 2017;31:650-662 pubmed publisher

product information

master code :

NB100-139

SKU :

NB100-139

product name :

EGLN3/PHD3 Antibody - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The EGLN3/PHD3 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to EGLN3/PHD3. This antibody reacts with human,mouse,rat. The EGLN3/PHD3 Antibody - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Electron Microscopy,Mass Spectrometry,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunohistochemistry,Knockdown Validated.

target :

EGLN3/PHD3

category :

Primary Antibodies

buffer :

PBS

clonality :

Polyclonal

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Synthetic peptide corresponding to residues between 50-100 of human PHD3/HIF Prolyl Hydroxylase 3 using the numbering given in entry NP_071356.1 (GeneID 112399).

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse,Rat

theoretical molecular weight :

28 kDa

gene symbol :

EGLN3

Antibody validation :

Knockout/Knockdown

accessionNumbers :

Q9H6Z9

applications :

Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Electron Microscopy,Mass Spectrometry,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunohistochemistry,Knockdown Validated

USD :

409 USD

alt names :

EC 1.14.11, EC 1.14.11.-, EGL nine (C.elegans) homolog 3, egl nine homolog 3, egl nine homolog 3 (C. elegans), egl nine-like protein 3 isoform, FLJ21620, HIF prolyl hydroxylase 3, HIF-PH3, HIFPH3 MGC125998, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 3, MGC125999, pdh3, PHD3, Prolyl hydroxylase domain-containing protein 3

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage