EGLN1/PHD2 Antibody - BSA Free | Novus Biologicals NB100-137 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

EGLN1/PHD2 Antibody - BSA Free

catalog :

NB100-137

quantity :

0.1 mg

price :

449 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 26

Reference
Nolan N, Cui X, Robbings B, Demirkol A, Pandey K, Wu W, et al. CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa. Cell Rep Med. 2024;5:101459 pubmed publisher
Luomala L, Mattila K, Vainio P, Nis xe9 n H, Pellinen T, Lohi J, et al. Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma. Cancer Med. 2024;13:e6998 pubmed publisher
Sallais J, Park C, Alahari S, Porter T, Liu R, Kurt M, et al. HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2. JCI Insight. 2022;7: pubmed publisher
Schlegel C, Liu K, Spring B, Dietz S, Poets C, Hudalla H, et al. Decreased expression of hypoxia-inducible factor 1α (HIF-1α) in cord blood monocytes under anoxia. Pediatr Res. 2022;: pubmed publisher
Jian C, Yu X, Gao H, Chen H, Jheng R, Chen C, et al. Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α. Nanomaterials (Basel). 2022;12: pubmed publisher
Li J, Lu X, Wei L, Ye D, Lin J, Tang X, et al. PHD2 attenuates high-glucose-induced blood retinal barrier breakdown in human retinal microvascular endothelial cells by regulating the Hif-1α/VEGF pathway. Inflamm Res. 2022;71:69-79 pubmed publisher
Bhute V, Harte J, Houghton J, Maxwell P. Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors. Kidney360. 2020;1:447-457 pubmed publisher
Iacobini C, Vitale M, Pugliese G, Menini S. Normalizing HIF-1α Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage. Biomedicines. 2021;9: pubmed publisher
Kumar P, Verma V, Mohania D, Gupta S, Babbar A, Rathi B, et al. Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells. J Cell Biochem. 2021;: pubmed publisher
Marinaccio C, Suraneni P, Celik H, Volk A, Wen Q, Ling T, et al. LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. Cancer Discov. 2021;11:1398-1410 pubmed publisher
Wang F, Yu H, Huang S, Zheng L, Zheng P, Zhang S, et al. Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling. Evid Based Complement Alternat Med. 2020;2020:8894257 pubmed publisher
Shi M, Dai W, Jia R, Zhang Q, Wei J, Wang Y, et al. APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma. Cancer Lett. 2021;496:144-155 pubmed publisher
Mei H, Wu N, Huang X, Cui Z, Xu J, Yang X, et al. Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats. J Ethnopharmacol. 2021;266:113448 pubmed publisher
Sundaramurthi H, Roche S, Grice G, Moran A, Dillion E, Campiani G, et al. Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness. Front Cell Dev Biol. 2020;8:689 pubmed publisher
Dey A, Prabhudesai S, Zhang Y, Rao G, Thirugnanam K, Hossen M, et al. Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. Sci Adv. 2020;6: pubmed publisher
Settelmeier S, Schreiber T, M ki J, Byts N, Koivunen P, Myllyharju J, et al. Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice. PLoS ONE. 2020;15:e0233261 pubmed publisher
Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal J, et al. Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. J Cell Mol Med. 2019;23:7785-7795 pubmed publisher
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza G, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nat Commun. 2019;10:2130 pubmed publisher
Kurelac I, Iommarini L, Vatrinet R, Amato L, De Luise M, Leone G, et al. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Nat Commun. 2019;10:903 pubmed publisher
Miikkulainen P, Högel H, Seyednasrollah F, Rantanen K, Elo L, Jaakkola P. Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma. J Biol Chem. 2019;294:3760-3771 pubmed publisher
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, et al. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018;9:5426 pubmed publisher
Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018;9:4545 pubmed publisher
Kim G, Das R, Rao X, Zhong J, Deiuliis J, Ramirez Bergeron D, et al. CITED2 Restrains Proinflammatory Macrophage Activation and Response. Mol Cell Biol. 2018;38: pubmed publisher
Hu J, Wang W, Zhang F, Li P, Boini K, Yi F, et al. Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells. Sci Rep. 2017;7:15878 pubmed publisher
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed publisher
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product information

master code :

NB100-137

SKU :

NB100-137

product name :

EGLN1/PHD2 Antibody - BSA Free

unit size :

0.1 mg

description :

The EGLN1/PHD2 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to EGLN1/PHD2. This antibody reacts with human,mouse,primate,rat. The EGLN1/PHD2 Antibody - BSA Free has been validated for the following applications: Western Blot,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Simple Western,Knockout Validated,Knockdown Validated.

target :

EGLN1/PHD2

category :

Primary Antibodies

buffer :

Tris-Citrate/Phosphate (pH 7 to 8)

clonality :

Polyclonal

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

The epitope recognized by this EGLN1/PHD2 antibody maps to a region between residues 1 and 50 of human PHD2/HIF Prolyl Hydroxylase 2 using the numbering given in entry NP_071334.1 (GeneID 54583).

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse,Primate,Rat

theoretical molecular weight :

46 kDa

gene symbol :

EGLN1

Antibody validation :

Knockout/Knockdown

accessionNumbers :

Q9GZT9

applications :

Western Blot,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Simple Western,Knockout Validated,Knockdown Validated

USD :

449 USD

alt names :

C1orf12, EC 1.14.11.29, EC:1.14.11.291, ECYT3, egl nine homolog 1, egl nine-like protein 1, EGLN1, HALAH, HIF prolyl hydroxylase 2, HIFPH2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH2, HPH-2, Hypoxia-inducible factor prolyl hydroxylase 2, PHD2, PNAS-118, PNAS-137, Prolyl hydroxylase domain-containing protein 2, SM20, SM-20, zinc finger MYND domain-containing protein 6, ZMYND6

storage :

Store at 4C. Do not freeze.

more info or order :

Novus Biologicals product webpage