| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig s13g
| Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 6a
- immunocytochemistry; mouse; loading ...; fig 6h
| Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher |
- chromatin immunoprecipitation; human; 1:1000; loading ...; fig 5c
- western blot; human; 1:3000; loading ...; fig 2a
| Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, et al. Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci. 2017;108:362-372 pubmed publisher |
- immunocytochemistry; mouse; 1:100; fig s5
| Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed publisher |
- western blot; human; loading ...; fig s7
| Kwak J, Lee N, Lee H, Hong I, Nam J. HIF2?/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy. Oncotarget. 2016;7:43518-43533 pubmed publisher |
- immunohistochemistry; mouse; 1:150; fig 5
| Espana Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson D, et al. Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS ONE. 2016;11:e0148055 pubmed publisher |
- immunohistochemistry; human; 1:200
| Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:150
- immunohistochemistry; mouse
| Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
- immunohistochemistry; mouse; loading ...; fig 4b
- western blot; mouse; loading ...; fig 2a
- immunohistochemistry - paraffin section; human
- western blot; human
| Her Y, Nelson Holte M, MAHER L. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS ONE. 2015;10:e0127471 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Påhlman S, Lund L, Jögi A. Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. PLoS ONE. 2015;10:e0125771 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed publisher |
| Chen T, Zhou G, Zhou Q, Tang H, Ibe J, Cheng H, et al. Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015;191:678-92 pubmed publisher |
- chromatin immunoprecipitation; human; fig s1
- immunoprecipitation; human; fig 1
- western blot; human; fig 1
- chromatin immunoprecipitation; mouse; 1,000 ug/ml; fig 2
- immunoprecipitation; mouse; fig 2
- western blot; mouse; 1:1000; fig 2
| Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Evans C, Wadoodi A, Humphries J, Lu X, Grover S, Saha P, et al. Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution. Thromb Res. 2014;134:757-60 pubmed publisher |
- immunohistochemistry - frozen section; rat
- western blot; rat
| Peng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed publisher |
| Carrera S, Senra J, Acosta M, Althubiti M, Hammond E, De Verdier P, et al. The role of the HIF-1? transcription factor in increased cell division at physiological oxygen tensions. PLoS ONE. 2014;9:e97938 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Toyoda H, Hirayama J, Sugimoto Y, Uchida K, Ohishi K, Hirayama M, et al. Polycythemia and paraganglioma with a novel somatic HIF2A mutation in a male. Pediatrics. 2014;133:e1787-91 pubmed publisher |
- immunohistochemistry - paraffin section; human
- immunocytochemistry; human
- western blot; human
| Gregg J, Turner R, Chang G, Joshi D, Zhan Y, Chen L, et al. NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2?. Cancer Res. 2014;74:3501-3511 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Raspaglio G, Petrillo M, Martinelli E, Li Puma D, Mariani M, De Donato M, et al. Sox9 and Hif-2? regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 2014;542:173-81 pubmed publisher |
| Duan L, Takeda K, Fong G. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014;184:1240-1250 pubmed publisher |
| Duan L, Takeda K, Fong G. Hypoxia inducible factor-2? regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS ONE. 2014;9:e84736 pubmed publisher |
| Anderson E, Taylor M, Xue X, Ramakrishnan S, Martin A, Xie L, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013;110:E4922-30 pubmed publisher |
| Zhang T, Niu X, Liao L, Cho E, Yang H. The contributions of HIF-target genes to tumor growth in RCC. PLoS ONE. 2013;8:e80544 pubmed publisher |
| Tsang W, Shu Y, Kwok P, Zhang F, Lee K, Tang M, et al. CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS ONE. 2013;8:e76153 pubmed publisher |
- immunohistochemistry; human
- western blot; human
- immunohistochemistry; mouse
- western blot; mouse
| Thompson A, Elks P, Marriott H, Eamsamarng S, Higgins K, Lewis A, et al. Hypoxia-inducible factor 2? regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123:366-76 pubmed publisher |
| Klotzsche von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, et al. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-?. Mol Cancer Res. 2013;11:1337-48 pubmed publisher |
| Yeh I, Ogba N, Bensigner H, Welford S, Montano M. HEXIM1 down-regulates hypoxia-inducible factor-1? protein stability. Biochem J. 2013;456:195-204 pubmed publisher |
| Bruells C, Maes K, Rossaint R, Thomas D, Cielen N, Bleilevens C, et al. Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model. PLoS ONE. 2013;8:e70524 pubmed publisher |
| Park Y, Park B, Lee S, Choi K, Moon Y, Park H. Hypoxia-inducible factor-2?-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013;288:26311-22 pubmed publisher |
| Gottfried E, Lang S, Renner K, Bosserhoff A, Gronwald W, Rehli M, et al. New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. PLoS ONE. 2013;8:e66987 pubmed publisher |
| Nakajima T, Nakajima E, Shearer T, Azuma M. Concerted inhibition of HIF-1? and -2? expression markedly suppresses angiogenesis in cultured RPE cells. Mol Cell Biochem. 2013;383:113-22 pubmed publisher |
| Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha. PLoS ONE. 2013;8:e65304 pubmed publisher |
| Nakayama K. cAMP-response element-binding protein (CREB) and NF-?B transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem. 2013;288:22584-95 pubmed publisher |
| Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka Kondoh S, Hiraoka M, et al. Development of a novel interferon-?2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro. Int J Clin Oncol. 2014;19:497-504 pubmed publisher |
| Lee W, Lee J, Lim C, Kim S, Kim S. Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90. Chem Biol Interact. 2013;204:49-57 pubmed publisher |
| Kucharzewska P, Christianson H, Welch J, Svensson K, Fredlund E, Ringner M, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A. 2013;110:7312-7 pubmed publisher |
- chromatin immunoprecipitation; human
| Scheuermann T, Li Q, Ma H, Key J, Zhang L, Chen R, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9:271-6 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Huang C, Hales B. Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. PLoS ONE. 2012;7:e51937 pubmed publisher |
- immunocytochemistry; human
| Sun H, Xu Y, Yang X, Wang W, Bai H, Shi R, et al. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology. 2013;57:1088-97 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1? stability and MGMT expression. Cell Death Dis. 2012;3:e412 pubmed publisher |
| Demachi Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K. Autophagy creates a CTL epitope that mimics tumor-associated antigens. PLoS ONE. 2012;7:e47126 pubmed publisher |
- chromatin immunoprecipitation; mouse
| Xue X, Shah Y. Hypoxia-inducible factor-2? is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis. 2013;34:163-9 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Vaapil M, Helczynska K, Villadsen R, Petersen O, Johansson E, Beckman S, et al. Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS ONE. 2012;7:e46543 pubmed publisher |
| Thomas S, Harding M, Smith S, Overdevest J, Nitz M, Frierson H, et al. CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res. 2012;72:5600-12 pubmed publisher |
| Muratsu Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. PLoS ONE. 2012;7:e41462 pubmed publisher |
| Mihaylova S, Killian A, Mayer K, Pullamsetti S, Schermuly R, Rosengarten B. Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats. J Neuroinflammation. 2012;9:183 pubmed publisher |
- immunoprecipitation; human
| Chen R, Xu M, Hogg R, Li J, Little B, Gerard R, et al. The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem. 2012;287:30800-11 pubmed publisher |
| Kiss J, Mollenhauer M, Walmsley S, Kirchberg J, Radhakrishnan P, Niemietz T, et al. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol. 2012;189:1955-65 pubmed publisher |
| Lim C, Kiriakidis S, Paleolog E, Davies A. The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent. J Vasc Surg. 2012;56:1069-77 pubmed publisher |
| El Naggar A, Clarkson P, Zhang F, Mathers J, Tognon C, Sorensen P. Expression and stability of hypoxia inducible factor 1? in osteosarcoma. Pediatr Blood Cancer. 2012;59:1215-22 pubmed publisher |
| Jeong C, Yoon C, Jeong S, Hong S, Byun S, Kwak C, et al. The role of hypoxia-inducible factor-1? and -2? in androgen insensitive prostate cancer cells. Urol Oncol. 2013;31:1448-56 pubmed publisher |
| Poey M, Albini M, Saona G, Laviña M. Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities. Microb Pathog. 2012;52:292-301 pubmed publisher |
| Holland W, Tepper C, Pietri J, Chinn D, Gandara D, Mack P, et al. Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy. Cancer Chemother Pharmacol. 2012;69:185-94 pubmed publisher |
| Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol Cancer Res. 2011;9:757-65 pubmed publisher |
| Heikkilä M, Pasanen A, Kivirikko K, Myllyharju J. Roles of the human hypoxia-inducible factor (HIF)-3? variants in the hypoxia response. Cell Mol Life Sci. 2011;68:3885-901 pubmed publisher |
- chromatin immunoprecipitation; mouse
- western blot; mouse
| Taylor M, Qu A, Anderson E, Matsubara T, Martin A, Gonzalez F, et al. Hypoxia-inducible factor-2? mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011;140:2044-55 pubmed publisher |
- chromatin immunoprecipitation; human
- western blot; human
| Chen R, Dioum E, Hogg R, Gerard R, Garcia J. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem. 2011;286:13869-78 pubmed publisher |
| Place T, Fitzgerald M, Venkataraman S, Vorrink S, Case A, Teoh M, et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE. 2011;6:e14617 pubmed publisher |
| Li Q, Michaud M, Canosa S, Kuo A, Madri J. GSK-3?: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Angiogenesis. 2011;14:173-85 pubmed publisher |
- immunocytochemistry; human
- immunohistochemistry; human
- western blot; human
| Bougatef F, Menashi S, Khayati F, Naimi B, Porcher R, Podgorniak M, et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. PLoS ONE. 2010;5:e12265 pubmed publisher |
| Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, et al. Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor. Clin Cancer Res. 2010;16:4809-21 pubmed publisher |
| Zimmer M, Lamb J, Ebert B, Lynch M, Neil C, Schmidt E, et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010;70:3071-9 pubmed publisher |
- immunohistochemistry; human
| Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr Relat Cancer. 2010;17:303-16 pubmed publisher |
| Volke M, Gale D, Maegdefrau U, Schley G, Klanke B, Bosserhoff A, et al. Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PLoS ONE. 2009;4:e7875 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Figlin R, De Souza P, McDermott D, Dutcher J, Berkenblit A, Thiele A, et al. Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer. 2009;115:3651-60 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Rasheed S, Harris A, Tekkis P, Turley H, Silver A, McDonald P, et al. Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. Br J Cancer. 2009;100:1666-73 pubmed publisher |
| Zimmer M, Ebert B, Neil C, Brenner K, Papaioannou I, Melas A, et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32:838-48 pubmed publisher |
- immunohistochemistry - paraffin section; human
- western blot; human
| Imamura T, Kikuchi H, Herraiz M, Park D, Mizukami Y, Mino Kenduson M, et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009;124:763-71 pubmed publisher |
- immunocytochemistry; human
| Westfall S, Sachdev S, Das P, Hearne L, Hannink M, Roberts R, et al. Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Stem Cells Dev. 2008;17:869-81 pubmed publisher |
- immunohistochemistry; human
| Evens A, Schumacker P, Helenowski I, Singh A, Dokic D, Keswani A, et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol. 2008;141:676-80 pubmed publisher |
| Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup K, et al. The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res. 2008;314:2016-27 pubmed publisher |
| Borger D, Gavrilescu L, Bucur M, Ivan M, DeCaprio J. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008;370:230-4 pubmed publisher |
- immunocytochemistry; human
| Monsef N, Helczynski L, Lundwall A, Påhlman S. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate. 2007;67:1219-29 pubmed |
| Rankin E, Biju M, Liu Q, Unger T, Rha J, Johnson R, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-77 pubmed |
| Lau K, Tian Y, Raval R, Ratcliffe P, Pugh C. Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br J Cancer. 2007;96:1284-92 pubmed |
- immunocytochemistry; human
| Harvey A, Kind K, Thompson J. Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine. Biol Reprod. 2007;77:93-101 pubmed |
- immunohistochemistry - paraffin section; rat
- immunohistochemistry; rat
| Bernhardt W, Wiesener M, Weidemann A, Schmitt R, Weichert W, Lechler P, et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol. 2007;170:830-42 pubmed |
- immunohistochemistry - paraffin section; human
- immunohistochemistry; human
| Carroll P, Kenerson H, Yeung R, Lagunoff M. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol. 2006;80:10802-12 pubmed |
| Isaacs J, Jung Y, Mole D, Lee S, Torres Cabala C, Chung Y, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 2005;8:143-53 pubmed |
- immunohistochemistry - paraffin section; human
| Beasley N, Leek R, Alam M, Turley H, Cox G, Gatter K, et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002;62:2493-7 pubmed |
- immunohistochemistry - paraffin section; human
| Giatromanolaki A, Koukourakis M, Sivridis E, Pastorek J, Wykoff C, Gatter K, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001;61:7992-8 pubmed |
- immunohistochemistry - paraffin section; human
| Koukourakis M, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res. 2001;61:1830-2 pubmed |
| Kling L, Eulenberg Gustavus C, Jerke U, Rousselle A, Eckardt K, Schreiber A, et al. β2-integrins control HIF1α activation in human neutrophils. Front Immunol. 2024;15:1406967 pubmed publisher |
| Xia J, Chen H, Wang X, Chen W, Lin J, Xu F, et al. Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α. Nat Commun. 2024;15:4755 pubmed publisher |
| Kim H, Liu Y, Kim J, Kim Y, Klouda T, Fisch S, et al. Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling. EMBO Rep. 2024;25:616-645 pubmed publisher |
| Berggren Nylund R, Ryde M, L xf6 fdahl A, Ib xe1 xf1 ez Fonseca A, K xe5 redal M, Westergren Thorsson G, et al. Effects of hypoxia on bronchial and alveolar epithelial cells linked to pathogenesis in chronic lung disorders. Front Physiol. 2023;14:1094245 pubmed publisher |
| Garcia J, Chen R, Xu M, Comerford S, Hammer R, Melton S, et al. Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis. PLoS ONE. 2023;18:e0282223 pubmed publisher |
| Akahori D, Inui N, Inoue Y, Yasui H, Hozumi H, Suzuki Y, et al. Effect of Hypoxia on Pulmonary Endothelial Cells from Bleomycin-Induced Pulmonary Fibrosis Model Mice. Int J Mol Sci. 2022;23: pubmed publisher |
| Moyama C, Fujita M, Ando S, Taniguchi K, Ii H, Tanigawa S, et al. Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a de novo murine brain cancer model. Am J Cancer Res. 2022;12:1129-1142 pubmed |
| Zhou X, Zheng Y, Sun W, Zhang Z, Liu J, Yang W, et al. D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner. Cell Prolif. 2021;54:e13134 pubmed publisher |
| Rodriguez L, Duchez P, Touya N, Debeissat C, Guitart A, Pasquet J, et al. α-Tocopherol Attenuates Oxidative Phosphorylation of CD34+ Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance. Biomolecules. 2021;11: pubmed publisher |
| Kuwano A, Kurokawa M, Kohjima M, Imoto K, Tashiro S, Suzuki H, et al. Microcirculatory disturbance in acute liver injury. Exp Ther Med. 2021;21:596 pubmed publisher |
| Pavlakis D, Kampantais S, Gkagkalidis K, Gourvas V, Memmos D, Tsionga A, et al. Hypoxia-Inducible Factor 2a Expression Is Positively Correlated With Gleason Score in Prostate Cancer. Technol Cancer Res Treat. 2021;20:1533033821990010 pubmed publisher |
| Menendez Montes I, Escobar B, Gómez M, Albendea Gomez T, Palacios B, Bonzon Kulichenko E, et al. Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice. iScience. 2021;24:102124 pubmed publisher |
| Lawler A, Brown A, Bouchard R, Toong N, Kim Y, Velraj N, et al. Cell Type-Specific Oxidative Stress Genomic Signatures in the Globus Pallidus of Dopamine-Depleted Mice. J Neurosci. 2020;40:9772-9783 pubmed publisher |
| Niklasson C, Fredlund E, Monni E, Lindvall J, Kokaia Z, Hammarlund E, et al. Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells. Dev Dyn. 2021;250:191-236 pubmed publisher |
| Albiñana V, Gallardo Vara E, de Rojas P I, Recio Poveda L, Aguado T, Canto Cano A, et al. Targeting β2-Adrenergic Receptors Shows Therapeutical Benefits in Clear Cell Renal Cell Carcinoma from Von Hippel-Lindau Disease. J Clin Med. 2020;9: pubmed publisher |
| Liu P, Harris J, Marchi E, D Arienzo V, Michler T, Wing P, et al. Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models. Sci Rep. 2020;10:14101 pubmed publisher |
| Hulley P, Papadimitriou Olivgeri I, Knowles H. Osteoblast-Osteoclast Coculture Amplifies Inhibitory Effects of FG-4592 on Human Osteoclastogenesis and Reduces Bone Resorption. JBMR Plus. 2020;4:e10370 pubmed publisher |
| Hong K, Hu L, Liu X, Simon J, Ptacek T, Zheng X, et al. USP37 promotes deubiquitination of HIF2α in kidney cancer. Proc Natl Acad Sci U S A. 2020;117:13023-13032 pubmed publisher |
| Gkagkalidis K, Kampantais S, Dimitriadis G, Gourvas V, Kapoukranidou D, Mironidou Tzouveleki M. Expression of HIF-2a in clear-cell renal cell carcinoma independently predicts overall survival. Med Mol Morphol. 2020;: pubmed publisher |
| Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, et al. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020;9: pubmed publisher |
| Persson C, von Stedingk K, Fredlund E, Bexell D, Påhlman S, Wigerup C, et al. ARNT-dependent HIF-2 transcriptional activity is not sufficient to regulate downstream target genes in neuroblastoma. Exp Cell Res. 2020;388:111845 pubmed publisher |
| Bacci L, Aiello A, Ripoli C, Loria R, Pugliese D, Pierconti F, et al. H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer. Int J Mol Sci. 2019;20: pubmed publisher |
| Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, et al. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019;: pubmed publisher |
| Mallikarjuna P, Raviprakash T, Aripaka K, Ljungberg B, Landström M. Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma. Cell Cycle. 2019;18:2141-2156 pubmed publisher |
| Das B, Pal B, Bhuyan R, Li H, Sarma A, Gayan S, et al. MYC regulates the HIF-2α stemness pathway via Nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells. Cancer Res. 2019;: pubmed publisher |
| Knowles H. The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments. Cells. 2019;8: pubmed publisher |
| Duan L, Fong G. Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism. Development. 2019;146: pubmed publisher |
| Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, et al. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018;9:5426 pubmed publisher |
| Delbrel E, Soumare A, Naguez A, Label R, Bernard O, Bruhat A, et al. HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Sci Rep. 2018;8:17939 pubmed publisher |
| Sasagawa T, Nagamatsu T, Morita K, Mimura N, Iriyama T, Fujii T, et al. HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts. Sci Rep. 2018;8:17375 pubmed publisher |
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