product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
FOXL2 Antibody
catalog :
NB100-1277
quantity :
0.1 mg (also 20 ug)
price :
479 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
DyLight680
clone name :
711-66
reactivity :
human, mouse, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 55
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s11a
Zhang T, He M, Zhao L, Qin S, Zhu Z, Du X, et al. HDAC6 regulates primordial follicle activation through mTOR signaling pathway. Cell Death Dis. 2021;12:559 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 2c
Gonen N, Futtner C, Wood S, Garcia Moreno S, Salamone I, Samson S, et al. Sex reversal following deletion of a single distal enhancer of Sox9. Science. 2018;360:1469-1473 pubmed publisher
Zhao T, He M, Zhu Z, Zhang T, Zheng W, Qin S, et al. P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1. Cell Mol Life Sci. 2024;81:221 pubmed publisher
Taelman J, Czukiewska S, Moustakas I, Chang Y, Hillenius S, van der Helm T, et al. Characterization of the human fetal gonad and reproductive tract by single-cell transcriptomics. Dev Cell. 2024;59:529-544.e5 pubmed publisher
Baskin L, Cao M, Askel S, Li Y, Cunha G. Ovotesticular cords and ovotesticular follicles: New markers in a model of human mixed ovotestis. Differentiation. 2024;135:100739 pubmed publisher
Danti L, Lundin K, Sepponen K, Yohannes D, Kere J, Tuuri T, et al. CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate. J Ovarian Res. 2023;16:194 pubmed publisher
Lim J, Lee H, Nguyen J, Shin J, Getze S, Quach C, et al. Adolescent exposure to low-dose Δ9-tetrahydrocannabinol depletes the ovarian reserve in female mice. Toxicol Sci. 2023;193:31-47 pubmed publisher
Pierson Smela M, Kramme C, Fortuna P, Adams J, Su R, Dong E, et al. Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. elife. 2023;12: pubmed publisher
Yu X, Wang N, Wang X, Ren H, Zhang Y, Zhang Y, et al. Oocyte Arrested at Metaphase II Stage were Derived from Human Pluripotent Stem Cells in vitro. Stem Cell Rev Rep. 2023;19:1067-1081 pubmed publisher
Zhang S, Mu L, Wang H, Xu X, Jia L, Niu S, et al. Quantitative proteomic analysis uncovers protein-expression profiles during gonadotropin-dependent folliculogenesis in mice†. Biol Reprod. 2023;108:479-491 pubmed publisher
Thomson E, Tran M, Robevska G, Ayers K, van der Bergen J, Gopalakrishnan Bhaskaran P, et al. Functional genomics analysis identifies loss of HNF1B function as a cause of Mayer-Rokitansky-Küster-Hauser syndrome. Hum Mol Genet. 2023;32:1032-1047 pubmed publisher
Cheng Y, Zhang Z, Zhang G, Chen L, Zeng C, Liu X, et al. The Male-Biased Expression of miR-2954 Is Involved in the Male Pathway of Chicken Sex Differentiation. Cells. 2022;12: pubmed publisher
Wang Y, Zhang J, Liang J, Jia L, Niu S, Cheng K, et al. In vivo promotion of primordial follicle activation by stem cell factor treatment in mice with premature ovarian insufficiency and advanced age. Mol Hum Reprod. 2022;29: pubmed publisher
Bridges K, Yao H, Nicol B. Loss of Runx1 Induces Granulosa Cell Defects and Development of Ovarian Tumors in the Mouse. Int J Mol Sci. 2022;23: pubmed publisher
Overland M, Li Y, Derpinghaus A, Aksel S, Cao M, Ladwig N, et al. Development of the human ovary: Fetal through pubertal ovarian morphology, folliculogenesis and expression of cellular differentiation markers. Differentiation. 2022;: pubmed publisher
Del Valle J, Mancini V, Laverde Garay M, Asseler J, Fan X, Metzemaekers J, et al. Dynamic in vitro culture of cryopreserved-thawed human ovarian cortical tissue using a microfluidics platform does not improve early folliculogenesis. Front Endocrinol (Lausanne). 2022;13:936765 pubmed publisher
Yu J, Xie X, Ma Y, Yang Y, Wang C, Xia G, et al. Effects and potential mechanism of Ca2+/calmodulin‑dependent protein kinase II pathway inhibitor KN93 on the development of ovarian follicle. Int J Mol Med. 2022;50: pubmed publisher
Mizuta K, Katou Y, Nakakita B, Kishine A, Nosaka Y, Saito S, et al. Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys. EMBO J. 2022;41:e110815 pubmed publisher
Rodriguez K, Brown P, Amato C, Nicol B, Liu C, Xu X, et al. Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B. Nat Commun. 2022;13:4130 pubmed publisher
Dai Y, Bo Y, Wang P, Xu X, Singh M, Jia L, et al. Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice. BMC Biol. 2022;20:109 pubmed publisher
Li Y, Overland M, Derpinghaus A, Aksel S, Cao M, Ladwig N, et al. Development of the human fetal testis: Morphology and expression of cellular differentiation markers. Differentiation. 2022;: pubmed publisher
Du H, Guo Y, Wu X, Gong Y. FOXL2 regulates the expression of the Col4a1 collagen gene in chicken granulosa cells. Mol Reprod Dev. 2022;89:95-103 pubmed publisher
Xu X, Mu L, Li L, Liang J, Zhang S, Jia L, et al. Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging. Sci Adv. 2022;8:eabi8683 pubmed publisher
Guo Y, Cheng L, Li X, Tang S, Zhang X, Gong Y. Transcriptional regulation of CYP19A1 expression in chickens: ESR1, ESR2 and NR5A2 form a functional network. Gen Comp Endocrinol. 2022;315:113939 pubmed publisher
Shen Y, Shami A, Moritz L, Larose H, Manske G, Ma Q, et al. TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Nat Commun. 2021;12:3876 pubmed publisher
Adeniran B, Bjarkadottir B, Appeltant R, Lane S, Williams S. Improved preservation of ovarian tissue morphology that is compatible with antigen detection using a fixative mixture of formalin and acetic acid. Hum Reprod. 2021;36:1871-1890 pubmed publisher
Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, et al. The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Rep. 2021;35:109075 pubmed publisher
Ikeda Y, Tagami A, Maekawa M, Nagai A. The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep. 2021;11:4486 pubmed publisher
Ruthig V, Yokonishi T, Friedersdorf M, Batchvarova S, Hardy J, Garness J, et al. A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†. Biol Reprod. 2021;104:861-874 pubmed publisher
Zhang J, Yan L, Wang Y, Zhang S, Xu X, Dai Y, et al. In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human. Clin Transl Med. 2020;10:e182 pubmed publisher
Murase Y, Yabuta Y, Ohta H, Yamashiro C, Nakamura T, Yamamoto T, et al. Long-term expansion with germline potential of human primordial germ cell-like cells in vitro. EMBO J. 2020;39:e104929 pubmed publisher
Nicol B, Rodriguez K, Yao H. Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice. Biol Reprod. 2020;103:966-977 pubmed publisher
Li Y, Chen T, Huang B, Yang S, Wu C, Lin Y, et al. FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture. Biol Reprod. 2020;103:1300-1313 pubmed publisher
Richardson N, Gillot I, Gregoire E, Youssef S, DE ROOIJ D, de Bruin A, et al. Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals. elife. 2020;9: pubmed publisher
De Cian M, Gregoire E, Le Rolle M, Lachambre S, Mondin M, Bell S, et al. R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth. Cell Death Differ. 2020;: pubmed publisher
Yamashiro C, Sasaki K, Yokobayashi S, Kojima Y, Saitou M. Generation of human oogonia from induced pluripotent stem cells in culture. Nat Protoc. 2020;15:1560-1583 pubmed publisher
Belli M, Secchi C, Stupack D, Shimasaki S. FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. J Endocr Soc. 2019;3:2064-2081 pubmed publisher
Garcia Moreno S, Lin Y, Futtner C, Salamone I, Capel B, Maatouk D. CBX2 is required to stabilize the testis pathway by repressing Wnt signaling. PLoS Genet. 2019;15:e1007895 pubmed publisher
Fujisawa M, Moh Moh Aung A, Zeng Z, Yoshimura T, Wani Y, Matsukawa A. Ovarian stromal cells as a source of cancer-associated fibroblasts in human epithelial ovarian cancer: A histopathological study. PLoS ONE. 2018;13:e0205494 pubmed publisher
Nicol B, Grimm S, Gruzdev A, Scott G, Ray M, Yao H. Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads. Hum Mol Genet. 2018;27:4273-4287 pubmed publisher
Liu C, Rodriguez K, Brown P, Yao H. Reproductive, Physiological, and Molecular Outcomes in Female Mice Deficient in Dhh and Ihh. Endocrinology. 2018;159:2563-2575 pubmed publisher
Belli M, Iwata N, Nakamura T, Iwase A, Stupack D, Shimasaki S. FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells. Endocrinology. 2018;159:1690-1703 pubmed publisher
Abe A, Ohishi Y, Miyazaki T, Ozono K, Mochidome N, Saeki K, et al. 'Microcystic pattern' should be recognised as part of the morphological spectrum of solid-pseudopapillary neoplasm of the pancreas. Histopathology. 2018;72:216-226 pubmed publisher
Gonen N, Quinn A, O Neill H, Koopman P, Lovell Badge R. Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 2017;13:e1006520 pubmed publisher
Ikeda Y, Tagami A, Komada M, Takahashi M. Expression of Kisspeptin in Gonadotrope Precursors in the Mouse Pituitary during Embryonic and Postnatal Development and in Adulthood. Neuroendocrinology. 2017;105:357-371 pubmed publisher
Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, et al. Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature. 2016;539:299-303 pubmed publisher
Batchvarov I, Taylor R, Bustamante Marín X, Czerwinski M, Johnson E, Kornbluth S, et al. A grafted ovarian fragment rescues host fertility after chemotherapy. Mol Hum Reprod. 2016;22:842-851 pubmed
Dörner J, Martinez Rodriguez V, Ziegler R, Röhrig T, Cochran R, Götz R, et al. GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue. Mol Cell Endocrinol. 2017;441:164-175 pubmed publisher
Arora R, Abby E, Ross A, Cantu A, Kissner M, Castro V, et al. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016;129:2493-9 pubmed publisher
Feng L, Wang Y, Cai H, Sun G, Niu W, Xin Q, et al. ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice. J Cell Sci. 2016;129:2202-12 pubmed publisher
Croce S, de Kock L, Boshari T, Hostein I, Velasco V, Foulkes W, et al. Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations. Int J Gynecol Pathol. 2016;35:301-8 pubmed publisher
Barratt C. Is there a robust future for research in reproduction?. Mol Hum Reprod. 2016;22:1-2 pubmed publisher
Kao C, Cornejo K, Ulbright T, Young R. Juvenile granulosa cell tumors of the testis: a clinicopathologic study of 70 cases with emphasis on its wide morphologic spectrum. Am J Surg Pathol. 2015;39:1159-69 pubmed publisher
Teng Z, Wang C, Wang Y, Huang K, Xiang X, Niu W, et al. S100A8, An Oocyte-Specific Chemokine, Directs the Migration of Ovarian Somatic Cells During Mouse Primordial Follicle Assembly. J Cell Physiol. 2015;230:2998-3008 pubmed publisher
Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, et al. Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. Mol Cell Endocrinol. 2015;399:122-30 pubmed publisher
product information
master code :
NB100-1277
SKU :
NB100-1277
product name :
FOXL2 Antibody
unit size :
0.1 mg (also 20 ug)
description :
The FOXL2 Antibody from Novus is a goat polyclonal antibody to FOXL2. This antibody reacts with avian - chicken,bovine,ferret,human,mouse. The FOXL2 Antibody has been validated for the following applications: Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Chemotaxis,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry Whole-Mount,Peptide ELISA,Chromatin Immunoprecipitation (ChIP).
target :
FOXL2
category :
Primary Antibodies
buffer :
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
clonality :
Polyclonal
concentration :
0.5 mg/ml
conjugate :
Unconjugated
host :
Goat
immunogen :
Peptide with sequence C-DSKTGALHSRLDL corresponding to C-Terminus according to NP_075555.1.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Avian - Chicken,Bovine,Ferret,Human,Mouse
gene symbol :
FOXL2
accessionNumbers :
P58012
applications :
Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Chemotaxis,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry Whole-Mount,Peptide ELISA,Chromatin Immunoprecipitation (ChIP)
USD :
479 USD
alt names :
BPES, BPES1PINTO, forkhead box L2, forkhead box protein L2, forkhead transcription factor FOXL2, PFRK, POF3
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.