ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free | Novus Biologicals NB100-124 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free

catalog :

NB100-124

quantity :

0.1 ml (also 0.025 ml)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

H1beta234

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, ChIP-Seq

more info or order :

Novus Biologicals product webpage

citations: 106

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5f	Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell W, Tan A, et al. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017;6:e287 pubmed publisher
ChIP-Seq; mouse; loading ...; fig s2b	Thienpont B, Steinbacher J, Zhao H, D Anna F, Kuchnio A, Ploumakis A, et al. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature. 2016;537:63-68 pubmed publisher
chromatin immunoprecipitation; human; fig 10	Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed publisher
western blot; human; fig 3	Altuntas S, Rossin F, Marsella C, D Eletto M, Diaz Hidalgo L, Farrace M, et al. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation. Oncotarget. 2015;6:44941-54 pubmed publisher
chromatin immunoprecipitation; human immunoprecipitation; human western blot; human	Xiang L, Gilkes D, Hu H, Luo W, Bullen J, Liang H, et al. HIF-1Î± and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 2015;6:11768-78 pubmed
chromatin immunoprecipitation; human	Xiang L, Gilkes D, Hu H, Takano N, Luo W, Lu H, et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014;5:12509-27 pubmed
western blot; human	Kim K, Kim D, Park J, Jung H, Cho Y, Kim H, et al. NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction. J Mol Med (Berl). 2015;93:499-509 pubmed publisher
immunohistochemistry - paraffin section; human immunocytochemistry; human western blot; human	Su E, Xin H, Yin P, Dyson M, Coon J, Farrow K, et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015;100:E30-40 pubmed publisher
chromatin immunoprecipitation; human	Hu H, Takano N, Xiang L, Gilkes D, Luo W, Semenza G. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014;5:8853-68 pubmed
western blot; rat	Peng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed publisher
chromatin immunoprecipitation; human	Wang T, Gilkes D, Takano N, Xiang L, Luo W, Bishop C, et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2014;111:E3234-42 pubmed publisher
chromatin immunoprecipitation; human	Chaturvedi P, Gilkes D, Takano N, Semenza G. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. 2014;111:E2120-9 pubmed publisher
western blot; human	Zhang J, Ma W. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet Mol Res. 2014;13:9324-35 pubmed publisher
western blot; human	Sena J, Wang L, Pawlus M, Hu C. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014;12:728-41 pubmed publisher
western blot; human	Suzuki K, Nishi K, Takabuchi S, Kai S, Matsuyama T, Kurosawa S, et al. Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions. Peerj. 2013;1:e220 pubmed publisher
chromatin immunoprecipitation; rat chromatin immunoprecipitation; human	Takano N, Peng Y, Kumar G, Luo W, Hu H, Shimoda L, et al. Hypoxia-inducible factors regulate human and rat cystathionine ?-synthase gene expression. Biochem J. 2014;458:203-11 pubmed publisher
chromatin immunoprecipitation; human	Gilkes D, Xiang L, Lee S, Chaturvedi P, Hubbi M, Wirtz D, et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A. 2014;111:E384-93 pubmed publisher
western blot; human	Xiang L, Gilkes D, Chaturvedi P, Luo W, Hu H, Takano N, et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 2014;92:151-64 pubmed publisher
chromatin immunoprecipitation; mouse western blot; mouse	Cai Z, Luo W, Zhan H, Semenza G. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proc Natl Acad Sci U S A. 2013;110:17462-7 pubmed publisher
chromatin immunoprecipitation; human western blot; human	Sena J, Wang L, Hu C. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013;33:3849-63 pubmed publisher
western blot; human	Yuan G, Peng Y, Reddy V, Makarenko V, Nanduri J, Khan S, et al. Mutual antagonism between hypoxia-inducible factors 1? and 2? regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A. 2013;110:E1788-96 pubmed publisher
western blot; human	Pawlus M, Wang L, Hu C. STAT3 and HIF1? cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014;33:1670-9 pubmed publisher
western blot; mouse	Balamurugan K, Sharan S, Klarmann K, Zhang Y, Coppola V, Summers G, et al. FBXW7Î± attenuates inflammatory signalling by downregulating C/EBPÎ´ and its target gene Tlr4. Nat Commun. 2013;4:1662 pubmed publisher
western blot; human	Storti P, Bolzoni M, Donofrio G, Airoldi I, Guasco D, Toscani D, et al. Hypoxia-inducible factor (HIF)-1? suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia. 2013;27:1697-706 pubmed publisher
chromatin immunoprecipitation; human	Chaturvedi P, Gilkes D, Wong C, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123:189-205 pubmed publisher
chromatin immunoprecipitation; human	Luo W, Chang R, Zhong J, Pandey A, Semenza G. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci U S A. 2012;109:E3367-76 pubmed publisher
western blot; human	Pawlus M, Wang L, Ware K, Hu C. Upstream stimulatory factor 2 and hypoxia-inducible factor 2? (HIF2?) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012;32:4595-610 pubmed publisher
western blot; human	Krishnamachary B, Penet M, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, et al. Hypoxia regulates CD44 and its variant isoforms through HIF-1? in triple negative breast cancer. PLoS ONE. 2012;7:e44078 pubmed publisher
immunoprecipitation; human western blot; human	Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol Dis. 2013;50:25-30 pubmed publisher
western blot; mouse	Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, et al. The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1? mRNA stability. J Biol Chem. 2012;287:34361-71 pubmed publisher
western blot; mouse	Singh A, Mukhopadhyay C, Biswas S, Singh V, Mukhopadhyay C. Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage. PLoS ONE. 2012;7:e38489 pubmed publisher
western blot; human	Uniacke J, Holterman C, Lachance G, Franovic A, Jacob M, Fabian M, et al. An oxygen-regulated switch in the protein synthesis machinery. Nature. 2012;486:126-9 pubmed publisher
immunohistochemistry; human	Kaira K, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, et al. Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer. Int J Surg Pathol. 2012;20:223-32 pubmed publisher
western blot; human	Zhou L, Yang H. The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR. PLoS ONE. 2011;6:e23936 pubmed publisher
western blot; human	Wong C, Gilkes D, Zhang H, Chen J, Wei H, Chaturvedi P, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A. 2011;108:16369-74 pubmed publisher
chromatin immunoprecipitation; human	Luo W, Hu H, Chang R, Zhong J, Knabel M, O Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145:732-44 pubmed publisher
western blot; human	Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol Cancer Res. 2011;9:757-65 pubmed publisher
immunohistochemistry; human western blot; human	Tamama K, Kawasaki H, Kerpedjieva S, Guan J, Ganju R, Sen C. Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. J Cell Biochem. 2011;112:804-17 pubmed publisher
western blot; mouse	Peng Y, Nanduri J, Khan S, Yuan G, Wang N, Kinsman B, et al. Hypoxia-inducible factor 2? (HIF-2?) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011;108:3065-70 pubmed publisher
western blot; rat western blot; human	Lunde I, Anton S, Bruusgaard J, Rana Z, Ellefsen S, Gundersen K. Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats. J Physiol. 2011;589:1443-54 pubmed publisher
western blot; human	Amir S, Wang R, Simons J, Mabjeesh N. SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation. J Biol Chem. 2009;284:11142-51 pubmed publisher
immunohistochemistry - paraffin section; rat	Kransler K, McGarrigle B, Swartz D, Olson J. Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2009;107:498-511 pubmed publisher
western blot; mouse	Aminova L, Siddiq A, Ratan R. Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line. Antioxid Redox Signal. 2008;10:1989-98 pubmed publisher
western blot; human	Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, et al. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol Cancer Ther. 2008;7:1974-84 pubmed publisher
western blot; human	Lauzier M, Robitaille G, Chan D, Giaccia A, Richard D. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Mol Pharmacol. 2008;74:282-8 pubmed publisher
immunoprecipitation; human western blot; human	Baek J, Liu Y, McDonald K, Wesley J, Zhang H, Semenza G. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007;282:33358-66 pubmed
immunoprecipitation; human western blot; human	Baek J, Liu Y, McDonald K, Wesley J, Hubbi M, Byun H, et al. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. J Biol Chem. 2007;282:23572-80 pubmed
western blot; human	Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller K, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007;11:407-20 pubmed
western blot; rat	Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, et al. Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H474-81 pubmed
western blot; human	Asikainen T, Chang L, Coalson J, Schneider B, Waleh N, Ikegami M, et al. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006;20:1698-700 pubmed
western blot; human	Slomiany M, Rosenzweig S. Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion. J Pharmacol Exp Ther. 2006;318:666-75 pubmed
immunoprecipitation; human western blot; human	Nakamura K, Martin K, Jackson J, Beppu K, Woo C, Thiele C. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006;66:4249-55 pubmed
western blot; human	Hu C, Iyer S, Sataur A, Covello K, Chodosh L, Simon M. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006;26:3514-26 pubmed
western blot; human	Okuyama H, Krishnamachary B, Zhou Y, Nagasawa H, Bosch Marce M, Semenza G. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem. 2006;281:15554-63 pubmed
western blot; rat	Hui A, Bauer A, Striet J, Schnell P, Czyzyk Krzeska M. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-75 pubmed
western blot; human	Amir S, Wang R, Matzkin H, Simons J, Mabjeesh N. MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Res. 2006;66:856-66 pubmed
western blot; human	Schultz K, Fanburg B, Beasley D. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;290:H2528-34 pubmed
western blot; human	Hirota K, Fukuda R, Takabuchi S, Kizaka Kondoh S, Adachi T, Fukuda K, et al. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J Biol Chem. 2004;279:41521-8 pubmed
western blot; human	Slomiany M, Rosenzweig S. IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci. 2004;45:2838-47 pubmed
western blot; mouse	Arsham A, Plas D, Thompson C, Simon M. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 2004;64:3500-7 pubmed
western blot; human	Slomiany M, Rosenzweig S. Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19. Am J Physiol Cell Physiol. 2004;287:C746-53 pubmed
western blot; human	Tissot van Patot M, Bendrick Peart J, Beckey V, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004;287:L525-32 pubmed
western blot; human	Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker R, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004;64:1475-82 pubmed
western blot; human	Alam H, Maizels E, Park Y, Ghaey S, Feiger Z, Chandel N, et al. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of f. J Biol Chem. 2004;279:19431-40 pubmed
western blot; human	Fukuda R, Kelly B, Semenza G. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res. 2003;63:2330-4 pubmed
western blot; human	Mabjeesh N, Escuin D, LaVallee T, Pribluda V, Swartz G, Johnson M, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-75 pubmed
western blot; human	Mabjeesh N, Willard M, Harris W, Sun H, Wang R, Zhong H, et al. Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF. Biochem Biophys Res Commun. 2003;303:279-86 pubmed
immunohistochemistry; human	Volm M, Koomagi R, Mattern J, Efferth T. Protein expression profiles indicative for drug resistance of non-small cell lung cancer. Br J Cancer. 2002;87:251-7 pubmed
western blot; human	Rapisarda A, Uranchimeg B, Scudiero D, Selby M, Sausville E, Shoemaker R, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 2002;62:4316-24 pubmed
western blot; human	Fukuda R, Hirota K, Fan F, Jung Y, Ellis L, Semenza G. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002;277:38205-11 pubmed
western blot; rat	Bernaudin M, Tang Y, Reilly M, Petit E, Sharp F. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem. 2002;277:39728-38 pubmed
western blot; human	Mabjeesh N, Post D, Willard M, Kaur B, Van Meir E, Simons J, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002;62:2478-82 pubmed
western blot; human	Zhong H, Hanrahan C, van der Poel H, Simons J. Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells. Biochem Biophys Res Commun. 2001;284:352-6 pubmed
immunohistochemistry; human western blot; human	Zagzag D, Zhong H, Scalzitti J, Laughner E, Simons J, Semenza G. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000;88:2606-18 pubmed
	Lee P, Suwa T, Kobayashi M, Yang H, Koseki L, Takeuchi S, et al. Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner. Br J Cancer. 2024;131:37-48 pubmed publisher
	Mayro B, Hoj J, Cerda Smith C, Hutchinson H, Caminear M, Thrash H, et al. ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1. Proc Natl Acad Sci U S A. 2023;120:e2210418120 pubmed publisher
	Lafleur V, Halim S, Choudhry H, Ratcliffe P, Mole D. Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma. Life Sci Alliance. 2023;6: pubmed publisher
	Tang J, Wu Z, Wang X, Hou Y, Bai Y, Tian Y. Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression. Cells. 2022;11: pubmed publisher
	Chen Y, Cattoglio C, Dailey G, Zhu Q, Tjian R, Darzacq X. Mechanisms governing target search and binding dynamics of hypoxia-inducible factors. elife. 2022;11: pubmed publisher
	Simmler P, Cortijo C, Koch L, Galliker P, Angori S, Bolck H, et al. SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer. Cell Rep. 2022;40:111266 pubmed publisher
	Niu N, Li H, Du X, Wang C, Li J, Yang J, et al. Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia. Gene. 2022;834:146565 pubmed publisher
	Suwa T, Kobayashi M, Shirai Y, Nam J, Tabuchi Y, Takeda N, et al. SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization. JCI Insight. 2021;6: pubmed publisher
	Sasagawa T, Nagamatsu T, Yanagisawa M, Fujii T, Shibuya M. Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts. Mol Hum Reprod. 2021;27: pubmed publisher
	Lu H, Lyu Y, Tran L, Lan J, Xie Y, Yang Y, et al. HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell Rep. 2021;36:109757 pubmed publisher
	Mehibel M, Xu Y, Li C, Moon E, Thakkar K, Diep A, et al. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest. 2021;131: pubmed publisher
	Samanta D, Huang T, Shah R, Yang Y, Pan F, Semenza G. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep. 2020;32:108073 pubmed publisher
	Tiwari A, Tashiro K, Dixit A, Soni A, Vogel K, Hall B, et al. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Gastroenterology. 2020;159:1882-1897.e5 pubmed publisher
	D Anna F, Van Dyck L, Xiong J, Zhao H, Berrens R, Qian J, et al. DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance. Genome Biol. 2020;21:182 pubmed publisher
	Olcina M, Balanis N, Kim R, Aksoy B, Kodysh J, Thompson M, et al. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018;25:3721-3732.e6 pubmed publisher
	Samanta D, Park Y, Ni X, Li H, Zahnow C, Gabrielson E, et al. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proc Natl Acad Sci U S A. 2018;115:E1239-E1248 pubmed publisher
	Lu H, Chen I, Shimoda L, Park Y, Zhang C, Tran L, et al. Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep. 2017;18:1946-1957 pubmed publisher
	Ju J, Godet I, Ye I, Byun J, Jayatilaka H, Lee S, et al. Hypoxia Selectively Enhances Integrin ?5?1 Receptor Expression in Breast Cancer to Promote Metastasis. Mol Cancer Res. 2017;15:723-734 pubmed publisher
	Taylor S, Bagnall J, Mason D, Levy R, Fernig D, See V. Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility. Open Biol. 2016;6: pubmed
	Li S, Heller J, Bostick J, Lee A, Schjerven H, Kastner P, et al. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016;45:185-97 pubmed publisher
	Frey J, Stonko D, Faugere M, Riddle R. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res. 2014;2:14005 pubmed publisher
	Rossin F, D Eletto M, Falasca L, Sepe S, Cocco S, Fimia G, et al. Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis. Cell Death Differ. 2015;22:408-18 pubmed publisher
	Autheman D, Sheldon R, Chaudhuri N, von Arx S, Siegenthaler C, Ferriero D, et al. Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning. Pediatr Res. 2012;72:568-75 pubmed publisher
	Terzuoli E, Puppo M, Rapisarda A, Uranchimeg B, Cao L, Burger A, et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010;70:6837-48 pubmed publisher
	Lysiak J, Kirby J, Tremblay J, Woodson R, Reardon M, Palmer L, et al. Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity. J Androl. 2009;30:146-56 pubmed publisher
	Engebretsen B, Irwin D, Valdez M, O Donovan M, Tucker A, van Patot M. Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats. High Alt Med Biol. 2007;8:312-21 pubmed
	Cheng G, Shao Z, Chaudhari B, Agrawal D. Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1339-47 pubmed
	Hu C, Sataur A, Wang L, Chen H, Simon M. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007;18:4528-42 pubmed
	Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, et al. Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol. 2006;291:C104-13 pubmed
	Hu C, Wang L, Chodosh L, Keith B, Simon M. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23:9361-74 pubmed
	Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, et al. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem. 2003;278:7520-30 pubmed
	Tendler D, Bao C, Wang T, Huang E, Ratovitski E, Pardoll D, et al. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 2001;61:3682-8 pubmed

product information

master code :

NB100-124

SKU :

NB100-124

product name :

ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free from Novus is a mouse monoclonal antibody to ARNT/HIF-1 beta. This antibody reacts with bovine,ferret,human,mouse,primate,rat,sheep. The ARNT/HIF-1 beta Antibody (H1beta234) - BSA Free has been validated for the following applications: Immunohistochemistry,Western Blot,Chemotaxis,Chip Cytometry,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunoblotting,Gel Supershift Assay,Immunocytochemistry/ Immunofluorescence,Gel Super Shift Assays,Chromatin Immunoprecipitation (ChIP),Chromatin Immunoprecipitation Sequencing.

target :

ARNT/HIF-1 beta

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

H1beta234

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

ARNT/HIF-1 beta Antibody (H1beta234) was developed against a fusion protein containing amino acids 496-789 of human HIF-1 beta. [Uniprot: P27540]

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Bovine,Ferret,Human,Mouse,Primate,Rat,Sheep

theoretical molecular weight :

86.6 kDa

gene symbol :

ARNT

Antibody validation :

Biological Validation

applications :

Chemotaxis,Chip Cytometry,IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunoblotting,Gel Supershift Assay,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Gel Super Shift Assays,Chromatin Immunoprecipitation (ChIP),Chromatin Immunoprecipitation Sequencing

USD :

459 USD

alt names :

ARNT, ARNT protein, aryl hydrocarbon receptor nuclear translocator, BHLHE2, Class E Basic Helix-Loop-Helix Protein 2, Dioxin Receptor, Nuclear Translocator, HIF-1 Beta, HIF1B, HIF-1beta, HIF-1-beta, HIF1-beta, HIF1BETA, hypoxia-inducible factor 1, beta subunit, Hypoxia-inducible factor 1-beta, TANGO

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage