HIF-1 alpha Antibody (H1alpha67) | Novus Biologicals NB100-123 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

HIF-1 alpha Antibody (H1alpha67)

catalog :

NB100-123

quantity :

0.1 ml (also 0.025 ml)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H1alpha67

reactivity :

birds , human, mouse, rat, dogs, bovine, pigs , domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

Novus Biologicals product webpage

citations: 178

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; loading ...; fig 2f	Jablonska B, Gierdalski M, Chew L, Hawley T, Catron M, Lichauco A, et al. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016;7:13866 pubmed publisher
western blot; mouse; 1:500; loading ...; fig 4c	Saw E, Pearson J, Schwenke D, Munasinghe P, Tsuchimochi H, Rawal S, et al. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovasc Diabetol. 2021;20:50 pubmed publisher
immunocytochemistry; mouse; 1:100; fig 1 western blot; mouse; 1:500; fig 5	Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed publisher
immunohistochemistry - paraffin section; human	Ohmoto T, Yoshitani N, Nishitsuji K, Takayama T, Yanagisawa Y, Takeya M, et al. CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: molecular analysis of aggressive invasion and metastasis. Pathol Int. 2015;65:264-70 pubmed publisher
western blot; mouse	HÃ©nique C, Mansouri A, Vavrova E, Lenoir V, Ferry A, Esnous C, et al. Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype. FASEB J. 2015;29:2473-83 pubmed publisher
immunoprecipitation; human	Su E, Xin H, Yin P, Dyson M, Coon J, Farrow K, et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015;100:E30-40 pubmed publisher
immunohistochemistry - paraffin section; human	Motzer R, Hutson T, Hudes G, Figlin R, Martini J, English P, et al. Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma. Cancer Chemother Pharmacol. 2014;74:739-50 pubmed publisher
immunocytochemistry; rat; 1:200	Ramamoorthy P, Shi H. Ischemia induces different levels of hypoxia inducible factor-1? protein expression in interneurons and pyramidal neurons. Acta Neuropathol Commun. 2014;2:51 pubmed publisher
western blot; human	Sun W, Depping R, Jelkmann W. Interleukin-1? promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production. Cell Death Dis. 2014;5:e1020 pubmed publisher
immunohistochemistry - paraffin section; human	Chaux A, Albadine R, Schultz L, Hicks J, Carducci M, Argani P, et al. Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. Hum Pathol. 2013;44:2323-30 pubmed publisher
immunocytochemistry; mouse western blot; mouse	Sceneay J, Liu M, Chen A, Wong C, Bowtell D, Möller A. The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo. PLoS ONE. 2013;8:e66388 pubmed publisher
immunocytochemistry; human	Li C, Hashimi S, Cao S, Mellick A, Duan W, Good D, et al. The mechanisms of chansu in inducing efficient apoptosis in colon cancer cells. Evid Based Complement Alternat Med. 2013;2013:849054 pubmed publisher
western blot; mouse	Li J, Levick S, Dipette D, Janicki J, Supowit S. Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure. Regul Pept. 2013;185:20-8 pubmed publisher
chromatin immunoprecipitation; human western blot; human	Tanaka T, Yamaguchi J, Higashijima Y, Nangaku M. Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. FASEB J. 2013;27:4059-75 pubmed publisher
immunohistochemistry - paraffin section; human	Toba H, Kondo K, Sadohara Y, Otsuka H, Morimoto M, Kajiura K, et al. 18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1?, glucose transporter-1 and vascular endothelial growth factor in thymic e. Eur J Cardiothorac Surg. 2013;44:e105-12 pubmed publisher
western blot; rat	Kar A, Macgibeny M, Gervasi N, Gioio A, Kaplan B. Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons. J Neurosci. 2013;33:7165-74 pubmed publisher
immunohistochemistry - paraffin section; human	Lundgrin E, Park M, Sharp J, Tang W, Thomas J, Asosingh K, et al. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc. 2013;10:1-9 pubmed publisher
immunohistochemistry; human	Aziz S, Sznol J, Adeniran A, Parisi F, Kluger Y, Camp R, et al. Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors. BMC Clin Pathol. 2013;13:3 pubmed publisher
western blot; rat	Reddy V, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu N. Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties. Mol Cell Biochem. 2013;375:39-47 pubmed publisher
immunohistochemistry; birds	Brenner R, Slayden O. Molecular and functional aspects of menstruation in the macaque. Rev Endocr Metab Disord. 2012;13:309-18 pubmed publisher
immunohistochemistry; human	Ioannou M, Pyrpasopoulou A, Simos G, Paraskeva E, Nikolaidou C, Venizelos I, et al. Upregulation of VEGF expression is associated with accumulation of HIF-1? in the skin of naïve scleroderma patients. Mod Rheumatol. 2013;23:1245-8 pubmed publisher
immunohistochemistry; human	Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, et al. MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma. Int J Urol. 2013;20:468-77 pubmed publisher
western blot; human	Salem A, Howell A, Sartini M, Sotgia F, Lisanti M. Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1?, autophagy and ketone body production. Cell Cycle. 2012;11:4167-73 pubmed publisher
western blot; mouse	Clarke D, Al Ahmad A, Lee B, Parham C, Auckland L, Fertala A, et al. Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin ?5?1 and ERK-dependent signaling pathways. PLoS ONE. 2012;7:e45257 pubmed publisher
immunocytochemistry; rat immunohistochemistry; rat	Ding A, Kalaignanasundaram P, Ricardo S, Abdelkader A, Witting P, Broughton B, et al. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clin Exp Pharmacol Physiol. 2012;39:917-29 pubmed publisher
immunohistochemistry - paraffin section; mouse	Gu H, Zheng X, Abu Seman N, Gu T, Botusan I, Sunkari V, et al. Impact of the hypoxia-inducible factor-1 ? (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. Diabetes Care. 2013;36:415-21 pubmed publisher
western blot; human	Zhao Y, Xiong X, Jia L, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death Dis. 2012;3:e386 pubmed publisher
immunohistochemistry; human	Mhawech Fauceglia P, Wang D, Samrao D, Menesses T, Godoy H, Ough F, et al. The role of hypoxic-inducible factor (HIF1?) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients. BMJ Open. 2012;2: pubmed publisher
immunocytochemistry; human western blot; human	Chiavarina B, Martinez Outschoorn U, Whitaker Menezes D, Howell A, Tanowitz H, Pestell R, et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1? and HIF2? in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle. 2012;11:3280-9 pubmed publisher
immunohistochemistry; human	Mayer A, Schneider F, Vaupel P, Sommer C, Schmidberger H. Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. Int J Oncol. 2012;41:1260-70 pubmed publisher
immunohistochemistry; human western blot; human	Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu G, et al. Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol. 2012;48:1120-7 pubmed publisher
western blot; rat	Jiang W, Zhu Z, McGinley J, El Bayoumy K, Manni A, Thompson H. Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids. Cancer Res. 2012;72:3795-806 pubmed publisher
flow cytometry; human immunocytochemistry; human	Galzio R, Cristiano L, Fidoamore A, Cifone M, Benedetti E, Cinque B, et al. Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy. J Cell Biochem. 2012;113:3342-52 pubmed publisher
immunohistochemistry; human	Weber D, Tille J, Combescure C, Egger J, Laouiti M, Hammad K, et al. The prognostic value of expression of HIF1?, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy. Radiat Oncol. 2012;7:66 pubmed publisher
immunohistochemistry; human	Chaux A, Schultz L, Albadine R, Hicks J, Kim J, Allaf M, et al. Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas. Hum Pathol. 2012;43:2129-37 pubmed publisher
western blot; human	Jeong C, Yoon C, Jeong S, Hong S, Byun S, Kwak C, et al. The role of hypoxia-inducible factor-1? and -2? in androgen insensitive prostate cancer cells. Urol Oncol. 2013;31:1448-56 pubmed publisher
immunohistochemistry - paraffin section; human western blot; human	Kaira K, Serizawa M, Koh Y, Takahashi T, Hanaoka H, Oriuchi N, et al. Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma. Eur J Cancer. 2012;48:1244-54 pubmed publisher
immunohistochemistry - paraffin section; mouse	Hölscher M, Schafer K, Krull S, Farhat K, Hesse A, Silter M, et al. Unfavourable consequences of chronic cardiac HIF-1α stabilization. Cardiovasc Res. 2012;94:77-86 pubmed publisher
immunohistochemistry; human	Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, et al. L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma. Anticancer Res. 2011;31:4075-82 pubmed
immunocytochemistry; rat western blot; rat	Chu W, Wan L, Zhao D, Qu X, Cai F, Huo R, et al. Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1?-mediated TRPC signalling. J Cell Mol Med. 2012;16:2022-34 pubmed publisher
immunohistochemistry; human	Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, et al. 18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study. Eur J Radiol. 2012;81:2423-9 pubmed publisher
immunohistochemistry; human	Kaira K, Okumura T, Nakagawa K, Ohde Y, Takahashi T, Murakami H, et al. MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer. Pathol Oncol Res. 2012;18:439-47 pubmed publisher
immunohistochemistry; human	Kaira K, Ohde Y, Nakagawa K, Okumura T, Murakami H, Takahashi T, et al. Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma. Med Oncol. 2012;29:1663-72 pubmed publisher
western blot; human	Sreekumar P, Hinton D, Kannan R. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World J Biol Chem. 2011;2:184-92 pubmed publisher
immunohistochemistry; human	Peurala E, Koivunen P, Bloigu R, Haapasaari K, Jukkola Vuorinen A. Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients. Breast Cancer Res Treat. 2012;133:179-88 pubmed publisher
western blot; mouse	Schneider C, Krischke G, Rascher W, Gassmann M, Trollmann R. Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation. Brain Dev. 2012;34:261-73 pubmed publisher
immunohistochemistry; human	Kaira K, Ohde Y, Endo M, Nakagawa K, Okumura T, Takahashi T, et al. Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors. Oncol Rep. 2011;26:931-7 pubmed publisher
immunohistochemistry; human	Monzon F, Alvarez K, Peterson L, Truong L, Amato R, Hernandez McClain J, et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol. 2011;24:1470-9 pubmed publisher
immunohistochemistry - paraffin section; mouse immunocytochemistry; mouse	Evenou F, Hamon M, Fujii T, Takeuchi S, Sakai Y. Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues. Biotechnol Prog. 2011;27:1146-53 pubmed publisher
western blot; mouse	Namas R, Metukuri M, Dhupar R, Velosa C, Jefferson B, Myer E, et al. Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1? in mouse hepatocytes. Shock. 2011;36:196-202 pubmed publisher
western blot; human	Park H, Baek K, Lee H, Kwon A, Hwang H, Qadir A, et al. Hypoxia inducible factor-1? directly induces the expression of receptor activator of nuclear factor-?B ligand in periodontal ligament fibroblasts. Mol Cells. 2011;31:573-8 pubmed publisher
immunohistochemistry; human	Weroha S, Oberg A, Ziegler K, Dakhilm S, Rowland K, Hartmann L, et al. Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma. Gynecol Oncol. 2011;122:116-20 pubmed publisher
immunohistochemistry - paraffin section; human immunohistochemistry; human	Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Oriuchi N, et al. Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors. J Nucl Med. 2011;52:705-11 pubmed publisher
western blot; rat	Huang L, Chuang I, Dong H, Yang R. Hypoxia-inducible factor 1? regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver. Shock. 2011;36:90-6 pubmed publisher
immunohistochemistry - paraffin section; mouse	Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem. 2011;286:11185-94 pubmed publisher
western blot; rat	Gibbings S, Elkins N, Fitzgerald H, Tiao J, Weyman M, Shibao G, et al. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}. J Biol Chem. 2011;286:961-75 pubmed publisher
immunohistochemistry; human	Monsef N, Soller M, Panagopoulos I, Abrahamsson P. HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation. BMC Cancer. 2010;10:385 pubmed publisher
immunohistochemistry; human	Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, et al. Biologic correlates of ¹?F-FDG uptake on PET in pulmonary pleomorphic carcinoma. Lung Cancer. 2011;71:144-50 pubmed publisher
immunohistochemistry; human	Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, et al. Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors. J Clin Oncol. 2010;28:3746-53 pubmed publisher
western blot; human	Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, et al. Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay. Oncol Rep. 2010;24:161-9 pubmed
immunohistochemistry; human	Choudhury K, Yagle K, Swanson P, Krohn K, Rajendran J. A robust automated measure of average antibody staining in immunohistochemistry images. J Histochem Cytochem. 2010;58:95-107 pubmed publisher
immunohistochemistry - paraffin section; mouse immunocytochemistry; mouse western blot; mouse	Lee D, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal M, et al. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J Biol Chem. 2009;284:29065-76 pubmed publisher
immunohistochemistry; human	Evenou F, Fujii T, Sakai Y. Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane. Tissue Eng Part C Methods. 2010;16:311-8 pubmed publisher
immunohistochemistry - paraffin section; human western blot; human	Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed publisher
immunocytochemistry; rat western blot; rat	Rhoads R, Johnson R, Rathbone C, Liu X, Temm Grove C, Sheehan S, et al. Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway. Am J Physiol Cell Physiol. 2009;296:C1321-8 pubmed publisher
immunohistochemistry; pigs	Gossl M, Versari D, Lerman L, Chade A, Beighley P, Erbel R, et al. Low vasa vasorum densities correlate with inflammation and subintimal thickening: potential role in location--determination of atherogenesis. Atherosclerosis. 2009;206:362-8 pubmed publisher
chromatin immunoprecipitation; human	Hatipoglu O, Hirohata S, Cilek M, Ogawa H, Miyoshi T, Obika M, et al. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. J Biol Chem. 2009;284:16325-33 pubmed publisher
immunohistochemistry - paraffin section; mouse	Stagg J, Sharkey J, Pommey S, Young R, Takeda K, Yagita H, et al. Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response. Proc Natl Acad Sci U S A. 2008;105:16254-9 pubmed publisher
immunohistochemistry - paraffin section; human	Flynn J, Wang L, Gillespie D, Stoddard G, Reid J, Owens J, et al. Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme. Cancer. 2008;113:1032-42 pubmed publisher
immunohistochemistry - paraffin section; rat	Rosenberger C, Rosen S, Shina A, Frei U, Eckardt K, Flippin L, et al. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant. 2008;23:3472-8 pubmed publisher
western blot; rat western blot; mouse	Radek K, Kovacs E, Gallo R, DiPietro L. Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol. 2008;295:H174-84 pubmed publisher
immunohistochemistry - paraffin section; human	Klatte T, Seligson D, Riggs S, Leppert J, Berkman M, Kleid M, et al. Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clin Cancer Res. 2007;13:7388-93 pubmed
immunohistochemistry - paraffin section; human	Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, et al. Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat. 2008;110:465-75 pubmed
chromatin immunoprecipitation; mouse	Tracy K, Dibling B, Spike B, Knabb J, Schumacker P, Macleod K. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007;27:6229-42 pubmed
immunocytochemistry; human	Monsef N, Helczynski L, Lundwall A, Påhlman S. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate. 2007;67:1219-29 pubmed
immunohistochemistry; human western blot; human	Anderson K, Tsui P, Guinan P, Rubenstein M. The proliferative response of hela cells to 2-deoxy-D-glucose under hypoxic or anoxic conditions: an analogue for studying some properties of in vivo solid cancers. Anticancer Res. 2006;26:4155-62 pubmed
western blot; mouse	Gagnon P, Simmons D, Bao J, Lei D, Ortmann A, Ohlemiller K. Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice. Hear Res. 2007;226:79-91 pubmed
ELISA; mouse ELISA; human	Ramanathan M, Pinhal Enfield G, Hao I, Leibovich S. Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell. 2007;18:14-23 pubmed
immunohistochemistry - paraffin section; rat immunocytochemistry; rat immunohistochemistry; rat	Khan Z, Michalopoulos G, Stolz D. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006;169:1251-69 pubmed
western blot; mouse western blot; human	An H, Maeng O, Kang K, Lee J, Kim Y, Paik S, et al. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem. 2006;281:33939-48 pubmed
western blot; mouse	Laderoute K, Amin K, Calaoagan J, Knapp M, Le T, Orduna J, et al. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol. 2006;26:5336-47 pubmed
immunoprecipitation; domestic rabbit western blot; domestic rabbit	Zheng X, Ruas J, Cao R, Salomons F, Cao Y, Poellinger L, et al. Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Mol Cell Biol. 2006;26:4628-41 pubmed
immunohistochemistry - paraffin section; human western blot; human	Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung A, et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res. 2006;66:3639-48 pubmed
immunohistochemistry; human	Michelsen J, Thiesson H, Walter S, Ottosen P, Skøtt O, Jensen B. Tissue expression and plasma levels of adrenomedullin in renal cancer patients. Clin Sci (Lond). 2006;111:61-70 pubmed
immunocytochemistry; human western blot; human	Lu H, Dalgard C, Mohyeldin A, McFate T, Tait A, Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem. 2005;280:41928-39 pubmed
western blot; mouse	Murphy B, Sato B, Dalton T, Laderoute K. The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress. Biochem Biophys Res Commun. 2005;337:860-7 pubmed
ELISA; human	Isaacs J, Jung Y, Mole D, Lee S, Torres Cabala C, Chung Y, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 2005;8:143-53 pubmed
western blot; rat	Brown N, Streeter E, Jones A, Harris A, Bicknell R. Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma. Br J Cancer. 2005;92:1696-701 pubmed
immunohistochemistry; rat	Luyendyk J, Maddox J, Green C, Ganey P, Roth R. Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology. 2004;40:1342-51 pubmed
immunohistochemistry - paraffin section; human	TEZEL G, Wax M. Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch Ophthalmol. 2004;122:1348-56 pubmed
immunohistochemistry; human	Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet. 2004;5:27 pubmed
immunocytochemistry; human	Uchida T, Rossignol F, Matthay M, Mounier R, Couette S, Clottes E, et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem. 2004;279:14871-8 pubmed
immunohistochemistry - paraffin section; mouse	de Candia P, Solit D, Giri D, Brogi E, Siegel P, Olshen A, et al. Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. Proc Natl Acad Sci U S A. 2003;100:12337-42 pubmed
immunohistochemistry; human	Burke B, Giannoudis A, Corke K, Gill D, Wells M, Ziegler Heitbrock L, et al. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol. 2003;163:1233-43 pubmed
immunohistochemistry - paraffin section; human	Mandriota S, Turner K, Davies D, Murray P, Morgan N, Sowter H, et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell. 2002;1:459-68 pubmed
immunocytochemistry; human	Fujii T, Otsuki T, Moriya T, Sakaguchi H, Kurebayashi J, Yata K, et al. Effect of hypoxia on human seminoma cells. Int J Oncol. 2002;20:955-62 pubmed
western blot; human	Tang T, Arbiser J, Brandt S. Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. J Biol Chem. 2002;277:18365-72 pubmed
western blot; human	Duyndam M, Hulscher T, Fontijn D, Pinedo H, Boven E. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem. 2001;276:48066-76 pubmed
western blot; human	Tacchini L, Dansi P, Matteucci E, Desiderio M. Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis. 2001;22:1363-71 pubmed
immunohistochemistry - paraffin section; human western blot; human immunohistochemistry - paraffin section; mouse western blot; mouse	Zhong H, De Marzo A, Laughner E, Lim M, Hilton D, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830-5 pubmed
	Kerry J, Specker E, Mizzoni M, Brumwell A, Fell L, Goodbrand J, et al. Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival. FEBS Lett. 2024;598:503-520 pubmed publisher
	Clark E, Kase Tanno L, Vo T, Blanc B, Demoly P, Caimmi D. Anaphylaxis management in a French pediatric emergency department: Lessons from the ANA-PED study. Clin Transl Allergy. 2023;13:e12289 pubmed publisher
	Yeh J, Kuo C, Shih P, Hsu J, I Chen P, Huang Y. Xanthine derivative KMUP-1 ameliorates retinopathy. Biomed Pharmacother. 2023;165:115109 pubmed publisher
	Heyer V, Reina San Martin B. Optimal AID expression and efficient immunoglobulin class switch recombination are dependent on the hypoxia-inducible factor. Eur J Immunol. 2023;53:e2350373 pubmed publisher
	Li X, Ma T, Wang M, Zhang X, Liu T, Liu Y, et al. YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway. Front Pharmacol. 2023;14:1069348 pubmed publisher
	Zheng Z, Xu T, Liu Z, Tian W, Jiang Z, Zhu G, et al. Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis. Biomed Pharmacother. 2022;153:113319 pubmed publisher
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product information

master code :

NB100-123

SKU :

NB100-123

product name :

HIF-1 alpha Antibody (H1alpha67)

unit size :

0.1 ml (also 0.025 ml)

description :

The HIF-1 alpha Antibody (H1alpha67) from Novus is a mouse monoclonal antibody to HIF-1 alpha. This antibody reacts with avian,bovine,canine,ferret,human,mouse,ovine,porcine,primate,rabbit,rat,sheep. The HIF-1 alpha Antibody (H1alpha67) has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry,Simple Western,Chemotaxis,IF/IHC,ELISA,Flow Cytometry,Immunoprecipitation,Gel Supershift Assay,Knockout Validated,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunoblotting,Gel Super Shift Assays,Chromatin Immunoprecipitation (ChIP),Knockdown Validated.

target :

HIF-1 alpha

category :

Primary Antibodies

buffer :

PBS with 1% BSA

clonality :

Monoclonal

clone :

H1alpha67

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

This HIF-1 alpha Antibody (H1alpha67) was developed against a fusion protein containing amino acids 432 - 528 of human HIF-1 alpha [Uniprot# Q16665].

isotype :

IgG2b

purity :

Protein A purified

species :

Avian,Bovine,Canine,Ferret,Human,Mouse,Ovine,Porcine,Primate,Rabbit,Rat,Sheep

theoretical molecular weight :

93 kDa

gene symbol :

HIF1A

Antibody validation :

Biological Validation

applications :

Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Chemotaxis,IF/IHC,ELISA,Flow Cytometry,Immunoprecipitation,Gel Supershift Assay,Knockout Validated,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Immunoblotting,Gel Super Shift Assays,Chromatin Immunoprecipitation (ChIP),Knockdown Validated

USD :

469 USD

alt names :

AINT, anti-HIF-1 alpha, anti-HIF1A, ARNT interacting protein, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, H1alpha67, HIF1, HIF-1 alpha, HIF1A, HIF-1A, HIF-1alpha, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1, PAS domain-containing protein 8, PASD8

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage