| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig 3
- western blot; human; fig 3
| Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 1d, s2
- western blot; human; 1:1000; loading ...; fig 1a
| Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, et al. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Sci Adv. 2021;7: pubmed publisher |
- western blot; mouse; fig 3c
| Geng G, Liu J, Xu C, Pei Y, Chen L, Mu C, et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. elife. 2021;10: pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 1d
- western blot; mouse; loading ...; fig 1b
| Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2f, 2g
| Dufies M, Verbiest A, Cooley L, Ndiaye P, He X, Nottet N, et al. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Commun Biol. 2021;4:166 pubmed publisher |
- western blot; mouse; loading ...; fig 1a, 5b
| Lee Y, Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019;5:eaaw4176 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 4c
| Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed publisher |
- western blot; mouse; loading ...; fig s4c
| Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson J. Putative role of NF-kB but not HIF-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells. Antioxid Redox Signal. 2019;: pubmed publisher |
- western blot; mouse; 1:100; loading ...; fig 1j
| Santana Codina N, Gableske S, Quiles Del Rey M, Małachowska B, Jedrychowski M, Biancur D, et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019;: pubmed publisher |
- western blot; mouse; loading ...; fig 6c
| Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; fig 2g
| Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed publisher |
- immunohistochemistry - frozen section; mouse; loading ...; fig 3b
| Kim Y, Lee M, Gu H, Kim J, Jeong S, Yeo S, et al. HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice. Dis Model Mech. 2018;11: pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 1d
| Bäcker V, Cheung F, Siveke J, Fandrey J, Winning S. Knockdown of myeloid cell hypoxia-inducible factor-1? ameliorates the acute pathology in DSS-induced colitis. PLoS ONE. 2017;12:e0190074 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| He X, Zeng H, Chen S, Roman R, Aschner J, Didion S, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104-113 pubmed publisher |
- western blot; human; 1:500; tbl s1
| Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed publisher |
- immunocytochemistry; mouse; 1:200; loading ...; fig 6c
- western blot; mouse; loading ...; fig 6a
| Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed publisher |
- western blot; mouse; loading ...; fig 5b
| Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed publisher |
- western blot; human; loading ...; fig s2
| Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed publisher |
- western blot; human; fig 1e
| Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4f
| Chen W, Hill H, Christie A, Kim M, Holloman E, Pavía Jiménez A, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016;539:112-117 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Lee M, Huang H, Chang T, Huang H, Hsieh S, Chen Y, et al. Genome-wide analysis of HIF-2? chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep. 2016;6:29311 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3a
| Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed publisher |
- western blot; human; loading ...; fig 1a
- western blot; African green monkey; loading ...; fig 3
| Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed publisher |
- immunohistochemistry; human; fig 1B
- western blot; human; 1:500; fig 1B
| Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
| Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed publisher |
- chromatin immunoprecipitation; human; 1:150; loading ...; fig 3b
| Brooks D, Schwab L, Krutilina R, Parke D, Sethuraman A, Hoogewijs D, et al. ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer. 2016;15:26 pubmed publisher |
- western blot; human; fig 3
| German P, Bai S, Liu X, Sun M, Zhou L, Kalra S, et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016;35:4973-80 pubmed publisher |
- western blot; human; fig 1c
| Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed publisher |
- western blot; mouse; 1:1000; fig 4f
| Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher |
- chromatin immunoprecipitation; human; fig 10
- immunoprecipitation; human; fig 1
- western blot; human; fig 1
| Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed publisher |
- chromatin immunoprecipitation; human; fig 4d
- western blot; human; fig 2a
| Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed publisher |
- western blot; mouse; 1:1000; fig s2
| Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed publisher |
- western blot; human; 1:500; fig 7
| Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed publisher |
- immunocytochemistry; human; 1:100; fig 4
- western blot; human; 1:500; fig 3
| Aquino Gálvez A, González Ãvila G, Delgado Tello J, Castillejos López M, Mendoza Milla C, Zúñiga J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016;35:577-83 pubmed publisher |
- immunoprecipitation; human; 1:2000; loading ...; fig 2a
| Taïeb D, Barlier A, Yang C, Pertuit M, Tchoghandjian A, Rochette C, et al. Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas. J Neurooncol. 2016;126:473-81 pubmed publisher |
| Zhu M, Dai J, Dai Z, Peng Y, Zhao Y. GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension. JCI Insight. 2024;9: pubmed publisher |
| Czopik A, McNamee E, Vaughn V, Huang X, Bang I, Clark T, et al. HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis. Nat Commun. 2024;15:8042 pubmed publisher |
| Dvorakova T, Finisguerra V, Formenti M, Loriot A, Boudhan L, Zhu J, et al. Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cells. Nat Commun. 2024;15:7789 pubmed publisher |
| Peng S, Guo Y, Irondelle M, Mazzu A, Kahi M, Ferreira Montenegro P, et al. The marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes. Cell Mol Biol Lett. 2024;29:101 pubmed publisher |
| Ting K, Yu P, Dow R, Ibrahim H, Karim S, Polenz C, et al. Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway. Sci Rep. 2024;14:11162 pubmed publisher |
| Nguyen C, Col xf3 n Emeric B, Murakami S, Shujath M, Yi C. PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer. Cell Rep. 2024;43:114176 pubmed publisher |
| Billig S, Hein M, Kirchner C, Schumacher D, Habigt M, Mechelinck M, et al. Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury. Biomedicines. 2024;12: pubmed publisher |
| Saddouk F, Kuzemczak A, Saito J, Greif D. Endothelial HIFα/PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI Insight. 2024;9: pubmed publisher |
| Prajapati M, Zhang J, Chiu L, Chong G, Mercadante C, Kowalski H, et al. Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency. JCI Insight. 2024;9: pubmed publisher |
| Martin J, Bernstein I, Lyons J, Brady A, Mabotuwana N, Stanger S, et al. EPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary. Sci Rep. 2024;14:8770 pubmed publisher |
| Nolan N, Cui X, Robbings B, Demirkol A, Pandey K, Wu W, et al. CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa. Cell Rep Med. 2024;5:101459 pubmed publisher |
| Jeong J, Kang B, Ju S, Park N, Kim D, Dinh N, et al. Lactiplantibacillus plantarum K8 lysates regulate hypoxia-induced gene expression. Sci Rep. 2024;14:6275 pubmed publisher |
| Luomala L, Mattila K, Vainio P, Nis xe9 n H, Pellinen T, Lohi J, et al. Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma. Cancer Med. 2024;13:e6998 pubmed publisher |
| Kerry J, Specker E, Mizzoni M, Brumwell A, Fell L, Goodbrand J, et al. Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival. FEBS Lett. 2024;598:503-520 pubmed publisher |
| Kim Y, Park N, Jo D, Bae J, Kim J, Park K, et al. Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells. Molecules. 2024;29: pubmed publisher |
| Wittig F, Koch F, Pannenberg L, Bekeschus S, Ramer R, Hinz B. β-Caryophyllene Inhibits Endothelial Tube Formation by Modulating the Secretome of Hypoxic Lung Cancer Cells-Possible Role of VEGF Downregulation. Int J Mol Sci. 2024;25: pubmed publisher |
| DeFrates K, Tong E, Cheng J, Heber Katz E, Messersmith P. A Pro-Regenerative Supramolecular Prodrug Protects Against and Repairs Colon Damage in Experimental Colitis. Adv Sci (Weinh). 2024;11:e2304716 pubmed publisher |
| Kim H, Liu Y, Kim J, Kim Y, Klouda T, Fisch S, et al. Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling. EMBO Rep. 2024;25:616-645 pubmed publisher |
| Nakai A, Lee D, Shoda C, Negishi K, Nakashizuka H, Yamagami S, et al. Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells. J Ophthalmol. 2023;2023:6617981 pubmed publisher |
| Suh J, Kim H, Min J, Yeon H, Hemberg M, Scimeca L, et al. Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis. Cell Rep Med. 2023;:101342 pubmed publisher |
| Li H, Song C, Zhang Y, Liu G, Mi H, Li Y, et al. Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation. Adv Sci (Weinh). 2023;:e2305620 pubmed publisher |
| Bernstein I, Nixon B, Lyons J, Damyanova K, De Oliveira C, Mabotuwana N, et al. The hypoxia-inducible factor EPAS1 is required for spermatogonial stem cell function in regenerative conditions. iScience. 2023;26:108424 pubmed publisher |
| Liao Q, Deng H, Wang Z, Yu G, Zhu C, Jia S, et al. Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance. J Biol Chem. 2023;299:105420 pubmed publisher |
| Contenti J, Guo Y, Larcher M, Mirabal Ortega L, Rouleau M, Irondelle M, et al. HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. bioRxiv. 2023;: pubmed publisher |
| Henning Y, Willbrand K, Larafa S, Wei xdf enberg G, Matschke V, Theiss C, et al. Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia. Cell Death Discov. 2023;9:398 pubmed publisher |
| Wittig F, Pannenberg L, Schwarz R, Bekeschus S, Ramer R, Hinz B. Antiangiogenic Action of JZL184 on Endothelial Cells via Inhibition of VEGF Expression in Hypoxic Lung Cancer Cells. Cells. 2023;12: pubmed publisher |
| Zhang F, Zhang B, Wang Y, Jiang R, Liu J, Wei Y, et al. An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature. 2023;622:834-841 pubmed publisher |
| Ting K, Yu P, Dow R, Floro E, Ibrahim H, Scipione C, et al. Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway. J Immunol. 2023;211:1561-1577 pubmed publisher |
| Alexander K, Yu R, Skuli N, Coffey N, Nguyen S, Faunce C, et al. Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer. bioRxiv. 2023;: pubmed publisher |
| Hall C, Lanis J, Dowdell A, Murphy E, Bhagavatula G, Neuhart R, et al. Fundamental role for the creatine kinase pathway in protection from murine colitis. Mucosal Immunol. 2023;16:817-825 pubmed publisher |
| Liao Q, Zhu C, Sun X, Wang Z, Chen X, Deng H, et al. Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. J Biol Chem. 2023;:105074 pubmed publisher |
| Zhang T, Xu D, Liu J, Wang M, Duan L, Liu M, et al. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nat Cell Biol. 2023;25:950-962 pubmed publisher |
| Kubaichuk K, Kietzmann T. USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis. Cells. 2023;12: pubmed publisher |
| Yue Y, Tang Y, Huang H, Zheng D, Liu C, Zhang H, et al. VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. J Biol Chem. 2023;299:104829 pubmed publisher |
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| Qu M, Long Y, Wang Y, Yin N, Zhang X, Zhang J. Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner. Int J Mol Sci. 2023;24: pubmed publisher |
| Leu T, Denda J, Wrobeln A, Fandrey J. Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog. Mol Cell Biol. 2023;43:174-183 pubmed publisher |
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| Sun H, Pratt R, Dzau V, Hodgkinson C. Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity. J Biol Chem. 2023;299:104694 pubmed publisher |
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| Ye J, Chen J, Li Y, Sun L, Lu H. Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon tetrachloride-induced liver fibrosis in mice. Peerj. 2023;11:e15191 pubmed publisher |
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| Sabharwal S, Dudley V, Landwerlin C, Schumacker P. H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo. J Biol Chem. 2023;299:104624 pubmed publisher |
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| Colson A, Depoix C, Lambert I, Leducq C, Bedin M, De Beukelaer M, et al. Specific HIF-2α (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP). Hypertension. 2023;80:1011-1023 pubmed publisher |
| Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, et al. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Rep. 2023;42:112164 pubmed publisher |
| Kostyunina D, Rowan S, Pakhomov N, Dillon E, Rochfort K, Cummins P, et al. Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells. Am J Respir Cell Mol Biol. 2023;68:551-565 pubmed publisher |
| Quan Y, Dai J, Zhou S, Zhao L, Jin L, Long Y, et al. HIF2α-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma. FEBS Open Bio. 2023;13:638-654 pubmed publisher |
| Hashimoto Y, Tsuzuki Nakao T, Kida N, Matsuo Y, Maruyama T, Okada H, et al. Inflammatory Cytokine-Induced HIF-1 Activation Promotes Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells. Biomedicines. 2023;11: pubmed publisher |
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| Chen Z, Bordieanu B, Kesavan R, Lesner N, Venigalla S, Shelton S, et al. Lactate metabolism is essential in early-onset mitochondrial myopathy. Sci Adv. 2023;9:eadd3216 pubmed publisher |
| Park S, Yoo H, Ahn E, Luo E, Kim Y, Sung Y, et al. Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer. Cancer Res. 2023;: pubmed publisher |
| D xe1 tilo M, Formigari G, de Faria J, de Faria J. AMP kinase activation by Omega-3 polyunsaturated fatty acid protects the retina against ischemic insult: An in vitro and in vivo study. Exp Eye Res. 2023;226:109345 pubmed publisher |
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| Al Gharaibeh N, Shively S, Vortmeyer A. Characterization of Microscopic Multicellular Foci in Grossly Normal Renal Parenchyma of Von Hippel-Lindau Kidney. Medicina (Kaunas). 2022;58: pubmed publisher |
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| Li G, Liu J, Guo M, Gu Y, Guan Y, Shao Q, et al. Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation. Cell Death Discov. 2022;8:473 pubmed publisher |
| Chen Y, Cattoglio C, Dailey G, Zhu Q, Tjian R, Darzacq X. Mechanisms governing target search and binding dynamics of hypoxia-inducible factors. elife. 2022;11: pubmed publisher |
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| Ma Q, Beal J, Song X, Bhurke A, Bagchi I, Bagchi M. Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy. Endocrinology. 2022;163: pubmed publisher |
| Dowdell A, Cartwright I, Kitzenberg D, Kostelecky R, Mahjoob O, Saeedi B, et al. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022;40:111409 pubmed publisher |
| Tiwari R, Bommi P, Gao P, Schipma M, Zhou Y, Quaggin S, et al. Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming. iScience. 2022;25:105086 pubmed publisher |
| Melanson G, Du Bois A, Webster C, Uniacke J. ISGylation directly modifies hypoxia-inducible factor-2α and enhances its polysome association. FEBS Lett. 2022;596:2834-2850 pubmed publisher |
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| Zhang B, Chen Y, Bao L, Luo W. GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth. Cells. 2022;11: pubmed publisher |
| Yan M, Komatsu N, Muro R, Huynh N, Tomofuji Y, Okada Y, et al. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Nat Immunol. 2022;23:1330-1341 pubmed publisher |
| Henning Y, Blind U, Larafa S, Matschke J, Fandrey J. Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction. Cell Death Dis. 2022;13:662 pubmed publisher |
| Ji L, Su S, Xin M, Zhang Z, Nan X, Li Z, et al. Luteolin ameliorates hypoxia-induced pulmonary hypertension via regulating HIF-2α-Arg-NO axis and PI3K-AKT-eNOS-NO signaling pathway. Phytomedicine. 2022;104:154329 pubmed publisher |
| Tapio J, Halmetoja R, Dimova E, M xe4 ki J, Laitala A, Walkinshaw G, et al. Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism. J Biol Chem. 2022;298:102222 pubmed publisher |
| Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, et al. Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome. Nat Metab. 2022;4:739-758 pubmed publisher |
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