| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 4c
| Yang C, Sengupta S, Hegde P, Mitra J, Jiang S, Holey B, et al. Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic Acids Res. 2017;45:739-748 pubmed publisher |
- western blot; mouse; fig 5e
| Amenya H, Tohyama C, Ohsako S. Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver. Sci Rep. 2016;6:34989 pubmed publisher |
- western blot; mouse; fig s6
| Ahuja A, Jodkowska K, Teloni F, Bizard A, Zellweger R, Herrador R, et al. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016;7:10660 pubmed publisher |
| Pojo M, Gonçalves C, Xavier Magalhães A, Oliveira A, Gonçalves T, Correia S, et al. A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide. Oncotarget. 2015;6:7657-74 pubmed |
- chromatin immunoprecipitation; human
| Yang S, Zhang J, Zhang Y, Wan X, Zhang C, Huang X, et al. KDM1A triggers androgen-induced miRNA transcription via H3K4me2 demethylation and DNA oxidation. Prostate. 2015;75:936-46 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Woo J, Park H, Sung S, Moon B, Suh H, Lim W. Prognostic value of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in breast cancer. PLoS ONE. 2014;9:e99528 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Xie J, Zhang L, Li M, Du J, Zhou L, Yang S, et al. Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma. BMC Cancer. 2014;14:11 pubmed publisher |
| Karmahapatra S, Saha T, Adhikari S, Woodrick J, Roy R. Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis. Mol Cell Biochem. 2014;388:185-93 pubmed publisher |
- chromatin immunoprecipitation; human
- immunoprecipitation; human
| Madlener S, Strobel T, Vose S, Saydam O, Price B, Demple B, et al. Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance. Proc Natl Acad Sci U S A. 2013;110:17844-9 pubmed publisher |
- chromatin immunoprecipitation; human
- immunoprecipitation; human
| Sengupta S, Mitra S, Bhakat K. Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression. PLoS ONE. 2013;8:e68467 pubmed publisher |
| Cun Y, Dai N, Xiong C, Li M, Sui J, Qian C, et al. Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model. PLoS ONE. 2013;8:e55313 pubmed publisher |
| Chen S, Xiong G, Wu S, Mo J. Downregulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 enhances the sensitivity of human pancreatic cancer cells to radiotherapy in vitro. Cancer Biother Radiopharm. 2013;28:169-76 pubmed publisher |
- immunocytochemistry; mouse
| Linke M, May A, Reifenberg K, Haaf T, Zechner U. The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos. Cytogenet Genome Res. 2013;139:71-9 pubmed publisher |
| Corniola R, Zou Y, Leu D, Fike J, Huang T. Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects. PLoS ONE. 2012;7:e49367 pubmed publisher |
- immunocytochemistry; mouse
| Singh S, Englander E. Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons. Free Radic Biol Med. 2012;53:1782-90 pubmed publisher |
- immunohistochemistry; human
| Cai X, Wang J, Xin X. CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer. World J Surg Oncol. 2012;10:112 pubmed publisher |
| Hill J, Poddar R, Thompson J, Rosenberg G, Yang Y. Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons. Neuroscience. 2012;220:277-90 pubmed publisher |
- immunocytochemistry; mouse
| Siddiqui A, Rivera Sánchez S, Castro M, Acevedo Torres K, Rane A, Torres Ramos C, et al. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. Free Radic Biol Med. 2012;53:1478-88 pubmed publisher |
- chromatin immunoprecipitation; rat
- chromatin immunoprecipitation; human
| Clark D, Phang T, Edwards M, Geraci M, Gillespie M. Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription. Free Radic Biol Med. 2012;53:51-9 pubmed publisher |
| Li M, Vascotto C, Xu S, Dai N, Qing Y, Zhong Z, et al. Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1. Free Radic Biol Med. 2012;53:237-48 pubmed publisher |
- immunoprecipitation; human
- immunoprecipitation; rat
| Mantha A, Dhiman M, Taglialatela G, Perez Polo R, Mitra S. Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J Neurosci Res. 2012;90:1230-9 pubmed publisher |
| Castro M, Suarez E, Kraiselburd E, Isidro A, Paz J, Ferder L, et al. Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Exp Gerontol. 2012;47:29-37 pubmed publisher |
- EMSA; human
- immunoprecipitation; human
- western blot; human
| Zhang Z, Yang X, Wang D, Wang G, Yang Z, Qing Y, et al. Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells. Cell Biochem Biophys. 2011;61:561-72 pubmed publisher |
- chromatin immunoprecipitation; human
| Luo W, Hu H, Chang R, Zhong J, Knabel M, O Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145:732-44 pubmed publisher |
| Singh Gupta V, Joiner M, Runyan L, Yunker C, Sarkar F, Miller S, et al. Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. J Thorac Oncol. 2011;6:688-98 pubmed publisher |
| Jaiswal A, Narayan S. Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity. Biochemistry. 2011;50:1901-9 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Bobola M, Jankowski P, Gross M, Schwartz J, Finn L, Blank A, et al. Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma. Int J Cancer. 2011;129:2370-9 pubmed publisher |
| Warters R, Cassidy P, Sunseri J, Parsawar K, Zhuplatov S, Kramer G, et al. The nuclear matrix shell proteome of human epidermis. J Dermatol Sci. 2010;58:113-22 pubmed publisher |
- chromatin immunoprecipitation; mouse
- immunoprecipitation; mouse
- chromatin immunoprecipitation; human
- immunoprecipitation; human
| Ray S, Lee C, Hou T, Bhakat K, Brasier A. Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response. Mol Endocrinol. 2010;24:391-401 pubmed publisher |
- immunohistochemistry - paraffin section; mouse
| Jones L, Ying L, Hofseth A, Jelezcova E, Sobol R, Ambs S, et al. Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Carcinogenesis. 2009;30:2123-9 pubmed publisher |
| Batuello C, Kelley M, Dynlacht J. Role of Ape1 and base excision repair in the radioresponse and heat-radiosensitization of HeLa Cells. Anticancer Res. 2009;29:1319-25 pubmed |
| Unnikrishnan A, Raffoul J, Patel H, Prychitko T, Anyangwe N, Meira L, et al. Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice. Free Radic Biol Med. 2009;46:1488-99 pubmed publisher |
- chromatin immunoprecipitation; human
- immunocytochemistry; human
| Chattopadhyay R, Das S, Maiti A, Boldogh I, Xie J, Hazra T, et al. Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol. 2008;28:7066-80 pubmed publisher |
- immunocytochemistry; mouse
| May A, Kirchner R, Muller H, Hartmann P, El Hajj N, Tresch A, et al. Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres. Biol Reprod. 2009;80:194-202 pubmed publisher |
| Breit J, Ault Ziel K, Al Mehdi A, Gillespie M. Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter. FASEB J. 2008;22:19-29 pubmed |
| Yang S, Misner B, Chiu R, Meyskens F. Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells. Carcinogenesis. 2007;28:2382-90 pubmed |
- immunocytochemistry; human
| Lam W, Leung C, Bussom S, Cheng Y. The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine. Mol Pharmacol. 2007;72:536-44 pubmed |
| Kundu C, Balusu R, Jaiswal A, Narayan S. Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways. Carcinogenesis. 2007;28:2089-95 pubmed |
- immunocytochemistry; human
| Lam W, Park S, Leung C, Cheng Y. Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (g. Mol Pharmacol. 2006;69:1607-14 pubmed |
- immunocytochemistry; human
| Yang S, Irani K, Heffron S, Jurnak F, Meyskens F. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor. Mol Cancer Ther. 2005;4:1923-35 pubmed |
- immunohistochemistry - paraffin section; human
| Bobola M, Finn L, Ellenbogen R, Geyer J, Berger M, Braga J, et al. Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors. Clin Cancer Res. 2005;11:7405-14 pubmed |
| Cabelof D, Raffoul J, Nakamura J, Kapoor D, Abdalla H, Heydari A. Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency. J Biol Chem. 2004;279:36504-13 pubmed |
- immunohistochemistry; human
| Wang D, Luo M, Kelley M. Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Mol Cancer Ther. 2004;3:679-86 pubmed |
| Raffoul J, Cabelof D, Nakamura J, Meira L, Friedberg E, Heydari A. Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair. J Biol Chem. 2004;279:18425-33 pubmed |
- immunocytochemistry; human
- western blot; human
| Shen G, Galick H, Inoue M, Wallace S. Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts. DNA Repair (Amst). 2003;2:673-93 pubmed |
| Fishel M, Seo Y, Smith M, Kelley M. Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing. Cancer Res. 2003;63:608-15 pubmed |
- western blot; mouse
- western blot; human
| Seo Y, Fishel M, Amundson S, Kelley M, Smith M. Implication of p53 in base excision DNA repair: in vivo evidence. Oncogene. 2002;21:731-7 pubmed |
- immunohistochemistry; human
| Thomson B, Tritt R, Davis M, Kelley M. Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas. J Pediatr Hematol Oncol. 2001;23:234-9 pubmed |
- immunocytochemistry; human
- western blot; human
| Park S, Lam W, Cheng Y. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Cancer Res. 2002;62:459-65 pubmed |
- immunohistochemistry; human
| Schindl M, Oberhuber G, Pichlbauer E, Obermair A, Birner P, Kelley M. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol. 2001;19:799-802 pubmed |
- immunohistochemistry; human
- western blot; human
| Kelley M, Cheng L, Foster R, Tritt R, Jiang J, Broshears J, et al. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Clin Cancer Res. 2001;7:824-30 pubmed |
- immunohistochemistry - paraffin section; human
| Robertson K, Bullock H, Xu Y, Tritt R, Zimmerman E, Ulbright T, et al. Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Res. 2001;61:2220-5 pubmed |
- immunohistochemistry; human
| Thomson B, Tritt R, Davis M, Perlman E, Kelley M. Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors. Anticancer Res. 2000;20:4153-7 pubmed |
| Chou K, Kukhanova M, Cheng Y. A novel action of human apurinic/apyrimidinic endonuclease: excision of L-configuration deoxyribonucleoside analogs from the 3' termini of DNA. J Biol Chem. 2000;275:31009-15 pubmed |
- immunohistochemistry - paraffin section; human
- western blot; human
| Moore D, Michael H, Tritt R, Parsons S, Kelley M. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers. Clin Cancer Res. 2000;6:602-9 pubmed |
| Hartman G, Muniyandi A, Sishtla K, Kpenu E, Miller W, Kaplan B, et al. Ref-1 redox activity regulates retinal neovascularization by modulating transcriptional activation of HIF-1α. FASEB J. 2025;39:e70348 pubmed publisher |
| Ito M, Ducasa G, Molina J, Santos J, Mallela S, Kim J, et al. ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease. Sci Rep. 2023;13:9616 pubmed publisher |
| Chen Y, Kuo Y, You Y, Lin Y, Chen P. Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease. J Neurochem. 2023;165:741-755 pubmed publisher |
| Latino D, Chieffi Baccari G, Di Fiore M, Cioffi F, Venditti M, Giacco A, et al. Autophagy and mitochondrial damage in the testis of high-fat diet fed rats. Gen Comp Endocrinol. 2022;328:114104 pubmed publisher |
| Chieffi Baccari G, Falvo S, Di Fiore M, Cioffi F, Giacco A, Santillo A. High-fat diet affects autophagy and mitochondrial compartment in rat Harderian gland. J Exp Zool A Ecol Integr Physiol. 2022;337:1025-1038 pubmed publisher |
| Rios Covian D, Butcher L, Ablack A, den Hartog G, Matsubara M, Ly H, et al. A Novel Hypomorphic Apex1 Mouse Model Implicates Apurinic/Apyrimidinic Endonuclease 1 in Oxidative DNA Damage Repair in Gastric Epithelial Cells. Antioxid Redox Signal. 2022;: pubmed publisher |
| Pramanik S, Chen Y, Song H, Khutsishvili I, Marky L, Ray S, et al. The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells. Nucleic Acids Res. 2022;50:3394-3412 pubmed publisher |
| Song H, Xi S, Chen Y, Pramanik S, Zeng J, Roychoudhury S, et al. Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation. Cancer Lett. 2021;520:201-212 pubmed publisher |
| Shen J, Varshney D, Simeone A, Zhang X, Adhikari S, Tannahill D, et al. Promoter G-quadruplex folding precedes transcription and is controlled by chromatin. Genome Biol. 2021;22:143 pubmed publisher |
| Gampala S, Shah F, Zhang C, Rhodes S, Babb O, Grimard M, et al. Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours. Br J Cancer. 2021;124:1566-1580 pubmed publisher |
| Bacolla A, Sengupta S, Ye Z, Yang C, Mitra J, De Paula R, et al. Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. Nucleic Acids Res. 2021;49:221-243 pubmed publisher |
| Sengupta S, Wang H, Yang C, Szczesny B, Hegde M, Mitra S. Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription. Proc Natl Acad Sci U S A. 2020;117:22183-22192 pubmed publisher |
| Roychoudhury S, Pramanik S, Harris H, Tarpley M, Sarkar A, Spagnol G, et al. Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome. Proc Natl Acad Sci U S A. 2020;117:11409-11420 pubmed publisher |
| Hu M, Lou Y, Liu S, Mao Y, Le F, Wang L, et al. Altered expression of DNA damage repair genes in the brain tissue of mice conceived by in vitro fertilization. Mol Hum Reprod. 2020;26:141-153 pubmed publisher |
| Cho H, Kumari N, Thakur N, Vu H, Kim H, Choi S. Decreased APE-1 by Nitroxoline Enhances Therapeutic Effect in a Temozolomide-resistant Glioblastoma: Correlation with Diffusion Weighted Imaging. Sci Rep. 2019;9:16613 pubmed publisher |
| Song H, Zeng J, Roychoudhury S, Biswas P, Mohapatra B, Ray S, et al. Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer. Mol Cancer Ther. 2020;19:258-269 pubmed publisher |
| Sun Y, Feng Y, Zhang G, Xu Y. The endonuclease APE1 processes miR-92b formation, thereby regulating expression of the tumor suppressor LDLR in cervical cancer cells. Ther Adv Med Oncol. 2019;11:1758835919855859 pubmed publisher |
| Malfatti M, Gerratana L, Dalla E, Isola M, Damante G, Di Loreto C, et al. APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC. J Exp Clin Cancer Res. 2019;38:309 pubmed publisher |
| Lee Y, Joo H, Lee E, Cho H, Choi S, Kim C, et al. ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1. Int J Mol Sci. 2019;20: pubmed publisher |
| George J, Bessho M, Bessho T. Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine. J Nucleic Acids. 2019;2019:6357609 pubmed publisher |
| Zhang Q, Chao T, Patil V, Qin Y, Tiwari S, Chiou J, et al. The long noncoding RNA ROCKI regulates inflammatory gene expression. EMBO J. 2019;38: pubmed publisher |
| Cho W, Jin X, Pang J, Wang Y, Mivechi N, Moskophidis D. The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways. Mol Cell Biol. 2019;39: pubmed publisher |
| Frossi B, Antoniali G, Yu K, Akhtar N, Kaplan M, Kelley M, et al. Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination. J Biol Chem. 2019;294:5198-5207 pubmed publisher |
| Antoniali G, Serra F, Lirussi L, Tanaka M, D Ambrosio C, Zhang S, et al. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Nat Commun. 2017;8:797 pubmed publisher |
| Nath S, Roychoudhury S, Kling M, Song H, Biswas P, Shukla A, et al. The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression. Cell Signal. 2017;39:18-31 pubmed publisher |
| Roychoudhury S, Nath S, Song H, Hegde M, Bellot L, Mantha A, et al. Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Mol Cell Biol. 2017;37: pubmed publisher |
| Szczesny B, Marcatti M, Zatarain J, Druzhyna N, Wiktorowicz J, Nagy P, et al. Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Sci Rep. 2016;6:36125 pubmed publisher |
| Sengupta S, Mantha A, Song H, Roychoudhury S, Nath S, Ray S, et al. Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair. Oncotarget. 2016;7:75197-75209 pubmed publisher |
| Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, et al. Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses. J Biol Chem. 2016;291:23672-23680 pubmed |
| Kelley M, Wikel J, Guo C, Pollok K, Bailey B, Wireman R, et al. Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy. J Pharmacol Exp Ther. 2016;359:300-309 pubmed |
| Nikitaki Z, Nikolov V, Mavragani I, Mladenov E, Mangelis A, Laskaratou D, et al. Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET). Free Radic Res. 2016;50:S64-S78 pubmed |
| Lee Y, Lim J, Shin J, Choi S, Joo H, Jeon B. Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer. Int Neurourol J. 2016;20:S30-37 pubmed publisher |
| Wang H, Cai S, Bailey B, Reza Saadatzadeh M, Ding J, Tonsing Carter E, et al. Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist. J Neurosurg. 2017;126:446-459 pubmed publisher |
| Moreli J, Santos J, Lorenzon Ojea A, Correa Silva S, Fortunato R, Rocha C, et al. Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response. Int J Biol Sci. 2016;12:466-77 pubmed publisher |
| Bhakat K, Sengupta S, Adeniyi V, Roychoudhury S, Nath S, Bellot L, et al. Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. Oncotarget. 2016;7:22590-604 pubmed publisher |
| Aamann M, Nørregaard R, Kristensen M, Stevnsner T, Frøkiær J. Unilateral ureteral obstruction induces DNA repair by APE1. Am J Physiol Renal Physiol. 2016;310:F763-F776 pubmed publisher |
| Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed publisher |
| Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun. 2014;5:5513 pubmed publisher |
| Kim H, Koedrith P, Lee S, Kim Y, Seo Y. Base excision DNA repair defect in thioredoxin-1 (Trx1)-deficient cells. Mutat Res. 2013;751-752:1-7 pubmed |
| Cun Y, Dai N, Li M, Xiong C, Zhang Q, Sui J, et al. APE1/Ref-1 enhances DNA binding activity of mutant p53 in a redox-dependent manner. Oncol Rep. 2014;31:901-9 pubmed publisher |
| Yang Z, Misner B, Ji H, Poulos T, Silverman R, Meyskens F, et al. Targeting nitric oxide signaling with nNOS inhibitors as a novel strategy for the therapy and prevention of human melanoma. Antioxid Redox Signal. 2013;19:433-47 pubmed publisher |
| Sengupta S, Chattopadhyay R, Mantha A, Mitra S, Bhakat K. Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. J Hypertens. 2012;30:917-25 pubmed publisher |
| Kim Y, Kim D, Illuzzi J, Delaplane S, Su D, Bernier M, et al. S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity. J Mol Biol. 2011;414:313-26 pubmed publisher |
| Weis E, Schoen H, Victor A, Spix C, Ludwig M, Schneider Raetzke B, et al. Reduced mRNA and protein expression of the genomic caretaker RAD9A in primary fibroblasts of individuals with childhood and independent second cancer. PLoS ONE. 2011;6:e25750 pubmed publisher |
| Karimi Busheri F, Rasouli Nia A, Mackey J, Weinfeld M. Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res. 2010;12:R31 pubmed publisher |
| Chattopadhyay R, Bhattacharyya A, Crowe S. Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection. Cancer Res. 2010;70:2799-808 pubmed publisher |
| Jelezcova E, Trivedi R, Wang X, Tang J, Brown A, Goellner E, et al. Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage. Mutat Res. 2010;686:57-67 pubmed publisher |
| Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, et al. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol. 2007;14:1182-90 pubmed |
| Ziel K, Grishko V, Campbell C, Breit J, Wilson G, Gillespie M. Oxidants in signal transduction: impact on DNA integrity and gene expression. FASEB J. 2005;19:387-94 pubmed |
| Elchuri S, Oberley T, Qi W, Eisenstein R, Jackson Roberts L, Van Remmen H, et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene. 2005;24:367-80 pubmed |
| Marenstein D, Wilson D, Teebor G. Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA. DNA Repair (Amst). 2004;3:527-33 pubmed |
