| Published Application/Species/Sample/Dilution | Reference |
|---|
- chromatin immunoprecipitation; human; loading ...; fig 1d, s2
| Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, et al. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Sci Adv. 2021;7: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3c
| Chen J, Haller C, Jernigan F, Koerner S, Wong D, Wang Y, et al. Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists. Sci Adv. 2020;6:eaay8230 pubmed publisher |
- ChIP-Seq; human; loading ...; fig 1a
| Platt J, Salama R, Smythies J, Choudhry H, Davies J, Hughes J, et al. Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. EMBO Rep. 2016;17:1410-1421 pubmed |
| Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, et al. Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes. Cell Rep. 2024;43:113972 pubmed publisher |
| Naas S, Kr xfc ger R, Knaup K, Naas J, Grampp S, Schiffer M, et al. Hypoxia controls expression of kidney-pathogenic MUC1 variants. Life Sci Alliance. 2023;6: pubmed publisher |
| Grampp S, Kraus A, Skoczynski K, Schiffer M, Kr xfc ger R, Naas S, et al. Hypoxia induces polycystin-1 expression in the renal epithelium. R Soc Open Sci. 2023;10:220992 pubmed publisher |
| Heyer V, Reina San Martin B. Optimal AID expression and efficient immunoglobulin class switch recombination are dependent on the hypoxia-inducible factor. Eur J Immunol. 2023;53:e2350373 pubmed publisher |
| Grampp S, Kr xfc ger R, Lauer V, Uebel S, Knaup K, Naas J, et al. Hypoxia hits APOL1 in the kidney. Kidney Int. 2023;104:53-60 pubmed publisher |
| Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, et al. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Rep. 2023;42:112164 pubmed publisher |
| Lafleur V, Halim S, Choudhry H, Ratcliffe P, Mole D. Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma. Life Sci Alliance. 2023;6: pubmed publisher |
| Yang Y, Chen C, Zuo Q, Lu H, Salman S, Lyu Y, et al. NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification. Sci Adv. 2022;8:eabo5000 pubmed publisher |
| Lombardi O, Li R, Halim S, Choudhry H, Ratcliffe P, Mole D. Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature. Cell Rep. 2022;41:111652 pubmed publisher |
| Salman S, Meyers D, Wicks E, Lee S, Datan E, Thomas A, et al. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy. J Clin Invest. 2022;132: pubmed publisher |
| Protze J, Naas S, Kr xfc ger R, St xf6 hr C, Kraus A, Grampp S, et al. The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. J Biol Chem. 2022;298:101699 pubmed publisher |
| Yang Y, Lu H, Chen C, Lyu Y, Cole R, Semenza G. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nat Commun. 2022;13:316 pubmed publisher |
| Sasagawa T, Nagamatsu T, Yanagisawa M, Fujii T, Shibuya M. Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts. Mol Hum Reprod. 2021;27: pubmed publisher |
| Lu H, Lyu Y, Tran L, Lan J, Xie Y, Yang Y, et al. HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell Rep. 2021;36:109757 pubmed publisher |
| Wang J, Liu R, Wang Y, Mo H, Niu Y, Xu Q, et al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression. J Cancer. 2021;12:5320-5330 pubmed publisher |
| Zeng Z, Shi Z, Liu Y, Zhao J, Lu Q, Guo J, et al. HIF-1α-activated TM4SF1-AS1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by enhancing TM4SF1 expression. Biochem Biophys Res Commun. 2021;566:80-86 pubmed publisher |
| Wang R, Godet I, Yang Y, Salman S, Lu H, Lyu Y, et al. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
| Seok S, Sun H, Kim Y, Kemper B, Kemper J. Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver. Diabetes. 2021;70:733-744 pubmed publisher |
| Orlando I, Lafleur V, Storti F, Spielmann P, Crowther L, Santambrogio S, et al. Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression. Haematologica. 2020;105:2774-2784 pubmed publisher |
| Xin X, Kumar V, Lin F, Kumar V, Bhattarai R, Bhatt V, et al. Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy. Sci Adv. 2020;6: pubmed publisher |
| Safi W, Kraus A, Grampp S, Schödel J, Buchholz B. Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner. J Mol Med (Berl). 2020;98:1547-1559 pubmed publisher |
| Ma X, Gao F, Chen Q, Xuan X, Wang Y, Deng H, et al. ACE2 modulates glucose homeostasis through GABA signaling during metabolic stress. J Endocrinol. 2020;246:223-236 pubmed publisher |
| Ho J, Balukoff N, Theodoridis P, Wang M, Krieger J, Schatz J, et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism. Nat Commun. 2020;11:2677 pubmed publisher |
| Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan N, et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest. 2020;: pubmed publisher |
| Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B, et al. HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis. Cancer Res. 2020;: pubmed publisher |
| Wierenga A, Cunningham A, Erdem A, Lopera N, Brouwers Vos A, Pruis M, et al. HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells. Cancer Metab. 2019;7:11 pubmed publisher |
| Orlando I, Lafleur V, Storti F, Spielmann P, Crowther L, Santambrogio S, et al. Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression. Haematologica. 2019;: pubmed publisher |
| Schmid V, Lafleur V, Lombardi O, Li R, Salama R, Colli L, et al. Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer. Sci Rep. 2019;9:18768 pubmed publisher |
| Lauer V, Grampp S, PLATT J, Lafleur V, Lombardi O, Choudhry H, et al. Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI. J Biol Chem. 2019;: pubmed publisher |
| Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, et al. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. Cell Rep. 2019;29:89-103.e7 pubmed publisher |
| Louphrasitthiphol P, Ledaki I, Chauhan J, Falletta P, Siddaway R, Buffa F, et al. MITF controls the TCA cycle to modulate the melanoma hypoxia response. Pigment Cell Melanoma Res. 2019;32:792-808 pubmed publisher |
| Smythies J, Sun M, Masson N, Salama R, Simpson P, Murray E, et al. Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin. EMBO Rep. 2019;20: pubmed publisher |
| Rahman M, Thomas P. Molecular cloning and characterization of two ARNT (ARNT-1 and ARNT-2) genes in Atlantic croaker and their expression during coexposure to hypoxia and PCB77. Environ Toxicol. 2019;34:160-171 pubmed publisher |
| Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discov. 2018;8:850-865 pubmed publisher |
| Kim Y, Seok S, Byun S, Kong B, Zhang Y, Guo G, et al. AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. Nat Commun. 2018;9:540 pubmed publisher |
| Tiana M, Acosta Iborra B, Puente Santamaría L, Hernansanz Agustín P, Worsley Hunt R, Masson N, et al. The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia. Nucleic Acids Res. 2017;: pubmed publisher |
| Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H. A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes. FEBS J. 2017;284:3804-3816 pubmed publisher |
| Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt J, et al. Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet. 2017;13:e1006872 pubmed publisher |
| Grampp S, Platt J, Lauer V, Salama R, Kranz F, Neumann V, et al. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nat Commun. 2016;7:13183 pubmed publisher |
| Kraus A, Grampp S, Goppelt Struebe M, Schreiber R, Kunzelmann K, Peters D, et al. P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016;12:687-695 pubmed |
| Salama R, Masson N, Simpson P, Sciesielski L, Sun M, Tian Y, et al. Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer. PLoS ONE. 2015;10:e0134645 pubmed publisher |
| Long F, Si L, Long X, YANG B, Wang X, Zhang F. 2ME2 increase radiation-induced apoptosis of keloid fibroblasts by targeting HIF-1α in vitro. Australas J Dermatol. 2016;57:e32-8 pubmed publisher |
| Wong W, Richardson T, Seykora J, Cotsarelis G, Simon M. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 2015;135:454-461 pubmed publisher |
| Rataj F, Möller F, Jähne M, Hönscheid P, Zierau O, Vollmer G, et al. Progesterone, as well as 17?-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus. Arch Toxicol. 2015;89:393-404 pubmed publisher |
