product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
MTH1 Antibody - BSA Free
catalog :
NB100-109
quantity :
0.2 ml (also 0.05 ml)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
L5
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 82
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig s1b
Zou X, Owusu M, Harris R, Jackson S, Loizou J, Nik Zainal S. Validating the concept of mutational signatures with isogenic cell models. Nat Commun. 2018;9:1744 pubmed publisher
Shen J, Guill xe9 n Mancina E, Chen S, Manolakou T, Gad H, Warpman Berglund U, et al. Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway. Oncogenesis. 2024;13:17 pubmed publisher
Ding Y, Gui X, Chu X, Sun Y, Zhang S, Tong H, et al. MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis. Nat Commun. 2023;14:4829 pubmed publisher
Henriksson S, Calder xf3 n Monta xf1 o J, Solvie D, Warpman Berglund U, Helleday T. Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules. 2022;12: pubmed publisher
Bialkowski K, Szpila A. Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer. Free Radic Biol Med. 2021;176:257-264 pubmed publisher
Sanjiv K, Calder xf3 n Monta xf1 o J, Pham T, Erkers T, Tsuber V, Alml xf6 f I, et al. MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia. Cancer Res. 2021;81:5733-5744 pubmed publisher
van den Boogaard M, Oka R, Hakkert A, Schild L, Ebus M, van Gerven M, et al. Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Karsten S, Fiskesund R, Zhang X, Marttila P, Sanjiv K, Pham T, et al. MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells. Cell Death Differ. 2021;: pubmed publisher
Zhang L, Misiara L, Samaranayake G, Sharma N, Nguyen D, Tahara Y, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021;40:101848 pubmed publisher
Arczewska K, Krasuska W, Stachurska A, Karpińska K, Sikorska J, Kiedrowski M, et al. hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage. DNA Repair (Amst). 2020;95:102954 pubmed publisher
Okubo T, Patella P, D Alessandro I, Wilson R. A Neural Network for Wind-Guided Compass Navigation. Neuron. 2020;107:924-940.e18 pubmed publisher
Godoy P, Pour Khavari A, Rizzo M, Sakamoto Hojo E, Haghdoost S. Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress. Oxid Med Cell Longev. 2020;2020:2534643 pubmed publisher
McKellar C, Siwanowicz I, Dickson B, Simpson J. Controlling motor neurons of every muscle for fly proboscis reaching. elife. 2020;9: pubmed publisher
Städele C, Keles M, Mongeau J, Frye M. Non-canonical Receptive Field Properties and Neuromodulation of Feature-Detecting Neurons in Flies. Curr Biol. 2020;30:2508-2519.e6 pubmed publisher
Rudd S, Gad H, Sanjiv K, Amaral N, Hagenkort A, Groth P, et al. MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG. Cancer Res. 2020;: pubmed publisher
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, et al. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020;139:1001-1024 pubmed publisher
Moukengue B, Brown H, Charrier C, Battaglia S, Baud huin M, Quillard T, et al. TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model. EBioMedicine. 2020;53:102704 pubmed publisher
Shiozaki H, Ohta K, Kazama H. A Multi-regional Network Encoding Heading and Steering Maneuvers in Drosophila. Neuron. 2020;106:126-141.e5 pubmed publisher
Tan G, Pryce B, Stabio A, Brigande J, Wang C, Xia Z, et al. Tgfβ signaling is critical for maintenance of the tendon cell fate. elife. 2020;9: pubmed publisher
Heath S, Christenson M, Oriol E, Saavedra Weisenhaus M, Kohn J, Behnia R. Circuit Mechanisms Underlying Chromatic Encoding in Drosophila Photoreceptors. Curr Biol. 2020;30:264-275.e8 pubmed publisher
Hernandez E, MacNamee S, Kaplan L, Lance K, Garcia Verdugo H, Farhadi D, et al. The astrocyte network in the ventral nerve cord neuropil of the Drosophila third-instar larva. J Comp Neurol. 2020;528:1683-1703 pubmed publisher
Bialkowski K, Kasprzak K. A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis. Free Radic Biol Med. 2020;148:1-21 pubmed publisher
Fisher Y, Lu J, D Alessandro I, Wilson R. Sensorimotor experience remaps visual input to a heading-direction network. Nature. 2019;576:121-125 pubmed publisher
Yadav S, Bhagat S, Gupta A, Samaiya A, Srivastava A, Shukla S. Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer. BMC Cancer. 2019;19:1031 pubmed publisher
Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, et al. Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene. 2020;39:617-636 pubmed publisher
Wang J, Nagy N, Masucci M. The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization. Oncogene. 2020;39:603-616 pubmed publisher
McPherson L, Troccoli C, Ji D, Bowles A, Gardiner M, Mohsen M, et al. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. DNA Repair (Amst). 2019;83:102644 pubmed publisher
Zhou W, Ma L, Yang J, Qiao H, Li L, Guo Q, et al. Potent and specific MTH1 inhibitors targeting gastric cancer. Cell Death Dis. 2019;10:434 pubmed publisher
Dolan M, Frechter S, Bates A, Dan C, Huoviala P, Roberts R, et al. Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body. elife. 2019;8: pubmed publisher
Losier T, Akuma M, McKee Muir O, LeBlond N, Suk Y, Alsaadi R, et al. AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Rep. 2019;26:2150-2165.e5 pubmed publisher
Andrade I, Riebli N, Nguyen B, Omoto J, Cardona A, Hartenstein V. Developmentally Arrested Precursors of Pontine Neurons Establish an Embryonic Blueprint of the Drosophila Central Complex. Curr Biol. 2019;29:412-425.e3 pubmed publisher
McKellar C, Lillvis J, Bath D, Fitzgerald J, Cannon J, Simpson J, et al. Threshold-Based Ordering of Sequential Actions during Drosophila Courtship. Curr Biol. 2019;29:426-434.e6 pubmed publisher
Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, et al. The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia. BMC Cancer. 2018;18:1190 pubmed publisher
Cosmanescu F, Katsamba P, Sergeeva A, Ahlsen G, Patel S, Brewer J, et al. Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron. 2018;100:1385-1400.e6 pubmed publisher
Barnhart E, Wang I, Wei H, Desplan C, Clandinin T. Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits. Neuron. 2018;100:229-243.e3 pubmed publisher
Chang Y, Tsao C, Sun Y. Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila. Sci Rep. 2018;8:12669 pubmed publisher
Wolff T, Rubin G. Neuroarchitecture of the Drosophila central complex: A catalog of nodulus and asymmetrical body neurons and a revision of the protocerebral bridge catalog. J Comp Neurol. 2018;526:2585-2611 pubmed publisher
Gupta A, Ajith A, Singh S, Panday R, Samaiya A, Shukla S. PAK2-c-Myc-PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect. Cell Death Dis. 2018;9:825 pubmed publisher
Ribeiro I, Drews M, Bahl A, Machacek C, Borst A, Dickson B. Visual Projection Neurons Mediating Directed Courtship in Drosophila. Cell. 2018;174:607-621.e18 pubmed publisher
Konstantinides N, Kapuralin K, Fadil C, Barboza L, Satija R, Desplan C. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Cell. 2018;174:622-635.e13 pubmed publisher
Imaimatsu K, Fujii W, Hiramatsu R, Miura K, Kurohmaru M, Kanai Y. CRISPR/Cas9-mediated knock-in of the murine Y chromosomal Sry gene. J Reprod Dev. 2018;64:283-287 pubmed publisher
Xie T, Ho M, Liu Q, Horiuchi W, Lin C, Task D, et al. A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep. 2018;23:652-665 pubmed publisher
Fan J, Zhao R, Parro C, Zhao W, Chou H, Robert J, et al. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. J Lipid Res. 2018;59:830-842 pubmed publisher
Saumweber T, Rohwedder A, Schleyer M, Eichler K, Chen Y, Aso Y, et al. Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila. Nat Commun. 2018;9:1104 pubmed publisher
Hashiguchi K, Hayashi M, Sekiguchi M, Umezu K. The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress. Mutat Res. 2018;808:10-19 pubmed publisher
Page B, Valerie N, Wright R, Wallner O, Isaksson R, Carter M, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat Commun. 2018;9:250 pubmed publisher
Tocker A, Durocher E, Jacob K, Trieschman K, Talento S, Rechnitzer A, et al. The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production. J Immunol. 2017;199:2896-2909 pubmed publisher
Yamamoto H, Umeda D, Matsumoto S, Kikuchi A. LDL switches the LRP6 internalization route from flotillin dependent to clathrin dependent in hepatic cells. J Cell Sci. 2017;130:3542-3556 pubmed publisher
Coleman S, Choi K, McGregor A. Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig. Virology. 2017;509:205-221 pubmed publisher
Hattori D, Aso Y, Swartz K, Rubin G, Abbott L, Axel R. Representations of Novelty and Familiarity in a Mushroom Body Compartment. Cell. 2017;169:956-969.e17 pubmed publisher
Wreden C, Meng J, Feng W, Chi W, Marshall Z, Heckscher E. Temporal Cohorts of Lineage-Related Neurons Perform Analogous Functions in Distinct Sensorimotor Circuits. Curr Biol. 2017;27:1521-1528.e4 pubmed publisher
Eshtad S, Mavajian Z, Rudd S, Visnes T, Bostrom J, Altun M, et al. hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis. 2016;5:e275 pubmed publisher
Earley L, Powers J, Adachi K, Baumgart J, Meyer N, Xie Q, et al. Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11. J Virol. 2017;91: pubmed publisher
Zhou H, Jian Y, Leng Y, Liu N, Tian Y, Wang G, et al. Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma. Int J Hematol. 2017;105:318-325 pubmed publisher
Shirangi T, Wong A, Truman J, Stern D. Doublesex Regulates the Connectivity of a Neural Circuit Controlling Drosophila Male Courtship Song. Dev Cell. 2016;37:533-44 pubmed publisher
Yokoi N, Fukata Y, Sekiya A, Murakami T, Kobayashi K, Fukata M. Identification of PSD-95 Depalmitoylating Enzymes. J Neurosci. 2016;36:6431-44 pubmed publisher
Zhou B, Ritt D, Morrison D, Der C, Cox A. Protein Kinase CK2? Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2? Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. J Biol Chem. 2016;291:17804-15 pubmed publisher
Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, et al. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Am J Hum Genet. 2016;98:1082-1091 pubmed publisher
Lacin H, Truman J. Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system. elife. 2016;5:e13399 pubmed publisher
Ichinose T, Aso Y, Yamagata N, Abe A, Rubin G, Tanimoto H. Reward signal in a recurrent circuit drives appetitive long-term memory formation. elife. 2015;4:e10719 pubmed publisher
Huber K, Olek K, Müller A, Tan C, Bennett K, Colinge J, et al. Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling. Nat Methods. 2015;12:1055-7 pubmed publisher
Hampel S, Franconville R, Simpson J, Seeds A. A neural command circuit for grooming movement control. elife. 2015;4:e08758 pubmed publisher
Carter M, Jemth A, Hagenkort A, Page B, Gustafsson R, Griese J, et al. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nat Commun. 2015;6:7871 pubmed publisher
Ohyama T, Schneider Mizell C, Fetter R, Aleman J, Franconville R, Rivera Alba M, et al. A multilevel multimodal circuit enhances action selection in Drosophila. Nature. 2015;520:633-9 pubmed publisher
Giribaldi M, Muñoz A, Halvorsen K, Patel A, Rai P. MTH1 expression is required for effective transformation by oncogenic HRAS. Oncotarget. 2015;6:11519-29 pubmed
Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed publisher
Earley L, Kawano Y, Adachi K, Sun X, Dai M, Nakai H. Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein. J Virol. 2015;89:3038-48 pubmed publisher
Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 2014;9:1841-55 pubmed publisher
Wolff T, Iyer N, Rubin G. Neuroarchitecture and neuroanatomy of the Drosophila central complex: A GAL4-based dissection of protocerebral bridge neurons and circuits. J Comp Neurol. 2015;523:997-1037 pubmed publisher
Oliverio S, Corazzari M, Sestito C, Piredda L, Ippolito G, Piacentini M. The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A. Amino Acids. 2014;46:2767-76 pubmed publisher
Patel A, Burton D, Halvorsen K, Balkan W, Reiner T, Perez Stable C, et al. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015;34:2586-96 pubmed publisher
Jun L, Showalter A, Ali N, Dai F, Ma W, Coskun T, et al. A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor. PLoS ONE. 2014;9:e93746 pubmed publisher
Andreou M, Yan C, Skourides P. 40LoVe and Samba are involved in Xenopus neural development and functionally distinct from hnRNP AB. PLoS ONE. 2014;9:e85026 pubmed publisher
Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H, et al. Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci. 2013;33:18161-74 pubmed publisher
Nam G, Lee Y, Lee H, Ma M, Araki M, Araki K, et al. Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces. J Immunol. 2013;191:5730-42 pubmed publisher
Gouttenoire E, Lupo V, Calpena E, Bartesaghi L, Schüpfer F, Medard J, et al. Sh3tc2 deficiency affects neuregulin-1/ErbB signaling. Glia. 2013;61:1041-51 pubmed publisher
Abdel Wahab O, Adli M, Lafave L, Gao J, Hricik T, Shih A, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012;22:180-93 pubmed publisher
Park Y, Park H. Differentiated embryo chondrocyte 1 (DEC1) represses PPAR?2 gene through interacting with CCAAT/enhancer binding protein ? (C/EBP?). Mol Cells. 2012;33:575-81 pubmed publisher
Kuver A, Shen H, Smith S. Regulation of the surface expression of ?4?2? GABAA receptors by high efficacy states. Brain Res. 2012;1463:1-20 pubmed publisher
Hubbi M, Luo W, Baek J, Semenza G. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011;42:700-12 pubmed publisher
Idoyaga J, Cheong C, Suda K, Suda N, Kim J, Lee H, et al. Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo. J Immunol. 2008;180:3647-50 pubmed
Park S, Cheong C, Idoyaga J, Kim J, Choi J, Do Y, et al. Generation and application of new rat monoclonal antibodies against synthetic FLAG and OLLAS tags for improved immunodetection. J Immunol Methods. 2008;331:27-38 pubmed
product information
master code :
NB100-109
SKU :
NB100-109
product name :
MTH1 Antibody - BSA Free
unit size :
0.2 ml (also 0.05 ml)
description :
The MTH1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to MTH1. This antibody reacts with human,mouse,rat. The MTH1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,IF/IHC,Immunohistochemistry-Frozen,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Simple Western,Knockout Validated,Single Cell Western,Knockdown Validated.
target :
MTH1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A C-terminal peptide derived from human MTH1, conjugated to KLH. [UniProt# P36639]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
theoretical molecular weight :
18 kDa
gene symbol :
NUDT1
Antibody validation :
Biological Validation
accessionNumbers :
P36639
applications :
Western Blot,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Simple Western,Knockout Validated,Single Cell Western,Knockdown Validated
USD :
459 USD
alt names :
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, EC 3.6.1.-, MTH1Nucleoside diphosphate-linked moiety X motif 1, mutT human homolog 1,8-oxo-dGTPase, nucleoside diphosphate-linked moiety X-type motif 17,8-dihydro-8-oxoguanine triphosphatase, nudix (nucleoside diphosphate linked moiety X)-type motif 1,8-oxo-7,8-dihydroguanosine triphosphatase, Nudix motif 1
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.