ATM Antibody - BSA Free | Novus Biologicals NB100-104 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

ATM Antibody - BSA Free

catalog :

NB100-104

quantity :

0.05 ml (also 0.025 ml)

price :

409 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

FITC

reactivity :

human, mouse, rat, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 28

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; fig s3 immunocytochemistry; human; 1:500; fig 5 western blot; human; fig s3	Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep. 2016;6:24700 pubmed publisher
	Urushihara Y, Hashimoto T, Fujishima Y, Hosoi Y. AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation. Int J Mol Sci. 2023;24: pubmed publisher
	Hashimoto T, Urushihara Y, Murata Y, Fujishima Y, Hosoi Y. AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines. Biochem Biophys Res Commun. 2022;590:82-88 pubmed publisher
	Roulston A, Zimmermann M, Papp R, Skeldon A, Pellerin C, Dumas B xe9 rube x, et al. RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. Mol Cancer Ther. 2022;21:245-256 pubmed publisher
	Sato H, Singer R. Cellular variability of nonsense-mediated mRNA decay. Nat Commun. 2021;12:7203 pubmed publisher
	Nishiyama Y, Morita A, Tatsuta S, Kanamaru M, Sakaue M, Ueda K, et al. Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome. Genes (Basel). 2021;12: pubmed publisher
	Chakraborty P, Hiom K. DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination. Nat Commun. 2021;12:4126 pubmed publisher
	Gupta M, Liu X, Teraoka S, Wright J, Gatti R, QUINLAN A, et al. Genes affecting ionizing radiation survival identified through combined exome sequencing and functional screening. Hum Mutat. 2021;42:1124-1138 pubmed publisher
	Suart C, Perez A, Al Ramahi I, Maiuri T, Botas J, Truant R. Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase. Hum Mol Genet. 2021;30:706-715 pubmed publisher
	Zhang J, Saravanabavan S, Chandra A, Munt A, Wong A, Harris P, et al. Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease. Am J Pathol. 2021;191:902-920 pubmed publisher
	Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, et al. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020;11:4766 pubmed publisher
	Habib R, Kim R, Neitzel H, Demuth I, Chrzanowska K, Seemanova E, et al. Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome. Aging (Albany NY). 2020;12:12342-12375 pubmed publisher
	Morita A, Aoshima K, Gulay K, Onishi S, Shibata Y, Yasui H, et al. High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines. Res Vet Sci. 2019;127:1-10 pubmed publisher
	Pugliese G, Salaris F, Palermo V, Marabitti V, Morina N, Rosa A, et al. Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes. Dis Model Mech. 2019;12: pubmed publisher
	Karki A, Putra J, Kim S, Laquaglia M, Perez Atayde A, Sadri Vakili G, et al. MDM4 expression in fibrolamellar hepatocellular carcinoma. Oncol Rep. 2019;42:1487-1496 pubmed publisher
	Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, et al. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 2019;18:11 pubmed publisher
	Dworak N, Mąkosa D, Chatterjee M, Jividen K, Yang C, Snow C, et al. A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling. Aging Cell. 2019;18:e12851 pubmed publisher
	Xu L, Ma E, Zeng T, Zhao R, Tao Y, Chen X, et al. ATM deficiency promotes progression of CRPC by enhancing Warburg effect. Endocr Relat Cancer. 2019;26:59-71 pubmed publisher
	Hashimoto T, Murata Y, Urushihara Y, Shiga S, Takeda K, Hosoi Y. Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways. Biochem Biophys Res Commun. 2018;505:13-19 pubmed publisher
	Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett. 2018;291:92-100 pubmed publisher
	Murata Y, Hashimoto T, Urushihara Y, Shiga S, Takeda K, Jingu K, et al. Knockdown of AMPKÎ± decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217. Biochem Biophys Res Commun. 2018;495:2566-2572 pubmed publisher
	Wang Z, He Y, Deng W, Lang L, Yang H, Jin B, et al. Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice. Oncogene. 2018;37:18-27 pubmed publisher
	Wu P, Wang J, Chen C, Chao K, Chang M, Chen W, et al. Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity. Stem Cells Transl Med. 2017;6:1504-1514 pubmed publisher
	Li Z, Li J, Kong Y, Yan S, Ahmad N, Liu X. Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response. Cancer Res. 2017;77:3169-3180 pubmed publisher
	Frum R, Love I, Damle P, Mukhopadhyay N, Palit Deb S, Deb S, et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016;14:423-36 pubmed publisher
	Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet. 2016;12:e1005791 pubmed publisher
	Murata Y, Uehara Y, Hosoi Y. Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6. Biochem Biophys Res Commun. 2015;468:684-90 pubmed publisher
	Parplys A, Zhao W, Sharma N, Groesser T, Liang F, Maranon D, et al. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015;43:9817-34 pubmed publisher

product information

master code :

NB100-104

SKU :

NB100-104

product name :

ATM Antibody - BSA Free

unit size :

0.05 ml (also 0.025 ml)

description :

The ATM Antibody - BSA Free from Novus is a rabbit polyclonal antibody to ATM. This antibody reacts with canine,human,kangaroo,mouse,rat. The ATM Antibody - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,IF/IHC,ELISA,Flow Cytometry,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunohistochemistry-Paraffin.

target :

ATM

category :

Primary Antibodies

buffer :

PBS, 50% Glycerol

clonality :

Polyclonal

concentration :

2.5 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

ATM Antibody was made to a fragment of the human ATM protein corresponding to the C-terminus (within the last third of the protein sequence). [Uniprot: Q13315]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Canine,Human,Kangaroo,Mouse,Rat

theoretical molecular weight :

351 kDa

gene symbol :

ATM

Antibody validation :

Biological Validation

accessionNumbers :

Q13315

applications :

Western Blot,IF/IHC,ELISA,Flow Cytometry,Immunoprecipitation,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunohistochemistry-Paraffin

USD :

409 USD

alt names :

AT mutated, A-T mutated, AT1, ATA, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATC, ATD, ATDC, ATE, ATM serine/threonine kinase, DKFZp781A0353, EC 2.7.11.1, MGC74674, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage