CHFR Antibody (1H3-A12) | Novus Biologicals H00055743-M01 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

CHFR Antibody (1H3-A12)

catalog :

H00055743-M01

quantity :

0.1 mg

price :

399 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H3-A12

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 9

Reference
Woo S, Lee H, Oh S, Kim S, Park S, Lee J, et al. Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells. Biochem Biophys Res Commun. 2018;503:1812-1818 pubmed publisher
Zhang D, Xu X, Li F, Sun H, Cui Y, Liu S, et al. Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers. Oncol Lett. 2017;14:8042-8050 pubmed publisher
Kashima L, Idogawa M, Mita H, Shitashige M, Yamada T, Ogi K, et al. CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation. J Biol Chem. 2012;287:12975-84 pubmed publisher
Fujita A, Yamamoto H, Imamura M, Nakamura N, Maehara Y, Tsuneyoshi M, et al. Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach. Virchows Arch. 2012;460:163-9 pubmed publisher
Hu S, Huang D, Sun Y, Wu L, Xu W, Yin S, et al. Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer. Med Oncol. 2011;28:447-54 pubmed publisher
Gao Y, Xin Y, Zhang J, Zhou J. Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma. World J Gastroenterol. 2008;14:5000-7 pubmed
Privette L, Weier J, Nguyen H, Yu X, Petty E. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia. 2008;10:643-52 pubmed
Privette L, Gonzalez M, Ding L, Kleer C, Petty E. Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression. Cancer Res. 2007;67:6064-74 pubmed
Milne A, Sitarz R, Carvalho R, Polak M, Ligtenberg M, Pauwels P, et al. Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. Hum Pathol. 2007;38:903-13 pubmed

product information

brand :

Novus

master code :

H00055743-M01

SKU :

H00055743-M01

product name :

CHFR Antibody (1H3-A12)

description :

The CHFR Antibody (1H3-A12) from Novus Biologicals is a mouse monoclonal antibody to CHFR. This antibody reacts with human. The CHFR Antibody (1H3-A12) has been validated for the following applications: Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, RNA Inhibition, Sandwich ELISA.

target :

CHFR

category :

Primary Antibodies

unit size :

0.1 mg

buffer :

In 1x PBS, pH 7.4

clonality :

Monoclonal

clone :

1H3-A12

conjugate :

Unconjugated

host :

Mouse

immunogen :

MERPEEGKQSPPPQPWGRLLRLGAEEGEPHVLLRKREWT
IGRRRGCDLSFPSNKLVSGDHCRIVVDEKSGQVTLEDTS
TSGTVINKLKVVKKQTCPLQTGDVIYLVYRKNEPEHNVA
YLYESLSEKQGMTQESFDTSGAGAGRGADPRVPPSSPAT
QVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSCG
SGGGGISPKGSGPSVASDEVSSFASALPDRKTASFSSLE
PQDQEDLEPVKKKMRGDGDLDLNGQLLVAQPRRNAQTVH
EDVRAAAGKPDKMEETLTCIICQDLLHDCVSLQPCMHTF
CAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYL
IQHPDKSRSEEDVQSMDARNKITQDMLQPKVRRSFSDEE
GSSEDLLELSDVDSESSDISQPYVVCRQCPEYRRQAAQP
PHCPAPEGEPGAPQALGDAPSTSVSLTTAVQDYVCPLQG
SHALCTCCFQPMPDRRVEREQDPRVAPQQCAVCLQPFCH
LYWGCTRTGCYGCLAPFCELNLGDKCLDGVLNNNSYESD
ILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGD
TVLCYCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCY
WGRNCRTQVKAHHAMKFNHICEQTRFKN
CHFR (AAH12072.1, 1 a.a. ~ 652 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

isotype :

IgG1 Kappa

purity :

IgG purified

species :

Human

specificity :

CHFR - checkpoint with forkhead and ring finger domains

gene symbol :

CHFR

catalog number base :

H00055743-M01

accessionNumbers :

AAH12072

applications :

Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, RNA Inhibition, Sandwich ELISA

2020 USD :

399

2021 USD :

399 USD

alt names :

checkpoint with forkhead and ring finger domains, Checkpoint with forkhead and RING finger domains protein, E3 ubiquitin-protein ligase CHFR, EC 6.3.2.-, FLJ10796, FLJ33629, RING finger protein 196, RNF196RNF116

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.