product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Filamin A Antibody (4E10-1B2) - Azide and BSA Free
catalog :
H00002316-M01
quantity :
0.1 mg
price :
529 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4E10-1B2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, proximity ligation assay
more info or order :
Novus Biologicals product webpage
citations: 14
Reference
Jobin M, Siddig S, Koszegi Z, Lanoisel xe9 e Y, Khayenko V, Sungkaworn T, et al. Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane. Nat Commun. 2023;14:34 pubmed publisher
Treppiedi D, Di Muro G, Mangili F, Catalano R, Giardino E, Barbieri A, et al. Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells. Mol Cell Endocrinol. 2021;524:111159 pubmed publisher
Catalano R, Giardino E, Treppiedi D, Mangili F, Morelli V, Elli F, et al. The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells. Cancer Lett. 2021;497:77-88 pubmed publisher
Peverelli E, Giardino E, Treppiedi D, Catalano R, Mangili F, Locatelli M, et al. A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment. Int J Cancer. 2018;142:1842-1852 pubmed publisher
Mingione A, Verdelli C, Ferrero S, Vaira V, Guarnieri V, Scillitani A, et al. Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors. J Mol Endocrinol. 2017;58:91-103 pubmed publisher
Gay O, Gilquin B, Assard N, Stuelsatz P, Delphin C, Lachuer J, et al. Refilins are short-lived Actin-bundling proteins that regulate lamellipodium protrusion dynamics. Biol Open. 2016;5:1351-1361 pubmed publisher
Vitali E, Cambiaghi V, Zerbi A, Carnaghi C, Colombo P, Peverelli E, et al. Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours. Endocr Relat Cancer. 2016;23:181-90 pubmed publisher
Bézie S, Picarda E, Tesson L, Renaudin K, Durand J, Ménoret S, et al. Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells. PLoS ONE. 2015;10:e0119686 pubmed publisher
Parrini E, Mei D, Pisanti M, Catarzi S, Pucatti D, Bianchini C, et al. Familial periventricular nodular heterotopia, epilepsy and Melnick-Needles Syndrome caused by a single FLNA mutation with combined gain-of-function and loss-of-function effects. J Med Genet. 2015;52:405-12 pubmed publisher
Peverelli E, Giardino E, Treppiedi D, Vitali E, Cambiaghi V, Locatelli M, et al. Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells. Endocrinology. 2014;155:2932-41 pubmed publisher
Sakane A, Alamir Mahmoud Abdallah A, Nakano K, Honda K, Kitamura T, Imoto I, et al. Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. Genes Cells. 2013;18:810-22 pubmed publisher
Oegema R, Hulst J, Theuns Valks S, van Unen L, Schot R, Mancini G, et al. Novel no-stop FLNA mutation causes multi-organ involvement in males. Am J Med Genet A. 2013;161A:2376-84 pubmed publisher
Peverelli E, Mantovani G, Vitali E, Elli F, Olgiati L, Ferrero S, et al. Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs. J Clin Endocrinol Metab. 2012;97:967-77 pubmed publisher
Valente E, Logan C, Mougou Zerelli S, Lee J, Silhavy J, Brancati F, et al. Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet. 2010;42:619-25 pubmed publisher
product information
master code :
H00002316-M01
SKU :
H00002316-M01
product name :
Filamin A Antibody (4E10-1B2) - Azide and BSA Free
unit size :
0.1 mg
description :
The Filamin A Antibody (4E10-1B2) - Azide and BSA Free from Novus is a mouse monoclonal antibody to Filamin A. This antibody reacts with human,mouse,rat. The Filamin A Antibody (4E10-1B2) - Azide and BSA Free has been validated for the following applications: ELISA,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Proximity Ligation Assay,Immunocytochemistry/ Immunofluorescence.
target :
Filamin A
category :
Primary Antibodies
buffer :
In 1x PBS, pH 7.4
clonality :
Monoclonal
clone :
4E10-1B2
conjugate :
Unconjugated
host :
Mouse
immunogen :
MPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDN
MHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFT
VNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLP
VLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKV
GSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRN
GHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSE
IGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSL
SIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFA
DQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHC
DLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYC
IRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGA
HKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEG
PSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHI
PDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAV
SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIP
RENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVS
AYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKV
KMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSP
FKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAP
GPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNM
LLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTL
VVKWGDEHIPGSPYRVVVP
FLNA (AAH14654, 1 a.a. ~ 838 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
isotype :
IgG1 Kappa
purity :
IgG purified
species :
Human,Mouse,Rat
specificity :
FLNA - filamin A, alpha (actin binding protein 280)
gene symbol :
FLNA
accessionNumbers :
AAH14654
applications :
ELISA,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Proximity Ligation Assay,Immunocytochemistry/ Immunofluorescence
USD :
529 USD
alt names :
ABP-280DKFZp434P031, ABPX, actin binding protein 280, Actin-binding protein 280, Alpha-filamin, CVD1, EC 2.1.1.43, EC 6.3.4.4, Endothelial actin-binding protein, filamin A, alpha, filamin A, alpha (actin binding protein 280), Filamin-1, filamin-A, FLN, FLN1OPD, FLN-A, FMD, MNS, NHBP, Non-muscle filamin, OPD1, OPD2, XLVD, XMVD
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.