product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Langerin/CD207 Antibody (DCGM4/122D5) - Azide and BSA Free
catalog :
DDX0363P-100
quantity :
0.1 mg
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
Alexa Fluor 405
clone name :
DCGM4/122D5
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 47
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:100; loading ...; fig 1d
Del Duca E, Pavel A, Dubin C, Song T, Wallace E, Peng X, et al. Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals. J Invest Dermatol. 2019;139:2228-2232.e10 pubmed publisher
Jackson R, Lukacs J, Zehbe I. The Potentials and Pitfalls of a Human Cervical Organoid Model Including Langerhans Cells. Viruses. 2020;12: pubmed publisher
Sanyal R, Pavel A, Glickman J, Chan T, Zheng X, Zhang N, et al. Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation. Ann Allergy Asthma Immunol. 2019;122:99-110.e6 pubmed publisher
Reinartz S, van Tongeren J, van Egmond D, de Groot E, Fokkens W, van Drunen C. Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects. PLoS ONE. 2016;11:e0154409 pubmed publisher
Fehres C, Bruijns S, Sotthewes B, Kalay H, Schaffer L, Head S, et al. Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells. PLoS ONE. 2015;10:e0143519 pubmed publisher
Ng W, Londrigan S, Nasr N, Cunningham A, Turville S, Brooks A, et al. The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. J Virol. 2016;90:206-21 pubmed publisher
van den Berg L, Ribeiro C, Zijlstra Willems E, de Witte L, Fluitsma D, Tigchelaar W, et al. Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells. Retrovirology. 2014;11:123 pubmed publisher
Schaeffer E, Flacher V, Papageorgiou V, Decossas M, Fauny J, Krämer M, et al. Dermal CD14(+) Dendritic Cell and Macrophage Infection by Dengue Virus Is Stimulated by Interleukin-4. J Invest Dermatol. 2015;135:1743-1751 pubmed publisher
Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, et al. Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. J Leukoc Biol. 2015;97:627-34 pubmed publisher
Milne P, Bigley V, Gunawan M, Haniffa M, Collin M. CD1c+ blood dendritic cells have Langerhans cell potential. Blood. 2015;125:470-3 pubmed publisher
Stoitzner P, Schaffenrath S, Tripp C, Reider D, Komenda K, Del Frari B, et al. Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors. Exp Dermatol. 2014;23:909-15 pubmed publisher
Flacher V, Tripp C, Mairhofer D, Steinman R, Stoitzner P, Idoyaga J, et al. Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance. EMBO Mol Med. 2014;6:1191-204 pubmed publisher
Nasr N, Lai J, Botting R, Mercier S, Harman A, Kim M, et al. Inhibition of two temporal phases of HIV-1 transfer from primary Langerhans cells to T cells: the role of langerin. J Immunol. 2014;193:2554-64 pubmed publisher
Larbi A, Mitjavila Garcia M, Flamant S, Valogne Y, Clay D, Usunier B, et al. Generation of multipotent early lymphoid progenitors from human embryonic stem cells. Stem Cells Dev. 2014;23:2983-95 pubmed publisher
Gulati N, Suárez Fariñas M, Fuentes Duculan J, Gilleaudeau P, Sullivan Whalen M, Correa Da Rosa J, et al. Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights. J Invest Dermatol. 2014;134:2531-2540 pubmed publisher
Stoll P, Heinz A, Bratke K, Bier A, Garbe K, Kuepper M, et al. Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD. Respir Res. 2014;15:48 pubmed publisher
Schuster C, Mildner M, Mairhofer M, Bauer W, Fiala C, Prior M, et al. Human embryonic epidermis contains a diverse Langerhans cell precursor pool. Development. 2014;141:807-15 pubmed publisher
Lommatzsch M, Kraeft U, Troebs L, Garbe K, Bier A, Stoll P, et al. Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial. Respir Res. 2013;14:114 pubmed publisher
Debeer S, Le Luduec J, Kaiserlian D, Laurent P, Nicolas J, Dubois B, et al. Comparative histology and immunohistochemistry of porcine versus human skin. Eur J Dermatol. 2013;23:456-66 pubmed publisher
Welty N, Staley C, Ghilardi N, Sadowsky M, Igyarto B, Kaplan D. Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J Exp Med. 2013;210:2011-24 pubmed publisher
Bonetti M, Bacci S, Santosuosso M, Mazzanti B, Aldinucci A, Ballerini C, et al. Rosiglitazone promotes the differentiation of Langerhans cells and inhibits that of other dendritic cell types from CD133 positive hematopoietic precursors. Histol Histopathol. 2014;29:323-32 pubmed publisher
Tjomsland V, Ellegård R, Kjölhede P, Wodlin N, Hinkula J, Lifson J, et al. Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions. Eur J Immunol. 2013;43:2361-72 pubmed publisher
Lenormand C, Spiegelhalter C, Cinquin B, Bardin S, Bausinger H, Angenieux C, et al. Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin. PLoS ONE. 2013;8:e60813 pubmed publisher
Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol. 2013;190:27-35 pubmed publisher
Mayumi N, Watanabe E, Norose Y, Watari E, Kawana S, Geijtenbeek T, et al. E-cadherin interactions are required for Langerhans cell differentiation. Eur J Immunol. 2013;43:270-80 pubmed publisher
Hitzler M, Majdic O, Heine G, Worm M, Ebert G, Luch A, et al. Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. PLoS ONE. 2012;7:e46776 pubmed publisher
Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, et al. Age-related changes in expression and function of Toll-like receptors in human skin. Development. 2012;139:4210-9 pubmed publisher
Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, et al. Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity. 2012;37:60-73 pubmed publisher
Schwingshackl P, Obermoser G, Nguyen V, Fritsch P, Sepp N, Romani N. Distribution and maturation of skin dendritic cell subsets in two forms of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome. Acta Derm Venereol. 2012;92:269-75 pubmed publisher
Segura E, Valladeau Guilemond J, Donnadieu M, Sastre Garau X, Soumelis V, Amigorena S. Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med. 2012;209:653-60 pubmed publisher
van der Vlist M, de Witte L, de Vries R, Litjens M, de Jong M, Fluitsma D, et al. Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4? T cells but are incapable of cross-presentation. Eur J Immunol. 2011;41:2619-31 pubmed publisher
Fujita H, Shemer A, Suárez Fariñas M, Johnson Huang L, Tintle S, Cardinale I, et al. Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets. J Allergy Clin Immunol. 2011;128:574-82.e1-12 pubmed publisher
Ouwehand K, Spiekstra S, Waaijman T, Scheper R, de Gruijl T, Gibbs S. Technical advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration. J Leukoc Biol. 2011;90:1027-33 pubmed publisher
Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H. Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-?1-dependent human epidermal Langerhans cells. J Invest Dermatol. 2011;131:2049-57 pubmed publisher
Bigley V, Haniffa M, Doulatov S, Wang X, Dickinson R, McGovern N, et al. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med. 2011;208:227-34 pubmed publisher
Stary G, Klein I, Bauer W, Koszik F, Reininger B, Kohlhofer S, et al. Glucocorticosteroids modify Langerhans cells to produce TGF-? and expand regulatory T cells. J Immunol. 2011;186:103-12 pubmed publisher
Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, et al. HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies. J Virol. 2011;85:1077-85 pubmed publisher
van de Laar L, van den Bosch A, van der Kooij S, Janssen H, Coffer P, van Kooten C, et al. A nonredundant role for canonical NF-?B in human myeloid dendritic cell development and function. J Immunol. 2010;185:7252-61 pubmed publisher
Bobr A, Olvera Gomez I, Igyarto B, Haley K, Hogquist K, Kaplan D. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol. 2010;185:4724-8 pubmed publisher
de Jong M, de Witte L, Taylor M, Geijtenbeek T. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol. 2010;185:1633-41 pubmed publisher
Huch J, Cunningham A, Arvin A, Nasr N, Santegoets S, Slobedman E, et al. Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. J Virol. 2010;84:4060-72 pubmed publisher
Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, et al. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. J Exp Med. 2009;206:169-81 pubmed publisher
Mayer W, Irschick U, Moser P, Wurm M, Huemer H, Romani N, et al. Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers. Invest Ophthalmol Vis Sci. 2007;48:4459-67 pubmed
Movassagh M, Spatz A, Davoust J, Lebecque S, Romero P, Pittet M, et al. Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma. Cancer Res. 2004;64:2192-8 pubmed
Valladeau J, Ravel O, Dezutter Dambuyant C, Moore K, Kleijmeer M, Liu Y, et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000;12:71-81 pubmed
Valladeau J, Duvert Frances V, Pin J, Dezutter Dambuyant C, Vincent C, Massacrier C, et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol. 1999;29:2695-704 pubmed
Ito T, Inaba M, Inaba K, Toki J, Sogo S, Iguchi T, et al. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol. 1999;163:1409-19 pubmed
product information
master code :
DDX0363P-100
SKU :
DDX0363P-100
product name :
Langerin/CD207 Antibody (DCGM4/122D5) - Azide and BSA Free
unit size :
0.1 mg
description :
The Langerin/CD207 Antibody (DCGM4/122D5) - Azide and BSA Free from Novus is a mouse monoclonal antibody to Langerin/CD207. This antibody reacts with canine,human. The Langerin/CD207 Antibody (DCGM4/122D5) - Azide and BSA Free has been validated for the following applications: Flow Cytometry,IF/IHC,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Binding Activity.
target :
Langerin/CD207
category :
Primary Antibodies
buffer :
Tris-NaCl (pH 8.0)
clonality :
Monoclonal
clone :
DCGM4/122D5
concentration :
0.5 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Langerin/CD207 was used as immunogen.
isotype :
IgG1
purity :
Ion exchange chromatography
species :
Canine,Human
gene symbol :
CD207
applications :
Flow Cytometry,IF/IHC,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Binding Activity
USD :
459 USD
alt names :
CD207 antigen, CD207 antigen, langerin, CD207 molecule, langerin, CLEC4KLangerhans cell specific c-type lectin, C-type lectin domain family 4 member K, C-type lectin domain family 4, member K, Langerin
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.