product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
PINK1 Antibody - BSA Free
catalog :
BC100-494
quantity :
0.1 ml (also 0.025 ml)
price :
489 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
HH1/1784R
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay, western blot knockout validation
more info or order :
citations: 208
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig s20c
Wettengel J, Reautschnig P, Geisler S, Kahle P, Stafforst T. Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res. 2017;45:2797-2808 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5c
  • western blot; human; 1:1000; loading ...; fig 6f
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  • western blot; human; 1:3000; loading ...; fig 3c
Choi G, Lee H, Chae C, Cho J, Jung Y, Kim J, et al. BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat Commun. 2021;12:487 pubmed publisher
  • western blot; rat; 1:50; loading ...; fig 3a
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed publisher
  • western blot; mouse; loading ...; fig 4, 7
Huang Y, Gu C, Wang Q, Xu L, Chen J, Zhou W, et al. The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury. FASEB J. 2020;34:2055-2074 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s2b
Walsh T, van den Bosch M, Lewis K, Williams C, Poole A. Loss of the mitochondrial kinase PINK1 does not alter platelet function. Sci Rep. 2018;8:14377 pubmed publisher
  • western blot; human; loading ...; fig 1a
Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3e
Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed publisher
  • western blot; human; 1:1000; fig 4
Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3g
  • immunocytochemistry; human; loading ...; fig 3h
  • western blot; human; loading ...; fig 4a
Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher
  • western blot; human; loading ...; fig 4a
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed publisher
  • proximity ligation assay; human; fig 2
  • western blot; human; fig 1
Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed publisher
  • western blot; human; loading ...; fig 3a
Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed publisher
Luo Y, Zeng X, Dai X, Tian Y, Li J, Zhang Q, et al. Copper Oxide Nanoparticles Impair Mouse Preimplantation Embryonic Development through Disruption of Mitophagy-Mediated Metabolism. ACS Nano. 2024;18:31244-31260 pubmed publisher
Lin R, Im G, Luo A, Zhu Y, Hong X, Neumeyer J, et al. Mitochondrial transfer mediates endothelial cell engraftment through mitophagy. Nature. 2024;629:660-668 pubmed publisher
You W, Knoops K, Berendschot T, Benedikter B, Webers C, Reutelingsperger C, et al. PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration. Cell Death Discov. 2024;10:180 pubmed publisher
Kinnart I, Manders L, Heyninck T, Imberechts D, Praschberger R, Schoovaerts N, et al. Elevated α-synuclein levels inhibit mitophagic flux. NPJ Parkinsons Dis. 2024;10:80 pubmed publisher
Sharma K, Kishore A, Lechado Terradas A, Passannanti R, Raimondi F, Sturm M, et al. A Novel PINK1 p.F385S Loss-of-Function Mutation in an Indian Family with Parkinson's Disease. Mov Disord. 2024;39:1217-1225 pubmed publisher
Naso F, Bruqi K, Manzini V, Chiurchi xf9 V, D Onofrio M, Arisi I, et al. miR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibition. Cell Death Discov. 2024;10:149 pubmed publisher
Jeon S, Chung K. The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1. J Biol Chem. 2024;300:107198 pubmed publisher
Hees J, Wanderoy S, Lindner J, Helms M, Murali Mahadevan H, Harbauer A. Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons. Nat Metab. 2024;6:514-530 pubmed publisher
Gurubaran I. Mitochondrial damage and clearance in retinal pigment epithelial cells. Acta Ophthalmol. 2024;102 Suppl 282:3-53 pubmed publisher
Jeong D, Um J, Kim Y, Shin D, Im S, Lee K, et al. The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress. Exp Mol Med. 2024;56:674-685 pubmed publisher
Choudhury D, Rong N, Senthil Kumar H, Swedick S, Samuel R, Mehrotra P, et al. Proline restores mitochondrial function and reverses aging hallmarks in senescent cells. Cell Rep. 2024;43:113738 pubmed publisher
Chen X, Han R, Liu Y, Huang W, Wang Q, Xiong X, et al. Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation. Zool Res. 2024;45:242-252 pubmed publisher
Guo H, Rogg M, Keller J, Scherzinger A, J xe4 ckel J, Meyer C, et al. ADP-Ribosylation Factor-Interacting Protein 2 Acts as a Novel Regulator of Mitophagy and Autophagy in Podocytes in Diabetic Nephropathy. Antioxidants (Basel). 2024;13: pubmed publisher
Neueder A, Kojer K, Gu Z, Wang Y, Hering T, Tabrizi S, et al. Huntington's disease affects mitochondrial network dynamics predisposing to pathogenic mitochondrial DNA mutations. Brain. 2024;147:2009-2022 pubmed publisher
Um J, Shin D, Choi S, Nathan A, Kim Y, Lee D, et al. Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models. Theranostics. 2024;14:56-74 pubmed publisher
Zhao Z, Xie L, Shi J, Liu T, Wang S, Huang J, et al. Neuroprotective Effect of Zishen Huoxue Decoction treatment on Vascular Dementia by activating PINK1/Parkin mediated Mitophagy in the Hippocampal CA1 Region. J Ethnopharmacol. 2024;319:117172 pubmed publisher
Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, et al. The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells. MBio. 2023;14:e0148023 pubmed publisher
Yang C, Yang X, Harrington A, Potts C, Kaija A, Ryzhova L, et al. Notch Signaling Regulates Mouse Perivascular Adipose Tissue Function via Mitochondrial Pathways. Genes (Basel). 2023;14: pubmed publisher
Righetti R, Grillini S, Del Dotto V, Costanzini A, Liuzzi F, Zanna C, et al. The Pro-Oncogenic Protein IF1 Promotes Proliferation of Anoxic Cancer Cells during Re-Oxygenation. Int J Mol Sci. 2023;24: pubmed publisher
Tang J, Lu X, Zhang T, Feng Y, Xu Q, Li J, et al. Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells. Heliyon. 2023;9:e20012 pubmed publisher
Jin Y, Kim T, Kim T. Effect of Physical Exercise on Mitochondrial Dysfunction and Purkinje Cell Survival in the Cerebellum of 3xTg-AD Mice. J Integr Neurosci. 2023;22:117 pubmed publisher
Levy S, Bribiescas R. Hierarchies in the energy budget: Thyroid hormones and the evolution of human life history patterns. Evol Anthropol. 2023;32:275-292 pubmed publisher
Jang H, Lee Y, Dao T, Jo Y, Khim K, Eom H, et al. Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy. Exp Mol Med. 2023;: pubmed publisher
Wang C, Wang Z, Xue S, Zhu Y, Jin J, Ren Q, et al. Urolithin A alleviates neuropathic pain and activates mitophagy. Mol Pain. 2023;19:17448069231190815 pubmed publisher
Reddy P, Kshirsagar S, Bose C, Pradeepkiran J, Hindle A, Singh S, et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells. 2023;12: pubmed publisher
Yang D, Li J, Li Z, Zhao M, Wang D, Sun Z, et al. Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction. Front Mol Neurosci. 2023;16:1163981 pubmed publisher
Rai P, Ratnaparkhi A, Kumar Roy J. Rab11 rescues muscle degeneration and synaptic morphology in the park13/+ Parkinson model of Drosophila melanogaster. Brain Res. 2023;1816:148442 pubmed publisher
Kamienieva I, Charzy x144 ska A, Duszy x144 ski J, Mali x144 ska D, Szczepanowska J. In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166787 pubmed publisher
Liu M, He H, Fan F, Qiu L, Zheng F, Guan Y, et al. Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis. J Mol Cell Cardiol. 2023;181:15-30 pubmed publisher
Van Acker Z, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, et al. Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism. Nat Commun. 2023;14:2847 pubmed publisher
Quarato G, Mari L, Barrows N, Yang M, Ruehl S, Chen M, et al. Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis. Sci Adv. 2023;9:eadg8156 pubmed publisher
Woo S, Mo Y, Lee Y, Park J, Hwang D, Park T, et al. ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation. J Invest Dermatol. 2023;143:2295-2310.e17 pubmed publisher
Panes J, Nguyen T, Gao H, Christensen T, Stojakovic A, Trushin S, et al. Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice. Cells. 2023;12: pubmed publisher
Kim B, Koh H. The role of CK2 in the regulation of mitochondrial autophagy induced by rotenone. Toxicol Lett. 2023;382:1-12 pubmed publisher
Yoo M, Choi D, Murphy A, Ahsan A, Junn E. MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1. J Biol Chem. 2023;299:104709 pubmed publisher
Lin Q, Li S, Jin H, Cai H, Zhu X, Yang Y, et al. Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis. Int J Biol Sci. 2023;19:1192-1210 pubmed publisher
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, et al. Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis. Acta Pharm Sin B. 2023;13:577-597 pubmed publisher
Chemello F, Pozzobon M, Tsansizi L, Varanita T, Quintana Cabrera R, Bonesso D, et al. Dysfunctional mitochondria accumulate in a skeletal muscle knockout model of Smn1, the causal gene of spinal muscular atrophy. Cell Death Dis. 2023;14:162 pubmed publisher
Choi Y, Choi Y, Ko S, Cheon C, Kim T. Investigation of Molecular Mechanisms Involved in Sensitivity to the Anti-Cancer Activity of Costunolide in Breast Cancer Cells. Int J Mol Sci. 2023;24: pubmed publisher
Xu D, Hu G, Luo J, Cheng J, Wu D, Cheng L, et al. Staphylococcus aureus induces mitophagy to promote its survival within bovine mammary epithelial cells. Vet Microbiol. 2023;280:109697 pubmed publisher
Xie X, Yang Y, Wang Q, Liu H, Fang X, Li C, et al. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria. Cell Res. 2023;33:215-228 pubmed publisher
Sharma N, Banerjee R, Davis R. Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2023;: pubmed publisher
Pol xe1 chov xe1 E, Bach K, Heuten E, Stanchev S, Tich xe1 A, Lampe P, et al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023;66:251-265 pubmed publisher
Zhang Y, Fang Q, Wang H, Qi J, Sun S, Liao M, et al. Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy. 2023;19:75-91 pubmed publisher
Kim H, Huh Y, Kim J, Jo M, Shin J, Park S, et al. Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice. Front Aging Neurosci. 2022;14:1030807 pubmed publisher
Lin C, Yang Q, Guo D, Xie J, Yang Y, Chaugule S, et al. Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration. Nat Commun. 2022;13:6869 pubmed publisher
Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher
Wang R, Santos J, Dufour J, Stephens E, Miranda J, Washburn R, et al. Ginger Root Extract Improves GI Health in Diabetic Rats by Improving Intestinal Integrity and Mitochondrial Function. Nutrients. 2022;14: pubmed publisher
Liu K, Li X, Li Z, Cao J, Li X, Xu Y, et al. Evaluating mitophagy in embryonic stem cells by using fluorescence-based imaging. Front Cell Dev Biol. 2022;10:910464 pubmed publisher
Kshirsagar S, Alvir R, Pradeepkiran J, Hindle A, Vijayan M, Ramasubramaniam B, et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease. Cells. 2022;11: pubmed publisher
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher
Nguyen J, Deering Rice C, Armstrong B, Massa C, Reilly C, Venosa A. Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung. Toxicol Sci. 2022;189:107-123 pubmed publisher
Duan P, Tan J, Miao Y, Zhang Q. PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury. Front Biosci (Landmark Ed). 2022;27:184 pubmed publisher
Vianello C, Cocetta V, Catanzaro D, Dorn G, De Milito A, Rizzolio F, et al. Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy. Cell Death Dis. 2022;13:398 pubmed publisher
Tulen C, Wang Y, Beentjes D, Jessen P, Ninaber D, Reynaert N, et al. Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models. Dis Model Mech. 2022;15: pubmed publisher
Kim M, Nikouee A, Sun Y, Zhang Q, Liu Z, ZANG Q. Evaluation of Parkin in the Regulation of Myocardial Mitochondria-Associated Membranes and Cardiomyopathy During Endotoxemia. Front Cell Dev Biol. 2022;10:796061 pubmed publisher
Sonn S, Song E, Seo S, Kim Y, Um J, Yeo F, et al. Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control. Redox Biol. 2022;51:102275 pubmed publisher
Gillmore T, Farrell A, Alahari S, Sallais J, Kurt M, Park C, et al. Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis. Cell Death Dis. 2022;13:191 pubmed publisher
Harbauer A, Hees J, Wanderoy S, Segura I, Gibbs W, Cheng Y, et al. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron. 2022;110:1516-1531.e9 pubmed publisher
Li J, Lai M, Zhang X, Li Z, Yang D, Zhao M, et al. PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease. Cell Death Dis. 2022;13:162 pubmed publisher
Yang L, Tao Y, Luo L, Zhang Y, Wang X, Meng X. Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis. J Ethnopharmacol. 2022;288:114988 pubmed publisher
Wang J, Zhu S, Wang Y, Wang F, An C, Jiang D, et al. Miro2 supplies a platform for Parkin translocation to damaged mitochondria. Sci Bull (Beijing). 2019;64:730-747 pubmed publisher
Jiang X, Wu Y, Ma R, Chang Y, Li L, Zhu J, et al. PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy. Front Cell Dev Biol. 2021;9:736267 pubmed publisher
Xing Y, Wei X, Liu Y, Wang M, Sui Z, Wang X, et al. Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. Autophagy. 2021;:1-23 pubmed publisher
Bradshaw A, Campbell P, Schapira A, Morris H, Taanman J. The PINK1-Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells. PLoS ONE. 2021;16:e0259903 pubmed publisher
Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, et al. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2021;:1-19 pubmed publisher
Song Y, Ge X, Chen Y, Hussain T, Liang Z, Dong Y, et al. Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival. Autophagy. 2021;:1-15 pubmed publisher
Francelin C, Mitter S, Qian Q, Barodia S, Ip C, Qi X, et al. BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage. Antioxidants (Basel). 2021;10: pubmed publisher
Uesugi R, Ishii S, Matsuura A, Itakura E. Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor. J Biol Chem. 2021;297:101279 pubmed publisher
Rabas N, Palmer S, Mitchell L, Ismail S, Gohlke A, Riley J, et al. PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. J Cell Biol. 2021;220: pubmed publisher
Duan K, Gu Q, Petralia R, Wang Y, Panja D, Liu X, et al. Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience. Neuron. 2021;109:3793-3809.e8 pubmed publisher
Cucarull B, Tutusaus A, Hernáez Alsina T, Garcia de Frutos P, Reig M, Colell A, et al. Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species. Antioxidants (Basel). 2021;10: pubmed publisher
Sopha P, Phutubtim N, Chantrathonkul B, Ploypradith P, Ruchirawat S, Chittchang M. Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity. Toxicology. 2021;462:152963 pubmed publisher
Baiano C, Job X, Santangelo G, Auvray M, Kirsch L. Interactions between interoception and perspective-taking: Current state of research and future directions. Neurosci Biobehav Rev. 2021;130:252-262 pubmed publisher
Jank xf3 L, Kov xe1 cs T, Laczik M, S xe1 ri Z, Ujlaki G, Kis G, et al. Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation. Cells. 2021;10: pubmed publisher
Wang L, Pelgrim C, Swart D, Krenning G, Van der Graaf A, Kraneveld A, et al. SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure. Int J Mol Sci. 2021;22: pubmed publisher
Soman S, Tingle D, Dagda R, Torres M, Dagda M, Dagda R. Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation. J Neurosci Res. 2021;99:2134-2155 pubmed publisher
Anzell A, Fogo G, Gurm Z, Raghunayakula S, Wider J, Maheras K, et al. Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons. Cell Death Dis. 2021;12:475 pubmed publisher
Wang C, Liu K, Cao J, Wang L, Zhao Q, Li Z, et al. PINK1-mediated mitophagy maintains pluripotency through optineurin. Cell Prolif. 2021;54:e13034 pubmed publisher
Wang B, Ye Y, Qian C, Zhang H, Mao H, Yao L, et al. Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease. Neural Regen Res. 2021;16:2521-2527 pubmed publisher
Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, et al. BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Sci Rep. 2021;11:8735 pubmed publisher
Reddy A, Sawant N, Morton H, Kshirsagar S, Bunquin L, Yin X, et al. Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2021;30:789-810 pubmed publisher
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, et al. miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes. Life Sci. 2021;276:119415 pubmed publisher
Roca Agujetas V, Barbero Camps E, de Dios C, Podlesniy P, Abadin X, Morales A, et al. Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease. Mol Neurodegener. 2021;16:15 pubmed publisher
Wang H, Dou S, Zhu J, Shao Z, Wang C, Xu X, et al. Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway. Neuropeptides. 2021;87:102134 pubmed publisher
Woo H, Park S, Kim H, Jung M, Pack C, Park J, et al. miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission. Mol Ther Nucleic Acids. 2021;23:643-656 pubmed publisher
Ragimbeau R, El Kebriti L, Sebti S, Fourgous E, Boulahtouf A, Arena G, et al. BAG6 promotes PINK1 signaling pathway and is essential for mitophagy. FASEB J. 2021;35:e21361 pubmed publisher
Vangrieken P, Al Nasiry S, Bast A, Leermakers P, Tulen C, Janssen G, et al. Hypoxia-induced mitochondrial abnormalities in cells of the placenta. PLoS ONE. 2021;16:e0245155 pubmed publisher
Wu D, Zhang H, Wu Q, Li F, Wang Y, Liu S, et al. Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages. Life Sci. 2021;267:118941 pubmed publisher
Uda M, Yoshihara T, Ichinoseki Sekine N, Baba T, Yoshioka T. Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats. PLoS ONE. 2020;15:e0243660 pubmed publisher
Ramakrishnan R, Bajbouj K, Hachim M, Mogas A, Mahboub B, Olivenstein R, et al. Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients. PLoS ONE. 2020;15:e0242695 pubmed publisher
Yu X, Sun Y, Cai Q, Zhao X, Liu Z, Xue X, et al. Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. Int J Mol Med. 2020;46:2126-2136 pubmed publisher
Jing R, Hu Z, Lin F, He S, Zhang S, Ge W, et al. Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway. Front Cell Dev Biol. 2020;8:819 pubmed publisher
Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle K, et al. Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. Cancer Treat Res Commun. 2020;25:100210 pubmed publisher
Sun C, Wang K, Stock A, Gong Y, Demarest T, Yang B, et al. Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. EMBO J. 2020;39:e103420 pubmed publisher
Zhang X, Griepentrog J, Zou B, Xu L, CYR A, Chambers L, et al. CaMKIV regulates mitochondrial dynamics during sepsis. Cell Calcium. 2020;92:102286 pubmed publisher
Gu C, Li L, Huang Y, Qian D, Liu W, Zhang C, et al. Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy. Oxid Med Cell Longev. 2020;2020:3549704 pubmed publisher
Liu Y, Lear T, Verma M, Wang K, Otero P, McKelvey A, et al. Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1. JCI Insight. 2020;5: pubmed publisher
Vilmen G, Glon D, Siracusano G, Lussignol M, Shao Z, Hernandez E, et al. BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction. Autophagy. 2021;17:1296-1315 pubmed publisher
Wang X, Feng L, Xin M, Hao Y, Wang X, Shang P, et al. Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis. Biomed Pharmacother. 2020;127:110125 pubmed publisher
Verma M, Zhu J, Wang K, Chu C. Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6). J Biol Chem. 2020;295:7865-7876 pubmed publisher
Nikolaou P, Efentakis P, Qourah F, Femminò S, Makridakis M, Kanaki Z, et al. Chronic Empaglifozin treatment reduces myocardial infarct size in non-diabetic mice through STAT-3 mediated protection on microvascular endothelial cells and reduction of oxidative stress. Antioxid Redox Signal. 2020;: pubmed publisher
Sridevi Gurubaran I, Viiri J, Koskela A, Hyttinen J, Paterno J, Kis G, et al. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model. Int J Mol Sci. 2020;21: pubmed publisher
Bhupana J, Huang B, Liou G, Calkins M, Lin Chao S. Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons. FASEB Bioadv. 2020;2:166-181 pubmed publisher
Franco Iborra S, Plaza Zabala A, Montpeyo M, Sebastian D, Vila M, Martinez Vicente M. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. Autophagy. 2020;:1-18 pubmed publisher
Sarkar A, Stellrecht C, Vangapandu H, Ayres M, Kaipparettu B, Park J, et al. Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma. Haematologica. 2020;: pubmed publisher
Igarashi R, Yamashita S, Yamashita T, Inoue K, Fukuda T, Fukuchi T, et al. Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. Sci Rep. 2020;10:1465 pubmed publisher
Park S, Koh H. FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells. Food Chem Toxicol. 2020;137:111163 pubmed publisher
Furlong R, O Keeffe G, O Neill C, Sullivan A. Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Neurosci Lett. 2020;720:134777 pubmed publisher
Ren Y, Zhang B, Zhao X, Zhang Z. Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria. J Neurochem. 2020;: pubmed publisher
Riis S, Murray J, O Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway. Cells. 2020;9: pubmed publisher
Qu F, Wang P, Zhang K, Shi Y, Li Y, Li C, et al. Manipulation of Mitophagy by "All-in-One" nanosensitizer augments sonodynamic glioma therapy. Autophagy. 2019;:1-23 pubmed publisher
Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed publisher
Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, et al. USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. Autophagy. 2019;:1-11 pubmed publisher
Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke A, et al. Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy. Am J Pathol. 2019;189:2061-2076 pubmed publisher
Tomita K, Takashi Y, Ouchi Y, Kuwahara Y, Igarashi K, Nagasawa T, et al. Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA. Cancer Sci. 2019;110:2856-2866 pubmed publisher
Guardia Laguarta C, Liu Y, Lauritzen K, Erdjument Bromage H, Martin B, Swayne T, et al. PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. J Neurosci. 2019;39:7074-7085 pubmed publisher
Martín Maestro P, Gargini R, Garcia E, Simon D, Avila J, García Escudero V. Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. J Alzheimers Dis. 2019;: pubmed publisher
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, et al. PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 2019;26:101254 pubmed publisher
Martín Maestro P, Sproul A, Martínez H, Paquet D, Gerges M, Noggle S, et al. Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells. Mol Neurobiol. 2019;: pubmed publisher
Yan C, Gong L, Chen L, Xu M, Abou Hamdan H, Tang M, et al. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy. 2019;:1-16 pubmed publisher
Ganzleben I, He G, Günther C, Prigge E, Richter K, Rieker R, et al. PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis. Cell Mol Life Sci. 2019;: pubmed publisher
Warnez Soulie J, Macia M, Lac S, Pecchi E, Bernard M, Bendahan D, et al. Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo. Physiol Rep. 2019;7:e14055 pubmed publisher
Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, et al. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. Nat Commun. 2019;10:2205 pubmed publisher
Livingston M, Wang J, Zhou J, Wu G, Ganley I, Hill J, et al. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Autophagy. 2019;:1-21 pubmed publisher
Audesse A, Dhakal S, Hassell L, Gardell Z, Nemtsova Y, Webb A. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. PLoS Genet. 2019;15:e1008097 pubmed publisher
Wauters F, Cornelissen T, Imberechts D, Martin S, Koentjoro B, Sue C, et al. LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. Autophagy. 2019;:1-20 pubmed publisher
Eid N, Ito Y, Horibe A, Otsuki Y, Kondo Y. Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy. Cells. 2019;8: pubmed publisher
Park J, Lee D, Lee Y, Oh E, Bae K, Oh K, et al. Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. Autophagy. 2019;:1-20 pubmed publisher
Cairó M, Campderros L, Gavaldà Navarro A, Cereijo R, Delgado Anglés A, Quesada López T, et al. Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis. EMBO Rep. 2019;20: pubmed publisher
Park H, Chung K, An H, Gim J, Hong J, Woo H, et al. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Front Mol Neurosci. 2019;12:46 pubmed publisher
Fang E, Hou Y, Palikaras K, Adriaanse B, Kerr J, Yang B, et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci. 2019;22:401-412 pubmed publisher
McWilliams T, Barini E, Pohjolan Pirhonen R, Brooks S, Singh F, Burel S, et al. Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018;8: pubmed publisher
Kim H, Joe Y, Rah S, Kim S, Park S, Park J, et al. Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell Death Dis. 2018;9:1060 pubmed publisher
Civiletto G, Doğan S, Cerutti R, Fagiolari G, Moggio M, Lamperti C, et al. Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis. EMBO Mol Med. 2018;10: pubmed publisher
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed publisher
Sun X, Duan Y, Qin C, Li J, Duan G, Deng X, et al. Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy. Cell Death Dis. 2018;9:953 pubmed publisher
Basso V, Marchesan E, Peggion C, Chakraborty J, von Stockum S, Giacomello M, et al. Regulation of ER-mitochondria contacts by Parkin via Mfn2. Pharmacol Res. 2018;138:43-56 pubmed publisher
Thomas H, Zhang Y, Stefely J, Veiga S, Thomas G, Kozma S, et al. Mitochondrial Complex I Activity Is Required for Maximal Autophagy. Cell Rep. 2018;24:2404-2417.e8 pubmed publisher
Xu G, Li T, Chen J, Li C, Zhao H, Yao C, et al. Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing. Autophagy. 2018;14:1818-1830 pubmed publisher
Yakhine Diop S, Niso Santano M, Rodríguez Arribas M, Gómez Sánchez R, Martínez Chacón G, Uribe Carretero E, et al. Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients. Mol Neurobiol. 2019;56:2466-2481 pubmed publisher
Lizama B, Palubinsky A, Raveendran V, Moore A, Federspiel J, Codreanu S, et al. Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein. J Neurosci. 2018;38:6825-6840 pubmed publisher
Marcassa E, Kallinos A, Jardine J, Rusilowicz Jones E, Martinez A, Kuehl S, et al. Dual role of USP30 in controlling basal pexophagy and mitophagy. EMBO Rep. 2018;19: pubmed publisher
Sun Y, Yao X, Zhang Q, Zhu M, Liu Z, Ci B, et al. Beclin-1-Dependent Autophagy Protects the Heart During Sepsis. Circulation. 2018;: pubmed publisher
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett. 2018;291:92-100 pubmed publisher
Ausman J, Abbade J, Ermini L, Farrell A, Tagliaferro A, Post M, et al. Ceramide-induced BOK promotes mitochondrial fission in preeclampsia. Cell Death Dis. 2018;9:298 pubmed publisher
Hawk M, Gorsuch C, Fagan P, Lee C, Kim S, Hamann J, et al. RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells. Nat Cell Biol. 2018;20:272-284 pubmed publisher
Song Y, Du Y, Zou W, Luo Y, Zhang X, Fu J. Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions. Sci Rep. 2018;8:3301 pubmed publisher
Biel T, Rao V. Mitochondrial dysfunction activates lysosomal-dependent mitophagy selectively in cancer cells. Oncotarget. 2018;9:995-1011 pubmed publisher
Bueno M, Brands J, Voltz L, Fiedler K, Mays B, St Croix C, et al. ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. Aging Cell. 2018;17: pubmed publisher
Kumar A, Shaha C. SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation. Sci Rep. 2018;8:615 pubmed publisher
Fiesel F, James E, Hudec R, Springer W. Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy. Oncotarget. 2017;8:106233-106248 pubmed publisher
Yoo L, Chung K. The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death. J Biol Chem. 2018;293:1286-1297 pubmed publisher
Sorrentino V, Romani M, Mouchiroud L, Beck J, Zhang H, D Amico D, et al. Enhancing mitochondrial proteostasis reduces amyloid-? proteotoxicity. Nature. 2017;552:187-193 pubmed publisher
Mizumura K, Justice M, Schweitzer K, Krishnan S, Bronova I, Berdyshev E, et al. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2017;: pubmed publisher
Tang C, Han H, Yan M, Zhu S, Liu J, Liu Z, et al. PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against Renal ischemia-reperfusion injury. Autophagy. 2017;:1-45 pubmed publisher
Kravic B, Harbauer A, Romanello V, Simeone L, Vögtle F, Kaiser T, et al. In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy. 2018;14:311-335 pubmed publisher
Huang E, Qu D, Huang T, Rizzi N, Boonying W, Krolak D, et al. PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Nat Commun. 2017;8:1399 pubmed publisher
Kim H, Ham S, Jo M, Lee G, Lee Y, Shin J, et al. CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation. Int J Mol Sci. 2017;18: pubmed publisher
Mart n Maestro P, Gargini R, A Sproul A, Garc a E, Ant n L, Noggle S, et al. Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. Front Mol Neurosci. 2017;10:291 pubmed publisher
Bartolomé A, García Aguilar A, Asahara S, Kido Y, Guillen C, Pajvani U, et al. MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Mol Cell Biol. 2017;37: pubmed publisher
Zhang C, Liu Z, Bunker E, Ramírez A, Lee S, Peng Y, et al. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017;292:15105-15120 pubmed publisher
Ando M, Fiesel F, Hudec R, Caulfield T, Ogaki K, Górka Skoczylas P, et al. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Mol Neurodegener. 2017;12:32 pubmed publisher
Orr A, Rutaganira F, de Roulet D, Huang E, Hertz N, Shokat K, et al. Long-term oral kinetin does not protect against ?-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017;109:106-116 pubmed publisher
Martinez A, Lectez B, Ramirez J, Popp O, Sutherland J, Urbé S, et al. Quantitative proteomic analysis of Parkin substrates in Drosophila neurons. Mol Neurodegener. 2017;12:29 pubmed publisher
Gelmetti V, De Rosa P, Torosantucci L, Marini E, Romagnoli A, Di Rienzo M, et al. PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy. 2017;13:654-669 pubmed publisher
Sato S, Furuya N. Induction of PINK1/Parkin-Mediated Mitophagy. Methods Mol Biol. 2018;1759:9-17 pubmed publisher
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, et al. Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects. Autophagy. 2017;13:201-211 pubmed publisher
Jamil S, Hojabrpour P, Duronio V. The small molecule 2-phenylethynesulfonamide induces covalent modification of p53. Biochem Biophys Res Commun. 2017;482:154-158 pubmed publisher
Wai T, Saita S, Nolte H, Müller S, König T, Richter Dennerlein R, et al. The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 2016;17:1844-1856 pubmed
Mannam P, Rauniyar N, Lam T, Luo R, Lee P, Srivastava A. MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. Free Radic Biol Med. 2016;101:102-115 pubmed publisher
Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, et al. BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J Biol Chem. 2016;291:21616-21629 pubmed
Xu Y, Zhi F, Shao N, Wang R, Yang Y, Xia Y. Cytoprotection against Hypoxic and/or MPP? Injury: Effect of ?-Opioid Receptor Activation on Caspase 3. Int J Mol Sci. 2016;17: pubmed publisher
Kim J, Fiesel F, Belmonte K, Hudec R, Wang W, Kim C, et al. miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol Neurodegener. 2016;11:55 pubmed publisher
Berezhnov A, Soutar M, Fedotova E, Frolova M, Plun Favreau H, Zinchenko V, et al. Intracellular pH Modulates Autophagy and Mitophagy. J Biol Chem. 2016;291:8701-8 pubmed publisher
Martín Maestro P, Gargini R, Perry G, Avila J, García Escudero V. PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease. Hum Mol Genet. 2016;25:792-806 pubmed publisher
Qu D, Hage A, Don Carolis K, Huang E, Joselin A, Safarpour F, et al. BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival. J Biol Chem. 2015;290:30441-52 pubmed publisher
Fiesel F, Ando M, Hudec R, Hill A, Castanedes Casey M, Caulfield T, et al. (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. EMBO Rep. 2015;16:1114-30 pubmed publisher
Srivastava A, McGinniss J, Wong Y, Shinn A, Lam T, Lee P, et al. MKK3 deletion improves mitochondrial quality. Free Radic Biol Med. 2015;87:373-84 pubmed publisher
Meissner C, Lorenz H, Hehn B, Lemberg M. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy. 2015;11:1484-98 pubmed publisher
Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed publisher
Peng M, Ostrovsky J, Kwon Y, Polyak E, Licata J, Tsukikawa M, et al. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Hum Mol Genet. 2015;24:4829-47 pubmed publisher
Lim G, Chua D, Basil A, Chan H, Chai C, Arumugam T, et al. Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy. J Biol Chem. 2015;290:16882-93 pubmed publisher
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed publisher
Yue M, Hinkle K, Davies P, Trushina E, Fiesel F, Christenson T, et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiol Dis. 2015;78:172-95 pubmed publisher
Seillier M, Pouyet L, N Guessan P, Nollet M, Capo F, Guillaumond F, et al. Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med. 2015;7:802-18 pubmed publisher
Han J, Kang M, Kim K, Han P, Kim H, Ha J, et al. Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy. J Biol Chem. 2015;290:10325-35 pubmed publisher
Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, et al. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy. 2015;11:166-82 pubmed publisher
Palubinsky A, Stankowski J, Kale A, Codreanu S, Singer R, Liebler D, et al. CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling. Antioxid Redox Signal. 2015;23:535-49 pubmed publisher
Bueno M, Lai Y, Romero Y, Brands J, St Croix C, Kamga C, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015;125:521-38 pubmed publisher
Aerts L, Craessaerts K, De Strooper B, Morais V. PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. J Biol Chem. 2015;290:2798-811 pubmed publisher
Lee S, Zhang C, Liu X. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem. 2015;290:904-17 pubmed publisher
Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed publisher
Rossin F, D Eletto M, Falasca L, Sepe S, Cocco S, Fimia G, et al. Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis. Cell Death Differ. 2015;22:408-18 pubmed publisher
product information
master code :
BC100-494
SKU :
BC100-494
product name :
PINK1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The PINK1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to PINK1. This antibody reacts with human,insect - drosophila,mouse,rabbit,rat. The PINK1 Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,IHC-F,Knockdown,Immunohistochemistry-Paraffin,Knockout Validated,Knockdown Validated,Immunohistochemistry-Frozen,Immunoblotting,Peptide ELISA,Electron Microscopy,SDS-Page.
target :
PINK1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
PINK1 antibody was developed using a synthetic peptide made to the human PINK1 protein sequence (between residues 175-250). [Swiss-Prot Q9BXM7]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Insect - Drosophila,Mouse,Rabbit,Rat
specificity :
Human PINK1 Antibody will be reactive to isoform 2
theoretical molecular weight :
62.7 kDa
gene symbol :
PINK1
Antibody validation :
Biological Validation
accessionNumbers :
Q9BXM7
applications :
Immunohistochemistry,Immunoprecipitation,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,IHC-F,Knockdown,Immunohistochemistry-Paraffin,Knockout Validated,Knockdown Validated,Immunohistochemistry-Frozen,Immunoblotting,Peptide ELISA,Electron Microscopy,SDS-Page
USD :
489 USD
alt names :
Anti-PINK1, BRPK, EC 2.7.11.1, FLJ27236, Mitochondrial, PARK6, Parkinson disease (autosomal recessive) 6, PINK1, PINK1 mouse, PINK1 polyclonal, protein kinase BRPK, PTEN Induced Kinase 1, PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, serine/threonine-protein kinase PINK1, mitochondrial
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.