Novatein Biosciences

ELISA/assay

Human Growth Differentiation Factor 11 GDF11 ELISA Kit

BG-HUM11023

96 Wells

549.00 USD

BG-HUM11023

Human Growth Differentiation Factor 11 GDF11 ELISA Kit

ELISA

96 Wells

549.00 USD

78.12--5000 pg/ml

GDF11 (Growth differentiation factor 11), also known as bone morphogenetic protein 11 (BMP-11), is a member of transforming growth factor beta superfamily (TGFβ). The mature 109 amino acid (aa) GDF11, derived from the full-length 407 aa GDF11 precursor protein, contains a canonical 7cysteine motif of the TGFβ superfamily members. GDF11 plays a key role in regulating embryonic development. This cytokine inhibits the proliferation of olfactory receptor neuron progenitors to regulate the number of olfactory receptor neurons occurring in the olfactory epithelium, and controls the competence of progenitor cells to regulate numbers of retinal ganglionic cells developing in the retina. Other studies in mice suggest that GDF11 is involved in mesodermal formation and neurogenesis during embryonic development. GDF11 knock-out mice show diverse abnormalities including palatal malformation, vertebral defects, elongated trunks with a reduced or absent tail, missing or malformed kidneys, and an increased number of neurons in the olfactory epithelium.

2-8 °C