Nordic BioSite

antibody

MBP

BSH-7697-1

1 ml

550 USD

monoclonal

mouse

nonconjugated

BS188

human, rat

BSH-7697-1

MBP

Antibodies, Primary

mouse

monoclonal

Unconjugated

BS188

1 ml

550 USD

Anti-MBP, mouse monoclonal - Optibodies

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Myelin based protein

TRIS with 0.03% sodium azide, pH7,2

IHC-P

Store at 4℃