E-Cadherin | Nordic BioSite BSH-7516-100 product information

product summary

company name :

Nordic BioSite

product type :

antibody

product name :

E-Cadherin

catalog :

BSH-7516-100

quantity :

100 µl

price :

190 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BS38

reactivity :

human, mouse

application :

immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Nordic BioSite product webpage

product information

Catalog Number :

BSH-7516-100

Product Name :

E-Cadherin

Product Type :

Antibodies, Primary

Host Species :

mouse

Clonality :

monoclonal

Conjugation :

Unconjugated

Clone Name :

BS38

Size :

100 µl

List Price (USD) :

190 USD

Product Description :

Anti-E-Cadherin, mouse monoclonal - Optibodies

Background :

E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

ALTnames :

ECAD, CDH1

Buffer :

TRIS with 0.03% sodium azide, pH7,2

Application Summary :

IHC-P,IHC-Fr

Storage :

Store at 4℃

more info or order :

Nordic BioSite product webpage