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company name :
Nordic BioSite
product type :
antibody
product name :
CK17
catalog :
BSH-7311-1
quantity :
1 ml
price :
550 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BS55
reactivity :
human
application :
immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
product information
Catalog Number :
BSH-7311-1
Product Name :
CK17
Product Type :
Antibodies, Primary
Host Species :
mouse
Clonality :
monoclonal
Conjugation :
Unconjugated
Clone Name :
BS55
Size :
1 ml
List Price (USD) :
550 USD
Product Description :
Anti-CK17, mouse monoclonal - Optibodies
Background :
CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
ALTnames :
KRT17
Buffer :
TRIS with 0.03% sodium azide, pH7,2
Application Summary :
IHC-P,IHC-Fr
Storage :
Store at 4℃
more info or order :
company information
Nordic BioSite
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