HER2 | Nordic BioSite BSH-7182-100 product information

product summary

company name :

Nordic BioSite

product type :

antibody

product name :

HER2

catalog :

BSH-7182-100

quantity :

100 µl

price :

190 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BS24

reactivity :

human

application :

immunohistochemistry - paraffin section

more info or order :

Nordic BioSite product webpage

product information

Catalog Number :

BSH-7182-100

Product Name :

HER2

Product Type :

Antibodies, Primary

Host Species :

mouse

Clonality :

monoclonal

Conjugation :

Unconjugated

Clone Name :

BS24

Size :

100 µl

List Price (USD) :

190 USD

Product Description :

Anti-HER2, mouse monoclonal - Optibodies

Background :

ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized

ALTnames :

HER-2/neu, ERBB2

Buffer :

TRIS with 0.03% sodium azide, pH7,2

Application Summary :

IHC-P

Storage :

Store at 4℃

more info or order :

Nordic BioSite product webpage