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company name :
Nordic BioSite
product type :
antibody
product name :
CD23
catalog :
BSH-3004-1
quantity :
1 ml
price :
550 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BS20
reactivity :
human
application :
immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
product information
Catalog Number :
BSH-3004-1
Product Name :
CD23
Product Type :
Antibodies, Primary
Host Species :
mouse
Clonality :
monoclonal
Conjugation :
Unconjugated
Clone Name :
BS20
Size :
1 ml
List Price (USD) :
550 USD
Product Description :
Anti-CD23, mouse monoclonal - Optibodies
Background :
The human leukocyte differentiation antigen CD23 (FCER2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle zone but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors.
ALTnames :
Fc epsilon RII, FcεRII
Buffer :
TRIS with 0.03% sodium azide, pH7,2
Application Summary :
IHC-P,IHC-Fr
Storage :
Store at 4℃
more info or order :
company information
Nordic BioSite
support-us@nordicbiosite.com
www.nordicbiosite.com