product summary
company name :
Neuromab
product type :
antibody
product name :
Arl13b
catalog :
75-287
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N295B/66
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:2000; fig 5a
Schembs L, Willems A, Hasenpusch Theil K, Cooper J, Whiting K, Burr K, et al. The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling. Cell Rep. 2022;39:110811 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1500; loading ...; fig 6a
Hasenpusch Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, et al. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; human; fig 4c
Barnat M, Capizzi M, Aparicio E, Boluda S, Wennagel D, Kacher R, et al. Huntington's disease alters human neurodevelopment. Science. 2020;369:787-793 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 1a
Sterpka A, Yang J, Strobel M, Zhou Y, Pauplis C, Chen X. Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults. Mol Brain. 2020;13:28 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 6a
Bowie E, Goetz S. TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1a
Uzquiano A, Cifuentes Diaz C, Jabali A, Romero D, Houllier A, Dingli F, et al. Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia. Cell Rep. 2019;28:1596-1611.e10 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 5a
Kleene S, Siroky B, Landero Figueroa J, Dixon B, Pachciarz N, Lu L, et al. The TRPP2-dependent channel of renal primary cilia also requires TRPM3. PLoS ONE. 2019;14:e0214053 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 5l
Nakagawa N, Li J, Yabuno Nakagawa K, Eom T, Cowles M, Mapp T, et al. APC sets the Wnt tone necessary for cerebral cortical progenitor development. Genes Dev. 2017;31:1679-1692 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 6
  • immunocytochemistry; mouse; 1:200; loading ...; fig 4
Hua K, Ferland R. Fixation methods can differentially affect ciliary protein immunolabeling. Cilia. 2017;6:5 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 5c
Badgandi H, Hwang S, Shimada I, Loriot E, Mukhopadhyay S. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J Cell Biol. 2017;216:743-760 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4c
Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 4b
Di Pietro C, Marazziti D, La Sala G, Abbaszadeh Z, Golini E, Matteoni R, et al. Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma. Cell Mol Neurobiol. 2017;37:145-154 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1500; fig s4
Laclef C, Anselme I, Besse L, Catala M, Palmyre A, Baas D, et al. The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor. Hum Mol Genet. 2015;24:4997-5014 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Wainwright E, Svingen T, Ng E, Wicking C, Koopman P. Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice. Dev Biol. 2014;395:342-54 pubmed publisher
Desai P, Stuck M, Lv B, Pazour G. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. J Cell Biol. 2020;219: pubmed publisher
Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, Bièche I, Rusconi F, et al. Tubulin glycylation controls primary cilia length. J Cell Biol. 2017;216:2701-2713 pubmed publisher
Monis W, Faundez V, Pazour G. BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. J Cell Biol. 2017;216:2131-2150 pubmed publisher
Pal K, Hwang S, Somatilaka B, Badgandi H, Jackson P, DeFea K, et al. Smoothened determines ?-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. J Cell Biol. 2016;212:861-75 pubmed publisher
Bhattacharyya S, Rainey M, Arya P, Mohapatra B, Mushtaq I, Dutta S, et al. Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. Sci Rep. 2016;6:20727 pubmed publisher
Stewart K, Gaitan Y, Shafer M, Aoudjit L, Hu D, Sharma R, et al. A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects. PLoS Genet. 2016;12:e1005785 pubmed publisher
Yao P, Petralia R, Ott C, Wang Y, Lippincott Schwartz J, Mattson M. Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation. J Neurosci. 2015;35:16126-41 pubmed publisher
Endicott S, Basu B, Khokha M, Brueckner M. The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry. Development. 2015;142:4068-79 pubmed publisher
Joiner A, Green W, McIntyre J, Allen B, Schwob J, Martens J. Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium. J Neurosci. 2015;35:13761-72 pubmed publisher
Garcia Gonzalo F, Phua S, Roberson E, Garcia G, Abedin M, Schurmans S, et al. Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Dev Cell. 2015;34:400-409 pubmed publisher
Kowal T, Falk M. Primary cilia found on HeLa and other cancer cells. Cell Biol Int. 2015;39:1341-7 pubmed publisher
Omori Y, Chaya T, Yoshida S, Irie S, Tsujii T, Furukawa T. Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control. PLoS ONE. 2015;10:e0128422 pubmed publisher
Yang N, Li L, Eguether T, Sundberg J, Pazour G, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015;142:2194-202 pubmed publisher
Chang R, Petersen J, Niswander L, Liu A. A hypomorphic allele reveals an important role of inturned in mouse skeletal development. Dev Dyn. 2015;244:736-47 pubmed publisher
Banda E, McKinsey A, Germain N, Carter J, Anderson N, Grabel L. Cell polarity and neurogenesis in embryonic stem cell-derived neural rosettes. Stem Cells Dev. 2015;24:1022-33 pubmed publisher
Menzl I, LeBeau L, Pandey R, Hassounah N, Li F, Nagle R, et al. Loss of primary cilia occurs early in breast cancer development. Cilia. 2014;3:7 pubmed publisher
Ruppersburg C, Hartzell H. The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis. Mol Biol Cell. 2014;25:1793-807 pubmed publisher
Tuz K, Bachmann Gagescu R, O Day D, Hua K, Isabella C, Phelps I, et al. Mutations in CSPP1 cause primary cilia abnormalities and Joubert syndrome with or without Jeune asphyxiating thoracic dystrophy. Am J Hum Genet. 2014;94:62-72 pubmed publisher
Hollingsworth T, Gross A. The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death. J Biol Chem. 2013;288:29047-55 pubmed publisher
Hassounah N, Nagle R, Saboda K, Roe D, Dalkin B, McDermott K. Primary cilia are lost in preinvasive and invasive prostate cancer. PLoS ONE. 2013;8:e68521 pubmed publisher
Piotrowska Nitsche K, Caspary T. Live imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog response. Cilia. 2012;1: pubmed publisher
Heydet D, Chen L, Larter C, Inglis C, Silverman M, Farrell G, et al. A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Dev Neurobiol. 2013;73:1-13 pubmed publisher
product information
TargetType :
Rare Disease
Target :
Arl13b
AccessionNum :
Q640N2
Clone :
N295B/66
HumanGeneName :
ARL13B
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N295B_66.pdf
IsoType :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
75-287
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States