product summary
company name :
Neuromab
product type :
antibody
product name :
Pan-Neurofascin (extracellular)
catalog :
75-172
quantity :
100 ug
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A12/18
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 30
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; 1:1000; loading ...; fig 1a
Alpizar S, BAKER A, Gulledge A, Hoppa M. Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment. Front Cell Neurosci. 2019;13:1 pubmed publisher
  • immunocytochemistry; rat; 1:200; fig 1
D Este E, Kamin D, Velte C, Göttfert F, Simons M, Hell S. Subcortical cytoskeleton periodicity throughout the nervous system. Sci Rep. 2016;6:22741 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 1
Norkett R, Modi S, Birsa N, Atkin T, Ivankovic D, Pathania M, et al. DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. J Biol Chem. 2016;291:613-29 pubmed publisher
  • immunocytochemistry; rat; 1:200
Franssen E, Zhao R, Koseki H, Kanamarlapudi V, Hoogenraad C, Eva R, et al. Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS. J Neurosci. 2015;35:8359-75 pubmed publisher
  • immunocytochemistry; rat; 1:500; fig 6
Chand A, Galliano E, Chesters R, Grubb M. A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment. J Neurosci. 2015;35:1573-90 pubmed publisher
Fréal A, Rai D, Tas R, Pan X, Katrukha E, van de Willige D, et al. Feedback-Driven Assembly of the Axon Initial Segment. Neuron. 2019;104:305-321.e8 pubmed publisher
Guardia C, De Pace R, Sen A, Saric A, Jarnik M, Kolin D, et al. Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning. PLoS Biol. 2019;17:e3000279 pubmed publisher
Farías G, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S, et al. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity. Neuron. 2019;102:184-201.e8 pubmed publisher
Schätzle P, Esteves da Silva M, Tas R, Katrukha E, Hu H, Wierenga C, et al. Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Curr Biol. 2018;28:2081-2093.e6 pubmed publisher
Eva R, Koseki H, Kanamarlapudi V, Fawcett J. EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment. J Cell Sci. 2017;130:3663-3675 pubmed publisher
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, et al. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017;216:2059-2074 pubmed publisher
Albrecht D, Winterflood C, Sadeghi M, Tschager T, Noe F, Ewers H. Nanoscopic compartmentalization of membrane protein motion at the axon initial segment. J Cell Biol. 2016;215:37-46 pubmed
Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed publisher
Sidenstein S, D Este E, Böhm M, Danzl J, Belov V, Hell S. Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses. Sci Rep. 2016;6:26725 pubmed publisher
Benned Jensen T, Christensen R, Denti F, Perrier J, Rasmussen H, Olesen S. Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed. J Neurosci. 2016;36:2261-6 pubmed publisher
Evans M, Dumitrescu A, Kruijssen D, Taylor S, Grubb M. Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing. Cell Rep. 2015;13:1233-1245 pubmed publisher
Ganguly A, Tang Y, Wang L, Ladt K, Loi J, Dargent B, et al. A dynamic formin-dependent deep F-actin network in axons. J Cell Biol. 2015;210:401-17 pubmed publisher
Papandréou M, Vacher H, Fache M, Klingler E, Rueda Boroni F, Ferracci G, et al. CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment. J Neurochem. 2015;134:527-37 pubmed publisher
D Este E, Kamin D, Göttfert F, El Hady A, Hell S. STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons. Cell Rep. 2015;10:1246-51 pubmed publisher
Freeman S, Desmazières A, Simonnet J, Gatta M, Pfeiffer F, Aigrot M, et al. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. Proc Natl Acad Sci U S A. 2015;112:E321-8 pubmed publisher
Jain S, Farías G, Bonifacino J. Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1. Mol Biol Cell. 2015;26:218-28 pubmed publisher
Notturno F, Di Febo T, Yuki N, Fernandez Rodriguez B, Corti D, Nobile Orazio E, et al. Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. J Neuroimmunol. 2014;276:207-12 pubmed publisher
Muir J, Kittler J. Plasticity of GABAA receptor diffusion dynamics at the axon initial segment. Front Cell Neurosci. 2014;8:151 pubmed publisher
Lukinavicius G, Reymond L, D Este E, Masharina A, Göttfert F, Ta H, et al. Fluorogenic probes for live-cell imaging of the cytoskeleton. Nat Methods. 2014;11:731-3 pubmed publisher
Jones S, Korobova F, Svitkina T. Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments. J Cell Biol. 2014;205:67-81 pubmed publisher
Yap C, Vakulenko M, Kruczek K, Motamedi B, Digilio L, Liu J, et al. Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding. J Neurosci. 2012;32:7439-53 pubmed publisher
Galiano M, Jha S, Ho T, Zhang C, Ogawa Y, Chang K, et al. A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly. Cell. 2012;149:1125-39 pubmed publisher
Dhaunchak A, Becker C, Schulman H, de Faria O, Rajasekharan S, Banwell B, et al. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol. 2012;71:601-13 pubmed publisher
Dhaunchak A, Huang J, De Faria Junior O, Roth A, Pedraza L, Antel J, et al. A proteome map of axoglial specializations isolated and purified from human central nervous system. Glia. 2010;58:1949-60 pubmed publisher
Hedstrom K, Ogawa Y, Rasband M. AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity. J Cell Biol. 2008;183:635-40 pubmed publisher
product information
TargetType :
CAMs
Target :
Pan-Neurofascin (extracellular)
Clone :
A12/18
HumanGeneName :
----
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/A12_18.pdf
IsoType :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
75-172
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States