product summary
company name :
Neuromab
product type :
antibody
product name :
RGS14
catalog :
75-170
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N133/21
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
citations: 11
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; fig 2c
  • western blot knockout validation; mouse; 1:1000; fig 2
Evans P, Lee S, Smith Y, Hepler J. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain. J Comp Neurol. 2014;522:186-203 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4a
Ramaglia V, Dubey M, Malpede M, Petersen N, de Vries S, Ahmed S, et al. Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory. Acta Neuropathol. 2021;142:643-667 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7k
Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed publisher
Alexander G, Farris S, Pirone J, Zheng C, Colgin L, Dudek S. Social and novel contexts modify hippocampal CA2 representations of space. Nat Commun. 2016;7:10300 pubmed publisher
Llorens Martín M, Jurado Arjona J, Avila J, Hernández F. Novel connection between newborn granule neurons and the hippocampal CA2 field. Exp Neurol. 2015;263:285-92 pubmed publisher
Hitti F, Siegelbaum S. The hippocampal CA2 region is essential for social memory. Nature. 2014;508:88-92 pubmed publisher
Kohara K, Pignatelli M, Rivest A, Jung H, Kitamura T, Suh J, et al. Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits. Nat Neurosci. 2014;17:269-79 pubmed publisher
Piskorowski R, Chevaleyre V. Delta-opioid receptors mediate unique plasticity onto parvalbumin-expressing interneurons in area CA2 of the hippocampus. J Neurosci. 2013;33:14567-78 pubmed publisher
Vellano C, Brown N, Blumer J, Hepler J. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by G?i1 and G?i-linked G protein-coupled receptors. J Biol Chem. 2013;288:3620-31 pubmed publisher
Vellano C, Shu F, Ramineni S, Yates C, Tall G, Hepler J. Activation of the regulator of G protein signaling 14-G?i1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 2011;50:752-62 pubmed publisher
Lee S, Simons S, Heldt S, Zhao M, Schroeder J, Vellano C, et al. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A. 2010;107:16994-8 pubmed publisher
product information
TargetType :
Other
Target :
RGS14
AccessionNum :
O08773
Clone :
N133/21
HumanGeneName :
RGS14
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N133_21.pdf
IsoType :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
75-170
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States