product summary
company name :
Neuromab
product type :
antibody
product name :
Nav1.8 Na+ channel
catalog :
75-166
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N134/12
reactivity :
mouse, rat
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry knockout validation, immunocytochemistry knockout validation
more info or order :
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; 1:500; loading ...; fig e6c
Yang N, Isensee J, Neel D, Quadros A, Zhang H, Lauzadis J, et al. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons. Nat Neurosci. 2022;25:168-179 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Lippoldt E, Elmes R, McCoy D, Knowlton W, McKemy D. Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain. J Neurosci. 2013;33:12543-52 pubmed publisher
Lu V, Ikeda S, Puhl H. A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal. J Neurosci. 2015;35:8021-34 pubmed publisher
Ritter D, Zemel B, Hala T, O Leary M, Lepore A, Covarrubias M. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury. J Neurosci. 2015;35:1260-73 pubmed publisher
Francois A, Schüetter N, Laffray S, Sanguesa J, Pizzoccaro A, Dubel S, et al. The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. Cell Rep. 2015;10:370-382 pubmed publisher
Montersino A, Brachet A, Ferracci G, Fache M, Angles d Ortoli S, Liu W, et al. Tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 constitutively interacts with ankyrin G. J Neurochem. 2014;131:33-41 pubmed publisher
Acosta C, Djouhri L, Watkins R, Berry C, Bromage K, Lawson S. TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain. J Neurosci. 2014;34:1494-509 pubmed publisher
Tsantoulas C, Farmer C, Machado P, Baba K, McMahon S, Raouf R. Probing functional properties of nociceptive axons using a microfluidic culture system. PLoS ONE. 2013;8:e80722 pubmed publisher
Zhao X, Tang Z, Zhang H, Atianjoh F, Zhao J, Liang L, et al. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat Neurosci. 2013;16:1024-31 pubmed publisher
Liang L, Fan L, Tao B, Yaster M, Tao Y. Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. J Pain. 2013;14:638-47 pubmed publisher
Knowlton W, Palkar R, Lippoldt E, McCoy D, Baluch F, Chen J, et al. A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia. J Neurosci. 2013;33:2837-48 pubmed publisher
Cachemaille M, Laedermann C, Pertin M, Abriel H, Gosselin R, Decosterd I. Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain. Neuroscience. 2012;227:370-80 pubmed publisher
Kim Y, Jung H, Kwon T, Kim C, Cho J, Ahn D, et al. Expression of transient receptor potential ankyrin 1 in human dental pulp. J Endod. 2012;38:1087-92 pubmed publisher
Tappe Theodor A, Constantin C, Tegeder I, Lechner S, Langeslag M, Lepcynzsky P, et al. G?(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain. 2012;153:184-96 pubmed publisher
Ruangsri S, Lin A, Mulpuri Y, Lee K, Spigelman I, Nishimura I. Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats. J Biol Chem. 2011;286:39836-47 pubmed publisher
Spofford C, Mohan S, Kang S, Jang J, Brennan T. Evaluation of leukemia inhibitory factor (LIF) in a rat model of postoperative pain. J Pain. 2011;12:819-32 pubmed publisher
Persson A, Black J, Gasser A, Cheng X, Fischer T, Waxman S. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. Mol Pain. 2010;6:84 pubmed publisher
Hoffman E, Schechter R, Miller K. Fixative composition alters distributions of immunoreactivity for glutaminase and two markers of nociceptive neurons, Nav1.8 and TRPV1, in the rat dorsal root ganglion. J Histochem Cytochem. 2010;58:329-44 pubmed publisher
product information
TargetType :
Na+ channels
Target :
Nav1.8 Na+ channel
AccessionNum :
Q62968
Clone :
N134/12
HumanGeneName :
SCN10A
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N134_12.pdf
IsoType :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Fail
ValidationBrIHC :
Fail
ValidationKO :
Pass
Catalog :
75-166
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States