product summary
company name :
Neuromab
product type :
antibody
product name :
Shank2
catalog :
75-088
quantity :
100 ug
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N23B/6
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 7
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  • western blot; rat; 1:50
Farley M, Swulius M, Waxham M. Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities. Neuroscience. 2015;304:286-301 pubmed publisher
  • immunohistochemistry; mouse
Braude J, Vijayakumar S, Baumgarner K, Laurine R, Jones T, Jones S, et al. Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear. Hear Res. 2015;321:52-64 pubmed publisher
Ha H, Leal Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore S, et al. Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Front Mol Neurosci. 2018;11:405 pubmed publisher
MacGillavry H, Kerr J, Kassner J, Frost N, Blanpied T. Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses. Eur J Neurosci. 2016;43:179-93 pubmed publisher
Tao Cheng J, Azzam R, Crocker V, Winters C, Reese T. Depolarization of Hippocampal Neurons Induces Formation of Nonsynaptic NMDA Receptor Islands Resembling Nascent Postsynaptic Densities. Eneuro. 2015;2: pubmed publisher
Peykov S, Berkel S, Schoen M, Weiss K, Degenhardt F, Strohmaier J, et al. Identification and functional characterization of rare SHANK2 variants in schizophrenia. Mol Psychiatry. 2015;20:1489-98 pubmed publisher
Schneider K, Seemann E, Liebmann L, Ahuja R, Koch D, Westermann M, et al. ProSAP1 and membrane nanodomain-associated syndapin I promote postsynapse formation and function. J Cell Biol. 2014;205:197-215 pubmed publisher
Baple E, Maroofian R, Chioza B, Izadi M, Cross H, Al Turki S, et al. Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures. Am J Hum Genet. 2014;94:87-94 pubmed publisher
Han K, Holder J, Schaaf C, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013;503:72-7 pubmed publisher
Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval O, et al. ?2-Adrenergic receptor supports prolonged theta tetanus-induced LTP. J Neurophysiol. 2012;107:2703-12 pubmed publisher
Berkel S, Tang W, TreviƱo M, Vogt M, Obenhaus H, Gass P, et al. Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology. Hum Mol Genet. 2012;21:344-57 pubmed publisher
Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, et al. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem. 2011;286:34839-50 pubmed publisher
Xie M, Rich T, Scheitrum C, Conti M, Richter W. Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP. Mol Pharmacol. 2011;80:281-93 pubmed publisher
Tao Cheng J, Dosemeci A, Gallant P, Smith C, Reese T. Activity induced changes in the distribution of Shanks at hippocampal synapses. Neuroscience. 2010;168:11-7 pubmed publisher
product information
TargetType :
Scaffolds
Target :
Shank2
AccessionNum :
Q9QX74
Clone :
N23B/6
HumanGeneName :
SHANK2
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N23B_6.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
75-088
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States