product summary
company name :
Neuromab
product type :
antibody
product name :
Nav1.6 Na+ channel
catalog :
75-026
quantity :
100 ug
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K87A/10
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section, immunohistochemistry - free floating section, immunocytochemistry knockout validation
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:300; fig 8
Alshammari M, Alshammari T, Laezza F. Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment. Front Cell Neurosci. 2016;10:5 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000
Wimmer V, Harty R, Richards K, Phillips A, Miyazaki H, Nukina N, et al. Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain. J Comp Neurol. 2015;523:814-30 pubmed publisher
  • western blot; mouse; fig 2
Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
  • immunohistochemistry - free floating section; rat; 10 ug/ml
King A, Manning C, Trimmer J. A unique ion channel clustering domain on the axon initial segment of mammalian neurons. J Comp Neurol. 2014;522:2594-608 pubmed publisher
Lujan R, Aguado C, Ciruela F, Arus X, Martín Belmonte A, Alfaro Ruiz R, et al. SK2 Channels Associate With mGlu1α Receptors and CaV2.1 Channels in Purkinje Cells. Front Cell Neurosci. 2018;12:311 pubmed publisher
Zhou L, Zhou L, Su L, Cao S, Xie Y, Wang N, et al. Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. J Neurosci. 2018;38:3346-3357 pubmed publisher
Jones J, Dionne L, Dell Orco J, Parent R, Krueger J, Cheng X, et al. Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder. Neurobiol Dis. 2016;89:36-45 pubmed publisher
Barbosa C, Tan Z, Wang R, Xie W, Strong J, Patel R, et al. Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons. Mol Pain. 2015;11:60 pubmed publisher
Brügger V, Engler S, Pereira J, Ruff S, Horn M, Welzl H, et al. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins. PLoS Biol. 2015;13:e1002258 pubmed publisher
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher
Baalman K, Marin M, Ho T, Godoy M, Cherian L, Robertson C, et al. Axon initial segment-associated microglia. J Neurosci. 2015;35:2283-92 pubmed publisher
Xiao M, Bosch M, Nerbonne J, Ornitz D. FGF14 localization and organization of the axon initial segment. Mol Cell Neurosci. 2013;56:393-403 pubmed publisher
Ruff C, Ye H, Legasto J, Stribbell N, Wang J, Zhang L, et al. Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance. J Neurosci. 2013;33:11899-915 pubmed publisher
Sun W, Wagnon J, Mahaffey C, Briese M, Ule J, Frankel W. Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice. J Physiol. 2013;591:241-55 pubmed publisher
Baalman K, Cotton R, Rasband S, Rasband M. Blast wave exposure impairs memory and decreases axon initial segment length. J Neurotrauma. 2013;30:741-51 pubmed publisher
Devaux J. Antibodies to gliomedin cause peripheral demyelinating neuropathy and the dismantling of the nodes of Ranvier. Am J Pathol. 2012;181:1402-13 pubmed publisher
Buttermore E, Piochon C, Wallace M, Philpot B, Hansel C, Bhat M. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci. 2012;32:4724-42 pubmed publisher
Duflocq A, Chareyre F, Giovannini M, Couraud F, Davenne M. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B. BMC Biol. 2011;9:66 pubmed publisher
Meehan C, MacDermid V, Montague S, Neuber Hess M, Rose P. Dendrite-derived supernumerary axons on adult axotomized motor neurons possess proteins that are essential for the initiation and propagation of action potentials and synaptic vesicle release. J Neurosci. 2011;31:6732-40 pubmed publisher
BINDER E, Rukavina M, Hassani H, Weber M, Nakatani H, Reiff T, et al. Peripheral nervous system progenitors can be reprogrammed to produce myelinating oligodendrocytes and repair brain lesions. J Neurosci. 2011;31:6379-91 pubmed publisher
Shepherd M, Pomicter A, Velazco C, Henderson S, Dupree J. Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system. Neurobiol Aging. 2012;33:203.e13-24 pubmed publisher
Tong M, Hernandez J, Purcell E, Altschuler R, Duncan R. The intrinsic electrophysiological properties of neurons derived from mouse embryonic stem cells overexpressing neurogenin-1. Am J Physiol Cell Physiol. 2010;299:C1335-44 pubmed publisher
Crawford D, Mangiardi M, Song B, Patel R, Du S, Sofroniew M, et al. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010;133:2999-3016 pubmed publisher
Howell O, Rundle J, Garg A, Komada M, Brophy P, Reynolds R. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. J Neuropathol Exp Neurol. 2010;69:1017-1033 pubmed publisher
Wimmer V, Reid C, Mitchell S, Richards K, Scaf B, Leaw B, et al. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Invest. 2010;120:2661-71 pubmed publisher
Lorincz A, Nusser Z. Molecular identity of dendritic voltage-gated sodium channels. Science. 2010;328:906-9 pubmed publisher
Wimmer V, Reid C, So E, Berkovic S, Petrou S. Axon initial segment dysfunction in epilepsy. J Physiol. 2010;588:1829-40 pubmed publisher
Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, et al. Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy. Brain. 2010;133:1403-14 pubmed publisher
Osorio N, Cathala L, Meisler M, Crest M, Magistretti J, Delmas P. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. J Physiol. 2010;588:651-70 pubmed publisher
Brackenbury W, Calhoun J, Chen C, Miyazaki H, Nukina N, Oyama F, et al. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A. 2010;107:2283-8 pubmed publisher
Crawford D, Mangiardi M, Xia X, López Valdés H, Tiwari Woodruff S. Functional recovery of callosal axons following demyelination: a critical window. Neuroscience. 2009;164:1407-21 pubmed publisher
Sharkey L, Cheng X, Drews V, Buchner D, Jones J, Justice M, et al. The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking. J Neurosci. 2009;29:2733-41 pubmed publisher
Lorincz A, Nusser Z. Cell-type-dependent molecular composition of the axon initial segment. J Neurosci. 2008;28:14329-40 pubmed publisher
O Malley H, Shreiner A, Chen G, Huffnagle G, Isom L. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci. 2009;40:143-55 pubmed publisher
Shakkottai V, Xiao M, Xu L, Wong M, Nerbonne J, Ornitz D, et al. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiol Dis. 2009;33:81-8 pubmed publisher
Mojumder D, Wensel T, Frishman L. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. Mol Vis. 2008;14:1600-13 pubmed
Duflocq A, Le Bras B, Bullier E, Couraud F, Davenne M. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Mol Cell Neurosci. 2008;39:180-92 pubmed publisher
Windrem M, Schanz S, Guo M, Tian G, Washco V, Stanwood N, et al. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell. 2008;2:553-65 pubmed publisher
Mojumder D, Frishman L, Otteson D, Sherry D. Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina. Mol Vis. 2007;13:2163-82 pubmed
Lopez Santiago L, Meadows L, Ernst S, Chen C, Malhotra J, McEwen D, et al. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 2007;43:636-47 pubmed
Lopez Santiago L, Pertin M, Morisod X, Chen C, Hong S, Wiley J, et al. Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci. 2006;26:7984-94 pubmed
Rush A, Wittmack E, Tyrrell L, Black J, Dib Hajj S, Waxman S. Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily. Eur J Neurosci. 2006;23:2551-62 pubmed
product information
TargetType :
Na+ channels
Target :
Nav1.6 Na+ channel
AccessionNum :
NP_062139
Clone :
K87A/10
HumanGeneName :
SCN8A
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K87A_10.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Fail
ValidationBrIHC :
Pass
ValidationKO :
Pass
Catalog :
75-026
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States