product summary
company name :
Neuromab
product type :
antibody
product name :
Nav1.1 Na+ channel
catalog :
75-023
quantity :
100 ug
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K74/71
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:500; fig 8
Alshammari M, Alshammari T, Laezza F. Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment. Front Cell Neurosci. 2016;10:5 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Bosch M, Nerbonne J, Townsend R, Miyazaki H, Nukina N, Ornitz D, et al. Proteomic analysis of native cerebellar iFGF14 complexes. Channels (Austin). 2016;10:297-312 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Wimmer V, Harty R, Richards K, Phillips A, Miyazaki H, Nukina N, et al. Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain. J Comp Neurol. 2015;523:814-30 pubmed publisher
Zhou L, Zhou L, Su L, Cao S, Xie Y, Wang N, et al. Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. J Neurosci. 2018;38:3346-3357 pubmed publisher
Kim K, Rutherford M. Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function. J Neurosci. 2016;36:2111-8 pubmed publisher
Freeman S, Desmazières A, Simonnet J, Gatta M, Pfeiffer F, Aigrot M, et al. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. Proc Natl Acad Sci U S A. 2015;112:E321-8 pubmed publisher
Tian C, Wang K, Ke W, Guo H, Shu Y. Molecular identity of axonal sodium channels in human cortical pyramidal cells. Front Cell Neurosci. 2014;8:297 pubmed publisher
Li T, Tian C, Scalmani P, Frassoni C, Mantegazza M, Wang Y, et al. Action potential initiation in neocortical inhibitory interneurons. PLoS Biol. 2014;12:e1001944 pubmed publisher
Puthussery T, Venkataramani S, Gayet Primo J, Smith R, Taylor W. NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina. J Neurosci. 2013;33:16045-59 pubmed publisher
Vega A, Avila G, Matthews G. Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression. Sci Rep. 2013;3:2809 pubmed publisher
Xiao M, Bosch M, Nerbonne J, Ornitz D. FGF14 localization and organization of the axon initial segment. Mol Cell Neurosci. 2013;56:393-403 pubmed publisher
Papale L, Makinson C, Christopher Ehlen J, Tufik S, Decker M, Paul K, et al. Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+). Epilepsia. 2013;54:625-34 pubmed publisher
Kaphzan H, Buffington S, Jung J, Rasband M, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011;31:17637-48 pubmed publisher
Wu C, Ivanova E, Cui J, Lu Q, Pan Z. Action potential generation at an axon initial segment-like process in the axonless retinal AII amacrine cell. J Neurosci. 2011;31:14654-9 pubmed publisher
Lysakowski A, Gaboyard Niay S, Calin Jageman I, Chatlani S, Price S, Eatock R. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011;31:10101-14 pubmed publisher
Wykes R, Kalmbach A, Eliava M, Waters J. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. Neurobiol Aging. 2012;33:1609-23 pubmed publisher
Ahn H, Black J, Zhao P, Tyrrell L, Waxman S, Dib Hajj S. Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons. Mol Pain. 2011;7:32 pubmed publisher
Kim D, Gersbacher M, Inquimbert P, Kovacs D. Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2011;286:8106-16 pubmed publisher
Persson A, Black J, Gasser A, Cheng X, Fischer T, Waxman S. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. Mol Pain. 2010;6:84 pubmed publisher
Wimmer V, Reid C, Mitchell S, Richards K, Scaf B, Leaw B, et al. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Invest. 2010;120:2661-71 pubmed publisher
Lorincz A, Nusser Z. Molecular identity of dendritic voltage-gated sodium channels. Science. 2010;328:906-9 pubmed publisher
Wimmer V, Reid C, So E, Berkovic S, Petrou S. Axon initial segment dysfunction in epilepsy. J Physiol. 2010;588:1829-40 pubmed publisher
Black J, Newcombe J, Waxman S. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5. Brain. 2010;133:835-46 pubmed publisher
Brackenbury W, Calhoun J, Chen C, Miyazaki H, Nukina N, Oyama F, et al. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A. 2010;107:2283-8 pubmed publisher
von Reyn C, Spaethling J, Mesfin M, Ma M, Neumar R, Smith D, et al. Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit. J Neurosci. 2009;29:10350-6 pubmed publisher
Tobin A, Joseph B, Al Kindi H, Albarwani S, Madden J, Nemetz L, et al. Loss of cerebrovascular Shaker-type K(+) channels: a shared vasodilator defect of genetic and renal hypertensive rats. Am J Physiol Heart Circ Physiol. 2009;297:H293-303 pubmed publisher
Lorincz A, Nusser Z. Cell-type-dependent molecular composition of the axon initial segment. J Neurosci. 2008;28:14329-40 pubmed publisher
O Malley H, Shreiner A, Chen G, Huffnagle G, Isom L. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci. 2009;40:143-55 pubmed publisher
Mojumder D, Wensel T, Frishman L. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. Mol Vis. 2008;14:1600-13 pubmed
Duflocq A, Le Bras B, Bullier E, Couraud F, Davenne M. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Mol Cell Neurosci. 2008;39:180-92 pubmed publisher
Vega A, Henry D, Matthews G. Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a. Neurosci Lett. 2008;442:69-73 pubmed publisher
Zhao P, Barr T, Hou Q, Dib Hajj S, Black J, Albrecht P, et al. Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. Pain. 2008;139:90-105 pubmed publisher
Mojumder D, Frishman L, Otteson D, Sherry D. Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina. Mol Vis. 2007;13:2163-82 pubmed
Lopez Santiago L, Meadows L, Ernst S, Chen C, Malhotra J, McEwen D, et al. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 2007;43:636-47 pubmed
Van Wart A, Trimmer J, Matthews G. Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol. 2007;500:339-52 pubmed
product information
TargetType :
Na+ channels
Target :
Nav1.1 Na+ channel
AccessionNum :
P04774
Clone :
K74/71
HumanGeneName :
SCN1A
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/K74_71.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
75-023
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States