product summary
company name :
Neuromab
product type :
antibody
product name :
KCC2
catalog :
75-013
quantity :
100 ug
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N1/12
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 12
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3a
Chen M, Wang J, Jiang J, Zheng X, Justice N, Wang K, et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. elife. 2017;6: pubmed publisher
Campbell S, Robel S, Cuddapah V, Robert S, Buckingham S, Kahle K, et al. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia. 2015;63:23-36 pubmed publisher
Markkanen M, Karhunen T, Llano O, Ludwig A, Rivera C, Uvarov P, et al. Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. J Comp Neurol. 2014;522:1897-914 pubmed publisher
He Q, Nomura T, Xu J, Contractor A. The developmental switch in GABA polarity is delayed in fragile X mice. J Neurosci. 2014;34:446-50 pubmed publisher
Gagnon M, Bergeron M, Lavertu G, Castonguay A, Tripathy S, Bonin R, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013;19:1524-8 pubmed publisher
Sun Y, Wu C, Renger J, Uebele V, Lu H, Beierlein M. GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons. J Neurosci. 2012;32:7782-90 pubmed publisher
Liu Q, Wong Riley M. Postnatal development of Na(+)-K(+)-2Cl(-) co-transporter 1 and K(+)-Cl(-) co-transporter 2 immunoreactivity in multiple brain stem respiratory nuclei of the rat. Neuroscience. 2012;210:1-20 pubmed publisher
Döding A, Hartmann A, Beyer T, Nothwang H. KCC2 transport activity requires the highly conserved L??? in the C-terminal ?1 strand. Biochem Biophys Res Commun. 2012;420:492-7 pubmed publisher
Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E. Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci. 2010;31:2142-55 pubmed publisher
Bragin D, Sanderson J, Peterson S, Connor J, Müller W. Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus. Eur J Neurosci. 2009;30:611-24 pubmed publisher
Hedstrom K, Ogawa Y, Rasband M. AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity. J Cell Biol. 2008;183:635-40 pubmed publisher
Lee H, Walker J, Williams J, Goodier R, Payne J, Moss S. Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. J Biol Chem. 2007;282:29777-84 pubmed
product information
TargetType :
Transporters
Target :
KCC2
AccessionNum :
NP_599190
Clone :
N1/12
HumanGeneName :
SLC12A5
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N1_12.pdf
IsoType :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
75-013
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States