product summary
company name :
Neuromab
product type :
antibody
product name :
Kv1.3 K+ channel
catalog :
75-009
quantity :
100 ug
price :
269 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
L23/27
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig s7
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1b
Jiménez Pérez L, Cidad P, Álvarez Miguel I, Santos Hipólito A, Torres Merino R, Alonso E, et al. Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation. J Biol Chem. 2016;291:3569-80 pubmed publisher
Xu L, Schaefer M, Linville R, Aggarwal A, Mbuguiro W, Wester B, et al. Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding. Exp Neurol. 2016;277:268-274 pubmed publisher
Martínez Mármol R, Comes N, Styrczewska K, Pérez Verdaguer M, Vicente R, Pujadas L, et al. Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis. Cell Mol Life Sci. 2016;73:1515-28 pubmed publisher
Cidad P, Novensa L, Garabito M, Batlle M, Dantas A, Heras M, et al. K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation. Cardiovasc Drugs Ther. 2014;28:501-11 pubmed publisher
Kundu Raychaudhuri S, Chen Y, Wulff H, Raychaudhuri S. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model. J Autoimmun. 2014;55:63-72 pubmed publisher
Dufour M, Woodhouse A, Goaillard J. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. J Neurosci Res. 2014;92:981-99 pubmed publisher
Peng Y, Lu K, Li Z, Zhao Y, Wang Y, Hu B, et al. Blockade of Kv1.3 channels ameliorates radiation-induced brain injury. Neuro Oncol. 2014;16:528-39 pubmed publisher
Hamilton D, Beall C, Jeromson S, Chevtzoff C, Cuthbertson D, Ashford M. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci. 2014;64:13-20 pubmed publisher
Duque A, Gazula V, Kaczmarek L. Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Dev Neurobiol. 2013;73:841-55 pubmed publisher
Ovsepian S, Steuber V, Le Berre M, O Hara L, O Leary V, Dolly J. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. J Physiol. 2013;591:1771-91 pubmed publisher
Nguyen H, Miyazaki H, Hoshi N, Smith B, Nukina N, Goldin A, et al. Modulation of voltage-gated K+ channels by the sodium channel ?1 subunit. Proc Natl Acad Sci U S A. 2012;109:18577-82 pubmed publisher
Yamada J, Jinno S. Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis. J Comp Neurol. 2013;521:1184-201 pubmed publisher
Zhu J, Yan J, Thornhill W. N-glycosylation promotes the cell surface expression of Kv1.3 potassium channels. FEBS J. 2012;279:2632-44 pubmed publisher
He S, Shao L, Rittase W, Bausch S. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology. 2012;37:1338-56 pubmed publisher
Roepke T, Kanda V, Purtell K, King E, Lerner D, Abbott G. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011;25:4264-73 pubmed publisher
Straub S, Perez S, Tan B, Coughlan K, Trebino C, Cosgrove P, et al. Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues. Am J Physiol Endocrinol Metab. 2011;301:E380-90 pubmed publisher
Ramirez Navarro A, Glazebrook P, Kane Sutton M, Padro C, Kline D, Kunze D. Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract. J Neurophysiol. 2011;105:2772-80 pubmed publisher
Fulton S, Thibault D, Mendez J, Lahaie N, Tirotta E, Borrelli E, et al. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. J Biol Chem. 2011;286:9360-72 pubmed publisher
Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, et al. Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol. 2010;299:F1258-69 pubmed publisher
Gazula V, Strumbos J, Mei X, Chen H, Rahner C, Kaczmarek L. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. J Comp Neurol. 2010;518:3205-20 pubmed publisher
Wang T, Lee M, Johnson T, Allie R, Hu L, Calabresi P, et al. Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers. J Neurosci. 2010;30:5020-7 pubmed publisher
Cidad P, Moreno Domínguez A, Novensa L, Roque M, Barquín L, Heras M, et al. Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010;30:1203-11 pubmed publisher
Miller M, Okaty B, Nelson S. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits. J Neurosci. 2008;28:13716-26 pubmed publisher
Doczi M, Morielli A, Damon D. Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation. Am J Physiol Regul Integr Comp Physiol. 2008;295:R733-40 pubmed publisher
product information
TargetType :
K+ channels
Target :
Kv1.3 K+ channel
AccessionNum :
P15384
Clone :
L23/27
HumanGeneName :
KCNA3
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/L23_27.pdf
IsoType :
IgG1
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
ND
Catalog :
75-009
more info or order :
company information
Neuromab
PO Box 1560 Davis, CA 95617-1560
http://neuromab.ucdavis.edu
headquarters: United States